Organic Chemistry

The aim of our project is to extend our previous successful work on the field of cross-coupling reactions of organosulfur compound. While inherent to previous type of coupling is use of stoichiometric amount of the metallic co-catalyst, the current project offers the alternative rout of mobilizing transition metal catalyst from inactive metal thiolates. Supported by the preliminary experiments we want to use oxidative, bio-mimetic way of releasing the catalyst from the strong bond with the thiolate. This part of the project will be complemented by our effort of putting the cross-coupling substrates on polymer support. In the focal point of our efforts is also the recycling of the polymer-bound by-products. On carefully crafted cross coupling substrates we want to demonstrate our understanding of sulfur metal interactions and eventually develop general methodology for environmentally benign mild synthetic process.