We study the physiology of mitochondria, cell organelles responsible for most of the energy production on the molecular level. We use both animal models and cells derived from patients harbouring various mitochondrial disorders. Our research is focused mainly on:
- Assembly of mitochondrial protein complexes and supercomplexes.
- Human diseases caused by mutations in assembly factors of these enzyme complexes.
- Development of protocols for diagnostics of mitochondrial diseases using patient-derived lymphocytes.
- Identification of new mitochondrial genes that play a causal role in the metabolic syndrome and heart failure.
Currently we are hiring new postdoscs into our team. Interested? Find out more here and here.
Projects
ATP produced by the mitochondrial FoF1-ATP synthase represents a major source of energy for aerobic organisms. The proposed project is aimed to shedding light on the functional consequences of ATP synthase deficiencies using a model of knock-down of small subunits of the catalytic F1 part of the mammalian ATP synthase (γ, δ and ε).
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To shed more light on whether OXPHOS defects can play a role in the development of heart failure, we analyse samples from patients undergoing heart transplants. We search for characteristic markers, which would be suitable for identification of new patients, as well as new potential targets for treatment.
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Using lymphocytes isolated from peripheral blood, we try to develop new diagnostic protocols for patients with suspected mitochondrial diseases.
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ATP synthase defects represent an important subgroup of inborn errors of metabolism. It may not be surprising if we take into account that ATP synthase is one of the key energy producing enzymes in a cell. We study biogenesis of this enzyme complex and the role of various other proteins in this process.
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Achievements
Animal models of human mitochondrial diseases enable detailed insight into pathogenic mechanisms, from molecular to organismal levels.
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Inborn disorders of energy provision by mitochondrial respiratory chain are the primary cause of numerous serious diseases, ranging from most severe encephalo-cardio-myopathies manifesting early after birth to various tissues-specific and milder disorders affecting mainly adults.
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Fourth year of the scienticic photography contest means success for our young guns.
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A developing organism requires high amounts of energy in the form of ATP. In higher eukaryotes, and thus in humans, more than 90 % of ATP is produced in mitochondria, a key organelle of the cellular catabolism. It is therefore not surprising that mitochondrial defects belong to the most frequent causes of metabolic diseases in children.
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A brief list of what we published in 2014
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Publications
Neckář, Jan - Svatoňová, Anna - Weissová, Romana - Drahota, Zdeněk - Zajíčková, Pavlína - Brabcová, I. - Kolář, D. - Alánová, Petra - Vašinová, Jana - Šilhavý, Jan - Hlaváčková, Markéta - Tauchmannová, Kateřina - Milerová, Marie - Ošťádal, Bohuslav - Červenka, L. - Žurmanová, J. - Kalous, M. - Nováková, Olga - Novotný, J. - Pravenec, Michal - Kolář, František
.
Selective replacement of mitochondrial DNA increases the cardioprotective effect of chronic continuous hypoxia in spontaneously hypertensive rats
.
Clinical science. 2017, roč. 131, 9, p. 865-881
.
IF = 4.936
[ASEP]
[
doi
]
Melenovský, V. - Petrák, J. - Mráček, Tomáš - Beneš, J. - Borlaug, B. A. - Nůsková, Hana - Pluháček, T. - Špatenka, J. - Kovalčíková, Jana - Drahota, Zdeněk - Kautzner, J. - Pirk, J. - Houštěk, Josef
.
Myocardial iron content and mitochondrial function in human heart failure: a direct tissue analysis
.
European Journal of Heart Failure. 2017, roč. 19, 4, p. 522-530
.
IF = 6.968
[ASEP]
[
doi
]
Endlicher, R. - Drahota, Zdeněk - Červinková, Z.
In vitro and in vivo activation of mitochondrial membrane permeability transition pore using triiodothyronine
.
Physiological Research. 2016, roč. 65, 2, p. 321-331
.
IF = 1.461
[ASEP]
Pravenec, Michal - Mlejnek, Petr - Zídek, Václav - Landa, Vladimír - Šimáková, Miroslava - Šilhavý, Jan - Strnad, Hynek - Eigner, Sebastian - Eigner-Henke, Kateřina - Škop, V. - Malínská, H. - Trnovská, J. - Kazdová, L. - Drahota, Zdeněk - Mráček, Tomáš - Houštěk, Josef
.
Autocrine effects of transgenic resistin reduce palmitate and glucose oxidation in brown adipose tissue
.
Physiological Genomics. 2016, roč. 48, 6, p. 420-427
.
IF = 3.044
[ASEP]
[
doi
]
Česneková, J. - Spáčilová, J. - Hansíková, H. - Houštěk, Josef - Zeman, J. - Stibůrek, L.
LACE1 interacts with p53 and mediates its mitochondrial translocation and apoptosis
.
OncoTarget. 2016, roč. 7, 30, p. 47687-47698
.
