Department of Experimental Hypertension is studying the mechanisms of blood pressure (BP) regulation and end-organ damage in rats with different types of experimental hypertension. Our research is focused mainly on:
- Elucidation of the mechanisms by which endothelin and renin-angiotensin systems participate in renal damage in transgenic rats with inserted mouse renin gene (Ren-2 TGR) – cooperation with IKEM (Prague).
- Comparison of the role of calcium sensitization (Rho kinase pathway) and calcium influx in the development of high BP in rats with genetic or salt hypertension – molecular biological analysis of alterations in these regulatory pathways.
- Study of the central mechanisms of blood pressure regulation in rats with genetic hypertension: focus on brain renin-angiotensin system, central corticoid effects, baroreflex control of sympathetic tone and oxidative stress.
- Investigation of cardiovascular effects of new analogs of neuropeptides regulating food intake in rats – cooperation with IOCHB CAS (Prague).
Projects
Achievements
Institute of Organic Chemistry and Biochemistry of the CAS (IOCB Prague) in collaboration with Institute of Physiology of the CAS developed new compounds with positive effects in experimental animal models of obesity and type II diabetes.
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Our colleagues were very successful at 26th International Meeting of International Society of Hypertension in Seoul - Michal Behuliak was awarded by the 2nd place in the section Young Investigator Award, Anna Vavřínová by Travel Grant and Josef Zicha was awarded by the 2nd place in the section Best Oral Presentation in Basic Sciences.
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Michal Behuliak was granted by the Czech Society for Hypertension, the price was awarded by the general manager of Servier in the Czech Republic.
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Mgr. Michal Behuliak, PhD. was granted with Otto Wicherle prize from the President of Czech Academy of Sciences on Monday, May 30, 2016.
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Publications
Vaněčková, Ivana - Hojná, Silvie - Kadlecová, Michaela - Vernerová, Z. - Kopkan, L. - Červenka, L. - Zicha, Josef
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Renoprotective Effects of ETA Receptor Antagonists Therapy in Experimental Non-Diabetic Chronic Kidney Disease: Is There Still Hope for the Future?
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Physiological Research 2018, roč. 67, Suppl.1, S55-S67
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IF = 1.324
[ASEP]
Rauchová, Hana - Vokurková, Martina - Pavelka, Stanislav - Vaněčková, Ivana - Tribulová, N. - Soukup, Tomáš
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Red palm oil supplementation does not increase blood glucose or serum lipids levels in Wistar rats with different thyroid status
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Physiological Research 2018, roč. 67, 2, p. 307-315
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IF = 1.324
[ASEP]
Popelová, A. - Pražienková, V. - Neprašová, Barbora - Kasperová, B. J. - Hrubá, L. - Holubová, M. - Zemenová, J. - Blum, D. - Železná, B. - Galas, M. C. - Kuneš, Jaroslav - Maletínská, L.
Novel Lipidized Analog of Prolactin-Releasing Peptide Improves Memory Impairment and Attenuates Hyperphosphorylation of Tau Protein in a Mouse Model of Tauopathy
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Journal of Alzheimer's Disease 2018, roč. 62, 4, p. 1725-1736
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IF = 3.476
[ASEP]
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doi
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Popelová, A. - Kákonová, A. - Hrubá, L. - Kuneš, Jaroslav - Maletínská, L. - Železná, B.
Potential neuroprotective and anti-apoptotic properties of a long-lasting stable analog of ghrelin: an in vitro study using SH-SY5Y cells
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Physiological Research 2018, roč. 67, 2, p. 339-346
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IF = 1.324
[ASEP]
Poledne, R. - Zicha, Josef
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Human genome evolution and development of cardiovascular risk factors through natural selection
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Physiological Research 2018, roč. 67, 2, p. 155-163
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IF = 1.324
[ASEP]
Mikulášková, Barbora - Holubová, M. - Pražienková, V. - Hrubá, L. - Zemenová, J. - Haluzík, M. - Železná, B. - Kuneš, Jaroslav - Maletínská, L.
Lipidized prolactin-releasing peptide improved glucose tolerance in metabolic syndrome: Koletsky and spontaneously hypertensive rat study
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Nutrition & Diabetes 2018, roč. 8, Jan 16, článku 5
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IF = 2.742
[ASEP]
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doi
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Holubová, M. - Hrubá, L. - Neprašová, Barbora - Majerčíková, Z. - Lacinová, Z. - Kuneš, Jaroslav - Maletínská, L. - Železná, B.
Prolactin-releasing peptide improved leptin hypothalamic signaling in obese mice
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Journal of Molecular Endocrinology 2018, roč. 60, 2, p. 85-94
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IF = 3.297
[ASEP]
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doi
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Holubová, M. - Blechová, M. - Kákonová, A. - Kuneš, Jaroslav - Železná, B. - Maletínská, L.
In Vitro and In Vivo Characterization of Novel Stable Peptidic Ghrelin Analogs: Beneficial Effects in the Settings of Lipopolysaccharide-Induced Anorexia in Mice
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Journal of Pharmacology and Experimental Therapeutics 2018, roč. 366, 3, p. 422-432
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IF = 3.706
[ASEP]
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doi
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Behuliak, Michal - Bencze, Michal - Polgárová, Kamila - Kuneš, Jaroslav - Vaněčková, Ivana - Zicha, Josef
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Hemodynamic Response to Gabapentin in Conscious Spontaneously Hypertensive Rats: The Role of Sympathetic Nervous System
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Hypertension 2018, roč. 72, 3, p. 676-685
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IF = 6.823
[ASEP]
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doi
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Zemenová, J. - Sýkora, D. - Maletínská, L. - Kuneš, Jaroslav
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Lipopeptides as therapeutics: applications and in vivo quantitative analysis
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Bioanalysis. 2017, roč. 9, 2, p. 215-230
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IF = 2.478
[ASEP]
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doi
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Overview of alterations in calcium sensitization during development of spontaneously hypertension in the rat The schematic representation of possible regulatory mechanisms involved in RhoA/Rho kinase pathway is demonstrated in normotensive (a), prehypertensive (b) and hypertensive (c) rats.
Recording of contraction of isolated femoral artery stimulated by norepinephrine (NE).
Aorta section – α-actin (red), nuclei (blue) and autofluorescence (green).
Adrenal section stained for tyrosine hydroxylase (detected by Vectastain ABC kit).
Recording of blood pressure.
