Úvod Oddělení Buněčná neurofyziologie

Buněčná neurofyziologie

Elektrofyziologické snímání glutamátem vyvolaných proudových odpovědí v kultuře hipokampálních neuronů.

Výzkum je zaměřen na studium funkčních a farmakologických vlastností ligandy řízených iontových kanálů včetně receptorů aktivovaných během synaptického přenosu. Při experimentech jsou používány elektrofyziologické techniky, především metoda terčíkového zámku ("patch clamp") v kombinaci s metodami molekulární biologie, metodami imunohistochemickými a mikrofluorometrickými (Ca²⁺ imaging). Pomocí těchto přístupů a metod jsou studovány vlastnosti excitabilních buněk, jako jsou v tkáňových kulturách pěstované neurony hipokampu a mozečku, či celých nervových okruhů tvořených pyramidálními neurony v tenkých tkáňových řízcích hipokampu. Ke studiu rekombinantních receptorů jsou používány buňky linií HEK293 a COS.

Cílem studia je přispět k poznání vztahu mezi strukturou a funkcí iontových kanálů, charakterizovat působení a identifikovat molekulární mechanizmus účinku farmakologických látek na ligandy řízené iontové kanály. Pro detailnější pochopení fyziologických mechanizmů a farmakologie ligandy aktivovaných iontových kanálů využíváme kvantitativních analytických technik (včetně analýzy jednotlivých iontových kanálů v buněčné membráně, měření intracelulární koncentrace vápenatých iontů, matematické modelování).

Více informací a aktuální projekty najdete na webu oddělení.

Publikace

Touška, Filip - Sattler, S. - Malsch, P. - Lewis, R. J. - Reeh, P. W. - Zimmermann, K. Ciguatoxins Evoke Potent CGRP Release by Activation of Voltage-Gated Sodium Channel Subtypes Na(V)1.9, Na(V)1.7 and Na(V)1.1 . Marine Drugs. 2017, roč. 15, 9, článku 269 . IF = 3.503 [ASEP] [ doi ]

Petrovič, Miloš - da Silva, S. V. - Clement, J. P. - Vyklický ml., Ladislav - Mulle, C. - González-González, I. M. - Henley, J. M. Metabotropic action of postsynaptic kainate receptors triggers hippocampal long-term potentiation . Nature Neuroscience. 2017, roč. 20, 4, p. 529-539 . IF = 17.839 [ASEP] [ doi ]

Maršáková, Lenka - Barvík, I. - Zíma, V. - Zímová, Lucie - Vlachová, Viktorie . The First Extracellular Linker Is Important for Several Aspects of the Gating Mechanism of Human TRPA1 Channel . Frontiers in Molecular Neuroscience. 2017, roč. 10, Jan 31, článku 16 . IF = 5.076 [ASEP] [ doi ]

Kádková, Anna - Synytsya, Viktor - Krůšek, Jan - Zímová, Lucie - Vlachová, Viktorie . Molecular Basis of TRPA1 Regulation in Nociceptive Neurons. A Review . Physiological Research. 2017, roč. 66, 3, p. 425-439 . IF = 1.461 [ASEP]

Horák, Martin - Holubová, K. - Nepovímová, E. - Krůšek, Jan - Kaniaková, Martina - Korábečný, J. - Vyklický ml., Ladislav - Kuča, K. - Stuchlík, Aleš - Říčný, J. - Valeš, K. - Soukup, O. The pharmacology of tacrine at N-methyl-D-aspartate receptors . Progress in Neuro-Psychopharmacology & Biological Psychiatry. 2017, roč. 75, Apr 3, p. 54-62 . IF = 4.187 [ASEP] [ doi ]

Gibalová, A. - Steinbachová, L. - Hafidh, S. - Bláhová, Veronika - Gadiou, Z. - Michailidis, Ch. - Müller, K. - Pleskot, Roman - Dupľáková, N. - Honys, D. Characterization of pollen-expressed bZIP protein interactions and the role of ATbZIP18 in the male gametophyte . Plant Reproduction. 2017, roč. 30, 1, p. 1-17 . IF = 2.629 [ASEP] [ doi ]

Gažová, Z. - Soukup, O. - Šepsová, V. - Šipošová, K. - Drtinová, L. - Jošt, P. - Spilovská, K. - Korábečný, J. - Nepovímová, E. - Fedunová, D. - Horák, Martin - Kaniaková, Martina - Wang, Z. J. - Hamouda, A. K. - Kuča, K. Multi-target-directed therapeutic potential of 7-methoxytacrine-adamantylamine heterodimers in the Alzheimer's disease treatment . Biochimica Et Biophysica Acta-Molecular Basis of Disease. 2017, roč. 1863, 2, p. 607-619 . IF = 5.476 [ASEP] [ doi ]

Bohuslavová, Romana - Dodd, Nicole - Mácová, Iva - Chumak, Tetyana - Horák, Martin - Syka, Josef - Fritzsch, B. - Pavlínková, Gabriela . Pax2-Islet1 Transgenic Mice Are Hyperactive and Have Altered Cerebellar Foliation . Molecular Neurobiology. 2017, roč. 54, 2, p. 1352-1368 . IF = 6.190 [ASEP] [ doi ]

