Publikace
2018
224. |
Panattoni A., Pohl R., Hocek M.:
Flexible Alkyne-Linked Thymidine Phosphoramidites and Triphosphates for Chemical or Polymerase Synthesis and Fast Post-Synthetic DNA Functionalization through Copper-Catalyzed Alkyne–Azide 1,3-Dipolar Cycloaddition. Org. Lett. in press: doi: 10.1021/acs.orglett.8b01533, 2018. |
223. |
Boháčová S., Vaníková Z., Poštová Slavětínská L., Hocek M.:
Protected 2'-deoxyribonucleoside triphosphate building blocks for photocaging of epigenetic 5-(hydroxymethyl)cytosine in DNA. Org. Biomol. Chem. in press: doi: 10.1039/C8OB01106K, 2018. |
222. |
Krömer M., Bártová K., Raindlová V., Hocek M.:
Synthesis of dihydroxyalkynyl and dihydroxyalkyl nucleotides as building blocks or precursors for introduction of diol or aldehyde functions to DNA for bioconjugations. Chem. Eur. J. in press: doi: 10.1002/chem.201802282, 2018. |
221. |
Slavíčková M., Janoušková M., Šimonová A., Cahová H., Kambová M., Šanderová H., Krásný L., Hocek M.:
Turning off transcription with bacterial RNA polymerase through CuAAC click reactions of DNA containing 5-ethynyluracil. Chem. Eur. J. 24: 8311-8314, 2018. |
220. |
Ghosh K., Perlíková P., Havlíček V., Yang C., Pohl R., Tloušťová E., Hodek J., Gurská S., Džubák P., Hajdúch M., Hocek M.:
Isomeric Naphtho-Fused 7-Deazapurine Nucleosides and Nucleotides. Synthesis, Biological Activity, Photophysical Properties and Enzymatic Incorporation to Nucleic Acids. Eur. J. Org. Chem. in press: doi: 10.1002/ejoc.201800165, 2018. |
219. |
Vosáhlová J., Koláčná L., Daňhel A., Fischer J., Balintová J., Hocek M., Schwarzová-Pecková K., Fojta M.:
Voltammetric and adsorption study of 4-nitrophenyl-triazole-labeled 2'-deoxycytidine and 7-deazaadenosine nucleosides at boron-doped diamond electrode. J. Electroanal. Chem. 821: 111-120, 2018. |
218. |
Sabat N., Poštová Slavětínská L., Klepetářová B., Hocek M.:
C-H imidation of 7-deazapurines. ACS Omega 3: 4674-4678, 2018. |
217. |
Boháčová S., Ludvíková L., Poštová Slavětínská L., Vaníková Z., Klán P., Hocek M.:
Protected 5-(hydroxymethyl)uracil nucleotides bearing visible-light photocleavable groups as building blocks for polymerase synthesis of photocaged DNA. Organic & Biomolecular Chemistry 16: 1527-1535, 2018. |
216. |
Havranová-Vidláková P., Špaček J., Vítová L., Hermanová M., Daďová J., Raindlová V., Hocek M., Fojta M., Havran L.:
Butylacrylate-nucleobase Conjugates as Targets for Two-step Redox Labeling of DNA with an Osmium Tetroxide Complex. Electroanalysis 30: 371-377, 2018. |
215. |
Daňhel A., Trošanová, Z., Balintová J., Simonova A., Pospíšil L., Cvačka J., Hocek M., Fojta M.:
Electrochemical reduction of azidophenyl-deoxynucleoside conjugates at mercury surface. Electrochimica Acta 259: 377-385, 2018. |
2017
214. |
Janoušková M., Vaníková Z., Nici F., Boháčová S., Vítovská D., Šanderová H., Hocek M., Krásný L.:
5-(Hydroxymethyl)uracil and -cytosine as potential epigenetic marks enhancing or inhibiting transcription with bacterial RNA polymerase. Chemical Communications 53: 13253-13255, 2017. |
213. |
Olszewska A., Pohl R., Hocek M.:
Trifluoroacetophenone-Linked Nucleotides and DNA for Studying of DNA–Protein Interactions by 19F NMR Spectroscopy. Journal of Organic Chemistry 82: 11431-11439, 2017. |
