The department focuses on the analysis of lipid mediators (eicosanoids, docosanoids, endocannabinoids) using the UPLC-MS/MS method, in particular to identify the source of production of various mediators and their effect on metabolism and immune cells (i.e. adipocytes vs. macrophages). Currently, the lab is exploring new anti-diabetic lipids, fatty acid esters of hydroxy fatty acids and lipid-related metabolic pathways using stable isotopes.
- Adipose Tissue Biology
- Animal Facility
- Bioenergetics
- Biological Controls
- Biomaterials and Tissue Engineering
- Biomathematics
- Cellular and Molecular Neuroendocrinology
- Cellular Neurophysiology
- Computational Neuroscience
- Developmental Cardiology
- Developmental Epileptology
- Economic Department
- Epithelial Physiology
- Experimental Hypertension
- Functional Morphology
- Genetics of Model Diseases
- IT Department
- Library
- Membrane Transport
- Metabolism of Bioactive Lipids
- Metabolomics
- Mitochondrial Physiology
- Molecular Neurobiology
- Neurochemistry
- Neurohumoral Regulations
- Neurophysiology of the Memory
- Property and facility management
- Radiometry
- Secretariat of the director
- Structural Biology of Signaling Proteins
- Translational Metabolism
Metabolism of Bioactive Lipids
Metabolism of bioactive lipids
Projects
Open science
Our lab participates in OPEN SCIENCE initiative and hosts high school students with their project in metabolomics. MoreBranched fatty acid esters of hydroxy fatty acids (FAHFA)
White adipose tissue (WAT) is a complex endocrine organ and its low-grade inflammation in obesity contributes to the development of metabolic disorders. In 2014, a class of WAT-born lipid mediators - fatty acid esters of hydroxy fatty acids (FAHFA) was discovered. FAHFAs are endogenous lipids with anti-inflammatory and anti-diabetic properties, including the enhancement of glucose tolerance, and insulin and glucagon-like peptide 1 (GLP-1) secretion while reducing inflammatory responses [1-5]. MoreAnti-inflammatory effects of novel lipokines of fatty acid esters of hydroxy fatty acids family in obesity
The main objective of this project is to explore structure, mechanisms of action, anti-inflammatory and anti-diabetic effects of novel lipokines – branched fatty acid esters of hydroxy fatty acids derived from polyunsaturated fatty acids of n-3 series (Omega-3) using obesity and inflammation models. MoreThe role of antioxidant defense in the synthesis of antidiabetic lipokines
Obesity is associated with an increased risk of developing metabolic syndrome, type 2 diabetes and cardiovascular disease. The adipose tissue significantly affects the whole-body metabolism of carbohydrates and lipids, which also involves fatty acid esters of hydroxy fatty acids (FAHFA), lipid mediators that affect glucose uptake and insulin sensitivity in target tissues. Our goal is to identify the metabolic pathways between lipid synthesis and antioxidant defense involved in FAHFA biosynthesis, to examine the substrate specifity of the candidate enzyme, and to introduce a methodology for the quantification of metabolic fluxes through redox reactions linking central carbon metabolism and nicotinamidadene cofactor-driven reductive biosynthesis. MoreAchievements
Lumina quaeruntur 2018
Ondrej Kuda has been awarded Lumina Quaeruntur praemium. MoreContacts
Institute of Physiology CAS
Metabolism of bioactive lipids
Vídeňská 1083
1422 0 Prague 4
Metabolism of bioactive lipids
Vídeňská 1083
1422 0 Prague 4
| tel. | +420 241 063 707 |
| email: | ondrej.kuda @ fgu.cas.cz |
People
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Ondrej Kuda, Ph.D. head of the department |
| Ing.Veronika Palůchová postgradual student |
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Mgr. Marina Oseeva postgradual student |
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Mgr. Marie Březinová postgradual student (maternity leave) |
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Mgr. Martina Rombaldová postgradual student (maternity leave) |
© 2014 INSTITUTE OF PHYSIOLOGY CAS