Adla, Santosh Kumar - Slavíková, Barbora - Šmídková, Markéta - Tloušťová, Eva - Svoboda, Martin - Vyklický, Vojtěch - Krausová, Barbora - Hubálková, Pavla - Nekardová, Michaela - Holubová, Kristina - Valeš, Karel - Buděšínský, Miloš - Vyklický ml., Ladislav - Chodounská, Hana - Kudová, Eva . Physicochemical and biological properties of novel amide-based steroidal inhibitors of NMDA receptors . Steroids. 2017, roč. 117, Jan, p. 52-61 . IF = 2.282 [ASEP] [ doi ]

Hynková, Anna - Maršáková, Lenka - Vašková, Jana - Vlachová, Viktorie . N-terminal tetrapeptide T/SPLH motifs contribute to multimodal activation of human TRPA1 channel . Scientific Reports. 2016, roč. 6, Jun 27, p. 28700 . IF = 4.259 [ASEP] [ doi ]

Bressan, E. - Touška, Filip - Vetter, I. - Kistner, K. - Kichko, T. I. - Teixeira, N. B. - Picolo, G. - Cury, Y. - Lewis, R. J. - Fischer, M. J. M. - Zimmermann, K. - Reeh, P. W. Crotalphine desensitizes TRPA1 ion channels to alleviate inflammatory hyperalgesia . Pain. 2016, roč. 157, 11, p. 2504-2516 . IF = 5.445 [ASEP] [ doi ]

Franco, R. - Casadó-Anguera, V. - Muňoz, A. - Petrovič, Miloš - Navarro, G. - Moreno, E. - Lanciego, J. L. - Labandeira-García, J. L. - Cortés, A. - Casadó, V. Hints on the Lateralization of Dopamine Binding to D-1 Receptors in Rat Striatum . Molecular Neurobiology. 2016, roč. 53, 8, p. 5436-5445 . IF = 6.190 [ASEP] [ doi ]

Vyklický, Vojtěch - Smejkalová, Tereza - Krausová, Barbora - Balík, Aleš - Kořínek, Miloslav - Borovská, Jiřina - Horák, Martin - Chvojková, Markéta - Kletečková, Lenka - Valeš, Karel - Černý, Jiří - Nekardová, Michaela - Chodounská, Hana - Kudová, Eva - Vyklický ml., Ladislav . Preferential Inhibition of Tonically over Phasically Activated NMDA Receptors by Pregnane Derivatives . Journal of Neuroscience. 2016, roč. 36, 7, p. 2161-2175 . IF = 5.988 [ASEP] [ doi ]

Kaniaková, Martina - Lichnerová, Katarina - Skřenková, Kristýna - Vyklický ml., Ladislav - Horák, Martin . Biochemical and electrophysiological characterization of N-glycans on NMDA receptor subunits . Journal of Neurochemistry. 2016, roč. 138, 4, p. 546-556 . IF = 4.083 [ASEP] [ doi ]

Slavíková, Barbora - Chodounská, Hana - Nekardová, Michaela - Vyklický, Vojtěch - Ladislav, Marek - Hubálková, Pavla - Krausová, Barbora - Vyklický ml., Ladislav - Kudová, Eva . Neurosteroid-like Inhibitors of N-Methyl-D-aspartate Receptor: Substituted 2-Sulfates and 2-Hemisuccinates of Perhydrophenanthrene . Journal of Medicinal Chemistry. 2016, roč. 59, 10, p. 4724-4739 . IF = 6.259 [ASEP] [ doi ]

Jirků, Michaela - Lánský, Zdeněk - Bednárová, L. - Šulc, Miroslav - Monincová, L. - Majer, P. - Vyklický ml., Ladislav - Vondrášek, J. - Teisinger, Jan - Boušová, Kristýna . The characterization of a novel S100A1 binding site in the N-terminus of TRPM1 . International Journal of Biochemistry and Cell Biology. 2016, roč. 78, Sep 2016, p. 186-193 . IF = 3.505 [ASEP] [ doi ]

Zíma, V. - Witschas, Katja - Hynková, Anna - Zímová, Lucie - Barvík, I. - Vlachová, Viktorie . Structural modeling and patch-clamp analysis of pain-related mutation TRPA1-N855S reveal inter-subunit salt bridges stabilizing the channel open state . Neuropharmacology. 2015, Vol. 93, Jun, p. 294-307 . IF = 4.936 [ASEP] [ doi ]

Kořínek, Miloslav - Vyklický, Vojtěch - Borovská, Jiřina - Lichnerová, Katarina - Kaniaková, Martina - Krausová, Barbora - Krůšek, Jan - Balík, Aleš - Smejkalová, Tereza - Horák, Martin - Vyklický ml., Ladislav . Cholesterol modulates open probability and desensitization of NMDA receptors . Journal of Physiology. 2015, Vol. 593, 10, p. 2279-2293 . IF = 4.731 [ASEP] [ doi ]

