|
|
|
Education |
|
2006-2010 |
Ph.D. in biochemistry, Faculty of Science, Charles University, Prague, Czech Republic.
Ph.D. thesis "Overcoming drug resistance: The discovery, design and characterization of new nonpeptidic inhibitors of HIV-1 protease" under supervision of Dr. Jan Konvalinka at the Institute of OrganicChemistry and Biochemistry AS CR, Prague. |
|
1998-2003 |
M.Sc. in biochemistry at the Faculty of Science, Charles University, Prague, Czech Republic.
Diploma thesis: "The viral resistance in HIV positive patiens treated with inhibitors of HIV protease" under supervision of Dr. J.Konvalinka at the Institute of Organic Chemistry and Biochemistry ASCR, Prague. |
|
|
|
Appointments |
|
since 2010 |
Postdoctoral fellow in Jan Konvalinka's laboratory. |
|
|
|
Awards |
|
2011 |
The Josef Hlávka Prize for year 2011. |
|
2008 |
Chairman´s award for the best poster "Kinetic, Structural and Thermodynamic Characterization of HIV Protease with Insertion in the Flap Region Isolated from and HIV-Positive Patient" at the conference Applications of Biocalorimetry (abc6), Heidelberg, Germany. |
|
2006 |
Chairman´s award for the best poster "Metallacarboranes as Specific and Potent Inhibitors of HIV Protease and its Resistant Mutants" at the conference HIV DART 2006: Frontiers in Drug Development for Antiretroviral Therapies, Cancun, Mexico. |
|
|
|
Patents and Inventions |
Král V., Cígler P., Konvalinka J., Kožíšek M., Pokorná J., Prejdová J., Lepšík M., Grüner B., Plešek J., Kraeuslich H.-G., Bodem J.:
Novel HIV protease inhibitors.
Mezinárodní patent WO/2005/073240.
Král V., Cígler P., Konvalinka J., Kožíšek M., Pokorná, J., Prejdová J., Lepšík M., Grüner B., Plešek J., Kraeuslich H.-G., Bodem J.:
Novel inhibitors of HIV protease.
Český patent CZ 295245.
|
|
|
|
Research interests |
-
HIV drug development focusing on HIV protease and viral assembly
-
ultrasensitive microcalorimetry in the study of biomolecular interactions and protein stability
-
drug development targeting neuraminidase from the Influenza virus
|