IF = 5.178
[ASEP]
[
doi
]
Wang, M. - Sips, P. - Khin, E. - Rotival, M. - Sun, X. - Ahmed, R. - Widjaja, A. A. - Schafer, S. - Yusoff, P. - Choksi, P. K. - Ko, N. S. J. - Singh, M. K. - Epstein, D. - Guan, Y. - Houštěk, Josef - Mráček, Tomáš - Nůsková, Hana - Mikell, B. - Tan, J. - Pesce, F. - Kolář, František - Bottolo, L. - Mancini, M. - Hubner, N. - Pravenec, Michal - Petretto, E. - MacRae, C. - Cook, S. A.
Wars2 is a determinant of angiogenesis
.
Nature Communications. 2016, roč. 7, Jul, p. 12061
.
IF = 12.124
[ASEP]
[
doi
]
Boukalová, Štěpána - Štursa, J. - Werner, L. - Ezrová, Zuzana - Černý, Jiří - Bezawork-Geleta, A. - Pecinová, Alena - Dong, L. - Drahota, Zdeněk - Neužil, Jiří
.
Mitochondrial Targeting of Metformin Enhances Its Activity against Pancreatic Cancer
.
Molecular Cancer Therapeutics. 2016, roč. 15, 12, p. 2875-2886
.
IF = 5.764
[ASEP]
[
doi
]
Milerová, Marie - Drahota, Zdeněk - Chytilová, Anna - Tauchmannová, Kateřina - Houštěk, Josef - Ošťádal, Bohuslav
.
Sex difference in the sensitivity of cardiac mitochondrial permeability transition pore to calcium load
.
Molecular and Cellular Biochemistry. 2016, roč. 412, 1-2, p. 147-154
.
IF = 2.669
[ASEP]
[
doi
]
Heřmanová, I. - Arruabarrena-Aristorena, A. - Vališ, Karel - Nůsková, Hana - Alberich-Jorda, Meritxell - Fišer, K. - Fernandez-Ruiz, S. - Kavan, Daniel - Pecinová, Alena - Niso-Santano, N. - Žaliová, M. - Novák, Petr - Houštěk, Josef - Mráček, Tomáš - Kroemer, G. - Carracedo, A. - Trka, J. - Starková, J.
Pharmacological inhibition of fatty-acid oxidation synergistically enhances the effect of L-asparaginase in childhood ALL cells
.
Leukemia. 2016, roč. 30, 1, p. 209-218
.
IF = 11.702
[ASEP]
[
doi
]
Ng, Y. S. - Alston, Ch. L. - Diodato, D. - Morris, A. A. - Ulrick, N. - Kmoch, S. - Houštěk, Josef - Martinelli, D. - Haghighi, A. - Atiq, M. - Gamero, M. A. - Garcia-Martinez, E. - Kratochvílová, H. - Santra, S. - Brown, R. M. - Brown, G. K. - Ragge, N. - Monavari, A. - Pysden, K. - Ravn, K. - Casey, J. P. - Khan, A. - Chakrapani, A. - Vassallo, G. - Simons, C. - McKeever, K. - O´Sullivan, S. - Childs, A.-M. - Ostergaard, E. - Vanderver, A. - Goldstein, A. - Vogt, J. - Taylor, R. W. - McFarland, R.
The clinical, biochemical and genetic features associated with RMND1-related mitochondrial disease
.
Journal of Medical Genetics. 2016, roč. 53, 11, p. 768-775
.
IF = 5.451
[ASEP]
[
doi
]
Sobotka, O. - Endlicher, R. - Drahota, Zdeněk - Kučera, O. - Rychtrmoc, D. - Raad, M. - Hakeem, K. - Červinková, Z.
Impaired mitochondrial functions contribute to 3-bromopyruvate toxicity in primary rat and mouse hepatocytes
.
Journal of Bioenergetics and Biomembranes. 2016, roč. 48, 4, p. 363-373
.
IF = 2.576
[ASEP]
[
doi
]
Vrbacký, Marek - Kovalčíková, Jana - Chawengsaksophak, Kallayanee - Beck, Inken - Mráček, Tomáš - Nůsková, Hana - Sedmera, David - Papoušek, František - Kolář, František - Sobol, Margaryta - Hozák, Pavel - Sedláček, Radislav - Houštěk, Josef
.
Knockout of Tmem70 alters biogenesis of ATP synthase and leads to embryonal lethality in mice
.
Human Molecular Genetics. 2016, roč. 25, 21, p. 4674-4685
.
IF = 5.340
[ASEP]
[
doi
]
Hartmannová, H. - Piherová, L. - Tauchmannová, Kateřina - Kidd, K. - Acott, P. D. - Crocker, J. F. S. - Oussedik, Y. - Mallet, M. - Hodaňová, K. - Stránecký, V. - Přistoupilová, A. - Barešová, V. - Jedličková, I. - Živná, M. - Sovová, J. - Hůlková, H. - Robins, V. - Vrbacký, Marek - Pecina, Petr - Kaplanová, Vilma - Houštěk, Josef - Mráček, Tomáš - Thibeault, Y. - Bleyer, A. J. - Kmoch, S.
