Ischemická choroba srdeční je hlavní příčinou úmrtí v celosvětovém měřítku. Studujeme odolnost srdečního svalu k poškození akutním nedostatkem kyslíku na úrovních od molekuly až k celému organismu s využitím zvířecích modelů. K hlavním směrům našeho výzkumu patří studium mechanismů, které jsou zodpovědné za:
- vysokou odolnost srdce k poškození v časných fázích ontogenetického vývoje,
- zvýšenou odolnost srdce vyvolanou adaptací na chronickou hypoxii a pravidelnou fyzickou zátěž,
- trvalé důsledky časných vývojových intervencí pro odolnost srdce v dospělosti s důrazem na pohlavní rozdíly
- a změny odolnosti srdce vyvolané různými patologickými stavy.
Aktuální projekty
Nezralé srdce je mnohem odolnější k ischemickému poškození než srdce dospělé, ale chronický nedostatek kyslíku v časných fázích ontogeneze může mít trvalé negativní následky. Zabýváme se proto mechanismy, které jsou zodpovědné za změny ischemické odolnosti srdce během vývoje.
Více
Systémová hypertenze je významným rizikovým faktorem ischemické choroby srdeční, může však paradoxně stimulovat protektivní mechanismy. Zabýváme se proto vlivem různých forem hypertenze na odolnost srdce k projevům ischemického poškození.
Více
Dlouhodobé vystavení organismu prostředí s nízkým obsahem kyslíku vede k adaptaci, která má pozitivní dopad na odolnost srdce k poškození vyvolanému akutní ischemií. Studujeme proto molekulární mechanismy, které jsou zodpovědné za kardioprotektivní účinky chronické hypoxie.
Více
Publikace
Wang, M. - Sips, P. - Khin, E. - Rotival, M. - Sun, X. - Ahmed, R. - Widjaja, A. A. - Schafer, S. - Yusoff, P. - Choksi, P. K. - Ko, N. S. J. - Singh, M. K. - Epstein, D. - Guan, Y. - Houštěk, Josef - Mráček, Tomáš - Nůsková, Hana - Mikell, B. - Tan, J. - Pesce, F. - Kolář, František - Bottolo, L. - Mancini, M. - Hubner, N. - Pravenec, Michal - Petretto, E. - MacRae, C. - Cook, S. A.
Wars2 is a determinant of angiogenesis
.
Nature Communications. 2016, roč. 7, Jul, p. 12061
.
IF = 11.329
[ASEP]
[
doi
]
Wang, M. - Sips, P. - Khin, E. - Rotival, M. - Sun, X. - Ahmed, R. - Widjaja, A. A. - Schafer, S. - Yusoff, P. - Choksi, P. K. - Ko, N. S. J. - Singh, M. K. - Epstein, D. - Guan, Y. - Houštěk, Josef - Mráček, Tomáš - Nůsková, Hana - Mikell, B. - Tan, J. - Pesce, F. - Kolář, František - Bottolo, L. - Mancini, M. - Hubner, N. - Pravenec, Michal - Petretto, E. - MacRae, C. - Cook, S. A.
Wars2 is a determinant of angiogenesis
.
Nature Communications. 2016, roč. 7, Jul, p. 12061
.
IF = 11.329
[ASEP]
[
doi
]
Slámová, Kristýna - Papoušek, František - Janovská, Petra - Kopecký, Jan - Kolář, František
.
Adverse Effects of AMP-Activated Protein Kinase alpha 2-Subunit Deletion and High-Fat Diet on Heart Function and Ischemic Tolerance in Aged Female Mice
.
Physiological Research. 2016, roč. 65, 1, p. 33-42
.
IF = 1.618
[ASEP]
Sedmera, David - Neckář, Jan - Beneš Jr., Jiří - Pospíšilová, J. - Petrák, J. - Sedláček, K. - Melenovský, V.
Changes in Myocardial Composition and Conduction Properties in Rat Heart Failure Model Induced by Chronic Volume Overload
.
Frontiers in physiology. 2016, roč. 7, Aug 25, p. 367
.
IF = 4.031
[ASEP]
[
doi
]
Ravingerová, T. - Farkasová, V. - Griecsová, L. - Čarnická, S. - Murariková, M. - Barlaka, E. - Kolář, František - Barteková, M. - Lonek, L. - Slezák, J. - Lazou, A.
Remote Preconditioning as a Novel "Conditioning" Approach to Repair the Broken Heart: Potential Mechanisms and Clinical Applications
.
Physiological Research. 2016, roč. 65, Suppl.1, S55-S64
.
IF = 1.618
[ASEP]
Milerová, Marie - Drahota, Zdeněk - Chytilová, Anna - Tauchmannová, Kateřina - Houštěk, Josef - Ošťádal, Bohuslav
.
Sex difference in the sensitivity of cardiac mitochondrial permeability transition pore to calcium load
.
Molecular and Cellular Biochemistry. 2016, roč. 412, 1-2, p. 147-154
.
IF = 2.613
[ASEP]
[
doi
]
Jíchová, Š. - Kopkan, L. - Husková, Z. - Doleželová, Š. - Neckář, Jan - Kujal, P. - Vernerová, Z. - Kramer, H. J. - Sadowski, J. - Kompanowska - Jezierska, E. - Reddy, N. R. - Falck, J. R. - Imig, J. D. - Červenka, L.
