Intranet Čeština

Biomaterials and Tissue Engineering

Biomaterials and Tissue Engineering Klinicky užívané cévní protézy vyrobené z expandovaného polytetrafluoroethylénu (ePTFE) a z polyethylén tereftalátu (PET). Materiál protéz je vysoce hydrofobní a neumožňuje rekonstrukci přirozených buněčných vrstev cévní stěny.

What is a tissue replacement?

Irreversible damage to various vitally important tissues and organs, such as blood vessels, heart valves, bones, joints, cartilage or skin, is a serious and frequent consequence of the lifestyle of the contemporary civilized society. It is associated with various metabolic disorders and also with traffic, sport and industrial accidents. Hereditary disorders, wear and aging of the organism also play an adverse role.

When prevention, conservative treatment and surgical interventions fail, it is necessary to replace the damaged tissue. Autologous tissue, i.e. the patient's own tissue, is still considered to be the “gold standard” for tissue substitution. However, autologous tissue is usually available only in limited quantities, and acquiring the tissue burdens the patient with additional surgery and donor site morbidity. For this reason, increasing attention is being paid to artificial materials that serve as scaffolds for reconstructing the damaged tissue.

The main tasks of our laboratory are:

  • to improve currently-used synthetic tissue replacements by introducing cell and other biological components
  • to construct completely new replacements on the basis of synthetic materials and cells
  • to achieve these two  goals, we carry out studies on the molecular mechanisms of cell behavior on synthetic materials, such as the adhesion, growth, differentiation and viability of cells on artificial materials, together with studies on potential damage and immune activation.

Projects

Achievements

Skin tissue engineering

Construction of the bilayer structure of human keratinocytes (the main cell type of the epidermis) and fibroblasts (the main cell type of the dermis) to nanofiber membranes of polylactide. More

Publications

Vetrík, Miroslav - Pařízek, Martin - Hadraba, Daniel - Kukačková, Olivia - Brus, Jiří - Hlídková, Helena - Kománková, Lucie - Hodan, Jiří - Sedláček, Ondřej - Šlouf, Miroslav - Bačáková, Lucie - Hrubý, Martin . Porous heat-treated polyacrylonitrile scaffolds for bone tissue engineering . ACS Applied Materials and Interfaces 2018, roč. 10, 10, p. 8496-8506 . IF = 8.097 [ASEP] [ doi ]
Straka, František - Schorník, David - Mašín, J. - Filová, Elena - Miřejovský, T. - Burdíková, Z. - Švindrych, Z. - Chlup, H. - Horný, L. - Daniel, M. - Machač, Jiří - Skibová, J. - Pirk, J. - Bačáková, Lucie . A human pericardium biopolymeric scaffold for autologous heart valve tissue engineering: cellular and extracellular matrix structure and biomechanical properties in comparison with a normal aortic heart valve . Journal of Biomaterial Science Polymer Edition 2018, roč. 29, 6, p. 599-634 . IF = 1.911 [ASEP] [ doi ]
Slepička, P. - Siegel, J. - Lyutakov, O. - Kasálková-Slepičková, N. - Kolská, Z. - Bačáková, Lucie - Švorčík, V. Polymer nanostructures for bioapplications induced by laser treatment . Biotechnology Advances 2018, roč. 36, 3, p. 839-855 . IF = 11.452 [ASEP] [ doi ]
Pajorová, Julie - Bačáková, Markéta - Musílková, Jana - Brož, Antonín - Hadraba, Daniel - Lopot, F. - Bačáková, Lucie . Morphology of a fibrin nanocoating influences dermal fibroblast behavior . International Journal of Nanomedicine 2018, roč. 13, June, p. 3367-3380 . IF = 4.370 [ASEP] [ doi ]
Lišková, Jana - Douglas, T.E.L. - Wijnants, R. - Samal, S. K. - Mendez, A. C. - Chronakis, I. - Bačáková, Lucie - Skirtach, A. G. Phytase-mediated enzymatic mineralization of chitosan-enriched hydrogels . Materials Letters 2018, roč. 214, Mar 1, p. 186-189 . IF = 2.687 [ASEP] [ doi ]

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Contacts

Institute of Physiology AS CR, v.v.i.
Department of Biomaterials and Tissue Engineering

Vídeňská 1083
14220 Prague 4
tel. +420 241 063 743
 

lucy@biomed.cas.cz

Lucie.Bacakova@fgu.cas.cz

People

Doc. MUDr. Lucie Bačáková, CSc.
head of the department

RNDr. Marta Vandrovcová, Ph.D.
deputy head of the department

Doc. MUDr. Vladislav Mareš, DrSc.
emeritus researcher
Mgr. Elena Filová, Ph.D.
researcher
Věra Lisá, prom. biol.
researcher
Mgr. Jana Lišková, Ph.D.
researcher (maternity leave)
RNDr. Jana Musílková, CSc.
researcher
RNDr. Lubica Staňková (née. Grausová), Ph.D.
researcher (maternity leave)

Mgr. Antonín Brož, Ph.D.
postdoctoral researcher

Ing. Markéta Bačáková, Ph.D.
postdoctoral researcher
MUDr. Jaroslav Chlupáč, Ph.D.
postdoctoral researcher
Mgr. Ivana Kopová, Ph.D.
postdoctoral researcher
RNDr. Martin Pařízek​, Ph.D.
postdoctoral researcher
Ing. Jana Zárubová (née. Havlíková), Ph.D.
postdoctoral researcher
Mgr. Martina Doubková
PhD student

Mgr. Júlia Pajorová
PhD student

Mgr. Marie Steinerová
PhD student (maternity leave)

MUDr. Martina Trávníčková
PhD student

Helena Dragounová
pregraduate student
Jana Voborníková
administrative worker
Mgr. Jarmila Knitlová
technician biologist
Ivana Zajanová
technician

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