Naše oddělení se zabývá studiem mitochondrií ve fyziologických a patofyziologických procesech buňky a organismu. Mitochondrie jsou hlavním zdrojem buněčné energie, ATP, potřebné pro chod buňky. Zároveň TÉŽ dochází k produkci kyslíkových radikálů, reaktivních molekul způsobujících oxidační stres. Ten má negativní dopad na funkci buňky samotné. Důsledkem oxidačního stresu dochází často k nevratnému poškození buněčných proteinů, lipidů i samotné mitochondriální/jaderné DNA, nositelky genetické informace, což v nejkrajnějších případech vede ke smrti buňky. Chronický, byť relativně mírnější oxidační stres doprovází řadu patofyziologických onemocnění mezi které patří neurodegenerativní onemocnění, jako jsou Parkinsonova či Alzheimerova choroba, ale např. i cukrovka 2. typu a pulmonární hypertenze, jejichž etiologii studujeme. Nevratně poškozené mitochondrie je nutno z buňky odstranit pomocí specifické dráhy autofagie – mitofagie. Mitofagie je důležitý proces pro udržení kvalitní mitochondriální výbavy a její narušení je doprovázeno řadou onemocnění, jako např. cukrovka 2. typu, kde tento proces studujeme. Mitochondrie jsou semiautonomní organely a mají tedy svoji DNA, mtDNA. Genetické manipulace mtDNA jsou poměrně obtížné a doposud nebyla vyvinuta uspokojivá metoda, která by umožnila např. genový silencing či in situ kvantifikace genetických mutací na mtDNA. O vývin takovéto techniky se snažíme. Jelikož mitochondrie jsou velmi malé organely a rozlišení běžně dostupné světelné i fluorescenční mikroskopie není dostačující pro jejich studium, využíváme techniky speciální vysokorezoluční fluorescenční mikroskopie, jejíž prototyp jsme nedávno zakoupily pro naše oddělení a dále tuto metodiku rozvíjíme pro využití při studiu mitochondriÍ. V neposlední řadě se zabýváme také úlohou rolí mitochondriální signalizace v rakovinných buňkách, kde ačkoliv mitochondriální aktivita je často velmi utlumena, přesto jsou zde specifické enzymatické reakce, dráhy, jejichž studium je důležité pro vývoj budoucích protinádorových léčiv.
V oblasti aplikovaného výzkumu se naše laboratoř zabývá vývinem nových nosičů léčiva, tzv. fotosintizéru, využívaného ve fotodynamické terapii při léčbě zhoubných nádorů. Prvotní výsledek přinesl nález, který byl patentován u Českého úřadu pro patenty a vynálezy.
Aktuální projekty
Publikace
Kahancová, Anežka - Sklenář, Filip - Ježek, Petr - Dlasková, Andrea
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Regulation of glucose-stimulated insulin secretion by ATPase Inhibitory Factor 1 (IF1)
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FEBS Letters 2018, roč. 592, 6, p. 999-1009
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IF = 2.999
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doi
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Ježek, Petr - Jabůrek, Martin - Holendová, Blanka - Plecitá-Hlavatá, Lydie
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Fatty Acid-Stimulated Insulin Secretion vs. Lipotoxicity
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Molecules 2018, roč. 23, 6, článku 1483
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IF = 3.098
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doi
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Ježek, Petr - Holendová, Blanka - Garlid, K. D. - Jabůrek, Martin
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Mitochondrial Uncoupling Proteins: Subtle Regulators of Cellular Redox Signaling
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Antioxidants & Redox Signaling 2018, roč. 29, 7, p. 667-714
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IF = 6.530
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doi
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Ježek, Jan - Plecitá-Hlavatá, Lydie - Ježek, Petr
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Aglycemic HepG2 Cells Switch From Aminotransferase Glutaminolytic Pathway of Pyruvate Utilization to Complete Krebs Cycle at Hypoxia
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Frontiers in Endocrinology 2018, 9(Oct 26)), 637
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IF = 3.519
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doi
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Jabůrek, Martin - Ježek, Jan - Ježek, Petr
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Cytoprotective activity of mitochondrial uncoupling protein‐2 in lung and spleen
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FEBS Open Bio 2018, roč. 8, 4, p. 692-701
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IF = 1.782
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doi
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Dlasková, Andrea - Engstová, Hana - Špaček, Tomáš - Kahancová, Anežka - Pavluch, Vojtěch - Smolková, Katarína - Špačková, Jitka - Bartoš, Martin - Plecitá-Hlavatá, Lydie - Ježek, Petr
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3D super-resolution microscopy reflects mitochondrial cristae alternations and mtDNA nucleoid size and distribution
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Biochimica Et Biophysica Acta-Bioenergetics 2018, roč. 1859, 9, p. 829-844
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IF = 4.280
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doi
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D'Alessandro, A. - El Kasmi, K. C. - Plecitá-Hlavatá, Lydie - Ježek, Petr - Li, M. - Zhang, H. - Gupte, S. A. - Stenmark, K. R.