Epoxyeicosatrienoic acid analog attenuates the development of malignant hypertension, but does not reverse it once established: a study in Cyp1a1-Ren-2 transgenic rats
.
Journal of Hypertension. 2016, roč. 34, 10, p. 2008-2025
.
IF = 5.062
[ASEP]
[
doi
]
Hahnová, K. - Kašparová, D. - Žurmanová, J. - Neckář, Jan - Kolář, František - Novotný, J.
Beta-Adrenergic signaling in rat heart is similarly affected by continuous and intermittent normobaric hypoxia
.
General Physiology and Biophysics. 2016, roč. 35, 2, p. 165-173
.
IF = 0.892
[ASEP]
[
doi
]
Alánová, Petra - Husková, Z. - Kopkan, L. - Sporková, A. - Jíchová, Š. - Neckář, Jan - Imig, J. D. - Klevstig, Martina - Kolář, František - Reddy, N. R. - Falck, J. R. - Sadowski, J. - Nishiyama, A. - Kramer, H. J. - Melenovský, V. - Červenková, L. - Kujal, P. - Vernerová, Z. - Červenka, L.
Orally active epoxyeicosatrienoic acid analog does not exhibit antihypertensive and reno- or cardioprotective actions in two-kidney, one-clip Goldblatt hypertensive rats
.
Vascular Pharmacology. 2015, Vol. 73, -, p. 45-56
.
IF = 2.5
[ASEP]
[
doi
]
Doul, J. - Charvátová, Z. - Ošťádalová, Ivana - Kohutiar, M. - Maxová, H. - Ošťádal, Bohuslav
.
Neonatal rat hearts cannot be protected by ischemic postconditioning
.
Physiological Research. 2015, Vol. 64, 6, p. 789-794
.
IF = 1.618
[ASEP]
Alánová, Petra - Kolář, František - Ošťádal, Bohuslav - Neckář, Jan
.
Role of NO/cGMP signaling pathway in cardiac ischemic tolerance of chronically hypoxic rats
.
Physiological Research. 2015, Vol. 64, 5, p. 783-787
.
IF = 1.618
[ASEP]
Horn, P. - Ošťádal, P. - Ošťádal, Bohuslav
.
Rowing increases stroke volume and cardiac output to a greater extent than cycling
.
Physiological Research. 2015, Vol. 64, 2, p. 203-207
.
IF = 1.618
[ASEP]
Holzerová, K. - Hlaváčková, Markéta - Žurmanová, J. - Borchert, Gudrun H. - Neckář, Jan - Kolář, František - Novák, F. - Nováková, O.
Involvement of PKC epsilon in cardioprotection induced by adaptation to chronic continuous hypoxia
.
Physiological Research. 2015, Vol. 64, 2, p. 191-201
.
IF = 1.618
[ASEP]
Kašparová, D. - Neckář, Jan - Dabrowská, L. - Novotný, J. - Mráz, J. - Kolář, František - Žurmanová, J.
Cardioprotective and nonprotective regimens of chronic hypoxia diversely affect the myocardial antioxidant systems
.
Physiological Genomics. 2015, Vol. 47, 12, p. 612-620
.
IF = 2.615
[ASEP]
[
doi
]
Kochová, P. - Cimrman, R. - Štengl, M. - Ošťádal, Bohuslav - Tonar, Z.
A mathematical model of the carp heart ventricle during the cardiac cycle
.
Journal of Theoretical Biology. 2015, Vol. 373, May 21, p. 12-25
.
IF = 2.049
[ASEP]
[
doi
]
Wasková-Arnoštová, P. - Elsnicová, B. - Kašparová, D. - Horníková, D. - Kolář, František - Novotný, J. - Žurmanová, J.
Cardioprotective adaptation of rats to intermittent hypobaric hypoxia is accompanied by the increased association of hexokinase with mitochondria
.
Journal of Applied Physiology. 2015, Vol. 119, 12, p. 1487-1493
.
IF = 3.004
[ASEP]
[
doi
]
Maslov, L. N. - Naryzhnaya, N. V. - Prokudina, E. S. - Kolář, František - Gorbunov, A. S. - Zhang, Y. - Wang, H. - Tsibulnikov, S.Yu. - Portnichenko, A. G. - Lasukova, T. V. - Lishmanov, Yu. B.
Preserved cardiac mitochondrial function and reduced ischaemia/reperfusion injury afforded by chronic continuous hypoxia: Role of opioid receptors
.
Clinical and Experimental Pharmacology and Physiology. 2015, Vol. 42, 5, p. 496-501
.
IF = 2.004
[ASEP]
[
doi
]
Mathur, P. - Ošťádal, Bohuslav - Romeo, F. - Mehta, J. L.
Gender-Related Differences in Atherosclerosis
.
Cardiovascular Drugs and Therapy. 2015, Vol. 29, 4, p. 319-327
.
IF = 3.189
[ASEP]
[
doi
]
Ravingerová, T. - Ledvényiová-Farkašová, V. - Ferko, M. - Barteková, M. - Bernátová, I. - Pecháňová, O. - Adameová, A. - Kolář, František - Lazou, A.
Pleiotropic preconditioning-like cardioprotective effects of hypolipidemic drugs in acute ischemia–reperfusion in normal and hypertensive rats
.