Acadian variant of Fanconi syndrome is caused by mitochondrial respiratory chain complex I deficiency due to a non-coding mutation in complex I assembly factor NDUFAF6
.
Human Molecular Genetics. 2016, roč. 25, 18, p. 4062-4079
.
IF = 5.340
[ASEP]
[
doi
]
Folbergrová, Jaroslava - Ješina, Pavel - Kubová, Hana - Druga, Rastislav - Otáhal, Jakub
.
Status Epilepticus in Immature Rats Is Associated with Oxidative Stress and Mitochondrial Dysfunction
.
Frontiers in Cellular Neuroscience. 2016, roč. 10, May 26, p. 136
.
IF = 4.555
[ASEP]
[
doi
]
Kovářová, Nikola - Pecina, Petr - Nůsková, Hana - Vrbacký, Marek - Zeviani, M. - Mráček, Tomáš - Viscomi, C. - Houštěk, Josef
.
Tissue- and species-specific differences in cytochrome c oxidase assembly induced by SURF1 defects
.
Biochimica Et Biophysica Acta-Molecular Basis of Disease. 2016, roč. 1862, 4, p. 705-715
.
IF = 5.388
[ASEP]
[
doi
]
Česneková, J. - Rodinová, M. - Hansíková, H. - Houštěk, Josef - Zeman, J. - Stibůrek, L.
The mammalian homologue of yeast Afg1 ATPase (lactation elevated 1) mediates degradation of nuclear-encoded complex IV subunits
.
Biochemical Journal. 2016, roč. 473, 6, p. 797-804
.
IF = 3.797
[ASEP]
[
doi
]
Trnovská, J. - Šilhavý, Jan - Zídek, Václav - Šimáková, Miroslava - Mlejnek, Petr - Landa, Vladimír - Eigner, Sebastian - Eigner-Henke, Kateřina - Škop, V. - Oliyarnyk, O. - Kazdová, L. - Mráček, Tomáš - Houštěk, Josef - Pravenec, Michal
.
Gender-related effects on substrate utilization and metabolic adaptation in hairless spontaneously hypertensive rat
.
Physiological Research. 2015, Vol. 64, 1, p. 51-60
.
IF = 1.618
[ASEP]
Sobotka, O. - Drahota, Zdeněk - Kučera, O. - Endlicher, R. - Rauchová, Hana - Červinková, Z.
The effect of alpha-tocopheryl succinate on succinate respiration in rat liver mitochondria.
Physiological Research. Vol. 64, Suppl.5 (2015), S609-S615. ISSN 0862-8408
.
IF = 1.618
[ASEP]
Klučková, Katarína - Sticha, M. - Černý, Jiří - Mráček, Tomáš - Dong, L. - Drahota, Zdeněk - Gottlieb, E. - Neužil, Jiří - Rohlena, Jakub
.
Ubiquinone-binding site mutagenesis reveals the role of mitochondrial complex II in cell death initiation
.
Cell Death & Disease. 2015, Vol. 6, May 2015, e1749
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IF = 5.378
[ASEP]
[
doi
]
Hejzlarová, Kateřina - Kaplanová, Vilma - Nůsková, Hana - Kovářová, Nikola - Ješina, Pavel - Drahota, Zdeněk - Mráček, Tomáš - Seneca, S. - Houštěk, Josef
.
Alteration of structure and function of ATP synthase and cytochrome c oxidase by lack of F-o-a and Cox3 subunits caused by mitochondrial DNA 9205delTA mutation
.
Biochemical Journal. 2015, Vol. 466, 3, p. 601-611
.
IF = 3.562
[ASEP]
[
doi
]
Nůsková, Hana - Mráček, Tomáš - Mikulová, Tereza - Vrbacký, Marek - Kovářová, Nikola - Kovalčíková, Jana - Pecina, Petr - Houštěk, Josef
.
Mitochondrial ATP synthasome: Expression and structural interaction of its components
.
Biochemical and Biophysical Research Communications. 2015, Vol. 464, 3, p. 787-793
.
IF = 2.371
[ASEP]
[
doi
]
Cahová, M. - Chrastina, P. - Hansíková, H. - Drahota, Zdeněk - Trnovská, J. - Škop, V. - Spáčilová, J. - Malínská, H. - Oliyarnyk, O. - Papáčková, Z. - Páleníčková, E. - Kazdová, L.
Carnitine supplementation alleviates lipid metabolism derangements and protects against oxidative stress in non-obese hereditary hypertriglyceridemic rats
.
