INSTITUTE OF PHYSIOLOGY CAS

Anti-epileptic drug gabapentin decreases blood pressure through the attenuation of sympathetic nerve transmission Our study reveals an important role of sympathetic nervous system in blood pressure lowering by acute administration of gabapentin in spontaneously hypertensive rats (SHR) which is the most widely used model of human hypertension.

Antioxidants and their possible use for epilepsy treatment Oxidative stress (resulting from the excessive free radicals production and the limited antioxidant defense) is implicated in the pathogenesis of many neurological and other disorders.

n-3 PUFA differentially modulate adipose tissue endocannabinoid levels and glucose metabolism in obese mice and type 2 diabetic subjects Increased intake of n-3 polyunsaturated fatty acids can ameliorate impaired glucose homeostasis in model experiments on obese mice, but has no effect in human patients with type 2 diabetes. This difference could reflect in part dissimilar regulation of endocannabinoid system activity in adipose tissue.

Elucidation of molecular basis of 14-3-3 protein-dependent activation of trehalase Nth1 in yeast cells The research team of Veronika Obsilova from the Institute of Physiology CAS and Tomas Obsil from the Faculty of Science, Charles University deciphered the mechanism by which the 14-3-3 protein regulates the function of yeast neutral trehalase Nth1.