Výzkum našeho oddělení je zaměřen na různé patofyziologické aspekty epilepsie a epileptických záchvatů, především v období vývoje mozku. Ke studiu využíváme moderních technik (elektrofyziologie, zobrazovacích metod, biochemie, farmakologie, morfologie) a výzkum provádíme na buněčné úrovni, na úrovni tkání, ale také in vivo v chronických a genetických modelech epilepsie.
Zabýváme se výzkumem v těchto oblastech:
- Důsledky časného poškození mozku a prevence vzniku epilepsie
- Studium mechanizmů odpovědných za vznik a ukončení epileptických záchvatů
- Odlišnosti vzniku epileptických záchvatů v nezralém mozku.
- Vývoj nových diagnostických metod v epileptologii
- Studium nových farmakologických postupů léčby epilepsie a neuroprotekce
- Studium kognitivních and behavioráních následků epilepsie
- Úloha oxidativního stresu v patogenezi epilepsie a záchvatů v nezralém mozku
- Důsledky podávání neurofarmak a psychofarmak pro další vývoj mozku
- Věkově specifické mechanismy vziku a šíření epileptické aktivity
Aktuální projekty
Poškození mozku v časných vývojových stadiích vede k celé řadě funkčních i neuropatologických změn, jejichž charakter závisí nejen na mechanismu, vedoucímu k poškození, ale i na věku, kdy k poškození došlo. Nervová tkáň reaguje na inzult spuštěním celé řady molekulárních, buněčných i strukturálních změn, které na jedné straně vedou k částečnému vyrovnání vzniklých deficitů, na druhé straně však mohou být zodpovědné za vznik epilepsie. Spolu s epilepsií může dojít i ke vzniku poruch chování, poškození kognitivních funkcí či zvýšení rizika vzniku psychiatrických onemocnění. Cílem našeho výzkumu je sledovat věkově specifický charakter těchto funkčních i neuropatologických změn a tyto poznatky dále využít pro hledání nových farmakologických postupů, které by mohly vzniku epilepsie a psychiatrických problémů zabránit.
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Vývoj jednotlivých systémů zapojených do excitability mozku a její regulace probíhá ještě dlouho po narození.
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V průběhu časného postnatálního vývoje může nezralý mozek reagovat na podávání nejrůznějších psychoaktivních látek dlouhodobými změnami na molekulární či buněčné úrovni, které se mohou projevit v pozdějším věku funkčními změnami.
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Oxidativní stres se spolu s narušením funkce mitochondrií uplatňuje v pathogeneze řady neurologických onemocnění, včetně epilepsie.
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Zobrazit více
Úspěchy
Cena European Epileptology Award 2016 byla udělena prof. Pavlovi Marešovi.
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Publikace
Vodička, Martin - Ergang, Peter - Hrnčíř, Tomáš - Mikulecká, Anna - Kvapilová, Pavlína - Vagnerová, Karla - Šestáková, Blanka - Fajstová, Alena - Hermanová, Petra - Hudcovic, Tomáš - Kozáková, Hana - Pácha, Jiří
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Microbiota affects the expression of genes involved in HPA axis regulation and local metabolism of glucocorticoids in chronic psychosocial stress
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Brain Behavior and Immunity 2018, 73(Oct 2018), 615-624
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IF = 6.306
[ASEP]
[
doi
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Uttl, Libor - Petrásek, Tomáš - Sengul, Hilal - Svojanovská, Markéta - Lobellová, Veronika - Valeš, Karel - Radostová, Dominika - Tsenov, Grygoriy - Kubová, Hana - Mikulecká, Anna - Svoboda, Jan - Stuchlík, Aleš
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Chronic MK-801 Application in Adolescence and Early Adulthood: A Spatial Working Memory Deficit in Adult Long-Evans Rats But No Changes in the Hippocampal NMDA Receptor Subunits
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Frontiers in Pharmacology 2018, roč. 9, Feb 12, článku 42
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IF = 3.831
[ASEP]
[
doi
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Szczurowska, E. - Ahuja, Nikhil - Jiruška, Přemysl - Kelemen, E. - Stuchlík, Aleš
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Impairment of neural coordination in hippocampal neuronal ensembles after a psychotomimetic dose of dizocilpine.
