Ischemic heart disease is the main cause of mortality worldwide. We study cardiac tolerance to injury caused by acute oxygen deprivation from the molecular level to the whole organism using animal models. Our research is focused mainly on the study of mechanisms that underlie:
- high cardiac tolerance to injury early ontogeny,
- increased cardiac tolerance induced by adaptation to chronic hypoxia and regular exercise training,
- permanent consequences of early developmental interventions for cardiac tolerance in adulthood,
- and altered cardiac tolerance associated with various pathological states.
Further we study heart development with special emphasis on the cardiac conduction system. Our current research is focused on the following projects:
- elucidating cardiac conduction system formation with phylogenetic approaches,
- dynamic imaging methods for cardiac conduction system,
- and development of new methods for quantitative analysis of fibrous structures to study branching patterns of the coronary vessels and cardiac conduction system.
Projects
This projects aims to obtain new insights into cardiac conduction system formation through comparative morphological and physiological approach.
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The immature heart is highly tolerant to ischemic injury, but chronic oxygen deficit during early ontogeny may have negative consequences that persist till adulthood. We study mechanisms responsible for developmental changes of cardiac ischemic tolerance.
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Systemic hypertension is a major risk factor of ischemic heart disease. However, it can also stimulate mechanisms that protect the heart against acute oxygen deprivation. We study the effects of various forms of hypertension on cardiac ischemic tolerance.
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Prolonged exposure to hypoxic environment leads to adaptation which is associated with improved cardiac tolerance to acute oxygen deprivation. We study molecular mechanisms underlying the cardioprotective effects of chronic hypoxia on various manifestations of ischemic injury.
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Publications
Tian, X. - Li, Y. - He, L. - Zhang, H. - Huang, X. - Liu, Q. - Pu, W. - Zhang, LB. - Li, Yi. - Zhao, H. - Wang, Z. - Zhu, J. - Nie, Y. - Hu, S. - Sedmera, David - Zhong, T. P. - Yu, Y. - Zhang, L. - Yan, Y. - Qiao, Z. - Wang, Q-D. - Wu, S. M. - Pu, W. T. - Anderson, R. H. - Zhou, B.
Identification of a hybrid myocardial zone in the mammalian heart after birth
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Nature Communications. 2017, roč. 8, Jul 20, článku 87
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IF = 12.124
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Novák, F. - Borovská, J. - Vecka, M. - Rychlíková, J. - Vávrová, L. - Petrásková, H. - Žák, A. - Nováková, Olga
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Plasma Phospholipid Fatty Acid Profile is Altered in Both Septic and Non-Septic Critically Ill: A Correlation with Inflammatory Markers and Albumin
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Lipids. 2017, roč. 52, 3, p. 245-254
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IF = 1.934
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Neckář, Jan - Svatoňová, Anna - Weissová, Romana - Drahota, Zdeněk - Zajíčková, Pavlína - Brabcová, I. - Kolář, D. - Alánová, Petra - Vašinová, Jana - Šilhavý, Jan - Hlaváčková, Markéta - Tauchmannová, Kateřina - Milerová, Marie - Ošťádal, Bohuslav - Červenka, L. - Žurmanová, J. - Kalous, M. - Nováková, Olga - Novotný, J. - Pravenec, Michal - Kolář, František
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Selective replacement of mitochondrial DNA increases the cardioprotective effect of chronic continuous hypoxia in spontaneously hypertensive rats
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Clinical science. 2017, roč. 131, 9, p. 865-881
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IF = 4.936
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doi
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Míčová, P. - Klevstig, Martina - Holzerová, Kristýna - Vecka, M. - Žurmanová, J. - Neckář, Jan - Kolář, František - Nováková, Olga - Novotný, J. - Hlaváčková, Markéta
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Antioxidant tempol suppresses heart cytosolic phospholipase A(2)alpha stimulated by chronic intermittent hypoxia
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Canadian Journal of Physiology and Pharmacology. 2017, roč. 95, 8, p. 920-927
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IF = 1.822
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Kolář, D. - Grešíková, M. - Wasková-Arnoštová, P. - Elsnicová, B. - Kohutová, J. - Horníková, D. - Vebr, P. - Neckář, Jan - Blahová, T. - Kašparová, D. - Novotný, J. - Kolář, František - Nováková, O. - Žurmanová, J.M.
Adaptation to chronic continuous hypoxia potentiates Akt/HK2 anti-apoptotic pathway during brief myocardial ischemia/reperfusion insult
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Molecular and Cellular Biochemistry. 2017, roč. 432, 1-2, p. 99-108
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IF = 2.669
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Alánová, Petra - Chytilová, Anna - Neckář, Jan - Hrdlička, Jaroslav - Míčová, P. - Holzerová, Kristýna - Hlaváčková, Markéta - Macháčková, Kristýna - Papoušek, František - Vašinová, Jana - Benák, Daniel - Nováková, Olga - Kolář, František
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Myocardial ischemic tolerance in rats subjected to endurance exercise training during adaptation to chronic hypoxia
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Journal of Applied Physiology. 2017, roč. 122, 6, p. 1452-1461
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IF = 3.351
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Ravingerová, T. - Farkasová, V. - Griecsová, L. - Čarnická, S. - Murariková, M. - Barlaka, E. - Kolář, František - Barteková, M. - Lonek, L. - Slezák, J. - Lazou, A.
Remote Preconditioning as a Novel "Conditioning" Approach to Repair the Broken Heart: Potential Mechanisms and Clinical Applications
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Physiological Research. 2016, roč. 65, Suppl.1, S55-S64
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IF = 1.461
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Hrdlička, Jaroslav - Neckář, Jan - Papoušek, František - Vašinová, Jana - Alánová, Petra - Kolář, František
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Beneficial effect of continuous normobaric hypoxia on ventricular dilatation in rats with post-infarction heart failure
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Physiological Research. 2016, roč. 65, 5, p. 867-870
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IF = 1.461
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Krejčí, Eliška - Peševski, Živorad - Naňka, O. - Sedmera, David
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Physiological role of FGF signaling in growth and remodeling of developing cardiovascular system
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Physiological Research. 2016, roč. 65, 3, p. 425-435
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IF = 1.461
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Slámová, Kristýna - Papoušek, František - Janovská, Petra - Kopecký, Jan - Kolář, František
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Adverse Effects of AMP-Activated Protein Kinase alpha 2-Subunit Deletion and High-Fat Diet on Heart Function and Ischemic Tolerance in Aged Female Mice
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Physiological Research. 2016, roč. 65, 1, p. 33-42
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IF = 1.461
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