Biochemistry

Iva Pichová

One third of the world’s population is infected with Mycobacterium tuberculosis (Mtb). In 95 % of infected individuals Mtb persists in a metabolically highly reduced stage of dormancy (latent infection). Metabolism of Mtb in this persistent stage is poorly understood. This thesis will be focused on identification of key metabolic enzymes, their cloning, expression, and characterization. The study will be combined with structure analysis and inhibitor design.