INSTITUTE OF PHYSIOLOGY CAS

Uncovering of signaling pathway regulating changes in energy metabolism during development of pulmonary hypertension Pulmonary hypertension is a syndrome characterized by high blood pressure in pulmonary circulation. This is often accompanied by some serious diseases and can be eventually fatal.  A pulmonary artery remodeling involving all layers of artery wall thus leading to artery wall hypertrophy is fundamental to pulmonary arterial hypertension development.

Sensor domain of TRPA1 channel contributes to detection of painful stimuli Acute pain is a normal reaction of the somatosensory system to noxious stimulation which serves a protective function and is the first symptom of disease, especially of inflammatory origin. In its chronic form, pain is maladaptive and has a significant impact on quality of life. The scientists from the Department of Cellular Neurophysiology, Institute of Physiology of the Czech Academy of Sciences, in collaboration with the Division of Biomolecular Physics at the Faculty of Mathematics and Physics, Charles University, investigate the function of a distinct group of proteins involved in the mechanisms of acute and chronic pain.

Elucidation of molecular basis of 14-3-3 protein-dependent activation of trehalase Nth1 in yeast cells The research team of Veronika Obsilova from the Institute of Physiology CAS and Tomas Obsil from the Faculty of Science, Charles University deciphered the mechanism by which the 14-3-3 protein regulates the function of yeast neutral trehalase Nth1.