Ischemic heart disease is the main cause of mortality worldwide. We study cardiac tolerance to injury caused by acute oxygen deprivation from the molecular level to the whole organism using animal models. Our research is focused mainly on the study of mechanisms that underlie:
- high cardiac tolerance to injury early ontogeny,
- increased cardiac tolerance induced by adaptation to chronic hypoxia and regular exercise training,
- permanent consequences of early developmental interventions for cardiac tolerance in adulthood,
- and altered cardiac tolerance associated with various pathological states.
Projects
The immature heart is highly tolerant to ischemic injury, but chronic oxygen deficit during early ontogeny may have negative consequences that persist till adulthood. We study mechanisms responsible for developmental changes of cardiac ischemic tolerance.
More
Systemic hypertension is a major risk factor of ischemic heart disease. However, it can also stimulate mechanisms that protect the heart against acute oxygen deprivation. We study the effects of various forms of hypertension on cardiac ischemic tolerance.
More
Prolonged exposure to hypoxic environment leads to adaptation which is associated with improved cardiac tolerance to acute oxygen deprivation. We study molecular mechanisms underlying the cardioprotective effects of chronic hypoxia on various manifestations of ischemic injury.
More
Publications
Wang, M. - Sips, P. - Khin, E. - Rotival, M. - Sun, X. - Ahmed, R. - Widjaja, A. A. - Schafer, S. - Yusoff, P. - Choksi, P. K. - Ko, N. S. J. - Singh, M. K. - Epstein, D. - Guan, Y. - Houštěk, Josef - Mráček, Tomáš - Nůsková, Hana - Mikell, B. - Tan, J. - Pesce, F. - Kolář, František - Bottolo, L. - Mancini, M. - Hubner, N. - Pravenec, Michal - Petretto, E. - MacRae, C. - Cook, S. A.
Wars2 is a determinant of angiogenesis
.
Nature Communications. 2016, roč. 7, Jul, p. 12061
.
IF = 11.329
[ASEP]
[
doi
]
Milerová, Marie - Drahota, Zdeněk - Chytilová, Anna - Tauchmannová, Kateřina - Houštěk, Josef - Ošťádal, Bohuslav
.
Sex difference in the sensitivity of cardiac mitochondrial permeability transition pore to calcium load
.
Molecular and Cellular Biochemistry. 2016, roč. 412, 1-2, p. 147-154
.
IF = 2.613
[ASEP]
[
doi
]
Ravingerová, T. - Farkasová, V. - Griecsová, L. - Čarnická, S. - Murariková, M. - Barlaka, E. - Kolář, František - Barteková, M. - Lonek, L. - Slezák, J. - Lazou, A.
Remote Preconditioning as a Novel "Conditioning" Approach to Repair the Broken Heart: Potential Mechanisms and Clinical Applications
.
Physiological Research. 2016, roč. 65, Suppl.1, S55-S64
.
IF = 1.643
[ASEP]
Vrbacký, Marek - Kovalčíková, Jana - Chawengsaksophak, Kallayanee - Beck, Inken - Mráček, Tomáš - Nůsková, Hana - Sedmera, David - Papoušek, František - Kolář, František - Sobol, Margaryta - Hozák, Pavel - Sedláček, Radislav - Houštěk, Josef
.
Knockout of Tmem70 alters biogenesis of ATP synthase and leads to embryonal lethality in mice
.
Human Molecular Genetics. 2016, roč. 25, 21, p. 4674-4685
.
IF = 5.985
[ASEP]
[
doi
]
Míčová, P. - Hahnová, K. - Hlaváčková, Markéta - Elsnicová, B. - Chytilová, Anna - Holzerová, Eliška - Žurmanová, J. - Neckář, Jan - Kolář, František - Nováková, Olga - Novotný, J.
Chronic intermittent hypoxia affects the cytosolic phospholipase A(2)alpha/cyclooxygenase 2 pathway via beta(2)-adrenoceptor-mediated ERK/p38 stimulation
.
Molecular and Cellular Biochemistry. 2016, roč. 423, 1-2, p. 151-163
.
IF = 2.613
[ASEP]
[
doi
]
Sedmera, David - Neckář, Jan - Beneš Jr., Jiří - Pospíšilová, J. - Petrák, J. - Sedláček, K. - Melenovský, V.
Changes in Myocardial Composition and Conduction Properties in Rat Heart Failure Model Induced by Chronic Volume Overload
.
Frontiers in physiology. 2016, roč. 7, Aug 25, p. 367
.
IF = 4.031
[ASEP]
[
doi
]
Jíchová, Š. - Kopkan, L. - Husková, Z. - Doleželová, Š. - Neckář, Jan - Kujal, P. - Vernerová, Z. - Kramer, H. J. - Sadowski, J. - Kompanowska - Jezierska, E. - Reddy, N. R. - Falck, J. R. - Imig, J. D. - Červenka, L.
Epoxyeicosatrienoic acid analog attenuates the development of malignant hypertension, but does not reverse it once established: a study in Cyp1a1-Ren-2 transgenic rats
.
Journal of Hypertension. 2016, roč. 34, 10, p. 2008-2025
.
IF = 5.062
[ASEP]
[
doi
]
Hahnová, K. - Kašparová, D. - Žurmanová, J. - Neckář, Jan - Kolář, František - Novotný, J.
Beta-Adrenergic signaling in rat heart is similarly affected by continuous and intermittent normobaric hypoxia
.
General Physiology and Biophysics. 2016, roč. 35, 2, p. 165-173
.
IF = 0.892
[ASEP]
[
doi
]
Hrdlička, Jaroslav - Neckář, Jan - Papoušek, František - Vašinová, Jana - Alánová, Petra - Kolář, František
.
Beneficial effect of continuous normobaric hypoxia on ventricular dilatation in rats with post-infarction heart failure
.
Physiological Research. 2016, roč. 65, 5, p. 867-870
.
IF = 1.643
[ASEP]
Slámová, Kristýna - Papoušek, František - Janovská, Petra - Kopecký, Jan - Kolář, František
.
Adverse Effects of AMP-Activated Protein Kinase alpha 2-Subunit Deletion and High-Fat Diet on Heart Function and Ischemic Tolerance in Aged Female Mice
.
Physiological Research. 2016, roč. 65, 1, p. 33-42
.
IF = 1.643
[ASEP]
Show more