Canadian Journal of Physiology and Pharmacology. 2015, Vol. 93, 7, p. 495-503
.
IF = 1.704
[ASEP]
[
doi
]
Chytilová, Anna - Borchert, Gudrun H. - Mandíková-Alánová, Petra - Hlaváčková, Markéta - Kopkan, L. - Khan, M. A. H. - Imig, J. D. - Kolář, František - Neckář, Jan
.
Tumour necrosis factor-alpha contributes to improved cardiac ischaemic tolerance in rats adapted to chronic continuous hypoxia
.
Acta Physiologica. 2015, Vol. 241, 1, p. 97-108
.
IF = 4.066
[ASEP]
[
doi
]
Wasková-Arnoštová, P. - Kašparová, D. - Elsnicová, B. - Novotný, J. - Neckář, Jan - Kolář, František - Žurmanová, J.
Chronic Hypoxia Enhances Expression and Activity of Mitochondrial Creatine Kinase and Hexokinase in the Rat Ventricular Myocardium
.
Cellular Physiology and Biochemistry 2014, roč. 33, 2, p. 310-320. ISSN 1015-8987.
IF = 2.875
[ASEP]
[
doi
]
Ošťádal, Bohuslav - Ošťádalová, Ivana - Kolář, František - Sedmera, David
.
Developmental determinants of cardiac sensitivity to hypoxia
.
Canadian Journal of Physiology and Pharmacology 2014, roč. 92, 7, p. 566-574. ISSN 0008-4212.
IF = 1.77
[ASEP]
[
doi
]
Ošťádal, Bohuslav - Ošťádal, P.
Sex-based differences in cardiac ischaemic injury and protection: therapeutic implications
.
British Journal of Pharmacology 2014, roč. 171, 3, p. 541-554. ISSN 0007-1188.
IF = 4.842
[ASEP]
[
doi
]
Khan, M. A. H. - Pavlov, T. S. - Christain, S. V. - Neckář, Jan - Staruschenko, A. - Gauthier, K. M. - Capdevila, J. H. - Falck, J. R. - Campbell, W. B. - Imig, J. D.
Epoxyeicosatrienoic acid analogue lowers blood pressure through vasodilation and sodium channel inhibition
.
Clinical science 2014, roč. 127, 7, p. 463-474. ISSN 0143-5221.
IF = 5.598
[ASEP]
[
doi
]
Khan, M. A. H. - Neckář, Jan - Haines, J. - Imig, J. D.
Azilsartan Improves Glycemic Status and Reduces Kidney Damage in Zucker Diabetic Fatty Rats
.
American Journal of Hypertension 2014, roč. 27, 8, p. 1087-1095. ISSN 0895-7061.
IF = 2.852
[ASEP]
[
doi
]
Khan, M. A. H. - Neckář, Jan - Cummens, B. - Wahl, G.M. - Imig, J. D.
Azilsartan Decreases Renal and Cardiovascular Injury in the Spontaneously Hypertensive Obese Rat
.
Cardiovascular Drugs and Therapy 2014, roč. 28, 4, p. 313-322. ISSN 0920-3206.
IF = 3.189
[ASEP]
[
doi
]
Houštěk, Josef - Vrbacký, Marek - Hejzlarová, Kateřina - Zídek, Václav - Landa, Vladimír - Šilhavý, Jan - Šimáková, Miroslava - Mlejnek, Petr - Kazdová, L. - Mikšík, Ivan - Neckář, Jan - Papoušek, František - Kolář, František - Kurtz, T. W. - Pravenec, Michal
.
Effects of mtDNA in SHR-mtF344 versus SHR conplastic strains on reduced OXPHOS enzyme levels, insulin resistance, cardiac hypertrophy, and systolic dysfunction
.
Physiological Genomics 2014, roč. 46, 18, p. 671-678. ISSN 1094-8341.
IF = 2.374
[ASEP]
[
doi
]
Drahota, Zdeněk - Páleníčková, E. - Endlicher, R. - Milerová, Marie - Brejchová, Jana - Vošahlíková, Miroslava - Svoboda, Petr - Kazdová, L. - Kalous, M. - Červinková, Z. - Cahová, M.
Biguanides Inhibit Complex I, II and IV of Rat Liver Mitochondria and Modify Their Functional Properties
.
Physiological Research 2014, roč. 63, 1, p. 1-11. ISSN 0862-8408.
IF = 1.293
[ASEP]
Bohuslavová, Romana - Kolář, František - Sedmera, David - Škvorová, Lada - Papoušek, František - Neckář, Jan - Pavlínková, Gabriela
.
Partial deficiency of HIF-1 alpha stimulates pathological cardiac changes in streptozotocin-induced diabetic mice
.
BMC ENDOCRINE DISORDERS 2014, roč. 14, 11. ISSN 1472-6823.
IF = 1.71
[ASEP]
[
doi
]
Wasková-Arnoštová, P. - Elsnicová, B. - Kašparová, D. - Šebesta, O. - Novotný, J. - Neckář, Jan - Kolář, František - Žurmanová, J.
Right-To-Left Ventricular Differences in the Expression of Mitochondrial Hexokinase and Phosphorylation of Akt
.
Cellular Physiology and Biochemistry, 2013, Vol. 31, 1, p. 66-79
.
