Institute of Physiology of the Czech Academy of  Sciences, Prague (www.fgu.cas.cz/en) announces a call for applications for a post-doc position at the Department of Mitochondrial Physiology.

The skillful applicant of any background, from molecular biology, CRISP/CAS9 technology, medical or biophysical background, will join our team for basic research on MOLECULAR MECHANISMS OF INSULIN SECRETION. Applicants should be no more than two years after their PhD defense (exempts for non-citizens of Czech Republic possible), while maternal leave period is not considered for the timing. The position will be available for 3 years.

Program Title: Postdoctoral position available in Department of Mitochondrial Physiology, Institute Physiology, CAS, Prague

Applicants should send by e-mail to fgu@fgu.cas.cz  their application intent containing structured curriculum vitae,  photocopies of educational attainment,  and two letters of recommendation from two scientists. After the commissioned approval, the contract will be signed for three years, with approximate salary of 1500 EUR/monthly (paid in Czech crowns) with possible surplus due to the candidate skills. The contract will obey the applicable Czech law.

The research subject will include studies of proteins essential for redox regulations during glucose-stimulated insulin secretion (GSIS), determination of their contribution to the type 2 diabetic etiology when impaired. Molecular biology studies will be performed with insulinoma INS1E cells or beta cells sorted from the accutase-digested Langerhans islets. Diabetology studies will include glucose-tolerance tests, tests of various secretagogues or GSIS potentiation by GLP-1. Beta-cell-specific transcription factors will be also studied. The role of mitochondria-morphology-shaping proteins will be elucidated. Overall, we'll determine which proteins are essential for redox regulations during GSIS and relate new findings to the possible development of glucotoxicity- and lipotoxicity- related oxidative stress initiating type-2 diabetes.        

The applicant will join a relatively young team of altogether 9 scientists, 2 postdocs, 3 PhD students and 3 technicians established in the Institute of Physiology, ASCR, and extending a new laboratory space in the EU supported BIOCEV institute, having access to all advanced facilities of BIOCEV. Mice breading, constructions of new knockouts or knockins will be done in cooperation with The Czech Centre for Phenogenomics (CCP) of the BIOCEV in Vestec u Prahy.

Application deadline is two months from the date of publication of the advertisement.