Organic Chemistry

Tutor	Ing. Dana Hocková, CSc.
Team	Zlatko Janeba
Topic	Synthesis of novel types of enzyme inhibitors of nucleotide/nucleoside metabolism with potential antiparasitic and antibacterial activity
Faculty	FCHT / FPBT VŠCHT, PřF UK
Abstract	In connection with the projects of the group, the topic of the Ph.D. project will be design and synthesis of novel types of nucleoside and nucleotide analogues as potential inhibitors of key enzymes of the metabolism of nucleic acid components. Emphasis will be placed on the selectivity of inhibition resulting from subtle differences in the active sites of enzymes of individual organisms. Biological activity of the prepared compounds, mainly antiparasitic (Plasmodium falciparum) and antibacterial (Mycobacterium tuberculosis), will be studied.