Oddělení experimentální hypertenze se věnuje studiu mechanizmů, které se podílejí na regulaci krevního tlaku a na vzniku orgánového poškození u potkanů s různými formami experimentální hypertenze.
Hlavní oblasti našeho současného výzkumu jsou:
- Studium centrálních mechanismů regulace krevního tlaku u potkanů s hypertenzí se zřetelem k mozkovému renin-angiotensinovému systému, oxidačnímu stresu a baroreflexní kontrole sympatického tonu (spolupráce s Translational Research in Biomedicine, Kaohsiung, Taiwan a s IKEM, Praha).
- Zkoumání mechanismů, kterými glifloziny - nová skupina antidiabetik - ovlivňují krevní tlak u zvířat s experimentální hypertenzí a chronickým onemocněním ledvin (spolupráce s IKEM).
- Objasnění podílu renin-angiotenzinového a endotelinového systému při vzniku renálního poškození u transgenních potkanů s vloženým myším reninovým genem (Ren-2 TGR) (Mossakowski Medical Research Centre, Warsaw, Poland).
- Zkoumání kardiovaskulárních účinků nových analogů neuropeptidů regulujících příjem potravy u potkanů (spolupráce s UOCHB AV ČR).
Aktuální projekty
Úspěchy
Ústav organické chemie a biochemie AV ČR (ÚOCHB) ve spolupráci s Fyziologickým ústavem AV ČR vyvinul nové látky, které mají pozitivní účinky v experimentálních zvířecích modelech obezity či diabetu typu II.
Více
Naši spolupracovníci byli letos velmi úspěšní na 26. mezinárodním kongresu Světové hypertenzní společnosti v Soulu - Michal Behuliak získal 2. místo v sekci Young Investigator Award, Anna Vavřínová Travel Grant a Josef Zicha získal 2. místo v sekci Best Oral Presentation in Basic Sciences.
Více
Více
Michal Behuliak převzal od generálního ředitele společnosti Servier Cenu České společnosti pro hypertenzi pro mladé autory do 40 let věku.
Více
Dne 30.5.2016 udělil předseda Akademie věd ČR, prof.Jiří Drahoš, Mgr. Michalu Behuliakovi, PhD. prestižní cenu Otto Wichterleho.
Více
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Publikace
Vaněčková, Ivana - Hojná, Silvie - Kadlecová, Michaela - Vernerová, Z. - Kopkan, L. - Červenka, L. - Zicha, Josef
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Renoprotective Effects of ETA Receptor Antagonists Therapy in Experimental Non-Diabetic Chronic Kidney Disease: Is There Still Hope for the Future?
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Physiological Research 2018, roč. 67, Suppl.1, S55-S67
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IF = 1.324
[ASEP]
Šilhavý, Jan - Mlejnek, Petr - Šimáková, Miroslava - Vaněčková, Ivana - Behuliak, Michal - Kuda, Ondřej - Sticová, E. - Jirsa, M. - Pravenec, Michal
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Acute toxic effects of telmisartan in spontaneously hypertensive rats fed a high fructose diet
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Physiological Research 2018, 67(6), 851-856
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IF = 1.324
[ASEP]
Sedláková, L. - Kikerlová, S. - Husková, Z. - Červenková, L. - Čertíková - Chábová, V. - Zicha, Josef - Falck, J. R. - Imig, J. D. - Kompanowska - Jezierska, E. - Sadowski, J. - Krátký, V. - Červenka, L. - Kopkan, L.
20-Hydroxyeicosatetraenoic acid antagonist attenuates the development of malignant hypertension and reverses it once established: a study in Cyp1a1-Ren-2 transgenic rats
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Bioscience Reports 2018, 38(5)), BSR20171496
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IF = 2.899
[ASEP]
[
doi
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Rauchová, Hana - Vokurková, Martina - Pavelka, Stanislav - Vaněčková, Ivana - Tribulová, N. - Soukup, Tomáš
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Red palm oil supplementation does not increase blood glucose or serum lipids levels in Wistar rats with different thyroid status
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Physiological Research 2018, roč. 67, 2, p. 307-315
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IF = 1.324
[ASEP]
Popelová, A. - Pražienková, V. - Neprašová, Barbora - Kasperová, B. J. - Hrubá, L. - Holubová, M. - Zemenová, J. - Blum, D. - Železná, B. - Galas, M. C. - Kuneš, Jaroslav - Maletínská, L.
