Our research focuses on the cellular and molecular mechanisms of desensitization of hormone response mediated by the activation of G protein coupled receptors (GPCR). G protein coupled receptors are plasma membrane integral proteins which serve as transducers of extracellular signals across the plasma membrane bilayer to the cell interior. GPCR play a key role in the regulation of many physiological processes and functions. Moreover, GPCRs represent one of the most important groups of targets for therapeutics.

The main areas of the research are:

• The role of cell membrane and membrane domains
• Opioid receptors and drug addiction
• The effect of monovalent ions on δ-opioid receptors – analysis of lithium effect in living cells and isolated cell membranes
• GABA-B - signalling cascades

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