INSTITUTE OF PHYSIOLOGY CAS

Antioxidants and their possible use for epilepsy treatment Oxidative stress (resulting from the excessive free radicals production and the limited antioxidant defense) is implicated in the pathogenesis of many neurological and other disorders.

n-3 PUFA differentially modulate adipose tissue endocannabinoid levels and glucose metabolism in obese mice and type 2 diabetic subjects Increased intake of n-3 polyunsaturated fatty acids can ameliorate impaired glucose homeostasis in model experiments on obese mice, but has no effect in human patients with type 2 diabetes. This difference could reflect in part dissimilar regulation of endocannabinoid system activity in adipose tissue.

Uncovering of signaling pathway regulating changes in energy metabolism during development of pulmonary hypertension Pulmonary hypertension is a syndrome characterized by high blood pressure in pulmonary circulation. This is often accompanied by some serious diseases and can be eventually fatal.  A pulmonary artery remodeling involving all layers of artery wall thus leading to artery wall hypertrophy is fundamental to pulmonary arterial hypertension development.

Elucidation of molecular basis of 14-3-3 protein-dependent activation of trehalase Nth1 in yeast cells The research team of Veronika Obsilova from the Institute of Physiology CAS and Tomas Obsil from the Faculty of Science, Charles University deciphered the mechanism by which the 14-3-3 protein regulates the function of yeast neutral trehalase Nth1.