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Bioenergetics

Bioenergetics

We study the physiology of mitochondria, cell organelles responsible for most of the energy production on the molecular level. We use both animal models and cells derived from patients harbouring various mitochondrial disorders. Our research is focused mainly on:

  • Assembly of mitochondrial protein complexes and supercomplexes.
  • Human diseases caused by mutations in assembly factors of these enzyme complexes.
  • Development of protocols for diagnostics of mitochondrial diseases using patient-derived lymphocytes.
  • Identification of new mitochondrial genes that play a causal role in the metabolic syndrome and heart failure.

 

Currently we are hiring new postdoscs into our team. Interested? Find out more here and here.

Projects

Functional characterization of ATP synthase deficiencies

ATP produced by the mitochondrial FoF1-ATP synthase represents a major source of energy for aerobic organisms. The proposed project is aimed to shedding light on the functional consequences of ATP synthase deficiencies using a model of knock-down of small subunits of the catalytic F1 part of the mammalian ATP synthase (γ, δ and ε). More

The role of mitochondria in heart failure

To shed more light on whether OXPHOS defects can play a role in the development of heart failure, we analyse samples from patients undergoing heart transplants. We search for characteristic markers, which would be suitable for identification of new patients, as well as new potential targets for treatment. More

Bioenergetics of rare diseases

ATP synthase defects represent an important subgroup of inborn errors of metabolism. It may not be surprising if we take into account that ATP synthase is one of the key energy producing enzymes in a cell. We study biogenesis of this enzyme complex and the role of various other proteins in this process. More

Achievements

Publications

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Contacts

Institute of Physiology AS CR, v.v.i.
Department of bioenergetics
Vídeňská 1083
14220 Prague 4
Czech Republic
tel. +420 241 063 727
fax. +420 241 062 149
   

tomas.mracek@fgu.cas.cz

People

RNDr. Tomáš Mráček, Ph.D.
head of the department
MUDr. Josef Houštěk, DrSc.
deputy head of the department
RNDr. Zdeněk Drahota, DrSc. 
senior researcher (emeritus)
Mgr. Petr Pecina, Ph.D.
senior researcher
Mgr. Vilma Kaplanová, Ph.D.
senior researcher
RNDr. Alena Pecinová, Ph.D.
senior researcher
RNDr. Marek Vrbacký, Ph.D.
senior researcher

Mgr. Kateřina Tauchmannová, Ph.D.

(née Hejzlarová)
postdoc

Mgr. Lukáš Alán, Ph.D.

postdoc

David Pajuelo Reguera, Ph.D.

postdoc

Ing. Andrea Brázdová, Ph.D.

postdoc

Mgr. Jana Kovalčíková
PhD student
Mgr. Michal Zima
PhD student
BSc. Hien Ho Dieu
master student

Kristýna Čunátová

undergraduate student

Julia Effimova

undergraduate student

Vladimíra Brožková
lab technician

© 2014 INSTITUTE OF PHYSIOLOGY CAS