Genome-wide association studies identified ORMDL3 protein as a significant asthma risk factor. Our studies focused on molecular action of ORMDL3 showed that it is a negative regulator of IgE receptor signaling in mast cells. This talk will focus on our recent studies on the role of ORMDL3 as an important regulator of sphingosines and leukotriens and will present data on physical and functional cross-talks between sphingolipid and arachidonic acid metabolism pathways.

IPHYS Contact Person: Jan Kopecký (jan.kopecky@fgu.cas.cz)