Kudová, Eva - Chodounská, Hana - Slavíková, Barbora - Buděšínský, Miloš - Nekardová, Michaela - Vyklický, Vojtěch - Krausová, Barbora - Švehla, Pavel - Vyklický ml., Ladislav . A New Class of Potent N-Methyl-D-Aspartate Receptor Inhibitors: Sulfated Neuroactive Steroids with Lipophilic D-Ring Modifications . Journal of Medicinal Chemistry. 2015, Vol. 58, 15, p. 5950-5966 . IF = 5.589 [ASEP] [ doi ]

Lichnerová, Katarina - Kaniaková, Martina - Park, S. P. - Skřenková, Kristýna - Wang, Y.- X. - Petralia, R. S. - Suh, Y. H. - Horák, Martin . Two N-glycosylation Sites in the GluN1 Subunit Are Essential for Releasing N-methyl-D-aspartate (NMDA) Receptors from the Endoplasmic Reticulum . Journal of Biological Chemistry. 2015, Vol. 290, 30, p. 18379-18390 . IF = 4.258 [ASEP] [ doi ]

Hubálková, Pavla . G-kvadruplexy v oblasti lidských telomer a jejich terapeutický potenciál . Chemické listy. 2015, Vol. 109, 12, p. 918-922 . IF = 0.279 [ASEP]

Šepsová, V. - Karasová, J. Z. - Tobin, G. - Jun, D. - Korábečný, J. - Cabelová, P. - Jánská, K. - Krůšek, Jan - Skřenková, K. - Kuča, M. - Valko, M. - Soukup, O. Cholinergic properties of new 7-methoxytacrine-donepezil derivatives . General Physiology and Biophysics. 2015, Vol. 34, 2, p. 189-200 . IF = 0.892 [ASEP] [ doi ]

Jirků, Michaela - Bumba, Ladislav - Bednárová, Lucie - Kubala, M. - Šulc, Miroslav - Franěk, M. - Vyklický ml., Ladislav - Vondrášek, Jiří - Teisinger, Jan - Boušová, Kristýna . Characterization of the part of N-terminal PIP2 binding site of the TRPM1 channel . Biophysical Chemistry. 2015, Vol. 207, Dec, p. 135-142 . IF = 2.363 [ASEP] [ doi ]

Witschas, Katja - Jobin, M.-L. - Korkut, D. N. - Vladan, M. M. - Salgado, G. - Lecomte, S. - Vlachová, Viktorie - Alves, I. D. Interaction of a peptide derived from C-terminus of human TRPA1 channel with model membranes mimicking the inner leaflet of the plasma membrane . Biochimica Et Biophysica Acta-Biomembranes. 2015, Vol. 1848, 5, p. 1147-1159 . IF = 3.687 [ASEP] [ doi ]

Boušová, Kristýna - Jirků, Michaela - Bumba, Ladislav - Bednárová, Lucie - Šulc, Miroslav - Franěk, M. - Vyklický ml., Ladislav - Vondrášek, Jiří - Teisinger, Jan . PIP2 and PIP3 interact with N-terminus region of TRPM4 channel . Biophysical Chemistry. 2015, Vol. 205, Oct 2015, p. 24-32 . IF = 2.363 [ASEP] [ doi ]

Vyklický, Vojtěch - Kořínek, Miloslav - Smejkalová, Tereza - Balík, Aleš - Krausová, Barbora - Kaniaková, Martina - Lichnerová, Katarina - Černý, Jiří - Krůšek, Jan - Dittert, Ivan - Horák, Martin - Vyklický ml., Ladislav . Structure, function, and pharmacology of NMDA receptor channels . Physiological Research 2014, roč. 63, suppl.1, s191-s203. ISSN 0862-8408. IF = 1.293 [ASEP]

Šepsová, V. - Krůšek, Jan - Zdarová Karasová, J. - Zemek, F. - Musílek, K. - Kuča, K. - Soukup, O. The interaction of quaternary reversible acetylcholinesterase inhibitors with the nicotinic receptor . Physiological Research. 2014, Vol. 63, 6, p. 771-777 . IF = 1.293 [ASEP]

Lichnerová, Katarina - Kaniaková, Martina - Skřenková, Kristýna - Vyklický ml., Ladislav - Horák, Martin . Distinct regions within the GluN2C subunit regulate the surface delivery of NMDA receptors . Frontiers in Cellular Neuroscience. 2014, roč. 8, nov 10, p. 375. ISSN 1662-5102. IF = 4.289 [ASEP] [ doi ]

Krůšek, Jan - Ďaďo, S. Electrode-less measurement of cell layers impedance . Physiological Research. 2014, Vol. 63, 6, p. 705-711 . IF = 1.293 [ASEP]

Khuzakhmetova, V. - Samigullin, D. - Nurullin, L. - Vyskočil, František - Nikolsky, E. - Bukharaeva, E. Kinetics of neurotransmitter release in neuromuscular synapses of newborn and adult rats . International Journal of Developmental Neuroscience 2014, roč. 34, may, p. 9-18. ISSN 0736-5748. IF = 2.58 [ASEP] [ doi ]

Kaniaková, Martina - Skřenková, Kristýna - Adámek, S. - Vyskočil, František - Krůšek, Jan . Different effects of lobeline on neuronal and muscle nicotinic receptors . European Journal of Pharmacology. 2014, roč. 738, sep 5, p. 352-359. ISSN 0014-2999. IF = 2.532 [ASEP] [ doi ]