Progress in Neuro-Psychopharmacology & Biological Psychiatry 2018, roč. 81, Feb 2, p. 275-283
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IF = 4.185
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doi
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Mareš, Pavel - Bernášková, Klára - Kubová, Hana
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Ontogenetic Development of Sensitivity of the Cerebral Cortex to an Antagonist of GABA(A) Receptor Bicuculline
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Physiological Research 2018, roč. 67, 1, p. 149-153
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IF = 1.324
[ASEP]
Mareš, Pavel
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Participation of GABA(B) receptors in cortical postictal excitability in immature rats
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European Journal of Pharmacology 2018, roč. 818, Jan 5, p. 26-29
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IF = 3.040
[ASEP]
[
doi
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Kubová, Hana - Folbergrová, Jaroslava - Rejchrtová, Jana - Tsenov, Grygoriy - Pařízková, Martina - Burchfiel, J. - Mikulecká, Anna - Mareš, Pavel
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The Free Radical Scavenger N-Tert-Butyl-alpha-Phenylnitrone (PBN) Administered to Immature Rats During Status Epilepticus Alters Neurogenesis and Has Variable Effects, Both Beneficial and Detrimental, on Long-Term Outcomes
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Frontiers in Cellular Neuroscience 2018, roč. 12, Aug 28, článku 266
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IF = 4.300
[ASEP]
[
doi
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Kubová, Hana - Bendová, Z. - Moravcová, S. - Pačesová, D. - Rocha, L. L. - Mareš, Pavel
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Neonatal Clonazepam Administration Induces Long-Lasting Changes in Glutamate Receptors
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Frontiers in Molecular Neuroscience 2018, 11(Oct 11)), 382
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IF = 3.902
[ASEP]
[
doi
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Kovács, R. - Gerevich, Z. - Friedman, A. - Otáhal, Jakub - Prager, O. - Gabriel, S. - Berndt, N.
Bioenergetic Mechanisms of Seizure Control
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Frontiers in Cellular Neuroscience 2018, 12(Oct 8)), 335
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IF = 4.300
[ASEP]
[
doi
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Janča, R. - Kršek, P. - Ježdík, P. - Čmejla, R. - Tomášek, M. - Komárek, V. - Marusič, P. - Jiruška, Přemysl
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The Sub-Regional Functional Organization of Neocortical Irritative Epileptic Networks in Pediatric Epilepsy
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Frontiers in Neurology 2018, roč. 9, Mar 23, článku 184
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IF = 3.508
[ASEP]
[
doi
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Chouzouris, T. - Omelchenko, I. - Zakharova, A. - Hlinka, Jaroslav - Jiruška, Přemysl - Schöll, E.
Chimera States in Brain Networks: Empirical Neural vs. Modular Fractal Connectivity
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Chaos 2018, roč. 28, 4, článku 045112
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IF = 2.415
[ASEP]
[
doi
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Chang, W.C. - Kudláček, Jan - Hlinka, Jaroslav - Chvojka, Jan - Hadrava, Michal - Kumpošt, Vojtěch - Powell, A. D. - Janča, R. - Maturana, M. I. - Karoly, P. J. - Freestone, D. R. - Cook, M. J. - Paluš, Milan - Otáhal, Jakub - Jefferys, J. G. R. - Jiruška, Přemysl
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Loss of neuronal network resilience precedes seizures and determines the ictogenic nature of interictal synaptic perturbations
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Nature Neuroscience 2018, 21(12), 1742-1752
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IF = 19.912
[ASEP]
[
doi
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Holubová, A. - Mikulecká, Anna - Pometlová, M. - Nohejlová, K. - Šlamberová, R.
Long-term early life adverse experience impairs responsiveness to exteroceptive stimuli in adult rats
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Behavioural Processes 2018, roč. 149, Apr, p. 59-64
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IF = 1.555
[ASEP]
[
doi
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Folbergrová, Jaroslava - Ješina, Pavel - Kubová, Hana - Otáhal, Jakub
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Effect of Resveratrol on Oxidative Stress and Mitochondrial Dysfunction in Immature Brain during Epileptogenesis
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Molecular Neurobiology 2018, roč. 55, 9, p. 7512-7522
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IF = 5.076
[ASEP]
[
doi
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Ergang, Peter - Mikulecká, Anna - Vodička, Martin - Vagnerová, Karla - Mikšík, Ivan - Pácha, Jiří
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Social defeat stimulates local glucocorticoid regeneration in lymphoid organs
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Endocrine Connections 2018, 7(12), 1389-1396
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IF = 3.041
[ASEP]
[
doi
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Abbasova, Kenul - Kubová, Hana - Mareš, Pavel
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Does status epilepticus modify the effect of ifenprodil on cortical epileptic afterdischarges in immature rats?
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Pharmacological Reports 2018, roč. 70, 1, p. 126-132
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IF = 2.787
[ASEP]
[
doi
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Vondráková, Kateřina - Uttl, Libor - Kubová, Hana - Tsenov, Grygoriy - Kačer, P.