IF = 3.415
[ASEP]
[
doi
]
Ravingerová, T. - Čarnická, S. - Ledvényiová, V. - Barlaka, E. - Galatou, E. - Chytilová, Anna - Mandíková, Petra - Nemčeková, M. - Adameová, A. - Kolář, František - Lazou, A.
Upregulation of genes involved in cardiac metabolism enhances myocardial resistance to ischemia/reperfusion in the rat heart
.
Physiological Research, 2013, Vol. 62, Suppl.1, S151-S163
.
IF = 1.531
[ASEP]
Neckář, Jan - Borchert, Gudrun H. - Hloušková, P. - Míčová, P. - Nováková, O. - Novák, F. - Hroch, M. - Papoušek, František - Ošťádal, Bohuslav - Kolář, František
.
Brief Daily Episode of Normoxia Inhibits Cardioprotection Conferred by Chronic Continuous Hypoxia. Role of Oxidative Stress and BKCa Channels
.
Current Pharmaceutical Design, 2013, Vol. 19, 39, p. 6880-6889
.
IF = 3.311
[ASEP]
Maslov, L. N. - Naryzhnaya, N. V. - Tsibulnikov, S.Yu. - Kolář, František - Zhang, Y. - Wang, H. - Gusakova, A. M. - Lishmanov, Yu. B.
Role of endogenous opioid peptides in the infarct size-limiting effect of adaptation to chronic continuous hypoxia
.
Life Sciences, 2013, Vol. 93, 9-11, p. 373-379
.
IF = 2.555
[ASEP]
[
doi
]
Kočková, Radka - Svatůňková, Jarmila - Novotný, J. - Hejnová, L. - Ošťádal, Bohuslav - Sedmera, David
.
Heart rate changes mediate the embryotoxic effect of antiarrhythmic drugs in the chick embryo
.
American Journal of Physiology-Heart and Circulatory Physiology, 2013, Vol. 304, 6, H895-H902
.
IF = 3.629
[ASEP]
[
doi
]
Kolář, František - Ošťádal, Bohuslav
.
Sex differences in cardiovascular function
.
Acta Physiologica, 2013, Vol. 207, 4, p. 584-587
.
IF = 4.382
[ASEP]
[
doi
]
Klevstig, M. - Manakov, D. - Kašparová, D. - Brabcová, I. - Papoušek, František - Žurmanová, J. - Zídek, Václav - Šilhavý, Jan - Neckář, Jan - Pravenec, Michal - Kolář, František - Nováková, O. - Novotný, J.
Transgenic rescue of defective Cd36 enhances myocardial adenylyl cyclase signaling in spontaneously hypertensive rats
.
Pflugers Archiv - European Journal of Physiology, 2013, Vol. 465, 10, p. 1477-1486
.
IF = 4.866
[ASEP]
[
doi
]
Khan, M. A. H. - Neckář, Jan - Manthati, V. - Errabelli, R. - Pavlov, T. S. - Staruschenko, A. - Falck, J. R. - Imig, J. D.
Orally Active Epoxyeicosatrienoic Acid Analog Attenuates Kidney Injury in Hypertensive Dahl Salt–Sensitive Rat
.
Hypertension, 2013, Vol. 62, 5, p. 905-913
.
IF = 6.873
[ASEP]
[
doi
]
Borchert, Gudrun H. - Hlaváčková, Markéta - Kolář, František
.
Pharmacological activation of mitochondrial BKCa channels protects isolated cardiomyocytes against simulated reperfusion-induced injury
.
Experimental Biology and Medicine, 2013, Vol. 238, 2, p. 233-241
.
IF = 2.803
[ASEP]
[
doi
]
Šnorek, M. - Hodyc, D. - Šedivý, V. - Ďurišová, J. - Skoumalová, A. - Wilhelm, J. - Neckář, Jan - Kolář, František - Herget, J.
Short-term fasting reduces the extent of myocardial infarction and incidence of reperfusion arrhythmias in rats
.
Physiological Research, 2012, Vol. 61, 6, p. 567-574
.
IF = 1.531
[ASEP]
Škrabalová, J. - Neckář, Jan - Hejnová, L. - Bartoňová, I. - Kolář, František - Novotný, J.
Antiarrhythmic effect of prolonged morphine exposure is accompanied by altered myocardial adenylyl cyclase signaling in rats
.
Pharmacological Reports, 2012, Vol. 64, 2, p. 351-359
.
IF = 1.965
[ASEP]
Říha, H. - Papoušek, František - Neckář, Jan - Pirk, J. - Ošťádal, Bohuslav
.
Effects of isoflurane concentration on basic echocardiographic parameters of the left ventricle in rats
.
Physiological Research, 2012, Vol. 61, 4, p. 419-423
.
IF = 1.531
[ASEP]
Wilhelm, Jiří - Ošťádalová, Ivana
.
Ontogenetic changes of lipofuscin-like pigments in the rat heart
.
Physiological Research, 2012, Vol. 61, Suppl.1, S173-S179
.
IF = 1.531
[ASEP]
Ravingerová, T. - Čarnická, S. - Nemčeková, M. - Ledvényiová, V. - Adameová, A. - Khandelwal, V. K. M. - Zálešák, M. - Kolář, František
.
The impact of lifestyle-related risk factors on cardiac response to ischemia and possibilities to restore impaired ischemic tolerance
.
