The biophysical events responsible for electrical and mechanical activity of cardiac cells under physiological and pathophysiological conditions are investigated. The program includes the exploration of specific conditions underlying development of irregular excitations in cardiac cells (the cause of cardiac arrhythmias) and exploration of possibilities of pharmacological interventions with therapeutic effects. The principal method of this research is computational modelling using mathematical models of cardiac cells formulated on the basis of experimental data obtained from electrophysiological experiments in laboratories of our and foreign collaborating institutions.

Collaboration:

Structural scheme of the mathematical model of a rat cardiac cell.
From Pásek et al.: Eur. Biophys. J., 2012, Vol. 41, p. 491-503.
 

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