Mikrodialýza a hmotnostní spektrometrie jako klíč k monitorování metabolitů v nezralém mozku
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Chemické listy. 2017, roč. 111, 1, p. 66-69
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IF = 0.26
[ASEP]
Tsenov, Grygoriy - Kubová, Hana - Mareš, Pavel
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Which component of treatment is important for changes of cortical epileptic afterdischarges after status epilepticus in immature rats?
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Neuroscience Letters. 2017, roč. 644, Mar 22, p. 1-4
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IF = 2.159
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[
doi
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Raimondo, J. V. - Heinemann, U. - de Curtis, M. - Goodkin, H. P. - Dulla, Ch. G. - Janigro, D. - Ikeda, A. - Lin, Ch.-Ch. K. - Jiruška, Přemysl - Galanopoulou, A. S. - Bernard, Ch.
Methodological standards for in vitro models of epilepsy and epileptic seizures. A TASK1-WG4 report of the AES/ILAE Translational Task Force of the ILAE
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Epilepsia.. 2017, roč. 58, Suppl.4, p. 40-52
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IF = 5.067
[ASEP]
[
doi
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Moyer, J. T. - Gnatkovsky, V. - Ono, T. - Otáhal, Jakub - Wagenaar, J. - Stacey, W. C. - Noebels, J. - Ikeda, A. - Staley, K. - de Curtis, M. - Litt, B. - Galanopoulou, A. S.
Standards for data acquisition and software-based analysis of in vivo electroencephalography recordings from animals. A TASK1-WG5 report of the AES/ILAE Translational Task Force of the ILAE
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Epilepsia.. 2017, roč. 58, Suppl.4, p. 53-67
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IF = 5.067
[ASEP]
[
doi
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Kudláček, Jan - Chvojka, Jan - Pošusta, Antonín - Kováčová, Ľubica - Hong, S.B. - Weiss, S. - Volná, K. - Marusič, P. - Otáhal, Jakub - Jiruška, Přemysl
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Lacosamide and Levetiracetam Have No Effect on Sharp-Wave Ripple Rate
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Frontiers in Neurology.. 2017, roč. 8, Dec 21, článku 687
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IF = 3.508
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doi
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Jiruška, Přemysl - Alvarado-Rojas, C. - Schevon, C.A. - Staba, R. - Stacey, W. - Wendling, F. - Avoli, M.
Update on the mechanisms and roles of high-frequency oscillations in seizures and epileptic disorders
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Epilepsia. 2017, roč. 58, 8, p. 1330-1339
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IF = 5.067
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doi
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Hejčl, Aleš - Vondráková, Kateřina - Kelbich, P. - Sameš, M. - Tsenov, Grygoriy - Kačer, P.
Model cerebrálních vazospasmů a metabolomické mapování
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Chemické listy. 2017, roč. 111, 1, p. 56-61
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IF = 0.26
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Kasal, Alexander - Buděšínský, Miloš - Mareš, Pavel - Krištofíková, Z. - Leitao, A. J. - Sá e Melo, M. L. - Silva, M. M. C.
Neurosteroids: Can a 2alpha,3alpha-epoxy ring make up for the 3alpha-hydroxyl group?
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Steroids. 2016, roč. 105, Jan, p. 12-18
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IF = 2.282
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doi
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Šlamberová, R. - Mikulecká, Anna - Macúchová, E. - Hrebíčková, I. - Ševčíková, M. - Nohejlová, K. - Pometlová, M.
Morphine Decreases Social Interaction of Adult Male Rats, While THC Does Not Affect It
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Physiological Research. 2016, roč. 65, Suppl.5, S547-S555
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IF = 1.461
[ASEP]
Riljak, V. - Kraf, J. - Daryanani, A. - Jiruška, Přemysl - Otáhal, Jakub
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Pathophysiology of perinatal hypoxic-ischemic encephalopathy – biomarkers, animal models and treatment perspectives
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Physiological Research. 2016, roč. 65, Suppl.5, S533-S545
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IF = 1.461
[ASEP]
Tykalová, T. - Pospíšilová, M. - Čmejla, R. - Jeřábek, J. - Mareš, Pavel - Rusz, J.
Speech changes after coordinative training in patients with cerebellar ataxia: a pilot study
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Neurological Sciences. 2016, roč. 37, 2, p. 293-296
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IF = 1.749
[ASEP]
[
doi
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Morris, G. - Jiruška, Přemysl - Jefferys, J. G. R. - Powell, A. D.