Physiological Research, 2012, Vol. 61, Suppl.2, S1-S10
.
IF = 1.531
[ASEP]
Ošťádalová, Ivana - Babický, A.
Periodization of the early postnatal development in the rat with particular attention to the weaning period
.
Physiological Research, 2012, Vol. 61, Suppl.1, S1-S7
.
IF = 1.531
[ASEP]
Ošťádalová, Ivana
.
Biological effects of selenium compounds with a particular attention to the ontogenetic development
.
Physiological Research, 2012, Vol. 61, Suppl.1, S19-S34
.
IF = 1.531
[ASEP]
Ošťádal, P. - Ošťádal, Bohuslav
.
Women and the management of acute coronary syndrome
.
Canadian Journal of Physiology and Pharmacology, 2012, Vol. 90, 9, p. 1151-1159
.
IF = 1.556
[ASEP]
[
doi
]
Novák, F. - Kolář, František - Voců, Š. - Vecka, M. - Nováková, O.
Pressure overload selectively increases n-3 PUFA in myocardial phospholipids during early postnatal period
.
Physiological Research, 2012, Vol. 61, Suppl.1, S155-S163
.
IF = 1.531
[ASEP]
Neckář, Jan - Boudíková, Adéla - Mandíková, Petra - Štěrba, M. - Popelová, O. - Mikšík, Ivan - Dabrowská, L. - Mráz, J. - Geršl, V. - Kolář, František
.
Protective effects of dexrazoxane against acute ischaemia/reperfusion injury of rat hearts
.
Canadian Journal of Physiology and Pharmacology, 2012, Vol. 90, 9, p. 1303-1310
.
IF = 1.556
[ASEP]
[
doi
]
Neckář, Jan - Kopkan, L. - Husková, Z. - Kolář, František - Papoušek, František - Kramer, H. J. - Hwang, S.H. - Hammock, B.D. - Imig, J. D. - Malý, J. - Netuka, I. - Ošťádal, Bohuslav - Červenka, L.
Inhibition of soluble epoxide hydrolase by cis-4-[4-(3-adamantan-1-ylureido)cyclohexyl-oxy]benzoic acid exhibits antihypertensive and cardioprotective actions in transgenic rats with angiotensin II-dependent hypertension
.
Clinical science, 2012, Vol. 122, 11, p. 513-525
.
IF = 4.859
[ASEP]
[
doi
]
Neckář, Jan - Šilhavý, Jan - Zídek, Václav - Landa, Vladimír - Mlejnek, Petr - Šimáková, Miroslava - Seidman, J. G. - Seidman, Ch. - Kazdová, L. - Klevstig, M. - Novák, F. - Vecka, M. - Papoušek, František - Houštěk, Josef - Drahota, Zdeněk - Kurtz, T. W.
CD36 overexpression predisposes to arrhythmias but reduces infarct size in spontaneously hypertensive rats: gene expression profile analysis
.
Physiological Genomics, 2012, Vol. 44, 2, p. 173-182
.
IF = 2.806
[ASEP]
[
doi
]
Drahota, Zdeněk - Milerová, Marie - Endlicher, R. - Rychtrmoc, D. - Červinková, Z. - Ošťádal, Bohuslav
.
Developmental changes of the sensitivity of cardiac and liver mitochondrial permeability transition pore to calcium load and oxidative stress
.
Physiological Research, 2012, Vol. 61, Suppl.1, S165-S172
.
IF = 1.531
[ASEP]
Drahota, Zdeněk - Endlicher, R. - Staňková, P. - Rychtrmoc, D. - Milerová, Marie - Červinková, Z.
Characterization of calcium, phosphate and peroxide interactions in activation of mitochondrial swelling using derivative of the swelling curves
.
Journal of Bioenergetics and Biomembranes, 2012, Vol. 44, 3, p. 309-315
.
IF = 1.604
[ASEP]
[
doi
]
Charvátová, Z. - Ošťádalová, Ivana - Zicha, Josef - Kuneš, Jaroslav - Maxová, H. - Ošťádal, Bohuslav
.
Cardiac tolerance to ischemia in neonatal spontaneously hypertensive rats
.
Physiological Research, 2012, Vol. 61, Suppl.1, S145-S153
.
IF = 1.531
[ASEP]
Drastichová, Z. - Škrabalová, J. - Jedelský, P. - Neckář, Jan - Kolář, František - Novotný, J.
Global Changes in the Rat Heart Proteome Induced by Prolonged Morphine Treatment and Withdrawal
.
PLoS ONE, 2012, Vol. 7, 10, e47167
.
IF = 3.730
[ASEP]
[
doi
]
Říha, H. - Neckář, Jan - Papoušek, František - Netuka, I. - Pirk, J. - Kolář, František - Ošťádal, Bohuslav
.
Suppression of ischemic and reperfusion ventricular arrhythmias by inhalational anesthetic-induced preconditioning in the rat heart
.
Physiological Research, 2011, Vol. 60, 4, p. 709-714
.
IF = 1.555
[ASEP]
Wilhelm, J. - Ošťádalová, Ivana - Vytášek, R. - Vajner, L.
Generation of hydrogen peroxide in the developing rat heart: the role of elastin metabolism
.
Molecular and Cellular Biochemistry, 2011, Vol. 358, 1-2, p. 215-220
.