Horák, Martin - Petralia, R. S. - Kaniaková, Martina - Sans, N. ER to synapse trafficking of NMDA receptors . Frontiers in Cellular Neuroscience. 2014, roč. 8, -, p. 394. ISSN 1662-5102. IF = 4.289 [ASEP] [ doi ]

Boukalová, Štěpána - Touška, Filip - Maršáková, Lenka - Hynková, Anna - Surá, Lucie - Chvojka, Štěpán - Dittert, Ivan - Vlachová, Viktorie . Gain-of-function mutations in the transient receptor potential channels TRPV1 and TRPA1: how painful? . Physiological Research 2014, roč. 63, suppl.1, s205-s213. ISSN 0862-8408. IF = 1.293 [ASEP]

Vetter, I. - Hein, A. - Sattler, S. - Hessler, S. - Touška, Filip - Bressan, E. - Parra, A. - Hager, U. - Leffler, A. - Boukalová, Štěpána - Nissen, M. - Lewis, R. J. - Belmonte, C. - Alzheimer, Ch. - Huth, T. - Vlachová, Viktorie - Reeh, P. W. - Zimmerma . Amplified Cold Transduction in Native Nociceptors by M-Channel Inhibition . Journal of Neuroscience, 2013, Vol. 33, 42, p. 16627-16641 . IF = 6.908 [ASEP] [ doi ]

Tariq, A. - Garncarz, W. - Handl, C. - Balík, Aleš - Pusch, O. - Jantsch, M.F. RNA-interacting proteins act as site-specific repressors of ADAR2-mediated RNA editing and fluctuate upon neuronal stimulation . Nucleic Acids Research, 2013, Vol. 41, 4, p. 2581-2593 . IF = 8.278 [ASEP] [ doi ]

Soukup, O. - Jun, D. - Zdarová Karasová, J. - Patočka, J. - Musílek, K. - Korábečný, J. - Krůšek, Jan - Kaniaková, Martina - Šepsová, V. - Mandíková, J. - Trejtnar, F. - Pohanka, M. - Drtinová, L. - Pavlík, M. - Tobin, G. - Kuča, K. A Resurrection of 7-MEOTA:a comparison with Tacrine . Current Alzheimer Research, 2013, Vol. 10, 8, p. 893-906 . IF = 3.676 [ASEP]

Penn, A.C. - Balík, Aleš - Greger, I. H. Steric antisense inhibition of AMPA receptor Q/R editing reveals tight coupling to intronic editing sites and splicing . Nucleic Acids Research, 2013, Vol. 41, 2, p. 1113-1123 . IF = 8.278 [ASEP] [ doi ]

Boukalová, Štěpána - Teisinger, Jan - Vlachová, Viktorie . Protons stabilize the closed conformation of gain-of-function mutants of the TRPV1 channel . Biochimica Et Biophysica Acta-Molecular Cell Research, 2013, Vol. 1833, 3, p. 520-528 . IF = 4.808 [ASEP] [ doi ]

Balík, Aleš - Penn, A.C. - Nemoda, Z. - Greger, I. H. Activity-regulated RNA editing in select neuronal subfields in hippocampus . Nucleic Acids Research, 2013, Vol. 41, 2, p. 1124-1134 . IF = 8.278 [ASEP] [ doi ]

Adamusová, Eva - Cais, Ondřej - Vyklický, Vojtěch - Kudová, Eva - Chodounská, Hana - Horák, Martin - Vyklický ml., Ladislav . Pregnenolone sulfate activates NMDA receptor channels . Physiological Research, 2013, Vol. 62, 6, p. 731-736 . IF = 1.531 [ASEP]

Černý, Ivan - Buděšínský, Miloš - Pouzar, Vladimír - Vyklický, Vojtěch - Krausová, Barbora - Vyklický ml., Ladislav . Neuroactive steroids with perfluorobenzoyl group . Steroids, 2012, Vol. 77, 12, p. 1233-1241 . IF = 2.803 [ASEP] [ doi ]

Vetter, I. - Touška, Filip - Hess, A. - Hinsbey, R. - Sattler, S. - Lampert, A. - Sergejeva, M. - Sharov, A. - Collins, L. S. - Eberhardt, M. - Engel, M. - Cabot, P. J. - Wood, J. N. - Vlachová, Viktorie - Reeh, P. W. - Lewis, R. J. - Zimmermann, K. Ciguatoxins activate specific cold pain pathways to elicit burning pain from cooling . EMBO Journal, 2012, Vol. 31, 19, p. 3795-3808 . IF = 9.822 [ASEP] [ doi ]

Valeš, Karel - Rambousek, Lukáš - Holubová, Kristina - Svoboda, Jan - Bubeniková-Valešová, V. - Chodounská, Hana - Vyklický ml., Ladislav - Stuchlík, Aleš . 3 alpha 5 beta-Pregnanolone glutamate, a use-dependent NMDA antagonist, reversed spatial learning deficit in an animal model of schizophrenia . Behavioural Brain Research, 2012, Vol. 235, 1, p. 82-88 . IF = 3.327 [ASEP] [ doi ]