A New Approach of Modified Submerged Patch Clamp Recording Reveals Interneuronal Dynamics during Epileptiform Oscillations
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Frontiers in Neuroscience. 2016, roč. 10, Nov 9, článku 519
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IF = 3.566
[ASEP]
[
doi
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Folbergrová, Jaroslava - Ješina, Pavel - Kubová, Hana - Druga, Rastislav - Otáhal, Jakub
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Status Epilepticus in Immature Rats Is Associated with Oxidative Stress and Mitochondrial Dysfunction
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Frontiers in Cellular Neuroscience. 2016, roč. 10, May 26, p. 136
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IF = 4.555
[ASEP]
[
doi
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Szczurowska, Ewa - Ergang, Peter - Kubová, Hana - Druga, Rastislav - Salaj, M. - Mareš, Pavel
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Influence of early life status epilepticus on the developmental expression profile of the GluA2 subunit of AMPA receptors
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Experimental Neurology. 2016, roč. 283, Part A, p. 97-109
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IF = 4.706
[ASEP]
[
doi
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Mareš, Pavel - Kubová, Hana
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Does status epilepticus induced at early postnatal period change excitability after cortical epileptic afterdischarges?
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Epilepsia. 2016, roč. 57, 8, E183-E186
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IF = 5.295
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[
doi
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Fábera, Petr - Krijtová, H. - Tomášek, M. - Krýsl, D. - Zámečník, J. - Mohapl, M. - Jiruška, Přemysl - Marusič, P.
Familial temporal lobe epilepsy due to focal cortical dysplasia type IIIa
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Seizure-European Journal of Epilepsy. 2015, Vol. 31, -, p. 120-123
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IF = 2.109
[ASEP]
[
doi
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Suchomelová, L. - Lopes-Meraz, M. L. - Niquet, J. - Kubová, Hana - Wasterlain, C. G.
Hyperthermia aggravates status epilepticus-induced epileptogenesis and neuronal loss in immature rats
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Neuroscience. 2015, Vol. 305, Oct 1, p. 209-224
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IF = 3.231
[ASEP]
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doi
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Mareš, Pavel - Kubová, Hana
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GABA(B), not GABA(A) receptors play a role in cortical postictal refractoriness
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Neuropharmacology. 2015, Vol. 88, Jan 2015, p. 99-102
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IF = 4.936
[ASEP]
[
doi
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Pošusta, Antonín - Sporka, A. J. - Poláček, O. - Rudolf, Š. - Otáhal, Jakub
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Control of word processing environment using myoelectric signals
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Journal on Multimodal User Interfaces. 2015, Vol. 9, 4, p. 299-311
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IF = 1.017
[ASEP]
[
doi
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Druga, Rastislav - Salaj, M. - Barinka, F. - Edelstein, L. - Kubová, Hana
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Calretinin immunoreactivity in the claustrum of the rat
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Frontiers in Neuroanatomy. 2015, Vol. 8, Jan 20, p. 160
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IF = 3.26
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doi
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Tsenov, Grygoriy - Vondráková, Kateřina - Otáhal, Jakub - Burchfiel, J. - Kubová, Hana
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Activation of either the ETA or the ETB receptors is involved in the development of electrographic seizures following intrahippocampal infusion of the endothelin-1 in immature rats
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Experimental Neurology. 2015, Vol. 265, Mar 2015, p. 40-47
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IF = 4.657
[ASEP]
[
doi
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Szczurowska, Ewa - Mareš, Pavel
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An antagonist of calcium permeable AMPA receptors, IEM1460: Anticonvulsant action in immature rats?
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Epilepsy Research. 2015, Vol. 109, Jan 2015, p. 106-113
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IF = 2.237
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[
doi
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Rektor, I. - Schachter, S.C. - Arya, R. - Arzy, S. - Braakman, H. - Brodie, M.J. - Brugger, P. - Chang, B. S. - Guekht, A. - Hermann, B. - Hesdorffer, D. C. - Jones-Gotman, M. - Kanner, A.M. - Garcia-Larrea, L. - Mareš, Pavel - Mula, M. - Neufeld, M. - Risse, G. L. - Ryvlin, P. - Seeck, M. - Tomson, T. - Korczyn, A.D.
Third International Congress on Epilepsy, Brain, and Mind: Part 2
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Epilepsy and Behavior. 2015, Vol. 50, Sep 2015, p. 138-159
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IF = 2.332
[ASEP]
[
doi
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Mareš, Pavel - Kubová, Hana
.
Developmental patterns of postictal refractoriness and potentiation akin to cortical stimulation
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Epilepsia. 2015, Vol. 56, 1, e10-e14
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IF = 4.706
[ASEP]
[
doi
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Janča, R. - Ježdík, P. - Čmejla, R. - Tomášek, M. - Worrell, G. A. - Stead, M. - Wagenaar, J. - Jefferys, J. G. R. - Kršek, P. - Komárek, V. - Jiruška, Přemysl - Marusič, P.
