INSTITUTE OF PHYSIOLOGY CAS

Role of Plzf gene in regulation of metabolic and cardiac traits An important role of Plzf in regulation of metabolic and cardiac traits in the rat that suggests a crosstalk between cell cycle regulators, metabolism, cardiac hypertrophy and fibrosis.

Mitochondria´a role in heart damage due to myocardial infarction Ischemic heart disease is the leading cause of morbidity and mortality in the Western world.

Mitochondria dysfunction and Fanconi syndrome Inborn disorders of energy provision by mitochondrial respiratory chain are the primary cause of numerous serious diseases, ranging from most severe encephalo-cardio-myopathies manifesting early after birth to various tissues-specific and milder disorders affecting mainly adults.

TMEM70 disease Animal models of human mitochondrial diseases enable detailed insight into pathogenic mechanisms, from molecular to organismal levels.