PhD positions / Master´s thesis
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Available PhD positions
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Master's thesis
Mitochondrial Physiology
PhD Project:
Role of mitochondria in etiology of breast cancer
Metabolic pathways of cancer cells are often adjusted to produce energy and building material for cancer growth in order to provide clonal advantage over the normal cells. The pathways which ale very well characterized include…
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Biomathematics
PhD project 1:
Alteration of plasma membrane protein and lipid composition by oxidative stress; studies of rat brain and model cell lines …
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Bioenergetics
PhD project1:
Characterisation of TMEM70 protein function in mammalian mitochondria.
Our team was involved in the description and subsequent characterisation of TMEM70 protein acting as assembly factor for ATP synthase. Using mouse model of inducible TMEM70 knockout and cellular knockout models…
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Structural Biology of Signaling Proteins
PhD project:
Molecular mechanisms of 14-3-3 proteins in signaling complexes
14-3-3 proteins have the ability of binding the functionally different signal proteins, including kinases, phosphatases and transmembrane receptors by changing their function. Through the…
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Adipose Tissue Biology
PhD project: Complex screening of gene expression using RNA sequencing analysis with the focus on the early human development
Early postnatal period is critical with respect to development of the key physiological functions and homeostatic mechanisms of the newborn, as well as for imprinting the…
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Analysis of Biologically Important Compounds
PhD Project1:
Influence of proteins and peptides in the protection against tooth caries
About 90% worldwide adults suffer from dental caries on enamel and root surfaces. The resistance of the lucky rest of population (10%) against the development of dental caries remains unclear. Dental caries…
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Molecular Neurobiology
PhD project:
Collapsin response mediator proteins in neurodevelopmental disorders
Precise regulation of neural development is essential for normal function of the adult nervous system. Defects in neuron migration, branching or growth have been linked to several…
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Neurochemistry
PhD project1:
Molecular mechanisms of signalling bias at muscarinic receptors.
Muscarinic acetylcholine receptors are G-protein coupled receptors (GPCRs) located in the plasma membrane of many cell types of various tissues. These receptors mediate extracellular to intracellular signalling.…
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Membrane Transport
PhD project:
Structure and function of proteins participating in the homeostasis of alkali metal cations and intracellular pH
Ion homeostasis is a crucial requirement for all cells. They have developed efficient transport systems to acquire and store the desired elements and robust…
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Functional Morphology
PhD Project:
Modulation of nociceptive signaling at spinal cord level.
We are highly interested in different aspects of spinal TRPV1 receptors modulation of nociceptive synaptic transmission at the spinal cord level. This project will be focused on their interaction with other types of receptors…
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Cellular Neurophysiology
PhD Project1:
Neurosteroid modulation of NMDA receptors
N-methyl-D-aspartate (NMDA) receptors are a type of ionotropic glutamate receptors mediating fast synaptic transmission and essential for learning and memory. Abnormal function of NMDA receptors underlies many neurological and…
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Cellular and Molecular Neuroendocrinology
PhD project:
Molecular physiology of P2X receptors and their role in regulation of neuroendocrine cell function
The P2X receptors are ligand gated ion channels activated by extracellular ATP. They play a role in neurotransmission, modulation of neurotransmitter and hormone release,…
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Functional Morphology
It is possible to develop a bachelor's, master's and doctoral theses on various topics related to the creation of mechanisms and pain syndromes at our department.
Periferní a centrální mechanizmy bolestivých stavů
Modulace nocicepce na míšní úrovni
Úloha synaptické modulace při nociceptivním…
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