Novel Lipidized Analog of Prolactin-Releasing Peptide Improves Memory Impairment and Attenuates Hyperphosphorylation of Tau Protein in a Mouse Model of Tauopathy
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Journal of Alzheimer's Disease 2018, roč. 62, 4, p. 1725-1736
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IF = 3.476
[ASEP]
[
doi
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Popelová, A. - Kákonová, A. - Hrubá, L. - Kuneš, Jaroslav - Maletínská, L. - Železná, B.
Potential neuroprotective and anti-apoptotic properties of a long-lasting stable analog of ghrelin: an in vitro study using SH-SY5Y cells
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Physiological Research 2018, roč. 67, 2, p. 339-346
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IF = 1.324
[ASEP]
Poledne, R. - Zicha, Josef
.
Human genome evolution and development of cardiovascular risk factors through natural selection
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Physiological Research 2018, roč. 67, 2, p. 155-163
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IF = 1.324
[ASEP]
Olejníková, Lucie - Polidarová, Lenka - Behuliak, Michal - Sládek, Martin - Sumová, Alena
.
Circadian alignment in a foster mother improves the offspring's pathological phenotype
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Journal of Physiology 2018, 596(23), 5757-5775
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IF = 4.540
[ASEP]
[
doi
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Mikulášková, Barbora - Holubová, M. - Pražienková, V. - Hrubá, L. - Zemenová, J. - Haluzík, M. - Železná, B. - Kuneš, Jaroslav - Maletínská, L.
Lipidized prolactin-releasing peptide improved glucose tolerance in metabolic syndrome: Koletsky and spontaneously hypertensive rat study
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Nutrition & Diabetes 2018, roč. 8, Jan 16, článku 5
.
IF = 2.742
[ASEP]
[
doi
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Holubová, M. - Hrubá, L. - Neprašová, Barbora - Majerčíková, Z. - Lacinová, Z. - Kuneš, Jaroslav - Maletínská, L. - Železná, B.
Prolactin-releasing peptide improved leptin hypothalamic signaling in obese mice
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Journal of Molecular Endocrinology 2018, roč. 60, 2, p. 85-94
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IF = 3.297
[ASEP]
[
doi
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Holubová, M. - Blechová, M. - Kákonová, A. - Kuneš, Jaroslav - Železná, B. - Maletínská, L.
In Vitro and In Vivo Characterization of Novel Stable Peptidic Ghrelin Analogs: Beneficial Effects in the Settings of Lipopolysaccharide-Induced Anorexia in Mice
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Journal of Pharmacology and Experimental Therapeutics 2018, roč. 366, 3, p. 422-432
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IF = 3.706
[ASEP]
[
doi
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Behuliak, Michal - Bencze, Michal - Polgárová, Kamila - Kuneš, Jaroslav - Vaněčková, Ivana - Zicha, Josef
.
Hemodynamic Response to Gabapentin in Conscious Spontaneously Hypertensive Rats: The Role of Sympathetic Nervous System
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Hypertension 2018, roč. 72, 3, p. 676-685
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IF = 6.823
[ASEP]
[
doi
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Zemenová, J. - Sýkora, D. - Maletínská, L. - Kuneš, Jaroslav
.
Lipopeptides as therapeutics: applications and in vivo quantitative analysis
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Bioanalysis. 2017, roč. 9, 2, p. 215-230
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IF = 2.478
[ASEP]
[
doi
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Sedláková, L. - Čertíková - Chábová, V. - Doleželová, Š. - Škaroupková, P. - Kopkan, L. - Husková, Z. - Červenková, L. - Kikerlová, S. - Vaněčková, Ivana - Sadowski, J. - Kompanowska - Jezierska, E. - Kujal, P. - Kramer, H. J. - Červenka, L.
