Laboratory of Growth Substances
Laboratory of Growth Regulators has been created in 1995 as a joined facility of the Faculty of Science, Palacký University (www.upol.cz) and Institute of Experimental Botany, Academy of Sciences of the Czech Republic (www.ueb.cas.cz).
Research program of the laboratory is aimed primary at small molecules that regulate cell division cycle, proliferation and growth of both plant and animal cells. Namely cytokinins and cytokinin-derived purine inhibitors of cyclin-dependent kinases belongs to the most intensively studied compounds. The representative of the latter, roscovitine (CYC202, seliciclib), already undergoes phase II clinical trials in patients as a novel anticancer drug held by Cyclacel Ltd (for more information see actual Press Release).
Our multidisciplinary research team is composed of experienced plant physiologists, biochemists as well as organic and analytical chemists. Many students are involved in the research during their pregradual and postgraduate studies of botany, analytical and organic chemistry, biochemistry or medicinal biology, respectively.
Laboratory of Growth Regulators guarantees the teaching for biological study programs. Members of the laboratory give lectures from general botany, plant physiology, microbiology, chemistry, molecular biology, including practical courses and seminars.
Several reseach projects are in progress in colaboration with international partners (University of Berlin, Germany; Swedish University of Agricultural Sciences, Sweden; University of Natal Pietermaritzburg, South Africa; Vienna Medical University, Austria).
Workers
head of the laboratorysenior scientist
- Prof. ing. Miroslav Strnad CSc.
scientist
- Jiří Grúz
- Mgr. Ondřej Novák Ph.D.
- Mgr. Lucie Plíhalová Ph.D.
- Mgr. Danuše Tarkowská Ph.D.
- PharmDr. Lubor Urbánek Ph.D.
graduated technical assistant
- Mgr. Ota Blahoušek
- Ivan Petřík
assistant
- Jitka Hansgutová DiS.
technician
- Mgr. Marie Karlická
Research projects
Publications
2007
- JOURNAL OF MEDICINAL CHEMISTRY 50 [15] 3667-3673 2007 Fulltext: public PDF link
- JOURNAL OF PLANT GROWTH REGULATION 26 [1] 1-14 2007 Fulltext: public PDF link
- PLANT PHYSIOLOGY 145 [3] 786-800 2007 Fulltext: public PDF link
- TOXICOLOGY IN VITRO 21 [7] 1304-1306 2007
- VETERINÁRNÍ MEDICÍNA 52 [1] 19-28 2007 Fulltext: public PDF link
- ACTA PHYSIOLOGIAE PLANTARUM 29 [1] S68-S69 2007 Fulltext: public PDF link
- ENVIRONMENTAL AND EXPERIMENTAL BOTANY 61 [2] 137-144 2007 Fulltext: public PDF link
2006
- BIOORGANIC AND MEDICAL CHEMISTRY 14 [3] 875-884 2006
- CHEMISTRY - A EUROPEAN JOURNAL 12 [16] 4297-4304 2006
- EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 41 1405-1411 2006