DFRP
Free Radical Pathophysiology
Head of the department:
Lukáš Kubala
Scientific interest:
- Modulation of mechanisms leading to the generation of reactive oxygen and nitrogen metabolites by phagocytes
- Effects of polyunsaturated fatty acids and products of their peroxidation on the metabolic activity of phagocytes
- Mutual interactions of phagocytes with other cell types and extracellular matrix components
- Antioxidative properties of body fluids, drugs and natural compounds
- Role of myeloperoxidase in the regulation of vascular physiology
- Redox regulation of intracellular signaling
- Role of NADPH oxidases in the physiology of non-phagocytic cells