IF = 2.057
[ASEP]
[
doi
]
Rivolta, I. - Lucchini, G. - Rocchetti, M. - Kolář, František - Palazzo, F. - Zaza, A. - Miserocchi, G.
Interstitial pressure and lung oedema in chronic hypoxia
.
European Respiratory Journal, 2011, Vol. 37, 4, p. 943-949
.
IF = 5.895
[ASEP]
[
doi
]
Melenovsky, V. - Beneš, J. - Škaroupková, P. - Sedmera, David - Strnad, Hynek - Kolář, Michal - Vlček, Čestmír - Petrák, J. - Beneš ml., J. - Papoušek, František - Oliyarnyk, O. - Kazdová, L. - Červenka, L.
Metabolic characterization of volume overload heart failure due to aorto-caval fistula in rats
.
Molecular and Cellular Biochemistry, 2011, Vol. 354, 1-2, p. 83-96
.
IF = 2.057
[ASEP]
[
doi
]
McDermott-Roe, Ch. - Ye, J. - Ahmed, R. - Sun, X. M. - Serafín, A. - Ware, J. - Bottolo, L. - Muckett, P. - Caňas, X. - Zhang, J. - Rowe, G. C. - Buchan, R. - Lu, H. - Braithwaite, A. - Mancini, M. - Hauton, D. - Martí, R. - García-Arumí, E. - Hubner, N.
Endonuclease G is a novel determinant of cardiac hypertrophy and mitochondrial function
.
Nature, 2011, Vol. 478, 7367, p. 114-118
.
IF = 36.280
[ASEP]
[
doi
]
Lukáč, R. - Kauerová, Z. - Mašek, J. - Bartheldyová, E. - Kulich, P. - Koudelka, Š. - Korvasová, Z. - Plocková, J. - Papoušek, František - Kolář, František - Schmidt, R. - Turánek, J.
Preparation of Metallochelating Microbubbles and Study on Their Site-Specific Interaction with rGFP-HisTag as a Model Protein
.
Langmuir, 2011, Vol. 27, 8, p. 4829-4837
.
IF = 4.186
[ASEP]
[
doi
]
Drastichová, Z. - Škrabalová, J. - Neckář, Jan - Kolář, František - Novotný, J.
Prolonged morphine administration alters protein expression in the rat myocardium
.
Journal of Biomedical Science, 2011, Vol. 18, -, e89
.
IF = 1.980
[ASEP]
[
doi
]
Borchert, Gudrun H. - Yang, Ch. - Kolář, František
.
Mitochondrial BKCa channels contribute to protection of cardiomyocytes isolated from chronically hypoxic rats
.
American Journal of Physiology-Heart and Circulatory Physiology, 2011, Vol. 300, 2, H507-H513
.
IF = 3.708
[ASEP]
[
doi
]
Balková, P. - Hlaváčková, M. - Milerová, Marie - Neckář, Jan - Kolář, František - Novák, F. - Nováková, O.
N-acetylcysteine treatment prevents the up-regulation of MnSOD in chronically hypoxic rat hearts
.
Physiological Research, 2011, Vol. 60, 3, p. 467-474
.
IF = 1.555
[ASEP]
Ošťádalová, Ivana - Charvátová, Zuzana - Wilhelm, J.
Lipofuscin-like pigments in the rat heart during early postnatal development: effect of selenium supplementation
.
Physiological Research, 2010, Vol. 59, 6, p. 881-886
.
IF = 1.646
[ASEP]
Netuka, I. - Szárszoi, Ondrej - Malý, J. - Říha, H. - Turek, D. - Ošťádalová, Ivana - Ošťádal, Bohuslav
.
Late effect of early hypoxic disturbance in the rat heart: gender differences
.
Physiological Research, 2010, Vol. 59, 1, p. 127-131
.
IF = 1.646
[ASEP]
Milerová, Marie - Charvátová, Zuzana - Škárka, Libor - Ošťádalová, Ivana - Drahota, Zdeněk - Fialová, Martina - Ošťádal, Bohuslav
.
Neonatal cardiac mitochondria and ischemia/reperfusion injury
.
Molecular and Cellular Biochemistry, 2010, Vol. 335, 1-2, p. 147-153
.
IF = 2.168
[ASEP]
[
doi
]
Hlaváčková, M. - Kožichová, K. - Neckář, Jan - Kolář, František - Musters, R.J.P. - Novák, O. - Nováková, O.
Up-regulation and redistribution of protein kinase C-delta in chronically hypoxic heart
.
Molecular and Cellular Biochemistry, 2010, Vol. 345, 1-2, p. 271-282
.
IF = 2.168
[ASEP]
[
doi
]
Hamplová, B. - Novák, F. - Kolář, František - Nováková, O.
Transient upregulation of protein kinase C in pressure-overloaded neonatal rat myocardium
.
Physiological Research, 2010, Vol. 59, 1, p. 25-33
.
IF = 1.646
[ASEP]
Calda, P. - Břešťák, M. - Tomek, V. - Ošťádal, Bohuslav - Sonek, J.
Left ventricle shortening fraction: a comparison between euploid and trisomy 21 fetuses in the first trimester
.
Prenatal Diagnosis, 2010, Vol. 30, 4, p. 368-371
.