Hallmarks of Pulmonary Hypertension: Mesenchymal and Inflammatory Cell Metabolic Reprogramming
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Antioxidants & Redox Signaling 2018, roč. 28, 3, p. 230-250
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IF = 6.530
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doi
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Zhang, H. - Wang, D. - Li, M. - Plecitá-Hlavatá, Lydie - D'Alessandro, A. - Tauber, Jan - Riddle, S. - Kumar, S. - Flockton, A. - McKeon, B. A. - Frid, M. G. - Reisz, J. A. - Caruso, P. - El Kasmi, K. C. - Ježek, Petr - Morrell, N. W. - Hu, Ch.-J. - Stenmark, K. R.
Metabolic and Proliferative State of Vascular Adventitial Fibroblasts in Pulmonary Hypertension Is Regulated Through a MicroRNA-124/PTBP1 (Polypyrimidine Tract Binding Protein 1)/Pyruvate Kinase Muscle Axis
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Circulation.. 2017, roč. 136, 25, p. 2468-2485
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IF = 18.88
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doi
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Špaček, Tomáš - Pavluch, Vojtěch - Alán, Lukáš - Capková, Nikola - Engstová, Hana - Dlasková, Andrea - Berková, Z. - Saudek, F. - Ježek, Petr
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Nkx6.1 decline accompanies mitochondrial DNA reduction but subtle nucleoid size decrease in pancreatic islet beta-cells of diabetic Goto Kakizaki rats
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Scientific Reports.. 2017, roč. 7, Nov 15, článku 15674
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IF = 4.122
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doi
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Rohlenová, Kateřina - Sachaphibulkij, K. - Stursa, J. - Bezawork-Geleta, A. - Blecha, Jan - Endaya, B. - Werner, L. - Černý, Jiří - Zobalová, Renata - Goodwin, J. - Špaček, Tomáš - Pesdar, E.A. - Yan, B. - Nguyen, M.N. - Vondrusová, Magdaléna - Sobol, Margaryta - Ježek, Petr - Hozák, Pavel - Truksa, Jaroslav - Rohlena, Jakub - Dong, L.F. - Neužil, Jiří
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Selective Disruption of Respiratory Supercomplexes as a New Strategy to Suppress Her2(high) Breast Cancer
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Antioxidants & Redox Signaling. 2017, roč. 26, 2, p. 84-103
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IF = 6.530
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doi
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Kostiv, Uliana - Rajsiglová, Lenka - Luptáková, Dominika - Pluháček, Tomáš - Vannucci, Luca - Havlíček, Vladimír - Engstová, Hana - Jirák, D. - Šlouf, Miroslav - Makovický, Peter - Sedláček, Radislav - Horák, Daniel
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Biodistribution of upconversion/magnetic silica-coated NaGdF4:Yb3+/Er3+ nanoparticles in mouse models
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RSC Advances. 2017, roč. 7, 73, p. 45997-46006
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IF = 2.936
[ASEP]
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doi
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Ježek, J. - Engstová, Hana - Ježek, Petr
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Antioxidant mechanism of mitochondria-targeted plastoquinone SkQ1 is suppressed in aglycemic HepG2 cells dependent on oxidative phosphorylation
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Biochimica Et Biophysica Acta-Bioenergetics. 2017, roč. 1858, 9, p. 750-762
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IF = 4.280
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doi
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Dvořák, Aleš - Zelenka, Jaroslav - Smolková, Katarína - Vítek, L. - Ježek, Petr
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Background Levels of Neomorphic 2-hydroxyglutarate Facilitate Proliferation of Primary Fibroblasts
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Physiological Research. 2017, roč. 66, 2, p. 293-304
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IF = 1.324
[ASEP]
Alán, Lukáš - Špaček, Tomáš - Pajuelo-Reguera, David - Jabůrek, Martin - Ježek, Petr
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Mitochondrial nucleoid clusters protect newly synthesized mtDNA during Doxorubicin- and Ethidium Bromide-induced mitochondrial stress
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Toxicology and Applied Pharmacology. 2016, roč. 302, Jul 1, p. 31-40
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IF = 3.791
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doi
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Zelenka, J. - Dvořák, Aleš - Alán, Lukáš - Zadinová, M. - Haluzík, M. - Vítek, L.