Applied Physiology Nutrition and Metabolism-Physiologie appliquee nutrition et metabolisme. 2015, Vol. 40, 3, p. 280-291
.
IF = 1.91
[ASEP]
[
doi
]
Cahová, M. - Páleníčková, E. - Danková, H. - Sticová, E. - Burian, M. - Drahota, Zdeněk - Červinková, Z. - Kučera, O. - Gladkova, Ch. - Stopka, Pavel - Křížová, Jana - Papáčková, Z. - Oliyarnyk, O. - Kazdová, L.
Metformin prevents ischemia reperfusion-induced oxidative stress in the fatty liver by attenuation of reactive oxygen species formation
.
American Journal of Physiology-Gastrointestinal and Liver Physiology. 2015, Vol. 309, 2, G100-G111
.
IF = 3.297
[ASEP]
[
doi
]
Shabalina, I.G. - Vrbacký, Marek - Pecinová, Alena - Kalinovich, A. V. - Drahota, Zdeněk - Houštěk, Josef - Mráček, Tomáš - Cannon, B. - Nedergaard, J.
ROS production in brown adipose tissue mitochondria: The question of UCP1-dependence
.
Biochimica Et Biophysica Acta-Bioenergetics. 2014, roč. 1837, 12, p. 2017-2030
.
IF = 5.353
[ASEP]
[
doi
]
Rauchová, Hana - Vokurková, Martina - Drahota, Zdeněk
.
Inhibition of mitochondrial glycerol-3-phosphate dehydrogenase by alpha-tocopheryl succinate
.
International Journal of Biochemistry and Cell Biology 2014, roč. 53, aug, p. 409-413. ISSN 1357-2725.
IF = 4.046
[ASEP]
[
doi
]
Mráček, Tomáš - Holzerová, Eliška - Drahota, Zdeněk - Kovářová, Nikola - Vrbacký, Marek - Ješina, Pavel - Houštěk, Josef
.
ROS generation and multiple forms of mammalian mitochondrial glycerol-3-phosphate dehydrogenase
.
Biochimica Et Biophysica Acta-Bioenergetics 2014, roč. 1837, 1, p. 98-111. ISSN 0005-2728.
IF = 5.353
[ASEP]
[
doi
]
Kratochvílová, H. - Hejzlarová, Kateřina - Vrbacký, Marek - Mráček, Tomáš - Karbanová, Vendula - Tesařová, M. - Gombitová, A. - Cmarko, D. - Wittig, I. - Zeman, J. - Houštěk, Josef
.
Mitochondrial membrane assembly of TMEM70 protein
.
Mitochondrion 2014, roč. 15, mar 2014, p. 1-9. ISSN 1567-7249.
IF = 3.249
[ASEP]
[
doi
]
Houštěk, Josef - Vrbacký, Marek - Hejzlarová, Kateřina - Zídek, Václav - Landa, Vladimír - Šilhavý, Jan - Šimáková, Miroslava - Mlejnek, Petr - Kazdová, L. - Mikšík, Ivan - Neckář, Jan - Papoušek, František - Kolář, František - Kurtz, T. W. - Pravenec, Michal
.
Effects of mtDNA in SHR-mtF344 versus SHR conplastic strains on reduced OXPHOS enzyme levels, insulin resistance, cardiac hypertrophy, and systolic dysfunction
.
Physiological Genomics 2014, roč. 46, 18, p. 671-678. ISSN 1094-8341.
IF = 2.374
[ASEP]
[
doi
]
Hejzlarová, Kateřina - Mráček, Tomáš - Vrbacký, Marek - Kaplanová, Vilma - Karbanová, Vendula - Nůsková, Hana - Pecina, Petr - Houštěk, Josef
.
Nuclear genetic defects of mitochondrial ATP synthase
.
Physiological Research 2014, roč. 63, suppl.1, s57-s71. ISSN 0862-8408.
IF = 1.293
[ASEP]
Garnol, T. - Endlicher, R. - Kučera, O. - Drahota, Zdeněk - Červinková, Z.
Impairment of mitochondrial function of rat hepatocytes by high fat diet and oxidative stress
.
Physiological Research 2014, roč. 63, 2, p. 271-274. ISSN 0862-8408.
IF = 1.293
[ASEP]
Drahota, Zdeněk - Páleníčková, E. - Endlicher, R. - Milerová, Marie - Brejchová, Jana - Vošahlíková, Miroslava - Svoboda, Petr - Kazdová, L. - Kalous, M. - Červinková, Z. - Cahová, M.
Biguanides Inhibit Complex I, II and IV of Rat Liver Mitochondria and Modify Their Functional Properties
.
Physiological Research 2014, roč. 63, 1, p. 1-11. ISSN 0862-8408.
