Department of Experimental Hypertension is studying the mechanisms of blood pressure (BP) regulation and end-organ damage in rats with different types of experimental hypertension. Our research is focused mainly on:
- Elucidation of the mechanisms by which endothelin and renin-angiotensin systems participate in renal damage in transgenic rats with inserted mouse renin gene (Ren-2 TGR) – cooperation with IKEM (Prague).
- Comparison of the role of calcium sensitization (Rho kinase pathway) and calcium influx in the development of high BP in rats with genetic or salt hypertension – molecular biological analysis of alterations in these regulatory pathways.
- Study of the central mechanisms of blood pressure regulation in rats with genetic hypertension: focus on brain renin-angiotensin system, central corticoid effects, baroreflex control of sympathetic tone and oxidative stress.
- Investigation of cardiovascular effects of new analogs of neuropeptides regulating food intake in rats – cooperation with IOCHB CAS (Prague).
Projects
Achievements
Institute of Organic Chemistry and Biochemistry of the CAS (IOCB Prague) in collaboration with Institute of Physiology of the CAS developed new compounds with positive effects in experimental animal models of obesity and type II diabetes.
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Our colleagues were very successful at 26th International Meeting of International Society of Hypertension in Seoul - Michal Behuliak was awarded by the 2nd place in the section Young Investigator Award, Anna Vavřínová by Travel Grant and Josef Zicha was awarded by the 2nd place in the section Best Oral Presentation in Basic Sciences.
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Michal Behuliak was granted by the Czech Society for Hypertension, the price was awarded by the general manager of Servier in the Czech Republic.
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Mgr. Michal Behuliak, PhD. was granted with Otto Wicherle prize from the President of Czech Academy of Sciences on Monday, May 30, 2016.
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Publications
Zemenová, J. - Sýkora, D. - Maletínská, L. - Kuneš, Jaroslav
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Lipopeptides as therapeutics: applications and in vivo quantitative analysis
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Bioanalysis. 2017, roč. 9, 2, p. 215-230
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IF = 2.673
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Sedláková, L. - Čertíková - Chábová, V. - Doleželová, Š. - Škaroupková, P. - Kopkan, L. - Husková, Z. - Červenková, L. - Kikerlová, S. - Vaněčková, Ivana - Sadowski, J. - Kompanowska - Jezierska, E. - Kujal, P. - Kramer, H. J. - Červenka, L.
Renin-angiotensin system blockade alone or combined with ETA receptor blockade: effects on the course of chronic kidney disease in 5/6 nephrectomized Ren-2 transgenic hypertensive rats
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Clinical and Experimental Hypertension. 2017, roč. 39, 2, p. 183-195
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IF = 1.162
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Pražienková, V. - Holubová, M. - Pelantová, H. - Bugáňová, M. - Pirník, Z. - Mikulášková, Barbora - Popelová, A. - Blechová, M. - Haluzík, M. - Železná, B. - Kuzma, M. - Kuneš, Jaroslav - Maletínská, L.
Impact of novel palmitoylated prolactin-eleasing peptide analogs on metabolic changes in mice with diet-induced obesity
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PLoS ONE. 2017, roč. 12, 8, článku e0183449
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IF = 2.806
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doi
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Pištíková, Adéla - Brožka, Hana - Bencze, Michal - Radostová, Dominika - Valeš, Karel - Stuchlík, Aleš
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The effect of hypertension on adult hippocampal neurogenesis in young adult spontaneously hypertensive rats and Dahl rats
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Physiological Research. 2017, roč. 66, 5, p. 881-887
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IF = 1.461
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Májovský, M. - Řezáčová, Lenka - Sumová, Alena - Pospíšilová, L. - Netuka, D. - Bradáč, O. - Beneš, V.
Melatonin and cortisol secretion profile in patients with pineal cyst before and after pineal cyst resection
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Journal of Clinical Neuroscience. 2017, roč. 39, May 2017, p. 155-163
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IF = 1.557
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doi
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Dobiášová, Milada
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Atherogenic Impact of Lecithin-Cholesterol Acyltransferase and Its Relation to Cholesterol Esterification Rate in HDL (FERHDL) and AIP [log(TG/HDL-C)] Biomarkers: The Butterfly Effect?
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Physiological Research. 2017, roč. 66, 2, p. 193-203
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IF = 1.461
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Bugáňová, M. - Pelantová, H. - Holubová, M. - Šedivá, B. - Maletínská, L. - Železná, B. - Kuneš, Jaroslav - Kačer, P. - Kuzma, M. - Haluzík, M.
The effects of liraglutide in mice with diet-induced obesity studied by metabolomics
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Journal of Endocrinology. 2017, roč. 233, 1, p. 93-104
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IF = 4.706
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doi
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Behuliak, Michal - Bencze, Michal - Vaněčková, Ivana - Kuneš, Jaroslav - Zicha, Josef
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Basal and Activated Calcium Sensitization Mediated by RhoA/Rho Kinase Pathway in Rats with Genetic and Salt Hypertension
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BioMed Research International. 2017, roč. 2017, January, článku 8029728
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IF = 2.476
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Lettrichová, I. - Tóthová, L. - Hodosy, J. - Behuliak, Michal - Celec, P.
Variability of salivary markers of oxidative stress and antioxidant status in young healthy individuals
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Redox Report. 2016, roč. 21, 1, p. 24-30
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IF = 2.070
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doi
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Bernátová, I. - Bališ, P. - Goga, R. - Behuliak, Michal - Zicha, Josef - Sekaj, I.
Lack of Reactive Oxygen Species Deteriorates Blood Pressure Regulation in Acute Stress
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Physiological Research. 2016, roč. 65, Suppl.3, S381-S390
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IF = 1.461
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Overview of alterations in calcium sensitization during development of spontaneously hypertension in the rat The schematic representation of possible regulatory mechanisms involved in RhoA/Rho kinase pathway is demonstrated in normotensive (a), prehypertensive (b) and hypertensive (c) rats.
Recording of contraction of isolated femoral artery stimulated by norepinephrine (NE).
Aorta section – α-actin (red), nuclei (blue) and autofluorescence (green).
Adrenal section stained for tyrosine hydroxylase (detected by Vectastain ABC kit).
Recording of blood pressure.