IF = 2.152
[ASEP]
[
doi
]
Bohuslavová, Romana - Kolář, František - Kuthanová, Lada - Neckář, Jan - Tichopád, Aleš - Pavlínková, Gabriela
.
Gene expression profiling of sex differences in HIF1-dependent adaptive cardiac responses to chronic hypoxia
.
Journal of Applied Physiology, 2010, Vol. 109, 4, p. 1195-1202
.
IF = 4.232
[ASEP]
[
doi
]
Šimko, F. - Pecháňová, Olga - Pelouch, Václav - Krajčírovičová, K. - Müllerová, M. - Bednárová, K. - Adamcová, M. - Paulis, L.
Effect of melatonin, captopril, spironolactone and simvastatin on blood pressure and left ventricular remodelling in spontaneously hypertensive rats
.
Journal of Hypertension, 2009, Vol. 27, Suppl.6, S5-S10
.
IF = 4.988
[ASEP]
[
doi
]
Wilhelm, J. - Vytášek, R. - Ošťádalová, Ivana - Vajner, L.
Evaluation of different methods detecting intracellular generation of free radicals
.
Molecular and Cellular Biochemistry, 2009, Vol. 328, 1-2, p. 167-176
.
IF = 1.896
[ASEP]
[
doi
]
Ravingerová, T. - Matejíková, J. - Pancza, D. - Kolář, František
.
Reduced susceptibility to ischemia-induced arrhythmias in the preconditioned rat heart is independent of PI3-kinase/Akt
.
Physiological Research, 2009, Vol. 58, 3, p. 443-447
.
IF = 1.430
[ASEP]
Ošťádal, Bohuslav
.
The past, the present and the future of experimental research on myocardial ischemia and protection
.
Pharmacological Reports, 2009, Vol. 61, 1, p. 3-12
.
IF = 2.086
[ASEP]
Ošťádal, Bohuslav - Ošťádalová, Ivana - Kolář, František - Charvátová, Zuzana - Netuka, I.
Ontogenetic development of cardiac tolerance to oxygen deprivation – possible mechanisms
.
Physiological Research, 2009, Vol. 58, Suppl.2, S1-S12
.
IF = 1.430
[ASEP]
Ošťádal, Bohuslav - Netuka, I. - Malý, J. - Bešík, J. - Ošťádalová, Ivana
.
Gender Differences in Cardiac Ischemic Injury and Protection - Experimental Aspects
.
Experimental Biology and Medicine, 2009, Vol. 234, 9, p. 1011-1019
.
IF = 2.635
[ASEP]
[
doi
]
Novák, F. - Kolář, František - Hamplová, B. - Mrnka, L. - Pelouch, Václav - Ošťádal, Bohuslav - Nováková, O.
Myocardial phospholipid remodeling under different types of load imposed during early postnatal development
.
Physiological Research, 2009, Vol. 58, Suppl.2, S13-S32
.
IF = 1.430
[ASEP]
Matejíková, J. - Ravingerová, T. - Pancza, D. - Čarnická, S. - Kolář, František
.
Mitochondrial K-ATP opening confers protection against lethal myocardial injury and ischaemia-induced arrhythmias in the rat heart via PI3K/Akt-dependent and -independent mechanisms
.
Canadian Journal of Physiology and Pharmacology, 2009, Vol. 87, 12, p. 1055-1062
.
IF = 1.341
[ASEP]
[
doi
]
Klusoňová, Petra - Řeháková, Lenka - Borchert, Gudrun H. - Vagnerová, Karla - Neckář, Jan - Ergang, Peter - Mikšík, Ivan - Kolář, František - Pácha, Jiří
.
Chronic Intermittent Hypoxia Induces 11Beta-Hydroxysteroid Dehydrogenase in Rat Heart
.
Endocrinology, 2009, Vol. 150, 9, p. 4270-4277
.
IF = 4.752
[ASEP]
[
doi
]
Balková, P. - Ježková, J. - Hlaváčková, M. - Neckář, Jan - Staňková, B. - Kolář, František - Novák, F. - Nováková, O.
Dietary polyunsaturated fatty acids and adaptation to chronic hypoxia alter acyl composition of serum and heart lipids
.
British Journal of Nutrition, 2009, Vol. 102, 9, p. 1297-1307
.
IF = 3.446
[ASEP]
[
doi
]
Szárszoi, Ondrej - Malý, J. - Ošťádal, P. - Netuka, I. - Bešík, J. - Kolář, František - Ošťádal, Bohuslav
.
Effect of acute and chronic simvastatin treatment on post-ischemic contractile dysfunction in isolated rat heart
.
Physiological Research, 2008, Vol. 57, 5, p. 793-796
.
IF = 1.653
[ASEP]
Naryzhnaya, N. V. - Maslov, L. N. - Lishmanov, Yu. B. - Kolář, František
.
Effect of stress adaptation on cyclic nucleotide content in myocardial tissue during acute ischemia/reperfusion
.
Bulletin of Experimental Biology and Medicine and Biulleten Eksperimentalnol Biologii i Meditsiny and Bulletin of Experimental Biology and Medicine, USSR, 2008, Vol. 145, 5, p. 588-591
.
IF = 0.258
[ASEP]
[
doi
]
Lishmanov, Yu. B. - Stakheev, D. L. - Krylatov, A. V. - Naryzhnaya, N. V. - Maslov, L. N. - Ovchinnikov, M. V. - Kolář, František
.