Hyperbilirubinemia Protects against Aging-Associated Inflammation and Metabolic Deterioration
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Oxidative Medicine and Cellular Longevity. 2016, roč. 2016, 2016, článku 6190609
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IF = 4.593
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doi
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Bartůněk, V. - Rak, J. - Pelánková, B. - Junková, J. - Mezlíková, M. - Král, V. - Kuchař, M. - Engstová, Hana - Ježek, Petr - Šmucler, R.
Large scale preparation of up-converting YF3:YbEr nanocrystals with various sizes by solvothermal syntheses using ionic liquid bmimCl
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Journal of Fluorine Chemistry. 2016, roč. 188, Aug, p. 14-17
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IF = 2.101
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doi
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Plecitá-Hlavatá, Lydie - Ježek, Petr
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Integration of superoxide formation and cristae morphology for mitochondrial redox signaling
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International Journal of Biochemistry and Cell Biology. 2016, roč. 80, Nov, p. 31-50
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IF = 3.505
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doi
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Plecitá-Hlavatá, Lydie - Engstová, Hana - Alán, Lukáš - Špaček, Tomáš - Dlasková, Andrea - Smolková, Katarína - Špačková, Jitka - Tauber, Jan - Strádalová, Vendula - Malínský, Jan - Lessard, M. - Bewersdorf, J. - Ježek, Petr
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Hypoxic HepG2 cell adaptation decreases ATP synthase dimers and ATP production in inflated cristae by mitofilin down-regulation concomitant to MICOS clustering
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FASEB Journal. 2016, roč. 30, 5, p. 1941-1957
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IF = 5.498
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doi
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Alán, Lukáš - Špaček, Tomáš - Ježek, Petr
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Delaunay algorithm and principal component analysis for 3D visualization of mitochondrial DNA nucleoids by Biplane FPALM/dSTORM
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European Biophysics Journal With Biophysics Letters. 2016, roč. 45, 5, p. 443-461
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IF = 1.472
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doi
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Li, M. - Riddle, S. - Zhang, H. - D´Alessandro, A. - Flockton, A. - Serkova, N. J. - Hansen, K. C. - Moldvan, R. - McKeon, B. A. - Frid, M. - Kumar, S. - Li, H. - Liu, H. - Canovas, A. - Medrano, J. F. - Thomas, M. G. - Iloska, D. - Plecitá-Hlavatá, Lydie - Ježek, Petr - Pullamsetti, S. - Fini, M. A. - El Kasmi, K. C. - Zhang, Q. H. - Stenmark, K. R.
Metabolic Reprogramming Regulates the Proliferative and Inflammatory Phenotype of Adventitial Fibroblasts in Pulmonary Hypertension Through the Transcriptional Corepressor C-Terminal Binding Protein-1
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Circulation. 2016, roč. 134, 15, p. 1105-1121
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IF = 19.309
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doi
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Plecitá-Hlavatá, Lydie - Tauber, Jan - Li, M. - Zhang, H. - Flockton, A. R. - Pullamsetti, S. S. - Chelladurai, P. - D´Allessandro, A. - El Kasmi, K. C. - Ježek, Petr - Stenmark, K. R.
Constitutive Reprogramming of Fibroblast Mitochondrial Metabolism in Pulmonary Hypertension
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American Journal of Respiratory Cell and Molecular Biology. 2016, roč. 55, 1, p. 47-57
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IF = 4.100
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doi
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Kostiv, Uliana - Kotelnikov, Ilya - Proks, Vladimír - Šlouf, Miroslav - Kučka, Jan - Engstová, Hana - Ježek, Petr - Horák, Daniel
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RGDS- and TAT-conjugated upconversion of NaYF4:Yb3+/Er3+&SiO2 nanoparticles: in vitro human epithelioid cervix carcinoma cellular uptake, imaging, and targeting
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ACS Applied Materials and Interfaces. 2016, roč. 8, 31, p. 20422-20431
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IF = 7.504
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doi
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Gabrielová, E. - Křen, Vladimír - Jabůrek, Martin - Modriansky, M.