Detection of Interictal Epileptiform Discharges Using Signal Envelope Distribution Modelling: Application to Epileptic and Non-Epileptic Intracranial Recordings
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Brain Topography. 2015, Vol. 28, 1, p. 172-183
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IF = 3.727
[ASEP]
[
doi
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Ferecskó, A. S. - Jiruška, Přemysl - Foss, L. - Powell, A. D. - Chang, W.C. - Sik, A. - Jefferys, J. G. R.
Structural and functional substrates of tetanus toxin in an animal model of temporal lobe epilepsy
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Brain Structure and Function. 2015, Vol. 220, 2, p. 1013-1029
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IF = 5.811
[ASEP]
[
doi
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Salaj, M. - Druga, Rastislav - Cerman, J. - Kubová, Hana - Barinka, F.
Calretinin and parvalbumin immunoreactive interneurons in the retrosplenial cortex of the rat brain: Qualitative and quantitative analyses
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Brain Research. 2015, Vol. 1627, Nov 19, p. 201-215
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IF = 2.561
[ASEP]
[
doi
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Szczurowska, Ewa - Mareš, Pavel
.
Different action of a specific NR2B/NMDA antagonist Ro 25-6981 on cortical evoked potentials and epileptic afterdischarges in immature rats
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Brain Research Bulletin. 2015, Vol. 111, Jan 2015, p. 1-8
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IF = 2.572
[ASEP]
[
doi
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Šlamberová, R. - Mikulecká, Anna - Macúchová, E. - Hrebíčková, I. - Ševčíková, M. - Nohejlová, K. - Pometlová, M.
Effects of psychostimulants on social interaction in adult male rats
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Behavioural Pharmacology. 2015, Vol. 26, 8, p. 776-785
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IF = 2
[ASEP]
[
doi
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Zavala-Tecuapetla, Cecília - Kubová, Hana - Otáhal, Jakub - Tsenov, Grygoriy - Mareš, Pavel
.
Age-dependent suppression of hippocampal epileptic afterdischarges by metabotropic glutamate receptor 5 antagonist MTEP
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Pharmacological Reports. 2014, roč. 66, 5, p. 927-930. ISSN 1734-1140.
IF = 1.928
[ASEP]
[
doi
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Vodička, Martin - Ergang, Peter - Mikulecká, Anna - Řeháková, Lenka - Klusoňová, Petra - Makal, J. - Soták, Matúš - Musílková, Jana - Zach, P. - Pácha, Jiří
.
Regulation of 11 beta-Hydroxysteroid Dehydrogenase Type 1 and 7 alpha-Hydroxylase CYP7B1 during Social Stress
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PLoS ONE 2014, roč. 9, 2, e89421. ISSN 1932-6203.
IF = 3.234
[ASEP]
[
doi
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Tchekalarova, J.D. - Kubová, Hana - Mareš, Pavel
.
Early caffeine exposure: Transient and long-term consequences on brain excitability
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Brain Research Bulletin 2014, roč. 104, -, p. 27-35. ISSN 0361-9230.
IF = 2.718
[ASEP]
[
doi
]
Powell, A. D. - Saintot, P.P. - Gill, K. K. - Bharathan, A. - Buck, S.C. - Morris, G. - Jiruška, Přemysl - Jefferys, J. G. R.
Reduced Gamma Oscillations in a Mouse Model of Intellectual Disability: A Role for Impaired Repetitive Neurotransmission?
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PLoS ONE 2014, roč. 9, 5, e95871. ISSN 1932-6203.
IF = 3.234
[ASEP]
[
doi
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Otáhal, Jakub - Folbergrová, Jaroslava - Kovacs, R. - Kunz, W.S. - Maggio, N.
Epileptic Focus and Alteration of Metabolism
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International Review of Neurobiology 2014, roč. 114, 2014, p. 209-243. ISSN 0074-7742.
IF = 1.921
[ASEP]
[
doi
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Nieto-Rostro, M. - Sandhu, G. - Bauer, C. S. - Jiruška, Přemysl - Jefferys, J. G. R. - Dolphin, A. C.
Altered expression of the voltage-gated calcium channel subunit alpha(2)delta-1: A comparison between two experimental models of epilepsy and a sensory nerve ligation model of neuropathic pain
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Neuroscience. 2014, roč. 283, dec, p. 124-137. ISSN 0306-4522.
IF = 3.357
[ASEP]
[
doi
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Mikulecká, Anna - Šubrt, Martin - Stuchlík, Aleš - Kubová, Hana
.
Consequences of early postnatal benzodiazepines exposure in rats. I. Cognitive-like behavior
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Frontiers in Behavioral Neuroscience 2014, roč. 8, -, p. 101. ISSN 1662-5153.
IF = 3.27
[ASEP]
[
doi
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Mikulecká, Anna - Šubrt, Martin - Pařízková, Martina - Mareš, Pavel - Kubová, Hana
.