212. |
Balintová J., Simonova A., Białek-Pietras M., Olejniczak A., Lesnikowski Z. J., Hocek M.:
Carborane-linked 2'-deoxyuridine 5'-O-triphosphate as building block for polymerase synthesis of carborane-modified DNA. Bioorganic & Medicinal Chemistry Letters 27: 4786-4788, 2017. |
211. |
Perlíková P., Hocek M.:
Pyrrolo[2,3-d]pyrimidine (7-deazapurine) as a privileged scaffold in design of antitumor and antiviral nucleosides. Medicinal Research Reviews 37: 1429-1460, 2017. |
211. |
Sabat N., Smoleń S., Nauš P., Perlíková P., Cebová M., Poštová Slavětínská L., Hocek M.:
Synthesis of 2,6-Substituted 7-(Het)aryl-7-deazapurine Nucleobases (2,4-Disubstituted 5-(Het)aryl-pyrrolo[2,3-d]pyrimidines). Synthesis 49: 4623-4650, 2017. |
209. |
Konč J., Tichý M., Pohl R., Hodek J., Džubák P., Hajdúch M., Hocek M.:
Sugar modified pyrimido[4,5-b]indole nucleosides: synthesis and antiviral activity. Medicinal Chemistry Communications 8: 1856-1862, 2017. |
208. |
Simonova A., Havran L., Pohl R., Fojta M., Hocek M.:
Phenothiazine-linked nucleosides and nucleotides for redox labelling of DNA. Organic & Biomolecular Chemistry, 15: 6984-6996, 2017. |
207. |
Downey A. M., Hocek M.:
Strategies toward protecting group-free glycosylation through selective activation of the anomeric center. Beilstein Journal of Organic Chemistry, 13: 1239-1279, 2017. |
206. |
Tichý M., Smoleń S., Tloušťová E., Pohl R., Oždian T., Hejtmánková K., Lišková B., Gurská S., Džubák P., Hajdúch M., Hocek M.:
Synthesis and Cytostatic and Antiviral Profiling of Thieno-Fused 7-Deazapurine Ribonucleosides. Journal of Medicinal Chemistry, 60: 2411-2424, 2017. |
205. |
Downey A. M., Pohl R., Roithová J., Hocek M.:
Synthesis of Nucleosides through Direct Glycosylation of Nucleobases with 5-O-Monoprotected or 5-Modified Ribose: Improved Protocol, Scope, and Mechanism. Chemistry A European Journal 23: 3910-3917, 2017. |
2016
204. |
Matyašovský J., Perlíková P., Malnuit V., Pohl R., Hocek M.:
2-Substituted dATP Derivatives as Building Blocks for Polymerase-Catalyzed Synthesis of DNA Modified in the Minor Groove. Angewandte Chemie International Edition 55: 15856-15859, 2016. |
203. |
Slavíčková M., Pohl R., Hocek M.:
Additions of Thiols to 7-Vinyl-7-deazaadenine Nucleosides and Nucleotides. Synthesis of Hydrophobic Derivatives of 2'-Deoxyadenosine, dATP and DNA. Journal of Organic Chemistry 81: 11115-11125, 2016. |
202. |
Cahová H., Panattoni A., Kielkowski P., Fanfrlík J., Hocek M.:
5-Substituted Pyrimidine and 7-Substituted 7-Deazapurine dNTPs as Substrates for DNA Polymerases in Competitive Primer Extension in the Presence of Natural dNTPs. ACS Chemical Biology 11: 3165-3171, 2016. |
201. |
Botha F., Slavíčková M., Pohl R., Hocek M.:
Copper-mediated arylsulfanylations and arylselanylations of pyrimidine or 7-deazapurine nucleosides and nucleotides. Organic & Biomolecular Chemistry 14: 10018-10022, 2016. |
200. |
Sabat N., Poštová Slavětínská L., Klepetářová B., Hocek M.:
C–H Phosphonation of Pyrrolopyrimidines: Synthesis of Substituted 7- and 9-Deazapurine-8-phosphonate Derivatives. Journal of Organic Chemistry 81: 9507-9514, 2016. |