Silymarin Component 2,3-dehydrosilybin Attenuates Cardiomyocyte Damage Following Hypoxia/Reoxygenation by Limiting Oxidative Stress
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Physiological Research. 2015, Vol. 64, 1, p. 79-91
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IF = 1.618
[ASEP]
Zelenka, Jaroslav - Dvořák, Aleš - Alán, Lukáš
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L-Lactate Protects Skin Fibroblasts against Aging-Associated Mitochondrial Dysfunction via Mitohormesis
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Oxidative Medicine and Cellular Longevity. 2015, Vol. 2015, 2015, ID351698
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IF = 4.492
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doi
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Kostiv, Uliana - Janoušková, Olga - Šlouf, Miroslav - Kotov, Nikolay - Engstová, Hana - Smolková, Katarína - Ježek, Petr - Horák, Daniel
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Silica-modified monodisperse hexagonal lanthanide nanocrystals: synthesis and biological properties
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Nanoscale. 2015, Vol. 7, 43, p. 18096-18104
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IF = 7.76
[ASEP]
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doi
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Olejár, Tomáš - Pajuelo-Reguera, David - Alán, Lukáš - Dlasková, Andrea - Ježek, Petr
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Coupled aggregation of mitochondrial single-strand DNA-binding protein tagged with Eos fluorescent protein visualizes synchronized activity of mitochondrial nucleoids
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Molecular Medicine Reports. 2015, Vol. 12, 4, p. 5185-5190
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IF = 1.559
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doi
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Bartůněk, V. - Pinc, J. - Ulbrich, P. - Rak, J. - Pelánková, B. - Král, V. - Kuchař, M. - Ježek, Petr - Engstová, Hana - Smolková, Katarína
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Tunable rapid microwave synthesis of up-converting hexagonal NaYxGdyYbzEr(1−x−y−z)F4 nanocrystals in large quantity
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Journal of Fluorine Chemistry. 2015, Vol. 178, Oct 2015, p. 56-60
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IF = 2.213
[ASEP]
[
doi
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Alán, Lukáš - Olejár, Tomáš - Cahová, M. - Zelenka, Jaroslav - Berková, Z. - Smětáková, M. - Saudek, F. - Matěj, R. - Ježek, Petr
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Delta Cell Hyperplasia in Adult Goto-Kakizaki (GK/MolTac) Diabetic Rats
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Journal of Diabetes Research. 2015, Vol. 2015, 2015, p. 385395
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IF = 2.431
[ASEP]
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doi
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Plecitá-Hlavatá, Lydie - Ježek, Jan - Ježek, Petr
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Aglycemia keeps mitochondrial oxidative phosphorylation under hypoxic conditions in HepG2 cells
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Journal of Bioenergetics and Biomembranes. 2015, Vol. 47, 6, p. 467-476
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IF = 2.8
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doi
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Dlasková, Andrea - Engstová, Hana - Plecitá-Hlavatá, Lydie - Lessard, M. - Alán, Lukáš - Reguera Pajuelo, David - Jabůrek, Martin - Ježek, Petr
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Distribution of mitochondrial DNA nucleoids inside the linear tubules vs. bulk parts of mitochondrial network as visualized by 4Pi microscopy
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Journal of Bioenergetics and Biomembranes. 2015, Vol. 47, 3, p. 255-263
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IF = 2.8
[ASEP]
[
doi
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Pajuelo-Reguera, David - Alán, Lukáš - Olejár, Tomáš - Ježek, Petr
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Dichloroacetate stimulates changes in the mitochondrial network morphology via partial mitophagy in human SH-SY5Y neuroblastoma cells
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International Journal of Oncology. 2015, Vol. 46, 6, p. 2409-2418
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IF = 3.018
[ASEP]
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doi
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Smolková, Katarína - Dvořák, Aleš - Zelenka, Jaroslav - Vítek, L. - Ježek, Petr
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Reductive carboxylation and 2-hydroxyglutarate formation by wild-type IDH2 in breast carcinoma cells
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International Journal of Biochemistry and Cell Biology. 2015, Vol. 65, AUG 15, p. 125-133
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IF = 3.905
[ASEP]
[
doi
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Matěj, R. - Rohan, Z. - Holada, K. - Olejár, Tomáš
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The Contribution of Proteinase-Activated Receptors to Intracellular Signaling, Transcellular Transport and Autophagy in Alzheimer´s Disease
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Current Alzheimer Research. 2015, Vol. 12, 1, p. 2-12
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IF = 3.145
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[
doi
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Kostiv, Uliana - Šlouf, Miroslav - Macková, Hana - Zhigunov, Alexander - Engstová, Hana - Smolková, Katarína - Ježek, Petr - Horák, Daniel
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Silica-coated upconversion lanthanide nanoparticles: the effect of crystal design on morphology, structure and optical properties
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Beilstein Journal of Nanotechnology. 2015, Vol. 6, 03 Dec, p. 2290-2299
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IF = 2.778
[ASEP]
[
doi
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Ježek, Jan - Dlasková, Andrea - Zelenka, Jaroslav - Jabůrek, Martin - Ježek, Petr
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H2O2-Activated Mitochondrial Phospholipase iPLA2 gamma Prevents Lipotoxic Oxidative Stress in Synergy with UCP2, Amplifies Signaling via G-Protein-Coupled Receptor GPR40, and Regulates Insulin Secretion in Pancreatic beta-Cells
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Antioxidants & Redox Signaling. 2015, Vol. 23, 12, p. 958-972
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IF = 7.093
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doi
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Zelenka, Jaroslav - Alán, Lukáš - Jabůrek, Martin - Ježek, Petr
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Import of desired nucleic acid sequences using addressing motif of mitochondrial ribosomal 5S-rRNA for fluorescent in vivo hybridization of mitochondrial DNA and RNA
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Journal of Bioenergetics and Biomembranes 2014, roč. 46, 2, p. 147-156. ISSN 0145-479X.
