Strukturovaný životopis:
Vzděláni:
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1991
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Vysoká škola chemicko-technologickáv Praze, Fakula potravinářské a biochemické technologie obory: Enzymové inženýrství; Chemie a technologie sacharidů
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2008
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Postrgraduální studium - Přírodovědecká fakulta Univerzity Karlovy v Praze obor: Vývojová biologie
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Zaměstnání:
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1991-1992
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Ústav hematologie a krevní transfuse, Praha - výzkumný pracovník
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Od 2001
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Ústav živočisné fyziologie a genetiky Akademie věd ČR v.v.i.
vědecký pracovník
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Specializace:
Molekulárně biologické metodiky - studium regulace genové exprese v průběhu maturace oocytů, expanze oocyt-kumulárních komplexů a časného embryonálního vývoje savců
Vybrané publikace:
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2006
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Nemcova L, Machatkova M, Hanzalova K, Horakova J, Kanka J. Gene expression in bovine embryos derived from oocytes with different developmental competence collected at the defined follicular developmental stage. Theriogenology. 2006 Apr 15;65(7):1254-64. Epub 2005 Sep 19.
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2007
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Nemcová L, Nagyová E, Petlach M, Tománek M, Procházka R.: Molecular mechanisms of insulin-like growth factor 1 promoted synthesis and retention of hyaluronic acid in porcine oocyte-cumulus complexes. Biol Reprod. 2007 Jun;76(6):1016-24. Epub 2007 Feb 28.
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2009
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Nagyova E, Nemcova L, Prochazka R: Expression of tumor necrosis factor alpha-induced protein 6 messenger RNA in porcine preovulatory ovarian follicles. J Reprod Dev. 2009 Jun;55(3):231-5. Epub 2009 Feb 5.
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Procházka R, Nemcová L, Nagyová E, Scsuková S, Mlynarcíková A.: Development of functional LH Receptors on pig cumulus-oocyte complexes cultured in vitro by a novel two-step culture system.Mol Reprod Dev. 2009 Aug;76(8):751-61.
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Kanka J, Kepková K, Nemcová L.:Gene expression during minor genome activation in preimplantation bovine development. Theriogenology. 2009 Sep 1;72(4):572-83. Epub 2009 Jun 5.
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Toralová T, Susor A, Nemcová L, Kepková K, Kanka J.:Silencing CENPF in bovine preimplantation embryo induces arrest at 8-cell stage. Reproduction. 2009 Nov;138(5):783-91. Epub 2009 Aug 3.
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2011
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Procházka R, Petlach M, Nagyová E, Nemcová L.:Effect of epidermal growth factor-like peptides on pig cumulus cell expansion, oocyte maturation, and acquisition of developmental competence in vitro: comparison with gonadotropins.Reproduction. 2011 Apr;141(4):425-35. Epub 2011 Jan 14.
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Nagyova E, Camaioni A, Scsukova S, Mlynarcikova A, Prochazka R, Nemcova L, Salustri A.:Activation of cumulus cell SMAD2/3 and epidermal growth factor receptor pathways are involved in porcine oocyte-cumulus cell expansion and steroidogenesis. Mol Reprod Dev. 2011 Jun;78(6):391-402.
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Machatkova M., Jeseta M., Hulinska P., Knitlova D., Nemcova L., Kanka J. Characteristics of bovine oocytes with different meiotic competence in terms of their mitochondrial status and expression of selected genes. Reprod Domest Anim. 2011 Oct 47(5):806-14.
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| 2012 |
Nagyova E, Scsukova S, Nemcova L, Mlynarcikova A, Yi YJ, Sutovsky M, Sutovsky P. (2012)Inhibition of proteasomal proteolysis affects expression of extracellular matrix components and steroidogenesis in porcine oocyte-cumulus complexes. Domest Anim Endocrinol. 2012 Jan 42(1):50-62.
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Prochazka R., Blaha M., Nemcova L Signaling pathways regulating FSH- and amphiregulin-induced meiotic resumption and cumulus cell expansion in the pig. Reproduction 2012 Nov 144(5):535-546.
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Kanka J, Nemcova L, Toralova T, Vodickova-Kepkova K, Vodicka P, Jeseta M, Machatkova M. Association of the transcription profile of bovine oocytes and embryos with developmental potential. Anim Reprod Sci. 2012 Sep 134(1-2):29-35.
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| 2013 |
Nagyova E, Nemcova L, Mlynarcikova A, Scsukova S, Kalous J. Lapatinib inhibits meiotic maturation of porcine oocyte-cumulus complexes cultured in vitro in gonadotropin-supplemented medium. 2013 Fertil Steril. 99(6):1739-48.
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Jeseta M, Ctvrtlikova Knitlova D, Hanzalova K, Hulinska P, Hanulakova S, Milakovic I, Nemcova L, Kanka J, Machatkova M. Mitochondrial patterns in bovine oocytes with different meiotic competence related to their in vitro maturation. Reprod Domest Anim. 2014 Jun 49(3):469-75.
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| 2015 |
Blaha M, Nemcova L, Prochazka R. Cyclic guanosine monophosphate does not inhibit gonadotropin-induced activation of mitogen-activated protein kinase 3/1 in pig cumulus-oocyte complexes. Reprod Biol Endocrinol. 2015 Jan 7;13:1. doi: 10.1186/1477-7827-13-1.
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