199. |
Olszewska A., Pohl R., Brázdová M., Fojta M., Hocek M.:
Chloroacetamide-Linked Nucleotides and DNA for Cross-Linking with Peptides and Proteins. Bioconjugate Chemistry 27: 2089-2094, 2016. |
198. |
Bosáková A., Perlíková P., Tichý M., Pohl R., Hocek M.:
6-Aryl-4-amino-pyrimido[4,5-b]indole 2'-deoxyribonucleoside triphosphates (benzo-fused 7-deaza-dATP analogues): Synthesis, fluorescent properties, enzymatic incorporation into DNA and DNA-protein binding study. Bioorganic & Medicinal Chemistry 24: 4528-4535, 2016. |
197. |
Dziuba D., Pospíšil P., Matyašovský J., Brynda J., Nachtigallová D., Rulíšek L., Pohl R., Hof M., Hocek M.:
Solvatochromic fluorene-linked nucleoside and DNA as color-changing fluorescent probes for sensing interactions. Chemical Science 7: 5775-5785, 2016. |
196. |
Danhel A., Trošanová Z., Balintová J., Havran L., Hocek M., Barek J., Fojta M.:
Voltammetric analysis of 5-(4-Azidophenyl)-2'-deoxycytidine nucleoside and azidophenyl-labelled single- and double-stranded DNAs. Electrochimica Acta 215: 72-83, 2016. |
195. |
Perlíková P., Rylová G., Nauš P., Elbert T., Tloušťová E., Bourderioux A., Poštová Slavětínská L., Motyka K., Doležal D., Znojek P., Nová A., Harvanová M., Džubák P., Šiller M., Hlaváč J., Hajdúch M., Hocek M.:
7-(2-Thienyl)-7-Deazaadenosine (AB61), a New Potent Nucleoside Cytostatic with a Complex Mode of Action. Molecular Cancer Therapy 15: 922-937, 2016. |
194. |
Raindlová V., Janoušková M., Slavíčková M., Perlíková P., Boháčová S., Milisavljevič N., Šanderová H., Benda M., Barvík I., Krásný L., Hocek M.:
Influence of major-groove chemical modifications of DNA on transcription by bacterial RNA polymerases. Nucleic Acids Research 44: 3000-3012, 2016. |
193. |
Daďová J., Cahová H., Hocek M.:
Polymerase Synthesis of Base-Modified DNA. K. Nakatani, Y. Tor (eds.), Modified Nucleic Acids, Nucleic Acids and Molecular Biology Series Vol. 31: 123-144, Springer 2016. |
192. |
Sabat N., Nauš P., Matyašovský J., Dziuba D., Poštová Slavetínská L., Hocek M.:
Synthesis of Fluorescent 2-Substituted 6-(Het)aryl-7-deazapurineBases {4-(Het)aryl-pyrrolo[2,3-d]pyrimidines} by Aqueous Suzuki–Miyaura Cross-Coupling Reactions. Synthesis 48: 1029-1045, 2016. |
191. |
Kielkowski P., Cahová H., Pohl R., Hocek M.:
Flexible double-headed cytosine-linked 2'-deoxycytidine nucleotides. Synthesis, polymerase incorporation to DNA and interaction with DNA methyltransferases. Bioorganic & Medicinal Chemistry 24: 1268-1276, 2016. |
190. |
Dziuba D., Jurkiewicz P., Cebecauer M., Hof M., Hocek M.:
A Rotational BODIPY Nucleotide: An Environment-Sensitive Fluorescence-Lifetime Probe for DNA Interactions and Applications in Live-Cell Microscopy. Angewandte Chemie International Edition 55: 174-178, 2016. |
189. |
Güixens-Gallardo P., Hocek M., Perlíková P.:
Inhibition of non-templated nucleotide addition by DNA polymerases in primer extension using twisted intercalating nucleic acid modified templates. Bioorganic & Medicinal Chemistry Letters 26: 288-291, 2016. |
2015
188. |
Tokarenko A., Poštová Slavětínská L., Klepetářová B., Hocek M.:
Synthesis of Benzene and Pyridine 2'-C-Methyl-C-ribonucleosides and -nucleotides. European Journal of Organic Chemistry 36: 7962-7983, 2015. |