IF = 1.293
[ASEP]
Sanderson, T. H. - Mahapatra, G. - Pecina, Petr - Ji, Q. - Yu, K. - Sinkler, Ch. - Varughese, A. - Kumar, R. - Bukowski, M. J. - Tousignant, R. N. - Salomon, A. R. - Lee, I. - Hüttemann, M.
Cytochrome c Is Tyrosine 97 Phosphorylated by Neuroprotective Insulin Treatment
.
PLoS ONE, 2013, Vol. 8, 11, e78627
.
IF = 3.534
[ASEP]
[
doi
]
Mráček, Tomáš - Drahota, Zdeněk - Houštěk, Josef
.
The function and the role of the mitochondrial glycerol-3-phosphate dehydrogenase in mammalian tissues
.
Biochimica Et Biophysica Acta-Bioenergetics, 2013, Vol. 1827, 3, p. 401-410
.
IF = 4.624
[ASEP]
[
doi
]
Kovářová, Nikola - Mráček, Tomáš - Nůsková, Hana - Holzerová, Eliška - Vrbacký, Marek - Pecina, Petr - Hejzlarová, Kateřina - Klučková, Katarína - Rohlena, Jakub - Neužil, Jiří - Houštěk, Josef
.
High Molecular Weight Forms of Mammalian Respiratory Chain Complex II
.
PLoS ONE, 2013, Vol. 8, 8, e71869
.
IF = 3.730
[ASEP]
[
doi
]
Folbergrová, Jaroslava - Ješina, Pavel - Nůsková, Hana - Houštěk, Josef
.
Antioxidant enzymes in cerebral cortex of immature rats following experimentally-induced seizures: upregulation of mitochondrial MnSOD (SOD2)
.
International Journal of Developmental Neuroscience, 2013, Vol. 31, 2, p. 123-130
.
IF = 2.692
[ASEP]
[
doi
]
Stibůrek, L. - Česneková, J. - Kostková, O. - Fornůsková, D. - Vinšová, K. - Wenchich, L. - Houštěk, Josef - Zeman, J.
YME1L controls the accumulation of respiratory chain subunits and is required for apoptotic resistance, cristae morphogenesis, and cell proliferation
.
Molecular Biology of the Cell, 2012, Vol. 23, 6, p. 1010-1023
.
IF = 4.604
[ASEP]
[
doi
]
Rauchová, Hana - Vokurková, Martina - Drahota, Zdeněk
.
Idebenone-induced recovery of glycerol-3-phosphate and succinate oxidation inhibited by digitonin
.
Physiological Research, 2012, Vol. 61, 3, p. 259-265
.
IF = 1.531
[ASEP]
Neckář, Jan - Šilhavý, Jan - Zídek, Václav - Landa, Vladimír - Mlejnek, Petr - Šimáková, Miroslava - Seidman, J. G. - Seidman, Ch. - Kazdová, L. - Klevstig, M. - Novák, F. - Vecka, M. - Papoušek, František - Houštěk, Josef - Drahota, Zdeněk - Kurtz, T. W.
CD36 overexpression predisposes to arrhythmias but reduces infarct size in spontaneously hypertensive rats: gene expression profile analysis
.
Physiological Genomics, 2012, Vol. 44, 2, p. 173-182
.
IF = 2.806
[ASEP]
[
doi
]
Kovářová, Nikola - Vrbacká-Čížková, Alena - Pecina, Petr - Stránecký, V. - Pronicka, E. - Kmoch, S. - Houštěk, Josef
.
Adaptation of respiratory chain biogenesis to cytochrome c oxidase deficiency caused by SURF1 gene mutations
.
Biochimica Et Biophysica Acta-Molecular Basis of Disease, 2012, Vol. 1822, 7, p. 1114-1124
.
IF = 4.910
[ASEP]
[
doi
]
Karbanová-Havlíčková, Vendula - Vrbacká-Čížková, Alena - Hejzlarová, Kateřina - Nůsková, Hana - Stránecký, V. - Potocká, Andrea - Kmoch, S. - Houštěk, Josef
.
Compensatory upregulation of respiratory chain complexes III and IV in isolated deficiency of ATP synthase due to TMEM70 mutation
.
Biochimica Et Biophysica Acta-Bioenergetics, 2012, Vol. 1817, 7, p. 1037-1043
.
IF = 4.624
[ASEP]
[
doi
]
Houštěk, Josef - Hejzlarová, Kateřina - Vrbacký, Marek - Drahota, Zdeněk - Landa, Vladimír - Zídek, Václav - Mlejnek, Petr - Šimáková, Miroslava - Šilhavý, Jan - Mikšík, Ivan - Kazdová, L. - Oliyarnyk, O. - Kurtz, T. - Pravenec, Michal
.
Nonsynonymous variants in mt-Nd2, mt-Nd4, and mt-Nd5 are linked to effects on oxidative phosphorylation and insulin sensitivity in rat conplastic strains
.
Physiological Genomics, 2012, Vol. 44, 9, p. 487-494
.