Surá, Lucie - Zíma, V. - Maršáková, Lenka - Hynková, Anna - Barvík, I. - Vlachová, Viktorie . C-terminal Acidic Cluster Is Involved in Ca2+-induced Regulation of Human Transient Receptor Potential Ankyrin 1 Channel . Journal of Biological Chemistry, 2012, Vol. 287, 22, p. 18067-18077 . IF = 4.651 [ASEP] [ doi ]

Pryazhnikov, E. - Ostroumov, A. - Druginina, O. - Vyskočil, František - Skorinkin, A. The mechanisms of inhibition of frog endplate currents with homologous derivatives of the 1,1-dimethyl-3-oxybutyl phosphonic acid . Physiological Research, 2012, Vol. 61, 4, p. 395-404 . IF = 1.531 [ASEP]

Palma-Cerda, F. - Auger, C. - Crawford, D.J. - Hodgson, A.C.C. - Reynolds, S.J. - Cowell, J.K. - Swift, K.A.D. - Cais, Ondřej - Vyklický ml., Ladislav - Corrie, J.E.T. - Ogden, D. New caged neurotransmitter analogs selective for glutamate receptor sub-types based on methoxynitroindoline and nitrophenylethoxycarbonyl caging groups . Neuropharmacology, 2012, Vol. 63, 4, p. 624-634 . IF = 4.114 [ASEP] [ doi ]

Maršáková, Lenka - Touška, Filip - Krůšek, Jan - Vlachová, Viktorie . Pore Helix Domain Is Critical to Camphor Sensitivity of Transient Receptor Potential Vanilloid 1 Channel . Anesthesiology, 2012, Vol. 116, 4, p. 903-917 . IF = 5.163 [ASEP] [ doi ]

Lindovský, Jiří - Petrov, K. - Krůšek, Jan - Reznik, V.S. - Nikolsky, E. E. - Vyskočil, František . Effect of tissue-specific acetylcholinesterase inhibitor C-547 on alpha 3 beta 4 and alpha beta epsilon delta acetylcholine receptors in COS cells . European Journal of Pharmacology, 2012, Vol. 688, 1-3, p. 22-26 . IF = 2.592 [ASEP] [ doi ]

Kapras, Vojtěch - Slavíčková, Alena - Šťastná, Eva - Vyklický ml., Ladislav - Valeš, Karel - Chodounská, Hana . Synthesis of deuterium labeled NMDA receptor inhibitor-20-Oxo-5 beta-[9,12,12-H-2(3)]pregnan-3 alpha-yl-L-glutamyl 1-ester . Steroids, 2012, Vol. 77, 3, p. 282-287 . IF = 2.803 [ASEP] [ doi ]

Kaniaková, Martina - Lichnerová, Katarina - Vyklický ml., Ladislav - Horák, Martin . Single amino acid residue in the M4 domain of GluN1 subunit regulates the surface delivery of NMDA receptors . Journal of Neurochemistry, 2012, Vol. 123, 3, p. 385-395 . IF = 3.973 [ASEP] [ doi ]

Kaniaková, Martina - Krausová, Barbora - Vyklický, Vojtěch - Kořínek, Miloslav - Lichnerová, Katarina - Vyklický ml., Ladislav - Horák, Martin . Key Amino Acid Residues within the Third Membrane Domains of NR1 and NR2 Subunits Contribute to the Regulation of the Surface Delivery of N-methyl-D-aspartate Receptors . Journal of Biological Chemistry, 2012, Vol. 287, 31, p. 26423-26434 . IF = 4.651 [ASEP] [ doi ]

Hřebabecký, Hubert - Dejmek, Milan - Dračínský, Martin - Šála, Michal - Leyssen, P. - Neyts, J. - Kaniaková, Martina - Krůšek, Jan - Nencka, Radim . Synthesis of novel azanorbornylpurine derivatives . Tetrahedron, 2012, Vol. 68, 4, p. 1286-1298 . IF = 2.803 [ASEP] [ doi ]

Borovská, Jiřina - Vyklický, Vojtěch - Šťastná, Eva - Kapras, Vojtěch - Slavíková, Barbora - Horák, Martin - Chodounská, Hana - Vyklický ml., Ladislav . Access of inhibitory neurosteroids to the NMDA receptor . British Journal of Pharmacology, 2012, Vol. 166, 3, p. 1069-1083 . IF = 5.067 [ASEP] [ doi ]

Penn, A.C. - Balík, Aleš - Wozny, Ch. - Cais, O. - Greger, I. H. Activity-Mediated AMPA Receptor Remodeling, Driven by Alternative Splicing in the Ligand-Binding Domain . Neuron, 2012, Vol. 76, 3, p. 503-510 . IF = 15.766 [ASEP] [ doi ]

Šťastná, Eva - Chodounská, Hana - Pouzar, Vladimír - Borovská, Jiřina - Vyklický ml., Ladislav . Synthesis of pregnane 3-carboxylic acids via Pd-catalyzed alkoxycarbonylation and their effect on NMDA receptor activity . Collection of Czechoslovak Chemical Communications, 2011, Vol. 76, 9, p. 1141-1161 . IF = 1.283 [ASEP] [ doi ]