IF = 3.212
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[
doi
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Olejár, Tomáš - Větvička, D. - Zadinová, M. - Poučková, P. - Kukal, J. - Ježek, Petr - Matěj, R.
Dual Role of Host Par2 in a Murine Model of Spontaneous Metastatic B16 Melanoma
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Anticancer Research 2014, roč. 34, 7, p. 3511-3515. ISSN 0250-7005.
IF = 1.826
[ASEP]
Matěj, R. - Vašáková, M. - Kukal, J. - Šterclová, M. - Olejár, Tomáš
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Higher TGF-beta With Lower CD124 and TSLP, But No Difference in PAR-2 Expression in Bronchial Biopsy of Bronchial Asthma Patients in Comparison With COPD Patients
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Applied Immunohistochemistry & Molecular Morphology 2014, roč. 22, 7, p. 543-549. ISSN 1541-2016.
IF = 2.012
[ASEP]
[
doi
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Matěj, R. - Smětáková, M. - Vašáková, M. - Nováková, J. - Šterclová, M. - Kukal, J. - Olejár, Tomáš
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PAR-2, IL-4R, TGF-beta and TNF-alpha in bronchoalveolar lavage distinguishes extrinsic allergic alveolitis from sarcoidosis
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Experimental and Therapeutic Medicine 2014, roč. 8, 2, p. 533-538. ISSN 1792-0981.
IF = 1.269
[ASEP]
[
doi
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Koníčková, R. - Vaňková, K. - Vaníková, J. - Váňová, K. - Muchová, L. - Subhanová, I. - Zadinová, M. - Zelenka, Jaroslav - Dvořák, Aleš - Kolář, Michal - Strnad, Hynek - Rimpelová, S. - Ruml, T. - Wong, R.J. - Vítek, L.
Anti-cancer effects of blue-green alga Spirulina platensis, a natural source of bilirubin-like tetrapyrrolic compounds
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Annals of Hepatology. 2014, roč. 13, 2, p. 273-283. ISSN 1665-2681.
IF = 2.065
[ASEP]
Ježek, Petr - Olejár, Tomáš - Smolková, Katarína - Ježek, Jan - Dlasková, Andrea - Plecitá-Hlavatá, Lydie - Zelenka, Jaroslav - Špaček, Tomáš - Engstová, Hana - Reguera Pajuelo, David - Jabůrek, Martin
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Antioxidant and regulatory role of mitochondrial uncoupling protein UCP2 in pancreatic beta-cells
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Physiological Research 2014, roč. 63, suppl.1, s73-s91. ISSN 0862-8408.
IF = 1.293
[ASEP]
Gbelcová, H. - Sveda, M. - Laubertová, L. - Varga, I. - Vítek, L. - Kolář, M. - Strnad, H. - Zelenka, Jaroslav - Boehmer, D. - Ruml, T.
The effect of simvastatin on lipid droplets accumulation in human embryonic kidney cells and pancreatic cancer cells
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Lipids in Health and Disease, 2013, Vol. 12, AUG 21, p. 126
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IF = 2.015
[ASEP]
[
doi
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Vašáková, M. - Šterclová, M. - Matěj, R. - Olejár, Tomáš - Kolesár, L. - Skibová, J. - Stříž, I.