187. |
Klečka M., Poštová Slavětínská L., Hocek M.:
Modification of Pyrrolo[2,3-d]pyrimidines by C–H Borylation Followed by Cross-Coupling or Other Transformations: Synthesis of 6,8-Disubstituted 7-Deazapurine Bases. European Journal of Organic Chemistry 36: 7943-7961, 2015. |
186. |
Nauš P., Caletková O., Perlíková P., Poštová Slavětínská L., Tloušťová E., Hodek J., Weber J., Džubák P., Hajdúch M., Hocek M.:
Synthesis and biological profiling of 6- or 7-(het)aryl-7-deazapurine 4'-C-methylribonucleosides. Bioorganic & Medicinal Chemistry 23: 7422-7438, 2015. |
185. |
Sabat N., Poštová Slavětínská L., Hocek M.:
Ir-catalyzed C–H silylations of phenyldeazapurines. Tetrahedron Letters 49: 6860-6862, 2015. |
184. |
Olszewska A., Daďová J., Mačková M., Hocek M.:
Cleavage of DNA containing 5-fluorocytosine or 5-fluorouracil by type II restriction endonucleases. Bioorganic & Medicinal Chemistry 21: 6885-6890, 2015. |
183. |
Daďová J., Vrábel M., Adámik M., Brázdová M., Pohl R., Fojta M., Hocek M.:
Azidopropylvinylsulfonamide as a New Bifunctional Click Reagent for Bioorthogonal Conjugations: Application for DNA–Protein Cross-Linking. Chemistry A European Journal 21: 16091-16102, 2015. |
182. |
Mačková M., Boháčová S., Perlíková P., Poštová Slavětínská L., Hocek M.:
Polymerase Synthesis and Restriction Enzyme Cleavage of DNA Containing 7-Substituted 7-Deazaguanine. ChemBioChem 16: 2225-2236, 2015. |
181. |
Downey A. M., Richter C., Pohl R., Mahrwald R., Hocek M.:
Direct One-Pot Synthesis of Nucleosides from Unprotected or 5-O-Monoprotected D-Ribose. Organic Letters 17: 4604-4607, 2015. |
180. |
Malnuit V., Poštová Slavětínská L., Nauš P., Džubák P., Hajdúch M., Stolaříková J., Snášel J., Pichová I., Hocek M.:
2-Substituted 6-(Het)aryl-7-deazapurine Ribonucleosides: Synthesis, Inhibition of Adenosine Kinases, and Antimycobacterial Activity. ChemMedChem 10: 1079-1093, 2015. |
179. |
Klečka M., Slavětínská L., Tloušťová E., Džubák P., Hajdúch M., Hocek M.:
Synthesis and cytostatic activity of 7-arylsulfanyl-7-deazapurine bases and ribonucleosides. MedChemComm 6: 576-580, 2015. |
178. |
Dziuba D., Pohl R., Hocek M.:
Polymerase synthesis of DNA labelled with benzylidene cyanoacetamide-based fluorescent molecular rotors: fluorescent light-up probes for DNA-binding proteins. Chemical Communications 51: 4880-4882, 2015. |
177. |
Ménová P., Dziuba D., Güixens-Gallardo P., Jurkiewicz P., Hof M., Hocek M.:
Fluorescence Quenching in Oligonucleotides Containing 7-Substituted 7-Deazaguanine Bases Prepared by the Nicking Enzyme Amplification Reaction. Bioconjugate Chemistry 26: 361-366, 2015. |
176. |
Balintová J., Špaček J., Pohl R., Brázdová M., Havran L., Fojta M., Hocek M.:
Azidophenyl as a click-transformable redox label of DNA suitable for electrochemical detection of DNA-protein interactions. Chemical Science 6: 575-587, 2015. |
2014
2013
2012
2011
2010
2009
2008
2007
2006
2005
2004
2003
2002
2001
19. |
Havelková M., Dvořák D., Hocek M.: The Suzuki-Miyaura Cross-Coupling Reactions of 2-, 6- or 8-Halopurines with Boronic Acids Leading to 2-, 6- or 8-Aryl- or -Alkenylpurine Derivatives. Synthesis 11: 1704-1710, 2001. |