Volkov, E. M. - Nurullin, L. F. - Volkov, M. E. - Nikolsky, E. E. - Vyskočil, František . Mechanisms of carbacholine and GABA action on resting membrane potential and Na+/K+-ATPase of Lumbricus terrestris body wall muscles . Comparative Biochemistry and Physiology A-Molecular & Integrative Physiology, 2011, Vol. 158, 4, p. 520-524 . IF = 2.235 [ASEP] [ doi ]

Vidrna, Lukáš - Černý, Ivan - Pouzar, Vladimír - Borovská, Jiřina - Vyklický, Vojtěch - Vyklický ml., Ladislav - Chodounská, Hana . Azido analogs of neuroactive steroids . Steroids, 2011, Vol. 76, 10/11, p. 1043-1050 . IF = 2.829 [ASEP] [ doi ]

Touška, Filip - Maršáková, Lenka - Teisinger, Jan - Vlachová, Viktorie . A “Cute” Desensitization of TRPV1 . Current Pharmaceutical Biotechnology, 2011, Vol. 12, 1, p. 122-129 . IF = 2.805 [ASEP]

Soukup, O. - Krůšek, Jan - Kaniaková, Martina - Kumar, U. K. - Oz, M. - Jun, D. - Fusek, J. - Kuča, K. - Tobin, G. Oxime reactivators and their in vivo and in vitro effects on nicotinic receptors . Physiological Research, 2011, Vol. 60, 4, p. 679-686 . IF = 1.555 [ASEP]

Samad, Abdul - Surá, Lucie - Benedikt, Jan - Ettrich, Rüdiger - Minofar, Babak - Teisinger, Jan - Vlachová, Viktorie . The C-terminal basic residues contribute to the chemical- and voltage-dependent activation of TRPA1 . Biochemical Journal, 2011, Vol. 433, 1, p. 197-204 . IF = 4.897 [ASEP] [ doi ]

Rambousek, Lukáš - Bubeníková-Valešová, V. - Kačer, P. - Syslová, K. - Kenney, Jana - Holubová, Kristina - Najmanová, V. - Zach, P. - Svoboda, Jan - Stuchlík, Aleš - Chodounská, Hana - Kapras, Vojtěch - Adamusová, Eva - Borovská, Jiřina - Vyklický ml., La . Cellular and behavioural effects of a new steroidal inhibitor of the N-methyl-d-aspartate receptor 3α5β-pregnanolone glutamate . Neuropharmacology, 2011, Vol. 61, 1-2, p. 61-68 . IF = 4.814 [ASEP]

Malomouzh, A. I. - Arkhipova, S. S. - Nikolsky, E. E. - Vyskočil, František . Immunocytochemical demonstration of M1 muscarinic acetylcholine receptors at the presynaptic and postsynaptic membranes of rat diaphragm endplates . Physiological Research, 2011, Vol. 60, 1, p. 185-188 . IF = 1.555 [ASEP]

Kořínek, Miloslav - Kapras, Vojtěch - Vyklický, Vojtěch - Adamusová, Eva - Borovská, Jiřina - Valeš, Karel - Stuchlík, Aleš - Horák, Martin - Chodounská, Hana - Vyklický ml., Ladislav . Neurosteroid modulation of N-methyl-d-aspartate receptors: Molecular mechanism and behavioral effects . Steroids, 2011, Vol. 76, 13, p. 1409-1418 . IF = 2.829 [ASEP] [ doi ]

Kaniaková, Martina - Lindovský, Jiří - Krůšek, Jan - Adámek, S. - Vyskočil, František . Dual effect of lobeline on alpha 4 beta 2 rat neuronal nicotinic receptors . European Journal of Pharmacology, 2011, Vol. 658, 2-3, p. 108-113 . IF = 2.516 [ASEP] [ doi ]

Adámek, S. - Vyskočil, František . Potassium-selective microelectrode revealed difference in threshold potassium concentration for cortical spreading depression in female and male rat brain . Brain Research, 2011, Vol. 1370, -, p. 215-219 . IF = 2.728 [ASEP] [ doi ]

Osičková, Adriana - Mašín, Jiří - Fayolle, C. - Krůšek, Jan - Basler, Marek - Pospíšilová, Eva - Leclerc, C. - Osička, Radim - Šebo, Peter . Adenylate cyclase toxin translocates across target cell membrane without forming a pore . Molecular Microbiology, 2010, Vol. 75, 6, p. 1550-1562 . IF = 4.819 [ASEP] [ doi ]

Kořínek, Miroslav - Sedláček, Miloslav - Cais, Ondřej - Dittert, Ivan - Vyklický ml., Ladislav . Temperature dependence of N-methyl-d-aspartate receptor channels and N-methyl-d-aspartate receptor excitatory postsynaptic currents . Neuroscience, 2010, Vol. 165, 3, p. 736-748 . IF = 3.215 [ASEP] [ doi ]