Consequences of early postnatal benzodiazepines exposure in rats. II. Social behavior
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Frontiers in Behavioral Neuroscience 2014, roč. 8, may 8, p. 169. ISSN 1662-5153.
IF = 3.27
[ASEP]
[
doi
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Mareš, Pavel - Tichá, Kateřina - Mikulecká, Anna
.
Anticonvulsant and behavioral effects of muscimol in immature rats
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Brain Research 2014, roč. 1582, sep 25, p. 227-236. ISSN 0006-8993.
IF = 2.843
[ASEP]
[
doi
]
Mareš, Pavel
.
Age and activation determines the anticonvulsant effect of ifenprodil in rats
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Naunyn-Schmiedeberg's Archives of Pharmacology 2014, roč. 387, 8, p. 753-761. ISSN 0028-1298.
IF = 2.471
[ASEP]
[
doi
]
Mareš, Pavel
.
A1 not A2A adenosine receptors play a role in cortical epileptic afterdischarges in immature rats
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Journal of Neural Transmission. 2014, roč. 121, 11, p. 1329-1336. ISSN 0300-9564 .
IF = 2.402
[ASEP]
[
doi
]
Kletečková, Lenka - Tsenov, Grygoriy - Kubová, Hana - Stuchlík, Aleš - Valeš, Karel
.
Neuroprotective effect of the 3 alpha 5 beta-pregnanolone glutamate treatment in the model of focal cerebral ischemia in immature rats
.
Neuroscience Letters 2014, roč. 564, apr 3, p. 11-15. ISSN 0304-3940.
IF = 2.03
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doi
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Jiruška, Přemysl - de Curtis, M. - Jefferys, J. G. R.
Modern Concepts of Focal Epileptic Networks
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International Review of Neurobiology 2014, roč. 114, 2014, p. 1-7. ISSN 0074-7742.
IF = 1.921
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doi
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Cho, J.R. - Koo, D.L. - Joo, E.Y. - Seo, D.W. - Hong, S.-Ch. - Jiruška, Přemysl - Hong, S.B.
Resection of individually identified high-rate high-frequency oscillations region is associated with favorable outcome in neocortical epilepsy
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Epilepsia 2014, roč. 55, 11, p. 1872-1883. ISSN 0013-9580.
IF = 4.571
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[
doi
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Fábera, Pavel - Mareš, Pavel
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Effect of GABAB receptor agonist SKF97541 on cortical and hippocampal epileptic afterdischarges
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Physiological Research. 2014, roč. 63, 4, p. 529-534
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IF = 1.293
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Brožíčková, Carole - Mikulecká, Anna - Otáhal, Jakub
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Effect of 7-nitroindazole, a neuronal nitric oxide synthase inhibitor, on behavioral and physiological parameters
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Physiological Research. 2014, roč. 63, 5, p. 637-648
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IF = 1.293
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Blauwblomme, T. - Jiruška, Přemysl - Huberfeld, G.
Mechanisms of Ictogenesis
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International Review of Neurobiology 2014, roč. 114, 2014, p. 155-185. ISSN 0074-7742.
IF = 1.921
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doi
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Tchekalarova, Jana - Kubová, Hana - Mareš, Pavel
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Effects of caffeine on cortical epileptic afterdischarges in adult rats are modulated by postnatal treatment
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Acta Neurologica Belgica, 2013, Vol. 113, 4, p. 493-500
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IF = 0.466
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doi
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Tchekalarova, Jana - Kubová, Hana - Mareš, Pavel
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Different effects of postnatal caffeine treatment on two pentylenetetrazole-induced seizure models persist into adulthood
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Pharmacological Reports, 2013, Vol. 65, 4, p. 847-853
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IF = 1.965
[ASEP]
Szczurowska, Ewa - Mareš, Pavel
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NMDA and AMPA receptors: development and status epilepticus
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Physiological Research, 2013, Vol. 62, Suppl.1, S21-S38
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IF = 1.531
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Ostrý, S. - Belšan, T. - Otáhal, Jakub - Beneš, V. - Netuka, D.
Is Intraoperative Diffusion tensor Imaging at 3.0T Comparable to Subcortical Corticospinal tract Mapping?
.
Neurosurgery, 2013, Vol. 73, 5, p. 797-807
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IF = 2.532
[ASEP]
Mareš, Pavel - Kubová, Hana - Hen, N. - Yagen, B. - Bialer, M.
Derivatives of valproic acid are active against pentetrazol-induced seizures in immature rats
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Epilepsy Research, 2013, Vol. 106, 1-2, p. 64-73
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IF = 2.241
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[
doi
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Mareš, Pavel - Tichá, Kateřina - Mikulecká, Anna
.