IL-4 polymorphisms, HRCT score and lung tissue markers in idiopathic pulmonary fibrosis
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Human Immunology, 2013, Vol. 74, 10, p. 1346-1351
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IF = 2.298
[ASEP]
[
doi
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Tauber, Jan - Dlasková, Andrea - Šantorová, Jitka - Smolková, Katarína - Alán, Lukáš - Špaček, Tomáš - Plecitá-Hlavatá, Lydie - Ježek, Petr
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Distribution of mitochondrial nucleoids upon mitochondrial network fragmentation and network reintegration in HEPG2 cells
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International Journal of Biochemistry and Cell Biology, 2013, Vol. 45, 3, p. 593-603
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IF = 4.152
[ASEP]
[
doi
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Sutoris, K. - Rakušan, J. - Karásková, M. - Mattová, J. - Beneš, J. - Nekvasil, Miloš - Ježek, Petr - Zadinová, M. - Poučková, P. - Větvička, D.
Novel Topical Photodynamic Therapy of Prostate Carcinoma Using Hydroxy-aluminum Phthalocyanine Entrapped in Liposomes
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Anticancer Research, 2013, Vol. 33, 4, p. 1563-1568
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IF = 1.713
[ASEP]
Malingriaux, E. A. - Rupprecht, A. - Gille, L. - Jovanovic, O. - Ježek, Petr - Jabůrek, Martin - Pohl, E. E.
Fatty Acids are Key in 4-Hydroxy-2-Nonenal-Mediated Activation of Uncoupling Proteins 1 and 2
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PLoS ONE, 2013, Vol. 8, 10, e77786
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IF = 3.730
[ASEP]
[
doi
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Lebiedzinska, M. - Karkucinska-Wieckowska, A. - Wojtala, A. - Suski, J.M. - Szabadkai, G. - Wilczynski, G. - Wlodarczyk, J. - Diogo, C.T. - Oliveira, P.J. - Tauber, Jan - Ježek, Petr - Pronicki, M. - Duszynski, J. - Pinton, P. - Wieckowski, M.R.
Disrupted ATP synthase activity and mitochondrial hyperpolarisation-dependent oxidative stress is associated with p66Shc phosphorylation in fibroblasts of NARP patients
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International Journal of Biochemistry and Cell Biology, 2013, Vol. 45, 1, p. 141-150
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IF = 4.152
[ASEP]
[
doi
]
Jabůrek, Martin - Ježek, Jan - Zelenka, Jaroslav - Ježek, Petr
.
Antioxidant activity by a synergy of redox-sensitive mitochondrial phospholipase A2 and uncoupling protein-2 in lung and spleen
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International Journal of Biochemistry and Cell Biology, 2013, Vol. 45, 4, p. 816-825
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IF = 4.152
[ASEP]
[
doi
]
Garlid, A. O. - Jabůrek, Martin - Jacobs, J. P. - Garlid, K. D.
Mitochondrial reactive oxygen species: which ROS signals cardioprotection?
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American Journal of Physiology-Heart and Circulatory Physiology, 2013, Vol. 305, 7, H960-H968
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IF = 3.629
[ASEP]
[
doi
]
Zelenka, Jaroslav - Muchová, L. - Zelenková, M. - Váňová, K. - Vreman, H.J. - Wong, R.J. - Vítek, L.
Intracellular accumulation of bilirubin as a defense mechanism against increased oxidative stress
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Biochimie, 2012, Vol. 94, 8, p. 1821-1827
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IF = 3.142
[ASEP]
[
doi
]
Sutoris, K. - Větvička, D. - Horák, L. - Beneš, J. - Nekvasil, Miloš - Ježek, Petr - Zadinová, M. - Poučková, P.
Evaluation of Topical Photodynamic Therapy of Mammary Carcinoma with an Experimental Gel Containing Liposomal Hydroxyl-aluminium Phthalocyanine
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Anticancer Research, 2012, Vol. 32, 9, p. 3769-3774
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Slaninová, Jiřina - Mlsová, V. - Kroupová, H. - Alán, Lukáš - Tůmová, Tereza - Monincová, Lenka - Borovičková, Lenka - Fučík, Vladimír - Čeřovský, Václav
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Toxicity study of antimicrobial peptides from wild bee venom and their analogs toward mammalian normal and cancer cells
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Peptides, 2012, Vol. 33, 1, p. 18-26
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IF = 2.522
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Matěj, R. - Olejár, Tomáš - Janoušková, O. - Holada, K.