18. |
Hocek M., Holý A., Votruba I., Dvořáková H.: Cytostatic 6-Arylpurine Nucleosides III. Synthesis and Structure-Activity Relationship Study in Cytostatic Activity of 6-Aryl-, 6-Hetaryl- and 6-Benzylpurine Ribonucleosides. Collection of Czechoslovak Chemical Communications 66: 483-499, 2001. |
17. |
Hocek M., Starý I., Stará I. G., Dvořáková H.: Cyclotrimerization of 6-ethynylpurines. Synthesis of 1,2,4- and 1,3,5-tris(purin-6-yl)benzenes as novel Hoogsteen-triplet analogues. Tetrahedron Letters 42: 519-521, 2001. |
2000
1999
12. |
Hocková D., Hocek M., Dvořáková H., Votruba I.: Synthesis and Cytostatic Activity of Nucleosides and Acyclic Nucleoside Analogues Derived from 6-(Trifluoromethyl)purines. Tetrahedron 55: 11109-11118, 1919. |
11. |
Havelková M., Hocek M., Česnek M., Dvořák D.: The Suzuki-Miyaura Cross-Coupling Reactions of 6-Halopurines with Boronic Acids Leading to 6-Aryl and 6-Alkenylpurines. Synlett 7: 1145-1147, 1919. |
10. |
Hocek M., Holý A.: Perfluoroalkylation of 6-Iodopurines by Trimethyl(perfluoroalkyl)silanes. Synthesis of 6-(Perfluoroalkyl)purine Bases, Nucleosides and Acyclic Nucleotide Analogues. Collection of Czechoslovak Chemical Communications 64: 229-241, 1919. |
1997
9. |
Hocek M., Masojídková M., Holý A.: Synthesis of Acyclic Nucleotide Analogues Derived from 6-Hetarylpurines via Cross-Coupling Reactions of 9-[2-(Diethoxyphosphonylmethoxy)ethyl]-6-iodopurine with Hetaryl Organometallic Reagents. Collection of Czechoslovak Chemical Communications 62: 136-146, 1997. |
8. |
Hocek M., Masojídková M., Holý A.: Synthesis of Acyclic Nucleotide Analogues Derived from N -Substituted 6-(1-Aminoethyl)purines via 6-Acetylpurine Derivatives. Tetrahedron 53: 2291-2302, 1997. |
1996
7. |
Hocek M., Masojídková M., Holý A., Andrei G., Snoeck R., Balzarini J., De Clercq E.: Synthesis and Antiviral Activity of Acyclic Nucleotide Analogues Derived from 6-(Aminomethyl)purines and Purine-6-carboxamidines. Collection of Czechoslovak Chemical Communications 61: 1525-1537, 1996. |
6. |
Hocek M., Holý A.: Acyclic Nucleotide Analogues Derived from 6-(1-Aminoalkyl)purines. Collection of Czechoslovak Chemical Communications 61 (Special issue): S55-S58, 1996. |
1995
5. |
Hocek M., Holý A.: A Facile Synthesis of 6-Cyanopurines. Collection of Czechoslovak Chemical Communications 60: 1386-1389, 1995. |
4. |
Hocek M., Masojídková M., Holý A.: Synthesis of Acyclic Nucleotide Analogues Derived from 2-(Aminomethyl)adenine and 2-(Aminomethyl)hypoxanthine. Collection of Czechoslovak Chemical Communications 60: 875-882, 1995. |
1994
3. |
Hocek M., Masojídková M., Holý A.: A Facile Synthesis of 2-(Aminomethyl)Purines. Synthesis 12: 1401-1402, 1994. |
2. |
Böhm S., Hocek M., Němeček J., Havlíček V., Kuthan J.: Preparation and Spectroscopic Properties of Spirocyclic 1-Methyl-2,4,4,6-tetraaryl-1,4-dihydropyridines. Collection of Czechoslovak Chemical Communications 59: 1105-1114, 1994. |
1. |
Böhm S., Hocek M., Nešpůrek S., Kuthan J.: Photocolouration of 2,4,4,6-Tetraaryl-1,4-dihydropyridines: A Semiempirical Quantum Chemical Study. Collection of Czechoslovak Chemical Communications 59: 262-272, 1994. |