Myocardial resistance to ischemic and reperfusion injuries under conditions of chronic administration of opioid receptor agonists and antagonists
.
Bulletin of Experimental Biology and Medicine and Biulleten Eksperimentalnol Biologii i Meditsiny and Bulletin of Experimental Biology and Medicine, USSR, 2008, Vol. 145, 6, p. 696-699
.
IF = 0.258
[ASEP]
[
doi
]
Kolář, František - Neckář, Jan - Ošťádal, Bohuslav - Maslov, L. N. - Stakheev, D. L. - Tayurskaya, A. S. - Lishmanov, Yu. B.
Role of ATP-sensitive K+-channels in antiarrhythmic and cardioprotective action of adaptation to intermittent hypobaric hypoxia
.
Bulletin of Experimental Biology and Medicine and Biulleten Eksperimentalnol Biologii i Meditsiny and Bulletin of Experimental Biology and Medicine, USSR, 2008, Vol. 145, 4, p. 418-421
.
IF = 0.258
[ASEP]
[
doi
]
Borchert, Gudrun H. - Giggey, M. - Kolář, František - Ming Wong, T. - Backx, P.H. - Escriba, P.V.
2-Hydroxyoleic acid affects cardiomyocyte [Ca2plus]i transient and contractility in a region-dependent manner
.
American Journal of Physiology-Heart and Circulatory Physiology, 2008, Vol. 294, 4, H1948-H1955
.
IF = 3.643
[ASEP]
Neckář, Jan - Ošťádal, Bohuslav - Kolář, František
.
Acute but not chronic tempol treatment increases ischemic and reperfusion ventricular arrhythmias in open-chest rats
.
Physiological Research, 2008, Vol. 57, 4, p. 653-656
.
IF = 1.653
[ASEP]
Ravingerová, T. - Matejíková, J. - Neckář, Jan - Andelová, E. - Kolář, František
.
Differential role of PI3K/Akt pathway in the infarct size limitation and antiarrhythmic protection in the rat heart
.
Molecular and Cellular Biochemistry, 2007, Vol. 297, 1-2, p. 111-120
.
IF = 1.707
[ASEP]
Rakusan, K. - Chvojková, Zuzana - Oliviero, P. - Ošťádalová, Ivana - Kolář, František - Chassagne, C. - Samuel, J. L. - Ošťádal, Bohuslav
.
ANG II type 1 receptor antagonist irbesartan inhibits coronary angiogenesis stimulated by chronic intermittent hypoxia in neonatal rats
.
American Journal of Physiology-Heart and Circulatory Physiology, 2007, Vol. 292, 3, H1237-H1244
.
IF = 3.973
[ASEP]
Ošťádalová, Ivana - Vobecký, Miloslav - Chvojková, Zuzana - Miková, D. - Hampl, V. - Wilhelm, J. - Ošťádal, Bohuslav
.
Selenium protects the immature rat heart against ischemia/reperfusion injury
.
Molecular and Cellular Biochemistry, 2007, Vol. 300, 1-2, p. 259-267
.
IF = 1.707
[ASEP]
Ošťádal, Bohuslav - Kolář, František
.
Cardiac adaptation to chronic high-altitude hypoxia: Beneficial and adverse effects
.
Respiratory Physiology & Neurobiology, 2007, Vol. 158, 2-3, p. 224-236
.
IF = 2.202
[ASEP]
Kolář, František - Ježková, J. - Balková, P. - Břeh, J. - Neckář, Jan - Novák, F. - Nováková, O. - Tomášová, H. - Srbová, M. - Ošťádal, Bohuslav - Wilhelm, J. - Herget, J.
Role of oxidative stress in PKC-delta upregulation and cardioprotection induced by chronic intermittent hypoxia
.
American Journal of Physiology-Heart and Circulatory Physiology, 2007, Vol. 292, 1, H224-H230
.
IF = 3.973
[ASEP]
Hlaváčková, M. - Neckář, Jan - Ježková, J. - Balková, P. - Staňková, B. - Nováková, O. - Kolář, František - Novák, F.
Dietary Polyunsaturated Fatty Acids Alter Myocardial Protein Kinase C Expression and Affect Cardioprotection Induced by Chronic Hypoxia
.
Experimental Biology and Medicine, 2007, Vol. 232, 6, p. 823-832
.
IF = 1.979
[ASEP]
Flachs, Pavel - Šponarová, Jana - Kopecký, P. - Horváth, Ondřej - Šedivá, A. - Nibbelink, M. - Casteilla, L. - Medříková, Daša - Neckář, Jan - Kolář, František - Kopecký, Jan
.
Mitochondrial uncoupling protein 2 gene transcript levels are elevated in maturating erythroid cells
.
FEBS Letters, 2007, Vol. 581, 6, p. 1093-1097
.
IF = 3.263
[ASEP]
Bešík, J. - Szárszoi, Ondrej - Kuneš, Jaroslav - Netuka, I. - Malý, J. - Kolář, František - Pirk, J. - Ošťádal, Bohuslav
.
Tolerance to acute ischemia in adult male and female spontaneously hypertensive rats
.
Physiological Research, 2007, Vol. 56, 3, p. 267-274
.
IF = 1.505
[ASEP]