Deletion of protease-activated receptor 2 prolongs survival of scrapie-inoculated mice
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Journal of General Virology, 2012, Vol. 93, 9, p. 2057-2061
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Ježek, Petr - Dlasková, Andrea - Plecitá-Hlavatá, Lydie
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Redox Homeostasis in Pancreatic beta Cells
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Oxidative Medicine and Cellular Longevity, 2012, Vol. 2012, 2012, p. 932838
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IF = 3.393
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doi
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Smolková, Katarína - Plecitá-Hlavatá, Lydie - Bellance, N. - Benard, G. - Rossignol, R. - Ježek, Petr
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Waves of gene regulation suppress and then restore oxidative phosphorylation in cancer cells
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International Journal of Biochemistry and Cell Biology, 2011, Vol. 43, 7, p. 950-968
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Mlodzianoski, M. J. - Schreiner, J. M. - Callahan, S. P. - Smolková, Katarína - Dlasková, Andrea - Šantorová, Jitka - Ježek, Petr - Bewersdorf, J.
Sample drift correction in 3D fluorescence photoactivation localization microscopy
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Optics Express, 2011, Vol. 19, 16, p. 15009-15019
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Alán, Lukáš - Špaček, Tomáš - Zelenka, Jaroslav - Tauber, Jan - Berková, Z. - Zacharovová, K. - Saudek, F. - Ježek, Petr
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Assessment of Mitochondrial DNA as an Indicator of Islet Quality: An Example in Goto Kakizaki Rats
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Transplantation Proceedings, 2011, Vol. 43, 9, p. 3281-3284
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IF = 1.005
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Smolková, Katarína - Bellance, N. - Scandurra, F. - Génot, E. - Gnaiger, E. - Plecitá-Hlavatá, Lydie - Ježek, Petr - Rossignol, R.
Mitochondrial bioenergetic adaptations of breast cancer cells to aglycemia and hypoxia
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Journal of Bioenergetics and Biomembranes, 2010, Vol. 42, 1, p. 55-67
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IF = 3.637
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Ruprecht, A. - Sokolenko, E. A. - Beck, V. - Ninnemann, O. - Jabůrek, Martin - Trimbuch, T. - Klishin, S. S. - Ježek, Petr - Skulachev, V. P. - Pohl, E. E.
Role of the Transmembrane Potential in the Membrane Proton Leak
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Biophysical Journal, 2010, Vol. 98, 8, p. 1503-1511
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Ježek, Petr - Plecitá-Hlavatá, Lydie - Smolková, Katarína - Rossignol, R.
Distinctions and similarities of cell bioenergetics and the role of mitochondria in hypoxia, cancer, and embryonic development
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International Journal of Biochemistry and Cell Biology, 2010, Vol. 42, 5, p. 604-622
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IF = 4.956
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Ježek, Petr - Jabůrek, Martin - Garlid, K. D.
Channel character of uncoupling protein-mediated transport
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FEBS Letters, 2010, Vol. 584, 10, p. 2135-2141
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IF = 3.601
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Ježek, Jan - Jabůrek, Martin - Zelenka, Jaroslav - Ježek, Petr
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Mitochondrial phospholipase A2 activated by reactive oxygen species in heart mitochondria induces mild uncoupling
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Physiological Research, 2010, Vol. 59, 5, p. 737-747
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IF = 1.646
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Gabrielová, E. - Jabůrek, Martin - Gažák, Radek - Vostálová, J. - Ježek, Jan - Křen, Vladimír - Modrianský, M.
Dehydrosilybin attenuates the production of ROS in rat cardiomyocyte mitochondria with an uncoupler-like mechanism
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Journal of Bioenergetics and Biomembranes, 2010, Vol. 42, 6, p. 499-509
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IF = 3.637
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Dlasková, Andrea - Špaček, Tomáš - Šantorová, Jitka - Plecitá-Hlavatá, Lydie - Berková, Z. - Saudek, F. - Lessard, M. - Bewersdorf, J. - Ježek, Petr
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4Pi microscopy reveals an impaired three-dimensional mitochondrial network of pancreatic islet beta-cells, an experimental model of type-2 diabetes
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Biochimica Et Biophysica Acta-Bioenergetics, 2010, Vol. 1797, 6-7, p. 1327-1341
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IF = 5.132
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Alán, Lukáš - Zelenka, Jaroslav - Ježek, Jan - Dlasková, Andrea - Ježek, Petr
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Fluorescent in situ hybridization of mitochondrial DNA and RNA
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Acta Biochimica Polonica, 2010, Vol. 57, 4, p. 403-408
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IF = 1.234
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Ježek, Petr - Plecitá-Hlavatá, Lydie
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Mitochondrial reticulum network dynamics in relation to oxidative stress, redox regulation, and hypoxia
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International Journal of Biochemistry and Cell Biology, 2009, Vol. 41, 10, p. 1790-1804
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Bellance, N. - Benard, G. - Furt, F. - Begueret, H. - Smolková, Katarína - Passerieux, E. - Delage, J.P. - Baste, J.M. - Moreau, P. - Rossignol, R.
