Selected results

Mechanisms of DNA binding by tumor suppressor protein p53

Recognition of specific binding sites in DNA by the tumor suppressor protein p53 is given not only by nucleotide sequence of the binding site, but also by local and global DNA structure.

Sequencing of telomeres in onion

Twenty years old challenge - unknown telomeric sequence in onion and garlic from genus Allium, plants with large genomes and relatively low chromosomal numbers was solved. New ″onion″ motif, (CTCGGTTATGGG)n, is the longest and the most divergent known plant telomere variant so far.

Sensitive and specific analysis of purine nucleobases, metabolites and drugs with mechanically roughened carbon electrodes

At mechanically roughened carbon electrodes, excellent separation of oxidation peaks of uric acid, xanthine, hypoxanthine, adenine, guanine, allopurinol and oxypurinol was attained.

Plant Genetics in Brno

Detecting DNA damage and monitoring of enzymatic DNA processing by electrochemical methods

Electrochemical approaches have been applied to detect specific nucleobase lesions and to design fast techniques for the monitoring of DNA-processing enzymes activity.

Further results