IF = 2.806
[ASEP]
[
doi
]
Drahota, Zdeněk - Milerová, Marie - Endlicher, R. - Rychtrmoc, D. - Červinková, Z. - Ošťádal, Bohuslav
.
Developmental changes of the sensitivity of cardiac and liver mitochondrial permeability transition pore to calcium load and oxidative stress
.
Physiological Research, 2012, Vol. 61, Suppl.1, S165-S172
.
IF = 1.531
[ASEP]
Drahota, Zdeněk - Endlicher, R. - Staňková, P. - Rychtrmoc, D. - Milerová, Marie - Červinková, Z.
Characterization of calcium, phosphate and peroxide interactions in activation of mitochondrial swelling using derivative of the swelling curves
.
Journal of Bioenergetics and Biomembranes, 2012, Vol. 44, 3, p. 309-315
.
IF = 1.604
[ASEP]
[
doi
]
Rohlena, Jakub - Dong, L.-F. - Klučková, Katarína - Zobalová, Renata - Goodwin, J. - Tilly, D. - Štursa, Jan - Pecinová, Alena - Philimonenko, Anatoly - Hozák, Pavel - Banerjee, J. - Ledvina, Miroslav - Sen, Ch.K. - Houštěk, Josef - Coster, M.J. - Neužil,
.
Mitochondrially Targeted alpha-Tocopheryl Succinate Is Antiangiogenic: Potential Benefit Against Tumor Angiogenesis but Caution Against Wound Healing
.
Antioxidants & Redox Signaling, 2011, Vol. 15, 12, p. 2923-2935
.
IF = 8.456
[ASEP]
[
doi
]
Páleníčková, E. - Cahová, M. - Drahota, Zdeněk - Kazdová, L. - Kalous, M.
Inhibitory effect of metformin on oxidation of NADH-dependent substrates in rat liver homogenate
.
Physiological Research, 2011, Vol. 60, 5, p. 835-839
.
IF = 1.555
[ASEP]
Pecinová, Alena - Drahota, Zdeněk - Nůsková, Hana - Pecina, Petr - Houštěk, Josef
.
Evaluation of basic mitochondrial functions using rat tissue homogenates
.
Mitochondrion, 2011, Vol. 11, 5, p. 722-728
.
IF = 3.615
[ASEP]
[
doi
]
Hejzlarová, Kateřina - Tesařová, M. - Vrbacká-Čížková, A. - Vrbacký, Marek - Hartmannová, H. - Kaplanová, Vilma - Nosková, L. - Kratochvílová, H. - Buzková, J. - Havlíčková, Vendula - Zeman, J. - Kmoch, S. - Houštěk, Josef
.
Expression and processing of the TMEM70 protein
.
Biochimica Et Biophysica Acta-Bioenergetics, 2011, Vol. 1807, 1, p. 144-149
.
IF = 4.843
[ASEP]
[
doi
]
Beneš, J. - Kazdová, L. - Drahota, Zdeněk - Houštěk, Josef - Medříková, Daša - Kopecký, Jan - Kovářová, Nikola - Vrbacký, Marek - Sedmera, David - Strnad, Hynek - Kolář, Michal - Petrák, J. - Benada, Oldřich - Škaroupková, P. - Červenka, L. - Melenovsky,
.
Effect of metformin therapy on cardiac function and survival in a volume-overload model of heart failure in rats
.
Clinical science, 2011, Vol. 121, 1, p. 29-41
.
IF = 4.317
[ASEP]
[
doi
]
Nůsková, Hana - Vrbacký, Marek - Drahota, Zdeněk - Houštěk, Josef
.
Cyanide inhibition and pyruvate-induced recovery of cytochrome c oxidase
.
Journal of Bioenergetics and Biomembranes, 2010, Vol. 42, 5, p. 395-403
.
IF = 3.637
[ASEP]
[
doi
]
Milerová, Marie - Charvátová, Zuzana - Škárka, Libor - Ošťádalová, Ivana - Drahota, Zdeněk - Fialová, Martina - Ošťádal, Bohuslav
.
Neonatal cardiac mitochondria and ischemia/reperfusion injury
.
Molecular and Cellular Biochemistry, 2010, Vol. 335, 1-2, p. 147-153
.
IF = 2.168
[ASEP]
[
doi
]
Mayr, J. A. - Havlíčková, Vendula - Zimmermann, F. - Magler, I. - Kaplanová, Vilma - Ješina, Pavel - Pecinová, Alena - Nůsková, Hana - Koch, J. - Sperl, W. - Houštěk, Josef
.
Mitochondrial ATP synthase deficiency due to a mutation in the ATP5E gene for the F1 e subunit
.
Human Molecular Genetics, 2010, Vol. 19, 17, p. 3430-3439
.
