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Mechanisms of DNA binding by tumor suppressor protein p53
Recognition of specific binding sites in DNA by the tumor suppressor protein p53 is given not only by nucleotide sequence of the binding site, but also by local and global DNA structure.
Sequencing of telomeres in onion
Twenty years old challenge - unknown telomeric sequence in onion and garlic from genus Allium, plants with large genomes and relatively low chromosomal numbers was solved. New ″onion″ motif, (CTCGGTTATGGG)n, is the longest and the most divergent known plant telomere variant so far.
Sensitive and specific analysis of purine nucleobases, metabolites and drugs with mechanically roughened carbon electrodes
At mechanically roughened carbon electrodes, excellent separation of oxidation peaks of uric acid, xanthine, hypoxanthine, adenine, guanine, allopurinol and oxypurinol was attained.
Detecting DNA damage and monitoring of enzymatic DNA processing by electrochemical methods
Electrochemical approaches have been applied to detect specific nucleobase lesions and to design fast techniques for the monitoring of DNA-processing enzymes activity.
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MU - Masarykova univerzita, Brno
VUT - Vysoké učení technické, Brno
UK - Karlova univerzita, Praha
GA ČR - Grantová agentura ČR
GA AV - Interní grantová agentura AV ČR
CEITEC - Středoevropský technologický institut
OPVK - Strukturální fondy EU
FNUSA-ICRC - Mezinárodní centrum klinického výzkumu