Department of Experimental Hypertension is studying the mechanisms of blood pressure (BP) regulation and end-organ damage in rats with different types of experimental hypertension. Our research is focused mainly on:
- Elucidation of the mechanisms by which endothelin and renin-angiotensin systems participate in renal damage in transgenic rats with inserted mouse renin gene (Ren-2 TGR) – cooperation with IKEM (Prague).
- Comparison of the role of calcium sensitization (Rho kinase pathway) and calcium influx in the development of high BP in rats with genetic or salt hypertension – molecular biological analysis of alterations in these regulatory pathways.
- Study of the central mechanisms of blood pressure regulation in rats with genetic hypertension: focus on brain renin-angiotensin system, central corticoid effects, baroreflex control of sympathetic tone and oxidative stress.
- Investigation of cardiovascular effects of new analogs of neuropeptides regulating food intake in rats – cooperation with IOCHB CAS (Prague).
Projects
Achievements
Our colleagues were very successful at 26th International Meeting of International Society of Hypertension in Seoul - Michal Behuliak was awarded by the 2nd place in the section Young Investigator Award, Anna Vavřínová by Travel Grant and Josef Zicha was awarded by the 2nd place in the section Best Oral Presentation in Basic Sciences.
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Michal Behuliak was granted by the Czech Society for Hypertension, the price was awarded by the general manager of Servier in the Czech Republic.
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Mgr. Michal Behuliak, PhD. was granted with Otto Wicherle prize from the President of Czech Academy of Sciences on Monday, May 30, 2016.
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Publications
Lettrichová, I. - Tóthová, L. - Hodosy, J. - Behuliak, Michal - Celec, P.
Variability of salivary markers of oxidative stress and antioxidant status in young healthy individuals
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Redox Report. 2016, roč. 21, 1, p. 24-30
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IF = 2.606
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Pelantová, H. - Bugáňová, M. - Holubová, M. - Šedivá, B. - Zemenová, J. - Sýkora, D. - Kaválková, P. - Haluzík, M. - Železná, B. - Maletínská, L. - Kuneš, Jaroslav - Kuzma, M.
Urinary metabolomic profiling in mice with diet-induced obesity and type 2 diabetes mellitus after treatment with metformin, vildagliptin and their combination
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Molecular and Cellular Endocrinology. 2016, roč. 431, C, p. 88-100
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IF = 3.859
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Mikulášková, Barbora - Maletínská, L. - Zicha, Josef - Kuneš, Jaroslav
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The role of food intake regulating peptides in cardiovascular regulation
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Molecular and Cellular Endocrinology. 2016, roč. 436, p. 78-92
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IF = 3.859
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doi
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Vranková, S. - Barta, A. - Klimentová, J. - Dovinová, I. - Líšková, Silvia - Dobešová, Zdenka - Pecháňová, O. - Kuneš, Jaroslav - Zicha, Josef
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The Regulatory Role of Nuclear Factor Kappa B in the Heart of Hereditary Hypertriglyceridemic Rat
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Oxidative Medicine and Cellular Longevity. 2016, roč. 2016, 2016, p. 9814038
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IF = 4.492
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Vokurková, Martina - Rauchová, Hana - Dobešová, Zdenka - Loukotová, Jana - Nováková, O. - Kuneš, Jaroslav - Zicha, Josef
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The influence of erythrocyte maturity on ion transport and membrane lipid composition in the rat
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Physiological Research. 2016, roč. 65, 1, p. 91-99
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IF = 1.643
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Vavřínová, Anna - Behuliak, Michal - Zicha, Josef
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The importance of the selection of appropriate reference genes for gene expression profiling in adrenal medulla or sympathetic ganglia of spontaneously hypertensive rat
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Physiological Research. 2016, roč. 65, 3, p. 401-411
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IF = 1.643
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Kuneš, Jaroslav - Pražienková, V. - Popelová, A. - Mikulášková, Barbora - Zemenová, J. - Maletínská, L.
Prolactin-releasing peptide: a new tool for obesity treatment
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Journal of Endocrinology. 2016, roč. 230, 2, R51-R58
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IF = 4.498
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Holubová, M. - Zemenová, J. - Mikulášková, Barbora - Panajotová, V. - Stöhr, J. - Haluzík, M. - Kuneš, Jaroslav - Železná, B. - Maletínská, L.
Palmitoylated PrRP analog decreases body weight in DIO rats but not in ZDF rats
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Journal of Endocrinology. 2016, roč. 229, 2, p. 85-96
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IF = 4.498
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doi
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Vaněčková, Ivana - Řezáčová, Lenka - Kuneš, Jaroslav - Zicha, Josef
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Moderate additive effects of endothelin receptor A blockade in Ren-2 transgenic rats subjected to various types of RAS blockade
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Life Sciences. 2016, roč. 159, Aug 15, p. 127-154
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IF = 2.685
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Bernátová, I. - Bališ, P. - Goga, R. - Behuliak, Michal - Zicha, Josef - Sekaj, I.
Lack of Reactive Oxygen Species Deteriorates Blood Pressure Regulation in Acute Stress
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Physiological Research. 2016, roč. 65, Suppl.3, S381-S390
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IF = 1.643
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Recording of blood pressure.
Adrenal section stained for tyrosine hydroxylase (detected by Vectastain ABC kit).
Aorta section – α-actin (red), nuclei (blue) and autofluorescence (green).
Recording of contraction of isolated femoral artery stimulated by norepinephrine (NE).
Overview of alterations in calcium sensitization during development of spontaneously hypertension in the rat The schematic representation of possible regulatory mechanisms involved in RhoA/Rho kinase pathway is demonstrated in normotensive (a), prehypertensive (b) and hypertensive (c) rats.
