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Education |
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1960-1963 |
Ph.D. study in the Institute of Organic Chemistry and Biochemistry, Academy of Sciences, Prague (1963) in synthetic organic chemistry. |
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1954-1959 |
University education at Faculty of Sciences, Charles University, Prague (1959) in organic chemistry. |
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Experience |
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1966 |
Postdoctoral stay: MPI für experimentelle Medizin, Goettingen (Prof. F.Cramer). |
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Appointments |
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2005 |
Professor of Organic Chemistry. |
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2004 |
Habilitation. |
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1996-2003 |
Director of the Institute (legally permitted two 4-year terms). |
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1986 |
Doctor of Sciences (the highest scientific degree in the Academy of Sciences). |
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1980-2010 |
Head of Department of Nucleic Acids Chemistry. |
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1974-2010 |
Head of the research group. |
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1963-1974 |
Research scientist in the group of nucleic acid chemistry, Institute of Organic Chemistry and Biochemistry. |
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Awards and Fellowships |
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2006 |
"De Scientia et Humanitate Optime meritis" (Supreme Medal of the Czech Academy of Sciences). |
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2004 |
Member of European Academy of Sciences. |
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2004 |
Prize "Prix Bohemia" for scientific achievements. |
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2003 |
Honorary membership of the Rega Institute, Catholic University Leuven (Belgium). |
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2002 |
René Descartes Prize of the European Union. |
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2001 |
G.Elion Prize of ISAR (International Society of Antiviral Research). |
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2001 |
State medal of the Czech Republic "Pour Merit". |
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1990 |
Medal of Czech Chemical Society. |
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1986 |
State Prize for Chemistry. |
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Honorary Doctorates and Professorships |
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2009 |
University of South Bohemia in České Budějovice |
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2008 |
University of Manchester's School of Chemistry |
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2006 |
Gilead Sciences Distinguished Chair in Medicinal Chemistry. |
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2005 |
University of Ghent (Belgium). |
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2001 |
Institute of Chemical Technology Prague and Votocek Medal. |
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2001 |
Palacký University Olomouc. |
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Publications and patents |
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Author of more than 600 original papers, 60 patents and numerous patent equivalents. Chapters in several scientific monographies. Author of original textbook "Principles of bioorganic chemistry in the design of antivirals and cytostatics (in Czech), edited 2005. |
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Present membership in Editorial Boards |
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Antiviral Research; Nucleosides, Nucleotides and Nucleic Acids. |
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Teaching |
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Special one-term course on bioorganic chemistry at the Faculties of Sciences of the Charles University in Prague and Palacký University in Olomouc. Educated numerous Ph.D. students and M.S.students (in the research group there are at present 6 Ph.D. students, 1 external Ph.D. student, 5 M.Sc. students). |
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Research interest |
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Medicinal chemistry, heterocyclic chemistry, carbohydrate chemistry, phosphorus chemistry, nucleic acid chemistry and biochemistry, development of antivirals and antineoplastics, enzymes of nucleoside metabolism and their inhibitors. |
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Major achievements |
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Design & synthesis of acyclic nucleosides and their phosphonomethyl ethers (acyclic nucleoside phosphonates, ANP); three of these compounds are themselves or active principles of antiviral drugs Vistide, Viread (AIDS), Hepsera (hepatitis B), Truvada (AIDS) and Atripla [three drug combination pill (AIDS)]. Additional drug candidates are in the process of development (NDA stage). |
