Ischemic heart disease is the main cause of mortality worldwide. We study cardiac tolerance to injury caused by acute oxygen deprivation from the molecular level to the whole organism using animal models. Our research is focused mainly on the study of mechanisms that underlie:
- high cardiac tolerance to injury early ontogeny,
- increased cardiac tolerance induced by adaptation to chronic hypoxia and regular exercise training,
- permanent consequences of early developmental interventions for cardiac tolerance in adulthood,
- and altered cardiac tolerance associated with various pathological states.
Projects
The immature heart is highly tolerant to ischemic injury, but chronic oxygen deficit during early ontogeny may have negative consequences that persist till adulthood. We study mechanisms responsible for developmental changes of cardiac ischemic tolerance.
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Systemic hypertension is a major risk factor of ischemic heart disease. However, it can also stimulate mechanisms that protect the heart against acute oxygen deprivation. We study the effects of various forms of hypertension on cardiac ischemic tolerance.
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Prolonged exposure to hypoxic environment leads to adaptation which is associated with improved cardiac tolerance to acute oxygen deprivation. We study molecular mechanisms underlying the cardioprotective effects of chronic hypoxia on various manifestations of ischemic injury.
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Publications
Wang, M. - Sips, P. - Khin, E. - Rotival, M. - Sun, X. - Ahmed, R. - Widjaja, A. A. - Schafer, S. - Yusoff, P. - Choksi, P. K. - Ko, N. S. J. - Singh, M. K. - Epstein, D. - Guan, Y. - Houštěk, Josef - Mráček, Tomáš - Nůsková, Hana - Mikell, B. - Tan, J. - Pesce, F. - Kolář, František - Bottolo, L. - Mancini, M. - Hubner, N. - Pravenec, Michal - Petretto, E. - MacRae, C. - Cook, S. A.
Wars2 is a determinant of angiogenesis
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Nature Communications. 2016, roč. 7, Jul, p. 12061
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IF = 11.329
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doi
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Slámová, Kristýna - Papoušek, František - Janovská, Petra - Kopecký, Jan - Kolář, František
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Adverse Effects of AMP-Activated Protein Kinase alpha 2-Subunit Deletion and High-Fat Diet on Heart Function and Ischemic Tolerance in Aged Female Mice
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Physiological Research. 2016, roč. 65, 1, p. 33-42
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IF = 1.618
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Sedmera, David - Neckář, Jan - Beneš Jr., Jiří - Pospíšilová, J. - Petrák, J. - Sedláček, K. - Melenovský, V.
Changes in Myocardial Composition and Conduction Properties in Rat Heart Failure Model Induced by Chronic Volume Overload
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Frontiers in physiology. 2016, roč. 7, Aug 25, p. 367
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IF = 4.031
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doi
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Ravingerová, T. - Farkasová, V. - Griecsová, L. - Čarnická, S. - Murariková, M. - Barlaka, E. - Kolář, František - Barteková, M. - Lonek, L. - Slezák, J. - Lazou, A.
Remote Preconditioning as a Novel "Conditioning" Approach to Repair the Broken Heart: Potential Mechanisms and Clinical Applications
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Physiological Research. 2016, roč. 65, Suppl.1, S55-S64
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IF = 1.618
[ASEP]
Milerová, Marie - Drahota, Zdeněk - Chytilová, Anna - Tauchmannová, Kateřina - Houštěk, Josef - Ošťádal, Bohuslav
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Sex difference in the sensitivity of cardiac mitochondrial permeability transition pore to calcium load
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Molecular and Cellular Biochemistry. 2016, roč. 412, 1-2, p. 147-154
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IF = 2.613
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doi
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Jíchová, Š. - Kopkan, L. - Husková, Z. - Doleželová, Š. - Neckář, Jan - Kujal, P. - Vernerová, Z. - Kramer, H. J. - Sadowski, J. - Kompanowska - Jezierska, E. - Reddy, N. R. - Falck, J. R. - Imig, J. D. - Červenka, L.
Epoxyeicosatrienoic acid analog attenuates the development of malignant hypertension, but does not reverse it once established: a study in Cyp1a1-Ren-2 transgenic rats
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Journal of Hypertension. 2016, roč. 34, 10, p. 2008-2025
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IF = 5.062
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doi
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Hahnová, K. - Kašparová, D. - Žurmanová, J. - Neckář, Jan - Kolář, František - Novotný, J.
Beta-Adrenergic signaling in rat heart is similarly affected by continuous and intermittent normobaric hypoxia
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General Physiology and Biophysics. 2016, roč. 35, 2, p. 165-173
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IF = 0.892
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doi
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Alánová, Petra - Husková, Z. - Kopkan, L. - Sporková, A. - Jíchová, Š. - Neckář, Jan - Imig, J. D. - Klevstig, Martina - Kolář, František - Reddy, N. R. - Falck, J. R. - Sadowski, J. - Nishiyama, A. - Kramer, H. J. - Melenovský, V. - Červenková, L. - Kujal, P. - Vernerová, Z. - Červenka, L.
Orally active epoxyeicosatrienoic acid analog does not exhibit antihypertensive and reno- or cardioprotective actions in two-kidney, one-clip Goldblatt hypertensive rats
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Vascular Pharmacology. 2015, Vol. 73, -, p. 45-56
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IF = 2.5
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doi
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Doul, J. - Charvátová, Z. - Ošťádalová, Ivana - Kohutiar, M. - Maxová, H. - Ošťádal, Bohuslav
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Neonatal rat hearts cannot be protected by ischemic postconditioning
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Physiological Research. 2015, Vol. 64, 6, p. 789-794
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IF = 1.618
[ASEP]
Alánová, Petra - Kolář, František - Ošťádal, Bohuslav - Neckář, Jan
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Role of NO/cGMP signaling pathway in cardiac ischemic tolerance of chronically hypoxic rats
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Physiological Research. 2015, Vol. 64, 5, p. 783-787
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IF = 1.618
[ASEP]
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