People

Name Lepšík Martin
Position Scientist
Ota Bludský

Martin Lepšík, Ph.D.

Scientist


Prof. Pavel Hobza Research Team
Institute of Organic Chemistry and Biochemistry ASCR, v.v.i.
Flemingovo nám. 2, CZ-166 10 Prague 6, Czech Republic

☎: (+420) 220 410 319

Education
1999-2004 Ph.D. in Molecular Biology and Virology (thesis "HIV-1 Protease Inhibition and Drug Resistance Studied by Structure Analysis and Computational Methods"), Faculty of Science, Charles University, Prague.
1994-1999 M.Sc. in biology, molecular biology, virology, genetics and immunology, Faculty of Science, Charles University, Prague.
 
Courses
1999-2004 Ph.D. in Molecular Biology and Virology (thesis "HIV-1 Protease Inhibition and Drug Resistance Studied by Structure Analysis and Computational Methods"), Faculty of Science, Charles University, Prague.
2001 (2 months) Crystallographic refinement, J.R. Mesters, Prof. R. Hilgenfeld, Institut für Molekulare Biotechnologie, Jena, Germany.
2001 (1 month) Summer school of quantum chemistry, Dr. P. Nachtigall, Prof. P.Hobza, J. Heyrovský Institute of Physical Chemistry, Prague.
2000 (1 month) Course on Combinatorial Chemistry, S. Miertus, International Centre for Genetic Engineering and Biotechnology, Trieste, Italy.
2000 (1 month) Course on biomolecular simulations, R. Wade, M. Nilges, European Molecular Biology Laboratories (EMBL), Heidelberg.
1999 (1 month) Computational “WHAT IF“ user course, G. Vriend, EMBL, Heidelberg.
 
Experience
since 2010 Scientist at the group of Prof. Pavel Hobza, Institute of Organic Chemistry and Biochemistry AS CR, Prague.
2007-2009 Post-doc with Dr. Lubomír Rulíšek and Dr. Jan Konvalinka, IOCB, Prague.
2006 (11 months) Post-doc with Dr. Martin J. Field, Institut de Biologie Structurale, Grenoble.
2004-2005 Post-doc with Prof. Pavel Hobza, IOCB, Prague.
 
Research interest
  • drug design
  • biomolecular simulations
  • borane chemistry
  • noncovalent interactions
  • reaction mechanisms
  • X-ray crystallography