Bioenergetics of lung tumors: Alteration of mitochondrial biogenesis and respiratory kapacity
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International Journal of Biochemistry and Cell Biology, 2009, Vol. 41, 12, p. 2566-2577
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IF = 4.887
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Alán, Lukáš - Smolková, Katarína - Kronusová, Eva - Šantorová, Jitka - Ježek, Petr
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Absolute levels of transcripts for mitochondrial uncoupling proteins UCP2, UCP3, UCP4, and UCP5 show different patterns in rat and mice tissues
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Journal of Bioenergetics and Biomembranes, 2009, Vol. 41, 1, p. 71-78
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IF = 4.015
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doi
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Plecitá-Hlavatá, Lydie - Ježek, Jan - Ježek, Petr
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Pro-oxidant mitochondrial matrix-targeted ubiquinone MitoQ10 acts as anti-oxidant at retarded electron transport or proton pumping within Complex I
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International Journal of Biochemistry and Cell Biology, 2009, Vol. 41, 8-9, p. 1697-1707
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Špaček, Tomáš - Šantorová, Jitka - Zacharovová, K. - Berková, Z. - Hlavatá, Lydie - Saudek, F. - Ježek, Petr
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Glucose-stimulated insulin secretion of insulinoma INS-1E cells is associated with elevation of both respiration and mitochondrial membrane potential
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International Journal of Biochemistry and Cell Biology, 2008, Vol. 40, 8, p. 1522-1535
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IF = 4.178
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doi
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Valoušková, E. - Smolková, Katarína - Šantorová, Jitka - Ježek, Petr - Modrianský, M.
Redistribution of cell death-inducing DNA fragmentation factor-like effecto-a (CIDE-a) from mitochondria to nucleus is associated with apoptosis in HeLa cells
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General Physiology and Biophysics, 2008, Vol. 27, 2, p. 92-100
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IF = 0.697
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Hlavatá, Lydie - Lessard, M. - Šantorová, Jitka - Bewersdorf, J. - Ježek, Petr
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Mitochondrial oxidative phosphorylation and energetic status are reflected by morphology of mitochondrial network in INS-1E and HEP-G2 cells viewed by 4Pi microscopy
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Biochimica Et Biophysica Acta-Bioenergetics, 2008, Vol. 1777, 7-8, p. 834-846
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IF = 4.447
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Hlavatá, Lydie - Nachin, L. - Ježek, Petr - Nyström, T.
Elevated Ras/protein kinase A activity in Saccharomyces cerevisiae reduces proliferation rate and lifespan by two different reactive oxygen species-dependent routes
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Aging Cell, 2008, Vol. 7, 2, p. 148-157
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Dlasková, Andrea - Hlavatá, Lydie - Ježek, Petr
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Oxidative stress caused by blocking of mitochondrial Complex I Hplus pumping as a link in aging/disease vicious cycle
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International Journal of Biochemistry and Cell Biology, 2008, Vol. 40, 9, p. 1792-1805
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IF = 4.178
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Dlasková, Andrea - Hlavatá, Lydie - Ježek, Jan - Ježek, Petr
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Mitochondrial Complex I superoxide production is attenuated by uncoupling
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International Journal of Biochemistry and Cell Biology, 2008, Vol. 40, 10, p. 2098-2109
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IF = 4.178
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Benard, G. - Faustin, B. - Galinier, A. - Rocher, C. - Bellance, N. - Smolková, Katarína - Casteilla, L. - Rossignol, R. - Letellier, T.
Functional dynamic compartmentalization of respiratory chain intermediate substrates: Implications for the control of energy production and mitochondrial diseases
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International Journal of Biochemistry and Cell Biology, 2008, Vol. 40, 8, p. 1543-1554
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IF = 4.178
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Nekvasil, Miloš - Zadinová, M. - Tahotná, Ludmila - Žáčková, Markéta - Poučková, P. - Ježek, Petr
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Optimum modality for photodynamic therapy of tumors: gels containing liposomes with hydrophobic photosensitizers
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Drug Development Research, 2007, Vol. 68, 5, p. 235-252
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Beck, V. - Jabůrek, Martin - Demina, T. - Rupprecht, A. - Porter, R. K. - Ježek, Petr - Pohl, E. E.
Polyunsaturated fatty acids activate human uncoupling proteins 1 and 2 in planar lipid bilayers
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FASEB Journal, 2007, Vol. 21, 4, p. 1137-1144
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