IF = 8.058
[ASEP]
[
doi
]
Honzík, T. - Tesařová, M. - Mayr, J. A. - Hansíková, H. - Ješina, P. - Bodamer, O. - Koch, J. - Magner, M. - Freisinger, P. - Huemer, M. - Kostková, O. - Van Coster, R. - Kmoch, S. - Houštěk, Josef - Sperl, W. - Zeman, J.
Mitochondrial encephalocardio-myopathy with early neonatal onset due to TMEM70 mutation
.
Archives of Disease in Childhood, 2010, Vol. 95, 4, p. 296-301
.
IF = 2.616
[ASEP]
[
doi
]
Havlíčková, Vendula - Kaplanová, Vilma - Nůsková, Hana - Drahota, Zdeněk - Houštěk, Josef
.
Knockdown of F1 epsilon subunit decreases mitochondrial content of ATP synthase and leads to accumulation of subunit c
.
Biochimica Et Biophysica Acta-Bioenergetics, 2010, Vol. 1797, 6-7, p. 1124-1129
.
IF = 5.132
[ASEP]
[
doi
]
Folbergrová, Jaroslava - Ješina, Pavel - Haugvicová, Renata - Lisý, Václav - Houštěk, Josef
.
Sustained deficiency of mitochondrial complex I activity during long periods of survival after seizures induced in immature rats by homocysteic acid
.
Neurochemistry International, 2010, Vol. 56, 3, p. 394-403
.
IF = 3.601
[ASEP]
[
doi
]
Drahota, Zdeněk - Vrbacký, Marek - Nůsková, Hana - Kazdová, L. - Zídek, Václav - Landa, Vladimír - Pravenec, Michal - Houštěk, Josef
.
Succinimidyl oleate, established inhibitor of CD36/FAT translocase inhibits complex III of mitochondrial respiratory chain
.
Biochemical and Biophysical Research Communications, 2010, Vol. 391, 3, p. 1348-1351
.
IF = 2.595
[ASEP]
[
doi
]
Červinková, Z. - Křiváková, P. - Lábajová, A. - Roušar, T. - Lotková, H. - Kučera, O. - Endlicher, R. - Červinka, M. - Drahota, Zdeněk
.
Mechanisms participating in oxidative damage of isolated rat hepatocytes
.
Archives of Toxicology, 2009, Vol. 83, 4, p. 363-372
.
IF = 3.312
[ASEP]
[
doi
]
Mráček, Tomáš - Pecinová, Alena - Vrbacký, Marek - Drahota, Zdeněk - Houštěk, Josef
.
High efficiency of ROS production by glycerophosphate dehydrogenase in mammalian mitochondria
.
Archives of Biochemistry and Biophysics, 2009, Vol. 481, 1, p. 30-36
.
IF = 3.046
[ASEP]
[
doi
]
Houštěk, Josef - Kmoch, S. - Zeman, J.
TMEM70 protein — A novel ancillary factor of mammalian ATP synthese
.
Biochimica Et Biophysica Acta-Bioenergetics, 2009, Vol. 1787, 5, p. 529-532
.
IF = 3.688
[ASEP]
[
doi
]
Endlicher, R. - Křiváková, P. - Rauchová, Hana - Nůsková, Hana - Červinková, Z. - Drahota, Zdeněk
.
Peroxidative damage of mitochondrial respiration is substrate-dependent
.
Physiological Research, 2009, Vol. 58, 5, p. 685-692
.
IF = 1.430
[ASEP]
Gažák, Radek - Sedmera, Petr - Vrbacký, Marek - Vostálová, J. - Drahota, Zdeněk - Marhol, Petr - Walterová, D. - Křen, Vladimír
.
Molecular mechanisms of silybin and 2,3-dehydrosilybin antiradical activity - role of individual hydroxyl groups
.
Free Radical Biology and Medicine, 2009, Vol. 46, 6, p. 745-758
.
IF = 6.081
[ASEP]
[
doi
]
Čížková, Alena - Stránecký, V. - Mayr, J. A. - Tesařová, M. - Havlíčková, Vendula - Paul, Jan - Ivánek, R. - Kuss, A. W. - Hansíková, H. - Kaplanová, Vilma - Vrbacký, Marek - Hartmannová, H. - Nosková, L. - Honzík, T. - Drahota, Zdeněk - Magner, M. - Hejz
.
TMEM70 mutations cause isolated ATP synthase deficiency and neonatal mitochondrial encephalocardiomyopathy
.
Nature Genetics, 2008, Vol. 40, 11, p. 1288-1290
.
IF = 30.259
[ASEP]
[
doi
]
Čížková, Alena - Stránecký, V. - Ivánek, Robert - Hartmannová, H. - Nosková, L. - Piherová, L. - Tesařová, M. - Hansíková, H. - Honzík, T. - Zeman, J. - Divina, Petr - Potocká, A. - Paul, J. - Sperl, W. - Mayr, J. A. - Seneca, S. - Houštěk, J. - Kmoch, S.