Anticonvulsant and behavioral effects of GABA(B) receptor positive modulator CGP7930 in immature rats
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Epilepsy and Behavior, 2013, Vol. 28, 1, p. 113-120
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IF = 1.844
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doi
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Mareš, Pavel
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Proconvulsant Action of Two GABA(B) Receptor Antagonists Is Age-Dependent
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Physiological Research, 2013, Vol. 62, Suppl.1, S109-S114
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IF = 1.531
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Kubová, Hana - Mareš, Pavel
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Are morphologic and functional consequences of status epilepticus in infant rats progressive?
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Neuroscience, 2013, Vol. 235, APR 3, p. 232-249
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IF = 3.122
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[
doi
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Korczyn, A.D. - Schachter, S.C. - Brodie, M.J. - Dalal, S.S. - Engel Jr., J. - Guekht, A. - Hecimovic, H. - Jerbi, K. - Kanner, A.M. - Landmark, C.J. - Mareš, Pavel - Marusič, P. - Meletti, S. - Mula, M. - Patsalos, P. N. - Reuber, M. - Ryvlin, P. - Štill
.
Epilepsy, cognition, and neuropsychiatry (Epilepsy, Brain, and Mind, part 2)
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Epilepsy and Behavior, 2013, Vol. 28, 2, p. 283-302
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IF = 1.844
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doi
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Jiruška, Přemysl - de Curtis, M. - Jefferys, J. G. R. - Schevon, C.A. - Schiff, S.J. - Schindler, K.
Synchronization and desynchronization in epilepsy: controversies and hypotheses
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Journal of Physiology, 2013, Vol. 591, 4, p. 787-797
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IF = 4.380
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doi
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Jiruška, Přemysl - Shtaya, A.B.Y. - Bodansky, D.M.S. - Chang, W.C. - Gray, W.P. - Jefferys, J. G. R.
Dentate gyrus progenitor cell proliferation after the onset of spontaneous seizures in the tetanus toxin model of temporal lobe epilepsy
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Neurobiology of Disease, 2013, Vol. 54, Jun 2013, p. 492-498
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IF = 5.624
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doi
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Folbergrová, Jaroslava - Ješina, Pavel - Nůsková, Hana - Houštěk, Josef
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Antioxidant enzymes in cerebral cortex of immature rats following experimentally-induced seizures: upregulation of mitochondrial MnSOD (SOD2)
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International Journal of Developmental Neuroscience, 2013, Vol. 31, 2, p. 123-130
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IF = 2.692
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doi
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Folbergrová, Jaroslava
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Oxidative stress in immature brain following experimentally-induced seizures
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Physiological Research, 2013, Vol. 62, Suppl.1, S39-S48
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IF = 1.531
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Brožíčková, Carole - Otáhal, Jakub
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Effect of an inhibitor of neuronal nitric oxide synthase 7-nitroindazole on cerebral hemodynamic response and brain excitability in urethane-anesthetized rats
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Physiological Research, 2013, Vol. 62, Suppl.1, S57-S66
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IF = 1.531
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Brima, Tufikameni - Otáhal, Jakub - Mareš, Pavel
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Increased susceptibility to pentetrazol-induced seizures in developing rats after cortical photothrombotic ischemic stroke at P7
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Brain Research, 2013, Vol. 1507, APR 24, p. 146-153
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IF = 2.879
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doi
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Brima, Tufikameni - Mikulecká, Anna - Otáhal, Jakub
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Impacts of perinatal induced photothrombotic stroke on sensorimotor performance in adult rats
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Physiological Research, 2013, Vol. 62, 1, p. 85-94
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IF = 1.531
[ASEP]
Zijlmans, M. - Jiruška, Přemysl - Zelmann, R. - Leijten, F. S. S. - Jefferys, J. G. R. - Gotman, J.
High-frequency oscillations as a new biomarker in epilepsy
.
Annals of Neurology, 2012, Vol. 71, 2, p. 169-178
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IF = 11.193
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doi
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Szczurowska, Ewa - Mareš, Pavel
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Positive allosteric modulator of mGluR4 PHCCC exhibits proconvulsant action in three models of epileptic seizures in immature rats
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Physiological Research, 2012, Vol. 61, 6, p. 619-628
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IF = 1.531
[ASEP]
Powell, A. D. - Gill, K. K. - Saintot, P.P. - Jiruška, Přemysl - Chelly, J. - Billuart, P. - Jefferys, J. G. R.
Rapid reversal of impaired inhibitory and excitatory transmission but not spine dysgenesis in a mouse model of mental retardation
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Journal of Physiology, 2012, Vol. 590, 4, p. 763-775
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IF = 4.380
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doi
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Mareš, Pavel
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Models of epileptic seizures in immature rats
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Physiological Research, 2012, Vol. 61, Suppl.1, S103-S108
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IF = 1.531
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Mareš, Pavel
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Anticonvulsant action of GABA(B) receptor positive modulator CGP7930 in immature rats
.