Renin-angiotensin system blockade alone or combined with ETA receptor blockade: effects on the course of chronic kidney disease in 5/6 nephrectomized Ren-2 transgenic hypertensive rats
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Clinical and Experimental Hypertension. 2017, roč. 39, 2, p. 183-195
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IF = 1.367
[ASEP]
[
doi
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Pražienková, V. - Holubová, M. - Pelantová, H. - Bugáňová, M. - Pirník, Z. - Mikulášková, Barbora - Popelová, A. - Blechová, M. - Haluzík, M. - Železná, B. - Kuzma, M. - Kuneš, Jaroslav - Maletínská, L.
Impact of novel palmitoylated prolactin-eleasing peptide analogs on metabolic changes in mice with diet-induced obesity
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PLoS ONE. 2017, roč. 12, 8, článku e0183449
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IF = 2.766
[ASEP]
[
doi
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Pištíková, Adéla - Brožka, Hana - Bencze, Michal - Radostová, Dominika - Valeš, Karel - Stuchlík, Aleš
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The effect of hypertension on adult hippocampal neurogenesis in young adult spontaneously hypertensive rats and Dahl rats
.
Physiological Research. 2017, roč. 66, 5, p. 881-887
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IF = 1.324
[ASEP]
Májovský, M. - Řezáčová, Lenka - Sumová, Alena - Pospíšilová, L. - Netuka, D. - Bradáč, O. - Beneš, V.
Melatonin and cortisol secretion profile in patients with pineal cyst before and after pineal cyst resection
.
Journal of Clinical Neuroscience. 2017, roč. 39, May 2017, p. 155-163
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IF = 1.640
[ASEP]
[
doi
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Dobiášová, Milada
.
Atherogenic Impact of Lecithin-Cholesterol Acyltransferase and Its Relation to Cholesterol Esterification Rate in HDL (FERHDL) and AIP [log(TG/HDL-C)] Biomarkers: The Butterfly Effect?
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Physiological Research. 2017, roč. 66, 2, p. 193-203
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IF = 1.324
[ASEP]
Bugáňová, M. - Pelantová, H. - Holubová, M. - Šedivá, B. - Maletínská, L. - Železná, B. - Kuneš, Jaroslav - Kačer, P. - Kuzma, M. - Haluzík, M.
The effects of liraglutide in mice with diet-induced obesity studied by metabolomics
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Journal of Endocrinology. 2017, roč. 233, 1, p. 93-104
.
IF = 4.012
[ASEP]
[
doi
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Behuliak, Michal - Bencze, Michal - Vaněčková, Ivana - Kuneš, Jaroslav - Zicha, Josef
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Basal and Activated Calcium Sensitization Mediated by RhoA/Rho Kinase Pathway in Rats with Genetic and Salt Hypertension
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BioMed Research International. 2017, roč. 2017, January, článku 8029728
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IF = 2.583
[ASEP]
[
doi
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Lettrichová, I. - Tóthová, L. - Hodosy, J. - Behuliak, Michal - Celec, P.
Variability of salivary markers of oxidative stress and antioxidant status in young healthy individuals
.
Redox Report. 2016, roč. 21, 1, p. 24-30
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IF = 2.070
[ASEP]
[
doi
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Bernátová, I. - Bališ, P. - Goga, R. - Behuliak, Michal - Zicha, Josef - Sekaj, I.
Lack of Reactive Oxygen Species Deteriorates Blood Pressure Regulation in Acute Stress
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Physiological Research. 2016, roč. 65, Suppl.3, S381-S390
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IF = 1.461
[ASEP]
Szeiffová Bačová, B. - Egan Beňová, T. - Viczenczová, C. - Soukup, Tomáš - Rauchová, Hana - Pavelka, Stanislav - Knezl, V. - Barančík, M. - Tribulová, N.
