![Functional Morphology](https://webarchiv.lib.cas.cz:443/wayback/20171021001241im_/http://www.fgu.cas.cz/img/upload/06cbgnig8h1fds8urznz.jpg)
Recording of electrophysiological activity from dorsal horn neurons in acute spinal cord slices with patch-clamp technique.
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The main research interest of our department is to study mechanisms of pain and to explore new possibilities of pain treatment, especially in chronic states. Our experimental work is concentrated on the modulation of nociceptive information at the spinal cord level that is the relay center between the periphery and the higher brain areas. Our goal is to study these modulatory mechanisms in order to improve therapy for pain conditions, such as allodynia, hyperalgesia, neuropathic and cancer related pain. Our focus is on the role of TRPV1 receptors and inflammatory cytokines. In our research we use mainly electrophysiological, immunohistochemical and behavioral methods. In addition, we finalize another project directed towards the role of thyroid hormones (THs) and omega-3-polyunsaturated fatty acid (n-3 PUFA) in the physiology of cardiac and skeletal muscles. Models of hyper- and hypothyroid status are used to analyze potential influence of n-3 PUFA on the induced pathological changes.
Obituary RNDr. Tomáš Soukup, CSc
Projects
Scientists from the Department of Functional Morphology in collaboration with colleagues from The University of Texas showed that paclitaxel induced pain is mediated by TRPV1 and TLR4 receptors.
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N-acylphosphatidylethanolamine (NAPE), as the precursor of anandamide, an endogenous agonist of TRPV1 and cannabinoid receptors, could play a role in modulation of nociceptive signalization in the spinal cord.
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Achievements
Aktualne.TV - interview, 18.3. 2015
The interview with Dr. Paleček about the research whose aim is to eliminate chronic pain.
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Altogether 70 scientists from 17 foreign countries and 6 from the Czech Republic have attended the meeting as registered participants.
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Publications
Szeiffová Bačová, B. - Vinczenzová, C. - Žurmanová, J. - Kašparová, Dita - Knezl, V. - Egan Beňová, T. - Pavelka, Stanislav - Soukup, Tomáš - Tribulová, N.
Altered thyroid status affects myocardial expression of connexin-43 and susceptibility of rat heart to malignant arrhythmias that can be partially normalized by red palm oil intake
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Histochemistry and Cell Biology. 2017, roč. 147, 1, p. 63-73
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IF = 2.553
[ASEP]
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Kalynovska, Nataliia - Adámek, Pavel - Paleček, Jiří
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TRPV1 receptors contribute to mediate paclitaxel-induced c-Fos expression in spinal cord dorsal horn neurons
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Physiological Research. 2017, roč. 66, 3, p. 549-532
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IF = 1.461
[ASEP]
Mrózková, Petra - Špicarová, Diana - Paleček, Jiří
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Hypersensitivity Induced by Activation of Spinal Cord PAR2 Receptors Is Partially Mediated by TRPV1 Receptors
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PLoS ONE. 2016, roč. 11, 10, článku e0163991
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IF = 2.806
[ASEP]
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doi
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Szeiffová Bačová, B. - Egan Beňová, T. - Viczenczová, C. - Soukup, Tomáš - Rauchová, Hana - Pavelka, Stanislav - Knezl, V. - Barančík, M. - Tribulová, N.
Cardiac Connexin-43 and PKC Signaling in Rats With Altered Thyroid Status Without and With Omega-3 Fatty Acids Intake
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Physiological Research. 2016, roč. 65, Suppl.1, S77-S90
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IF = 1.461
[ASEP]
Mrózková, Petra - Paleček, Jiří - Špicarová, Diana
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The role of protease-activated receptor type 2 in nociceptive signaling and pain
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Physiological Research. 2016, roč. 65, 3, p. 357-367
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IF = 1.461
[ASEP]
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