2011
Perlíková P, Pohl R., Votruba I., Shih R., Birkuš G., Cihlář T., Hocek M.:
Phosphoramidate pronucleotides of cytostatic 6-aryl-7-deazapurine ribonucleosides.
Bioorganic & Medicinal Chemistry 19: 229-242 (2011).
Mařák D., Otmar M., Votruba I., Dračinský M., Krečmerová M.
8-Aza-7,9-dideazaxanthine acyclic nucleoside phosphonate inhibitors of thymidine phosphorylase.
Bioorganic & Medicinal Chemistry Letters 21: 652-654 (2011).
Fulneček J., Matyášek R., Votruba I., Holý A., Křížová K., Kovařík A.
Inhibition of SAH-hydrolase activity during seed germination leads to deregulation of flowering genes and altered flower morphology in tobacco.
Molecular Genetics & Genomics 285: 225-236 (2011).
Jansa P., Baszczyňski, O., Dračínský M., Votruba I., Zídek Z., Gahador G., Stepan G., Cihlar T., Mackman R.L., Holy A., Janeba Z.:
A novel and efficient one-pot synthesis of symmetrical diamide (bis-amidate) prodrugs of acyclic nucleoside phosphonates and evaluation of their biological activities.
European Journal of Medicinal Chemistry 46: 3748-3754 (2011).
Baszczyňski O., Jansa P., Dračínský M., Klepetářová B., Holý A., Votruba I., De Clercq E., Balzarini J., Janeba Z.:
Synthesis and antiviral activity of N9-[3-fluoro-2-(phosphonomethoxy)propyl] analogues derived from N6-substituted adenines and 2,6-diaminopurines.
Bioorganic & Medicinal Chemistry 19: 2114-2124 (2011).
Jansa P., Špaček P., Votruba I., Břehová P., Dračínský M., Klepetářová B., Janeba Z.:
Efficient one-pot synthesis of polysubstituted 6-[(1h-1,2,3-triazol-1-yl)methyl]uracils through the "click" protocol.
Collection of Czechoslovak Chemical Communications 76: 1121-1131 (2011).
Špak J., Votruba I., Pavingerová D., Holý A., Špaková V., Petrzik K.:
Antiviral activity of tenofovir against Cauliflower mosaic virus and its metabolism in Brassica pekinensis.
Antiviral Research 92: 378-381 (2011).
Matoušová M., Votruba I., Otmar M., Tloušťová E., Günterová J., Mertlíková-Kaiserová H.:
2´-Deoxy-5,6-dihydro-5-azacytidine - a less toxic alternative of 2´-deoxy-5-azacytidine: a comparative study of hypomethylating potential.
Epigenetics 6: 769-776 (2011).
Bourderioux A., Nauš P., Perlíková P., Pohl R., Pichová I., Votruba I., Džubák P., Konečný P., Hajduch M., Stray K., Wang T., Ray A., Feng J., Birkuš G., Cihlar T., Hocek M.:
Synthesis and significant cytostatic activity of 7-hetaryl-7-deazaadenosines.
Journal of Medicinal Chemistry 54: 5498-5507 (2011).
Mertlíková-Kaiserová H., Rumlová M., Tloušťová E., Procházková E., Holý A., Votruba I.:
Point mutations in human guanylate kinase account for acquired resistance to anticancer nucleotide analogue PMEG.
Biochemical Pharmacology 82: 131-138 (2011).
Špak J., Pavingerová D., Špaková V., Petržík K.,Votruba I., Holý A.:
Použití acyklického nukleosidfosfonátu, tenofoviru, k eliminaci rostlinných ssDNA virů.
PV 2011-274 (10. 5. 2011)
Jansa P., Kolman V., Kostinová A., Dračínský M., Mertlíková-Kaiserová H., Janeba Z.:
Efficient synthesis and biological properties of the 2'-trifluoromethyl analogues of acyclic nucleosides and acyclic nucleoside phosphonates.
Collection of Czechoslovak Chemical Communications 76: 1187-1198 (2011).
Šála M., De Palma A.M., Hřebabecký H., Dejmek M., Dračínský M., Leyssen P., Neyts J., Mertlíková-Kaiserová H., Nencka R.:
SAR studies of 9-norbornylpurines as Coxsackievirus B3 inhibitors.
Bioorganic & Medicinal Chemistry Letters 21: 4271-4275 (2011).
Vávrová A., Popelová O., Štěrba M., Jirkovský E., Hašková P., Mertlíková-Kaiserová H., Geršl V., Šimůnek T.:
In vivo and in vitro assessment of the role of glutathione antioxidant system in anthracycline-induced cardiotoxicity.
Archives of Toxicology 85: 525-535 (2011).
Procházková E., Jansa P., Dračínský M., Holý A., Mertlíková-Kaiserová H.:
Determination of the antioxidant activity of substituted 5-aminopyrimidines.
Free Radical Research (in press)