Cardiac Connexin-43 and PKC Signaling in Rats With Altered Thyroid Status Without and With Omega-3 Fatty Acids Intake
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Physiological Research. 2016, roč. 65, Suppl.1, S77-S90
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IF = 1.461
[ASEP]
Vavřínová, Anna - Behuliak, Michal - Zicha, Josef
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The importance of the selection of appropriate reference genes for gene expression profiling in adrenal medulla or sympathetic ganglia of spontaneously hypertensive rat
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Physiological Research. 2016, roč. 65, 3, p. 401-411
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IF = 1.461
[ASEP]
Misárková, Eliška - Behuliak, Michal - Bencze, Michal - Zicha, Josef
.
Excitation-contraction coupling and excitation-transcription coupling in blood vessels: their possible interactions in hypertensive vascular remodeling
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Physiological Research. 2016, roč. 65, 2, p. 173-191
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IF = 1.461
[ASEP]
Vokurková, Martina - Rauchová, Hana - Dobešová, Zdenka - Loukotová, Jana - Nováková, O. - Kuneš, Jaroslav - Zicha, Josef
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The influence of erythrocyte maturity on ion transport and membrane lipid composition in the rat
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Physiological Research. 2016, roč. 65, 1, p. 91-99
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IF = 1.461
[ASEP]
Mikulášková, Barbora - Zemenová, J. - Pirník, Z. - Pražienková, V. - Bednárová, L. - Železná, B. - Maletínská, L. - Kuneš, Jaroslav
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Effect of palmitoylated prolactin-releasing peptide on food intake and neural activation after different routes of peripheral administration in rats
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Peptides. 2016, roč. 75, Jan, p. 109-117
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IF = 2.778
[ASEP]
[
doi
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Vranková, S. - Barta, A. - Klimentová, J. - Dovinová, I. - Líšková, Silvia - Dobešová, Zdenka - Pecháňová, O. - Kuneš, Jaroslav - Zicha, Josef
.
The Regulatory Role of Nuclear Factor Kappa B in the Heart of Hereditary Hypertriglyceridemic Rat
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Oxidative Medicine and Cellular Longevity. 2016, roč. 2016, 2016, p. 9814038
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IF = 4.593
[ASEP]
[
doi
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Mikulášková, Barbora - Maletínská, L. - Zicha, Josef - Kuneš, Jaroslav
.
The role of food intake regulating peptides in cardiovascular regulation
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Molecular and Cellular Endocrinology. 2016, roč. 436, p. 78-92
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IF = 3.754
[ASEP]
[
doi
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Pelantová, H. - Bugáňová, M. - Holubová, M. - Šedivá, B. - Zemenová, J. - Sýkora, D. - Kaválková, P. - Haluzík, M. - Železná, B. - Maletínská, L. - Kuneš, Jaroslav - Kuzma, M.
Urinary metabolomic profiling in mice with diet-induced obesity and type 2 diabetes mellitus after treatment with metformin, vildagliptin and their combination
.
Molecular and Cellular Endocrinology. 2016, roč. 431, C, p. 88-100
.
IF = 3.754
[ASEP]
[
doi
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Bencze, Michal - Behuliak, Michal - Vavřínová, Anna - Zicha, Josef
.
Altered contractile responses of arteries from spontaneously hypertensive rat: The role of endogenous mediators and membrane depolarization
.
Life Sciences. 2016, roč. 166, Dec 1, p. 46-53
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IF = 2.936
[ASEP]
[
doi
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Vaněčková, Ivana - Řezáčová, Lenka - Kuneš, Jaroslav - Zicha, Josef
.
Moderate additive effects of endothelin receptor A blockade in Ren-2 transgenic rats subjected to various types of RAS blockade
.
Life Sciences. 2016, roč. 159, Aug 15, p. 127-154
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IF = 2.936
[ASEP]
[
doi
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Kuneš, Jaroslav - Pražienková, V. - Popelová, A. - Mikulášková, Barbora - Zemenová, J. - Maletínská, L.
Prolactin-releasing peptide: a new tool for obesity treatment
.
Journal of Endocrinology. 2016, roč. 230, 2, R51-R58
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IF = 4.706
[ASEP]
[
doi
]
Holubová, M. - Zemenová, J. - Mikulášková, Barbora - Panajotová, V. - Stöhr, J. - Haluzík, M. - Kuneš, Jaroslav - Železná, B. - Maletínská, L.
