Selected Publications

*Ticha A., *Stanchev S., Skerle J., Began J., Ingr M., Svehlova K., Polovinkin L., Ruzicka M., Bednarova *L., Hadravova R., Polachova E., Rampirova P., *Brezinova J., Kasicka V., Majer P., Strisovsky K.:
Sensitive versatile fluorogenic transmembrane peptide substrates for rhomboid intramembrane proteases.
Journal of Biological Chemistry, in press, 2017.

Strisovsky K.:
Mechanism and inhibition of rhomboid proteases.
Methods in Enzymology 584: 279-293, 2017.

Arutyunova E., Panigrahi R., Strisovsky K., & Lemieux M.J.:
Production of recombinant rhomboid proteases.
Methods in Enzymology 584: 255-278, 2017.

Arutyunova E., Strisovsky K., & Lemieux M.J.:
Activity assays for rhomboid proteases.
Methods in Enzymology 584: 395-437, 2017.

Strisovsky K.:
Rhomboid protease inhibitors: emerging tools and future therapeutics.
Seminars in Cell & Developmental Biology 60: 52-62, 2016.

Wunderle L., Knopf J.D., Kuhnle N., Morle A., Hehn B., Adrain C., Strisovsky K., Freeman M. & Lemberg M.K.:
Rhomboid intramembrane protease RHBDL4 triggers ER-export and non-canonical secretion of membrane-anchored TGFalpha.
Scientific Reports 6: 27342, 2016.

Strisovsky K.:
Why cells need intramembrane proteases – a mechanistic perspective.
FEBS Journal 283: 1837-45, 2015.

Wolf E.V., Seybold M., Hadravova R., Strisovsky K. & Verhelst S.H.:
Activity-Based Protein Profiling of Rhomboid Proteases in Liposomes.
ChemBioChem 16: 1616-21, 2015.

Zoll S. Stanchev S., Began J., Skerle J., Lepsik M., Peclinovska L., Majer P. & Strisovsky K.:
Substrate binding and specificity of rhomboid intramembrane protease revealed by substrate-peptide complex structures.
EMBO Journal 33: 2408-2421, 2014.

Strisovsky K. & Freeman M.:
Sharpening rhomboid specificity by dimerisation and allostery.
EMBO Journal, 33: 1847–1848, 2014.

Strisovsky K.:
Structural and mechanistic principles of intramembrane proteolysis - lessons from rhomboids.
FEBS Journal 280: 1579-603, 2013.

Adrain C., Strisovsky K., Zettl M., Hu L.D.A., Lemberg M.K. & Freeman M.:
Mammalian EGF receptor activation by the rhomboid protease RHBDL2.
EMBO Reports 12: 421-427, 2011.

Pierrat* O.A., Strisovsky* K., Christova Y., Large J., Ansell K., Bouloc N., Smiljanic E. & Freeman M.:
Monocyclic beta-lactams are selective, mechanism-based inhibitors of rhomboid intramembrane proteases.
ACS Chemical Biology 6: 325-335, 2011.

Vinothkumar K.R., Strisovsky K., Andreeva A., Christova Y., Verhelst S. & Freeman M.:
The structural basis for catalysis and substrate specificity of a rhomboid protease.
EMBO Journal 29: 3797-3809, 2010.

Stevenson L.G., Strisovsky K., Clemmer K.M., Bhatt S., Freeman M. & Rather P.N.:
Rhomboid protease AarA mediates quorum-sensing in Providencia stuartii by activating TatA of the twin-arginine translocase.
Proceedings of the National Academy of Sciences of the United States of America 104: 1003-1008, 2007.

^{* equal contribution}