Organic Chemistry

Petr Beier

Fluorinated hypervalent iodine compounds such as Togni reagents have become widely used electrophilic trifluoromethylating reagents.1 They display a unique reactivity profile and functional group compatibility. Recently, in our group we have prepared substituted tetrafluoroethylene-containing reagents and have shown their application in reactions with various nucleophiles.2,3 In this project, we aim to synthetize fluoroalkylated hypervalent iodine reagents bearing a functional group and investigate their utilization in tagging biomolecules such as peptides in electrophilic or radical fashion. New bioconjugation approaches are of great interest to biochemists.

Key references:
1. J. Charpentier, N. Früh, A. Togni Chem. Rev. 2015, 115, 650.
2. V. Matoušek, J. Václavík, P. Hájek, J. Charpentier, Z. E. Blastik, E. Pietrasiak, A. Budinská, A. Togni, P. Beier Chem. Eur. J. 2016, 22, 417.
3. J. Václavík, R. Zschoche, I. Klimánková, V. Matoušek, P. Beier, D. Hilvert, A. Togni Chem. Eur. J. 2017, 23, 6490.