Boukalová, Štěpána - Maršáková, Lenka - Teisinger, Jan - Vlachová, Viktorie . Conserved Residues within the Putative S4–S5 Region Serve Distinct Functions among Thermosensitive Vanilloid Transient Receptor Potential (TRPV) Channels . Journal of Biological Chemistry, 2010, Vol. 285, 53, p. 41455-41462 . IF = 5.328 [ASEP] [ doi ]

Adámek, S. - Shakirzyanova, V. - Malomouzh, A. I. - Naumenko, N. V. - Vyskočil, František . Interaction of glutamate- and adenosine-induced decrease of acetylcholine quantal release at frog neuromuscular junction . Physiological Research, 2010, Vol. 59, 5, p. 803-810 . IF = 1.646 [ASEP]

Šťastná, Eva - Chodounská, Hana - Pouzar, Vladimír - Kapras, Vojtěch - Borovská, Jiřina - Cais, Ondřej - Vyklický ml., Ladislav . Synthesis of C3, C5, and C7 pregnane derivatives and their effect on NMDA receptor responses in cultured rat hippocampal neurons . Steroids, 2009, Vol. 74, 2, p. 256-263 . IF = 2.905 [ASEP] [ doi ]

Vyskočil, František - Malomouzh, A. I. - Nikolsky, E. E. Non-quantal acetylcholine release at the neuromuscular junction . Physiological Research, 2009, Vol. 58, 6, p. 763-784 . IF = 1.430 [ASEP]

Tyapkina, O. - Volkov, E. - Nurullin, L. - Shenkman, B. - Kozlovskaya, I. - Nikolsky, E. - Vyskočil, František . Resting membrane potential and Na+,K+-ATPase of rat fast and slow muscles during modeling of hypogravity . Physiological Research, 2009, Vol. 58, 4, p. 599-603 . IF = 1.430 [ASEP]

Shaihutdinova, A.R. - Nikolsky, E. E. - Vyskočil, František - Skorinkin, A.I. Mechanisms of the inhibition of endplate acetylcholine receptors by antiseptic chlorhexidine (experiments and models) . Naunyn-Schmiedeberg's Archiv of Pharmacology, 2009, Vol. 380, 6, p. 551-560 . IF = 2.631 [ASEP] [ doi ]

Petrovič, Miloš - Sedláček, Miloslav - Cais, Ondřej - Horák, Martin - Chodounská, Hana - Vyklický ml., Ladislav . Pregnenolone sulfate modulation of N-methyl-d-aspartate receptors is phosphorylation dependent . Neuroscience, 2009, Vol. 160, 3, p. 616-628 . IF = 3.292 [ASEP] [ doi ]

Petrov, K. - Kovyazina, I. - Zobov, V. - Bukharaeva, E. - Nikolsky, E. E. - Vyskočil, František . Different sensitivity of miniature endplate currents in rat external and internal intercostal muscles to the acetylcholinesterase inhibitor C-547 as compared with diaphragm and extensor digitorum Pontus . Physiological Research, 2009, Vol. 58, 1, p. 149-153 . IF = 1.430 [ASEP]

Brantová, O. - Asfaw, B. - Sládková, J. - Poupětová, H. - Živný, J. - Magner, M. - Krůšek, Jan - Veselá, K. - Hansíková, H. - Ledvinová, J. - Tesařová, M. - Zeman, J. Ultrastructural and functional abnormalities of mitochondria in cultivated fibroblasts from α -mannosidosis patiens . Biologia, 2009, Vol. 64, 2, p. 394-401 . IF = 0.617 [ASEP] [ doi ]

Benedikt, Jan - Samad, Abdul - Ettrich, Rüdiger - Teisinger, Jan - Vlachová, Viktorie . Essential role for the putative S6 inner pore region in the activation gating of the human TRPA1 channel . Biochimica Et Biophysica Acta-Molecular Cell Research, 2009, Vol. 1793, 7, p. 1279-1288 . IF = 4.374 [ASEP] [ doi ]

Vyklický st., Ladislav - Nováková-Toušová, Karolina - Benedikt, Jan - Samad, Abdul - Touška, Filip - Vlachová, Viktorie . Calcium-dependent desensitization of vanilloid receptor TRPV1: a mechanism possibly involved in analgesia induced by topical application of capsaicin . Physiological Research, 2008, Vol. 57, Suppl.3, S59-S68 . IF = 1.653 [ASEP]

Skorinkin, A.I. - Shaihutdinova, A.R. - Vyskočil, František . Model of concentration changes across the synaptic cleft during a single quantum release . General Physiology and Biophysics, 2008, Vol. 27, 1, p. 19-24 . IF = 0.697 [ASEP]

Sedláček, Miloslav - Kořínek, Miroslav - Petrovič, Miloš - Cais, Ondřej - Adamusová, Eva - Chodounská, Hana - Vyklický ml., Ladislav . Neurosteroid modulation of ionotropic glutamate receptors and excitatory synaptic transmission . Physiological Research, 2008, Vol. 57, Suppl.3, S49-S57 . IF = 1.653 [ASEP]

Petrovič, Miloš - Valeš, Karel - Putnikovič, B. - Djulejič, V. - Mitrovič, D. M. Ryanodine receptors, voltage-gated calcium channels and their relationship with protein kinase A in the myocardium . Physiological Research, 2008, Vol. 57, 2, p. 141-149 . IF = 1.653 [ASEP]