Palmitoylated PrRP analog decreases body weight in DIO rats but not in ZDF rats
.
Journal of Endocrinology. 2016, roč. 229, 2, p. 85-96
.
IF = 4.706
[ASEP]
[
doi
]
Zicha, Josef
.
Central Gi(2) proteins, sympathetic nervous system and blood pressure regulation
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Acta Physiologica. 2016, roč. 216, 3, p. 258-259
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IF = 4.867
[ASEP]
[
doi
]
Vokurková, Martina - Rauchová, Hana - Řezáčová, Lenka - Vaněčková, Ivana - Zicha, Josef
.
NADPH oxidase activity and reactive oxygen species production in brain and kidney of adult male hypertensive Ren-2 transgenic rats
.
Physiological Research. 2015, Vol. 64, 6, p. 849-856
.
IF = 1.618
[ASEP]
Kuneš, Jaroslav - Vaněčková, Ivana - Mikulášková, Barbora - Behuliak, Michal - Maletínská, L. - Zicha, Josef
.
Epigenetics and a new look on metabolic syndrome
.
Physiological Research. 2015, Vol. 64, 5, p. 611-620
.
IF = 1.618
[ASEP]
Brunová, Aneta - Bencze, Michal - Behuliak, Michal - Zicha, Josef
.
Acute and chronic role of nitric oxide, renin-angiotensin system and sympathetic nervous system in the modulation of calcium sensitization in Wistar Rats
.
Physiological Research. 2015, Vol. 64, 4, p. 447-457
.
IF = 1.618
[ASEP]
Vokurková, Martina - Rauchová, Hana - Řezáčová, Lenka - Vaněčková, Ivana - Zicha, Josef
.
ROS production is increased in the kidney but not in the brain of Dahl rats with salt hypertension elicited in adulthood
.
Physiological Research. 2015, Vol. 64, 3, p. 303-312
.
IF = 1.618
[ASEP]
Klíma, K. - Vaněček, Václav - Kohout, A. - Jiroušek, Josef - Foltán, R. - Štulík, J. - Machoň, V. - Pavlíková, G. - Jendelová, Pavla - Syková, Eva - Šedý, Jiří
.
Stem cells regenerative properties on new rat spinal fusion model
.
Physiological Research. 2015, Vol. 64, 1, p. 119-128
.
IF = 1.618
[ASEP]
Šedý, Jiří - Kuneš, Jaroslav - Zicha, Josef
.
Pathogenetic Mechanisms of Neurogenic Pulmonary Edema
.
Journal of Neurotrauma. 2015, Vol. 32, 15, p. 1135-1145
.
IF = 4.377
[ASEP]
[
doi
]
Behuliak, Michal - Vavřínová, Anna - Bencze, Michal - Polgárová, Kamila - Ergang, Peter - Kuneš, Jaroslav - Vaněčková, Ivana - Zicha, Josef
.
Ontogenetic changes in contribution of calcium sensitization and calcium entry to blood pressure maintenance of Wistar–Kyoto and spontaneously hypertensive rats
.
Journal of Hypertension. 2015, Vol. 33, 12, p. 2443-2454
.
IF = 5.062
[ASEP]
[
doi
]
Vaněčková, Ivana - Dobešová, Zdenka - Kuneš, Jaroslav - Vernerová, Z. - Zicha, Josef
.
Endothelin A receptor blocker atrasentan lowers blood pressure by the reduction of nifedipine-sensitive calcium influx in Ren-2 transgenic rats fed a high-salt diet
.
Journal of Hypertension. 2015, Vol. 33, 1, p. 161-169
.
IF = 5.062
[ASEP]
[
doi
]
Maletínská, L. - Nagelová, V. - Tichá, A. - Zemenová, J. - Pirník, Z. - Holubová, M. - Špolcová, A. - Mikulášková, Barbora - Blechová, M. - Sýkora, D. - Lacinová, Z. - Haluzík, M. - Železná, B. - Kuneš, Jaroslav
.
Novel lipidized analogs of prolactin-releasing peptide have prolonged half-lives and exert anti-obesity effects after peripheral administration
.
