Selected Publications
iTAP, a novel iRhom interactor, controls TNF secretion by policing the stability of iRhom/TACE.
eLife 7: e35032, 2018.
Goel P., Jumpertz,T., Tichá A., Ogorek I., Mikles D.C., Hubálek M., Pietrzik C.U., Strisovsky K., Schmidt B., Weggen S.:
Discovery and validation of 2-styryl substituted benzoxazin-4-ones as a novel scaffold for rhomboid protease inhibitors.
Bioorganic and Medicinal Chemistry Letters 28: 1417-1422, 2018.
Yang J., Barniol-Xicota M., Nguyen M.T.N., Tichá A., Strisovsky K., Verhelst S.H.L.:
Benzoxazin-4-ones as novel, easily accessible inhibitors for rhomboid proteases.
Bioorganic and Medicinal Chemistry Letters 28: 1423-1427, 2018.
Goel P., Jumpertz T., Mikles D.C., Ticha A., Nguyen M.T.N., Verhelst S., Hubalek M., Johnson D.C., Bachovchin D.A., Ogorek I., Pietrzik C.U., Strisovsky K.,
Schmidt B., Weggen S.:
Discovery and Biological Evaluation of Potent and Selective N-Methylene Saccharin-Derived Inhibitors for Rhomboid Intramembrane Proteases.
Biochemistry 56: 6713-6725, 2017.
*Ticha A., *Stanchev S., Vinothkumar K.R., Mikles D.C., Pachl P., Began J., Skerle J., Svehlova K., Nguyen M.T.N., Verhelst S.H.L., Johnson D.C., Bachovchin D.A.,
*Lepsik M., Majer P., Strisovsky K.:
General and modular strategy for designing potent, selective and pharmacologically compliant inhibitors of rhomboid proteases.
Cell Chemical Biology 24: 1-14, 2017.
Johnson N., Brezinova J., Stephens E., Burbridge E., Freeman M., Adrain C., Strisovsky K.:
Quantitative proteomics screen reveals a substrate repertoire of human rhomboid protease RHBDL2 in human cells and implicates it in epithelial homeostasis.
Scientific Reports 7: 7283, 2017.
*Ticha A., *Stanchev S., Skerle J., Began J., Ingr M., Svehlova K., Polovinkin L., Ruzicka M., Bednarova *L., Hadravova R., Polachova E., Rampirova P.,
*Brezinova J., Kasicka V., Majer P., Strisovsky K.:
Sensitive versatile fluorogenic transmembrane peptide substrates for rhomboid intramembrane proteases.
Journal of Biological Chemistry 292: 2703-2713, 2017.
Strisovsky K.:
Mechanism and inhibition of rhomboid proteases.
Methods in Enzymology 584: 279-293, 2017.
Arutyunova E., Panigrahi R., Strisovsky K., & Lemieux M.J.:
Production of recombinant rhomboid proteases.
Methods in Enzymology 584: 255-278, 2017.
Arutyunova E., Strisovsky K., & Lemieux M.J.:
Activity assays for rhomboid proteases.
Methods in Enzymology 584: 395-437, 2017.
Strisovsky K.:
Rhomboid protease inhibitors: emerging tools and future therapeutics.
Seminars in Cell & Developmental Biology 60: 52-62, 2016.
Wunderle L., Knopf J.D., Kuhnle N., Morle A., Hehn B., Adrain C., Strisovsky K., Freeman M. & Lemberg M.K.:
Rhomboid intramembrane protease RHBDL4 triggers ER-export and non-canonical secretion of membrane-anchored TGFalpha.
Scientific Reports 6: 27342, 2016.
Strisovsky K.:
Why cells need intramembrane proteases – a mechanistic perspective.
FEBS Journal 283: 1837-45, 2015.
Wolf E.V., Seybold M., Hadravova R., Strisovsky K. & Verhelst S.H.:
Activity-Based Protein Profiling of Rhomboid Proteases in Liposomes.
ChemBioChem 16: 1616-21, 2015.
Zoll S. Stanchev S., Began J., Skerle J., Lepsik M., Peclinovska L., Majer P. & Strisovsky K.:
Substrate binding and specificity of rhomboid intramembrane protease revealed by substrate-peptide complex structures.
EMBO Journal 33: 2408-2421, 2014.
Strisovsky K. & Freeman M.:
Sharpening rhomboid specificity by dimerisation and allostery.
EMBO Journal, 33: 1847–1848, 2014.
Strisovsky K.:
Structural and mechanistic principles of intramembrane proteolysis - lessons from rhomboids.
FEBS Journal 280: 1579-603, 2013.
Adrain C., Strisovsky K., Zettl M., Hu L.D.A., Lemberg M.K. & Freeman M.:
Mammalian EGF receptor activation by the rhomboid protease RHBDL2.
EMBO Reports 12: 421-427, 2011.
Pierrat* O.A., Strisovsky* K., Christova Y., Large J., Ansell K., Bouloc N., Smiljanic E. & Freeman M.:
Monocyclic beta-lactams are selective, mechanism-based inhibitors of rhomboid intramembrane proteases.
ACS Chemical Biology 6: 325-335, 2011.
Zettl M., Adrain C., Strisovsky K., Lastun V. & Freeman M.:
Rhomboid family pseudoproteases use the ER quality control machinery to regulate intercellular signaling.
Cell 145: 79-91, 2011.
Vinothkumar K.R., Strisovsky K., Andreeva A., Christova Y., Verhelst S. & Freeman M.:
The structural basis for catalysis and substrate specificity of a rhomboid protease.
EMBO Journal 29: 3797-3809, 2010.
Strisovsky K., Sharpe H.J. & Freeman M.:
Sequence-specific intramembrane proteolysis: identification of a recognition motif in rhomboid substrates.
Molecular Cell 36: 1048-1059, 2009.
Stevenson L.G., Strisovsky K., Clemmer K.M., Bhatt S., Freeman M. & Rather P.N.:
Rhomboid protease AarA mediates quorum-sensing in Providencia stuartii by activating TatA of the twin-arginine translocase.
Proceedings of the National Academy of Sciences of the United States of America 104: 1003-1008, 2007.
* equal contribution
Pubmed Search Kvido Strisovsky