Epilepsy Research, 2012, Vol. 100, 1-2, p. 49-54
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IF = 2.241
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doi
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Mareš, Pavel - Bernášková, Klára - Kubová, Hana
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An antagonist of GABA-B receptors potentiates activity of cortical epileptic foci
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Physiological Research, 2012, Vol. 61, 3, p. 325-329
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IF = 1.531
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Kubová, Hana - Mareš, Pavel
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Partial agonist of benzodiazepine receptors Ro 19-2088 elicits withdrawal symptoms after short-term administration in immature rats
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Physiological Research, 2012, Vol. 61, 3, p. 319-323
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IF = 1.531
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Konopková, Renata - Világi, I. - Borbély, S. - Kubová, Hana - Otáhal, Jakub
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Effect of endothelin-1 on the excitability of rat cortical and hippocampal slices in vitro
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Physiological Research, 2012, Vol. 61, 2, p. 215-219
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IF = 1.531
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Beamer, E. - Otáhal, Jakub - Sills, G.J. - Thippeswamy, T.
N-w-Propyl-L-arginine (L-NPA) reduces status epilepticus and early epileptogenic events in a mouse model of epilepsy: behavioural, EEG and immunohistochemical analyses
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European Journal of Neuroscience, 2012, Vol. 36, 9, p. 3194-3203
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IF = 3.753
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Barinka, F. - Salaj, M. - Rybář, J. - Krajčovičová, Eva - Kubová, Hana - Druga, Rastislav
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Calretinin, parvalbumin and calbindin immunoreactive interneurons in perirhinal cortex and temporal area Te3V of the rat brain: Qualitative and quantitative analyses
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Brain Research, 2012, Vol. 1436, FEB 3, p. 68-80
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IF = 2.879
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Folbergrová, Jaroslava - Kunz, W.S.
Mitochondrial dysfunction in epilepsy
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Mitochondrion, 2012, Vol. 12, 1, p. 35-40
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IF = 4.025
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Folbergrová, Jaroslava - Otáhal, Jakub - Druga, Rastislav
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Brain superoxide anion formation in immature rats during seizures: Protection by selected compounds
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Experimental Neurology, 2012, Vol. 233, 1, p. 421-429
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IF = 4.645
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doi
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Šlamberová, R. - Mikulecká, Anna - Pometlová, M. - Schutová, B. - Hrubá, L. - Deykun, K.
Sex differences in social interaction of methamphetamine-treated rats
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Behavioural Pharmacology, 2011, Vol. 22, 7, p. 617-623
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IF = 2.720
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doi
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Tolner, E. A. - Hochman, D. W. - Hassinen, P. - Otáhal, Jakub - Gaily, E. - Haglund, M. M. - Kubová, Hana - Schuchmann, S. - Vanhatalo, S. - Kaila, K.
Five percent CO2 is a potent, fast-acting inhalation anticonvulsant
.
Epilepsia, 2011, Vol. 52, 1, p. 104-114
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IF = 3.961
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doi
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Tichá, Kateřina - Mikulecká, Anna - Mareš, Pavel
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Behavioral consequences of the mGlu5 receptor antagonist MTEP in immature rats
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Pharmacology, Biochemistry and Behavior, 2011, Vol. 99, 4, p. 619-625
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IF = 2.532
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doi
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Mikulecká, Anna - Mareš, Pavel - Kubová, Hana
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Rebound increase in seizure susceptibility but not isolation-induced calls after single administration of clonazepam and Ro 19-8022 in infant rats
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Epilepsy and Behavior, 2011, Vol. 20, 1, p. 12-19
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IF = 2.335
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doi
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Flachs, Pavel - Rühl, R. - Hensler, Michal - Janovská, Petra - Zouhar, Petr - Kůs, Vladimír - Macek Jílková, Zuzana - Papp, E. - Kuda, Ondřej - Svobodová, Michaela - Rossmeisl, Martin - Tsenov, Grygoriy - Mohamed-Ali, V. - Kopecký, Jan
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Synergistic induction of lipid catabolism and anti-inflammatory lipids in white fat of dietary obese mice in response to calorie restriction and n-3 fatty acids
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Diabetologia, 2011, Vol. 54, 10, p. 2626-2638
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IF = 6.814
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doi
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Tchekalarova, Jana - Kubová, Hana - Mareš, Pavel
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Transient changes of cortical interhemispheric responses after repeated caffeine administration in immature rats
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Physiological Research, 2011, Vol. 60, 6, p. 961-969
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IF = 1.555
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