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Education |
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1987-1991 |
Ph.D. in biochemistry, Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Prague. |
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1981-1986 |
M.Sc. in biochemistry, Charles University, Prague, Czech Republic. |
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Experience |
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1996-1998 (18 months) |
Oklahoma Medical Research Foundation, Oklahoma City, USA. |
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1994 (2 months) |
Laboratory of Molecular Biophysics, Oxford University, UK. |
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1992 (3 months) |
European Molecular Biology Laboratory (EMBL), Heidelberg, Germany. |
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1991-1995 (8 months) |
Münster University, Germany. |
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Appointments |
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since 2007 |
Head of the IOCB Research Team (Cathepsin Proteases in Pathology). |
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2003-2006 |
Head of the Laboratory of Regulation of Proteolysis at IOCB. |
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2001-2006 |
Postdoctoral Fellow, Institute of Organic Chemistry and Biochemistry AS CR, Prague, Czech Republic. |
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since 1991 |
Researcher, Institute of Organic Chemistry and Biochemistry (IOCB), Academy of Sciences of the Czech Republic, Prague. |
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Research interest |
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Proteases and their regulation in pathological processes, cathepsin proteases in cancer, digestive proteolysis in blood-feeding parasites, allergenic proteases, plant protease inhibitors as insecticides.
Proteomics, protein 3D structures and structure-activity relationship, rational and combinatorial design of small bioactive molecules as chemotherapeutic agents.
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