Development of a human mitochondrial oligonucleotide microarray (h-MitoArray) and gene expression analysis of fibroblast cell lines from 13 patients with isolated F1Fo ATP synthase deficiency
.
B M C Genomics, 2008, Vol. 9, -, p. 38-38
.
IF = 3.926
[ASEP]
[
doi
]
Červinková, Z. - Rauchová, Hana - Křiváková, P. - Drahota, Zdeněk
.
Inhibition of Palmityl Carnitine Oxidation in Rat Liver Mitochondria by Tert-Butyl Hydroperoxide
.
Physiological Research, 2008, Vol. 57, 1, p. 133-136
.
IF = 1.653
[ASEP]
Rauchová, Hana - Drahota, Zdeněk - Bergamini, C. - Fato, R. - Lenaz, G.
Modification of respiratory-chain enzyme activities in brown adipose tissue mitochondria by idebenone (hydroxydecyl-ubiquinone)
.
Journal of Bioenergetics and Biomembranes, 2008, Vol. 40, 2, p. 85-93
.
IF = 2.480
[ASEP]
[
doi
]
Kůs, Vladimír - Pražák, Tomáš - Brauner, Petr - Hensler, Michal - Kuda, Ondřej - Flachs, Pavel - Janovská, Petra - Medříková, Daša - Rossmeisl, Martin - Jílková, Zuzana - Štefl, B. - Pašťálková, Eva - Drahota, Zdeněk - Houštěk, Josef - Kopecký, Jan
.
Induction of muscle thermogenesis by high-fat diet in mice: association with obesity-resistance
.
American Journal of Physiology, 2008, Vol. 295, 2, E356-E367
.
IF = 3.855
[ASEP]
[
doi
]
Kramarova, T. V. - Antonická, Hana - Houštěk, Josef - Cannon, B. - Nedergaard, J.
A sequence predicted to form a stem–loop is proposed to be required for formation of an RNA–protein complex involving the 3'UTR of beta-subunit F0F1-ATPase mRNA
.
Biochimica Et Biophysica Acta-Bioenergetics, 2008, Vol. 1777, 7-8, p. 747-757
.
IF = 4.447
[ASEP]
[
doi
]
Hervouet, E. - Čížková, Alena - Demont, J. - Vojtíšková, Alena - Pecina, Petr - Franssen-van Hal, N. - Keijer, J. - Simonnet, H. - Ivánek, Robert - Kmoch, S. - Godinot, C. - Houštěk, Josef
.
HIF and reactive oxygen species regulate oxidative phosphorylation in cancer
.
Carcinogenesis, 2008, Vol. 29, 8, p. 1528-1537
.
IF = 4.930
[ASEP]
[
doi
]
Červinková, Z. - Lotková, H. - Křiváková, P. - Roušar, T. - Kučera, O. - Tichý, L. - Červinka, M. - Drahota, Zdeněk
.
Evaluation of mitochondrial function in isolated rat hepatocytes and mitochondria during oxidative stress
.
Alternatives to Laboratory Animals, 2007, Vol. 35, 3, p. 353-361
.
IF = 3.203
[ASEP]
Vrbacký, Marek - Drahota, Zdeněk - Mráček, Tomáš - Vojtíšková, Alena - Ješina, Pavel - Stopka, Pavel - Houštěk, Josef
.
Respiratory chain components involved in the glycerophosphate dehydrogenase-dependent ROS production by brown adipose tissue mitochondria
.
Biochimica Et Biophysica Acta-Bioenergetics, 2007, Vol. 1767, 7, p. 989-997
.
IF = 3.835
[ASEP]
Pravenec, Michal - Hyakukoku, M. - Houštěk, Josef - Zídek, Václav - Landa, Vladimír - Mlejnek, Petr - Mikšík, Ivan - Mothejzíková-Dudová, Kristýna - Pecina, Petr - Vrbacký, Marek - Drahota, Zdeněk - Vojtíšková, Alena - Mráček, Tomáš - Kazdová, L. - Oliyar
.
Direct linkage of mitochondrial genome variation to risk factors for type 2 diabetes in conplastic strains
.
Genome Research, 2007, Vol. 17, 9, p. 1319-1326
.
IF = 11.224
[ASEP]
Folbergrová, Jaroslava - Ješina, Pavel - Drahota, Zdeněk - Lisý, Václav - Haugvicová, Renata - Vojtíšková, Alena - Houštěk, Josef
.
Mitochondrial complex I inhibition in cerebral cortex of immature rats following homocysteic acid-induced seizures
.
Experimental Neurology, 2007, Vol. 204, 2, p. 597-609
.
IF = 3.982
[ASEP]
Group photo - 2016
Blue native electrophoresis - important method to study membrane protein complexes
2D electrophoresis of heart mitochondria
Tissue cultures - our important model