International Journal of Obesity. 2015, Vol. 39, 6, p. 986-993
.
IF = 5.337
[ASEP]
[
doi
]
Bencze, Michal - Behuliak, Michal - Vavřínová, Anna - Zicha, Josef
.
Broad-range TRP channel inhibitors (2-APB, flufenamic acid, SKF-96365) affect differently contraction of resistance and conduit femoral arteries of rat
.
European Journal of Pharmacology. 2015, Vol. 765, Oct 15, p. 533-540
.
IF = 2.73
[ASEP]
[
doi
]
Ergang, Peter - Vodička, Martin - Soták, Matúš - Klusoňová, Petra - Behuliak, Michal - Řeháková, Lenka - Zach, P. - Pácha, Jiří
.
Differential impact of stress on hypothalamic–pituitary–adrenal axis: Gene expression changes in Lewis and Fisher rats
.
Psychoneuroendocrinology. 2015, Vol. 53, Mar 2015, p. 49-59
.
IF = 4.704
[ASEP]
[
doi
]
Kopecký, Jan - Zicha, Josef
.
Recent development of biomedical research at the Institute of Physiology of the Czech Academy of Sciences in Prague
.
Physiological Research. 2015, Vol. 64, 5, p. 595-609
.
IF = 1.618
[ASEP]
Sobotka, O. - Drahota, Zdeněk - Kučera, O. - Endlicher, R. - Rauchová, Hana - Červinková, Z.
The effect of alpha-tocopheryl succinate on succinate respiration in rat liver mitochondria.
Physiological Research. Vol. 64, Suppl.5 (2015), S609-S615. ISSN 0862-8408
.
IF = 1.618
[ASEP]
Zicha, Josef - Dobešová, Zdenka - Zídek, Václav - Šilhavý, Jan - Šimáková, Miroslava - Mlejnek, Petr - Vaněčková, Ivana - Kuneš, Jaroslav - Pravenec, Michal
.
Pharmacogenetic Analysis of Captopril Effects on Blood Pressure: Possible Role of the Ednrb (Endothelin Receptor Type B) Candidate Gene
.
Physiological Research 2014, roč. 63, 2, p. 263-265. ISSN 0862-8408.
IF = 1.293
[ASEP]
Zicha, Josef - Dobešová, Zdenka - Behuliak, Michal - Pintérová, Mária - Kuneš, Jaroslav - Vaněčková, Ivana
.
Nifedipine-sensitive blood pressure component in hypertensive models characterized by high activity of either sympathetic nervous system or renin-angiotensin system
.
Physiological Research 2014, roč. 63, 1, p. 13-26. ISSN 0862-8408.
IF = 1.293
[ASEP]
Zicha, Josef - Behuliak, Michal - Pintérová, Mária - Bencze, Michal - Kuneš, Jaroslav - Vaněčková, Ivana
.
The interaction of calcium entry and calcium sensitization in the control of vascular tone and blood pressure of normotensive and hypertensive rats
.
Physiological Research 2014, roč. 63, suppl.1, s19-s27. ISSN 0862-8408.
IF = 1.293
[ASEP]
Vrablík, M. - Dobiášová, Milada - Zlatohlávek, L. - Urbanová, Z. - Češka, R.
Biomarkers of cardiometabolic risk in obese/overweight children: effect of lifestyle intervention
.
Physiological Research. 2014, Vol. 63, 6, p. 745-752
.
IF = 1.293
[ASEP]
Vaněčková, Ivana - Maletínská, Lenka - Behuliak, Michal - Nagelová, Veronika - Zicha, Josef - Kuneš, Jaroslav
.
Obesity-related hypertension: possible pathophysiological mechanisms
.
Journal of Endocrinology. 2014, roč. 223, 3, r63-r78. ISSN 0022-0795.
IF = 3.718
[ASEP]
[
doi
]
Sollinger, D. - Eissler, R. - Lorenz, S. - Strand, S. - Chmielewski, S. - Aoqui, C. - Schmaderer, Ch. - Bluyssen, H. - Zicha, Josef - Witzke, O. - Scherer, E. - Lutz, J. - Heemann, U. - Baumann, M.