Ostašov, Pavel - Krůšek, Jan - Durchánková, Dana - Svoboda, Petr - Novotný, Jiří . Ca2plus responses to thyrotropin-releasing hormone and angiotensin II: the role of plasma membrane integrity and effect of G11 protein overexpression on homologous and heterologous desensitization . Cell Biochemistry and Function, 2008, Vol. 26, 2, p. 264-274 . IF = 1.333 [ASEP] [ doi ]

Lindovský, Jiří - Kaniaková, Martina - Svobodová, Lucie - Vyskočil, František - Krůšek, Jan . Role of negatively charged amino acids in beta4 F-loop in activation and desensitization of alfa3beta4 rat neuronal nicotinic receptors . Biochimica Et Biophysica Acta-Biomembranes, 2008, Vol. 1778, 4, p. 864-871 . IF = 4.180 [ASEP]

Gilmanov, I.R. - Samigullin, D. V. - Vyskočil, František - Nikolsky, E. E. - Bukharaeva, E. A. Modeling of quantal neurotransmitter release kinetics in the presence of fixed and mobile calcium buffers . Journal of Computational Neuroscience, 2008, Vol. 25, 2, p. 296-307 . IF = 2.750 [ASEP] [ doi ]

Ellederová, Zdeňka - Cais, Ondřej - Šušor, Andrej - Uhlířová, Kateřina - Kovářová, Hana - Jelínková, Lucie - Tomek, W. - Kubelka, Michal . ERK 1/2 kinase metabolic pathway is responsible for phosphorylation of translation initiation factor eIF4E during in vitro maturation of pig oocytes . Molecular Reproduction and Development, 2008, Vol. 75, 2, p. 309-317 . IF = 2.287 [ASEP]

Cais, Ondřej - Sedláček, Miloslav - Horák, Jaroslav - Dittert, Ivan - Vyklický ml., Ladislav . Temperature dependence of NR1/NR2B NMDA receptor channels . Neuroscience, 2008, Vol. 151, 2, p. 428-438 . IF = 3.556 [ASEP] [ doi ]

Volkov, E. M. - Nurullin, L. F. - Nikolsky, E. - Vyskočil, František . Miniature excitatory synaptic ion currents in the earthworm Lumbricus terrestris body wall muscles . Physiological Research, 2007, Vol. 56, 5, p. 655-658 . IF = 1.505 [ASEP]

Sušánková, Klára - Ettrich, Rüdiger - Vyklický st., Ladislav - Teisinger, Jan - Vlachová, Viktorie . Contribution of the putative inner-pore region to the gating of the Transient Receptor Potential Vanilloid Subtype 1 Channel (TRPV1) . Journal of Neuroscience, 2007, Vol. 27, 28, p. 7578-7585 . IF = 7.490 [ASEP]

Sedláček, Miloslav - Horák, Martin - Vyklický ml., Ladislav . Morphology and physiology of lamina I neurons of the caudal part of the trigeminal nucleus . Neuroscience, 2007, Vol. 147, 2, p. 325-333 . IF = 3.352 [ASEP]

Nováková-Toušová, Karolina - Vyklický st., Ladislav - Sušánková, Klára - Benedikt, Jan - Samad, Abdul - Teisinger, Jan - Vlachová, Viktorie . Functional changes in the vanilloid receptor subtype 1 channel during and after acute desensitization . Neuroscience, 2007, Vol. 149, 1, p. 144-154 . IF = 3.352 [ASEP]

Malomouzh, A. I. - Mukhtarov, M. R. - Nikolsky, E. E. - Vyskočil, František . Muscarinic M1 acetylcholine receptors regulate the non-quantal release of acetylcholine in the rat neuromuscular junction via NO-dependent mechanism . Journal of Neurochemistry, 2007, Vol. 102, 6, p. 2110-2117 . IF = 4.451 [ASEP]

Gryčová, Lenka - Lánský, Zdeněk - Friedlová, Eliška - Vlachová, Viktorie - Kubala, M. - Obšilová, Veronika - Obšil, Tomáš - Teisinger, Jan . ATP binding site on the C-terminus of the vanilloid . Archives of Biochemistry and Biophysics, 2007, Vol. 465, 2, p. 389-398 . IF = 2.578 [ASEP]

Fišer, Radovan - Mašín, Jiří - Basler, Marek - Krůšek, Jan - Špuláková, V. - Konopásek, Ivo - Šebo, Peter . Third Acivity of Bordetella Adenylate Cyclase (AC) Toxin-Hemolysin . Journal of Biological Chemistry, 2007, Vol. 282, 5, p. 2808-2820 . IF = 5.581 [ASEP]

Benedikt, Jan - Teisinger, Jan - Vyklický st., Ladislav - Vlachová, Viktorie . Ethanol inhibits cold-menthol receptor TRPM8 by modulating its interaction with membrane phosphatidylinositol 4,5-bisphosphate . Journal of Neurochemistry, 2007, Vol. 100, 1, p. 211-224 . IF = 4.451 [ASEP]