Biochemistry and Molecular Biology

Pavlína Řezáčová

The project will be focused on the knowledge-based design of active compounds targeting several proteins or protein-protein interactions, which are implicated in the development of hematological malignancies. The compounds will be developed using the fragment-based approach. The work on this project provides the opportunity to acquire an expertise in protein biochemistry, biophysics and structural biology, as well as to get an insight into the rational drug design process through a close collaboration with the medicinal and computational chemists.

Leading references:
Hnizda, A., et al., Oligomeric interface modulation causes misregulation of purine 5 -nucleotidase in relapsed leukemia. BMC biology 2016, 14 (1), 91.
Čermáková, K., et al., Validation and structural characterization of the LEDGF/p75-MLL interface as a new target for the treatment of MLL-dependent leukemia. Cancer Research, 2014. 74 (18): 5139