Damage-associated molecular pattern activated Toll-like receptor 4 signalling modulates blood pressure in L-NAME-induced hypertension
.
Cardiovascular Research 2014, roč. 101, 3, p. 464-472. ISSN 0008-6363.
IF = 5.94
[ASEP]
[
doi
]
Rauchová, Hana - Vokurková, Martina - Drahota, Zdeněk
.
Inhibition of mitochondrial glycerol-3-phosphate dehydrogenase by alpha-tocopheryl succinate
.
International Journal of Biochemistry and Cell Biology 2014, roč. 53, aug, p. 409-413. ISSN 1357-2725.
IF = 4.046
[ASEP]
[
doi
]
Pintérová, Mária - Behuliak, Michal - Kuneš, Jaroslav - Zicha, Josef
.
Involvement of BKCa and KV potassium channels in cAMP-induced vasodilation: their insufficient function in genetic hypertension
.
Physiological Research 2014, roč. 63, 3, p. 275-285. ISSN 0862-8408.
IF = 1.293
[ASEP]
Líšková, Silvia - Petrová, M. - Karen, Petr - Behuliak, Michal - Zicha, Josef
.
Contribution of Ca2+-Dependent Cl- Channels to Norepinephrine-Induced Contraction of Femoral Artery Is Replaced by Increasing EDCF Contribution during Ageing
.
BioMed Research International 2014, roč. 2014, 2014, p. 289361. ISSN 2314-6133.
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Čertíková - Chábová, V. - Vernerová, Z. - Kujal, P. - Husková, Z. - Škaroupková, P. - Tesař, V. - Kramer, H. J. - Kompanowska - Jezierska, E. - Walkowska, A. - Sadowski, J. - Červenka, L. - Vaněčková, Ivana
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Addition of ETA receptor blockade increases renoprotection provided by renin-angiotensin system blockade in 5/6 nephrectomized Ren-2 transgenic rats
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Life Sciences. 2014, roč. 118, 2, p. 297-305. ISSN 0024-3205 .
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Vaněček, Václav - Klíma, K. - Kohout, A. - Foltán, R. - Jiroušek, Ondřej - Šedý, Jiří - Štulík, J. - Syková, Eva - Jendelová, Pavla
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The combination of mesenchymal stem cells and a bone scaffold in the treatment of vertebral body defects
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European Spine Journal, 2013, Vol. 22, 12, p. 2777-2786
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Petrová, M. - Líšková, Silvia - Vojtko, R. - Villaris, R. - Varga, Z. - Zicha, Josef - Kristová, V.
Vascular reactivity of arteria femoralis in adult and aged spontaneously hypertensive and Wistar-Kyoto rats
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Bratislavske Lekarske Listy, 2013, Vol. 114, 10, p. 553-555
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Vaněčková, Ivana - Vokurková, Martina - Rauchová, Hana - Dobešová, Zdenka - Pecháňová, O. - Kuneš, Jaroslav - Vorlíček, Jaroslav - Zicha, Josef
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Chronic antioxidant therapy lowers blood pressure in adult but not in young Dahl salt hypertensive rats: the role of sympathetic nervous system
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Acta Physiologica, 2013, Vol. 208, 4, p. 340-349
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Rauchová, Hana - Vokurková, Martina - Pavelka, Stanislav - Behuliak, Michal - Tribulová, N. - Soukup, Tomáš
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N-3 Polyunsaturated Fatty Acids Supplementation Does not Affect Changes of Lipid Metabolism Induced in Rats by Altered Thyroid Status
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Hormone and Metabolic Research, 2013, Vol. 45, 7, p. 507-512
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Langley, S. R. - Bottolo, L. - Kuneš, Jaroslav - Zicha, Josef - Zídek, Václav - Hubner, N. - Cook, S.A. - Pravenec, Michal - Aitman, T. J. - Petretto, E.
Systems-level approaches reveal conservation of trans-regulated genes in the rat and genetic determinants of blood pressure in humans
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Cardiovascular Research, 2013, Vol. 97, 4, p. 653-665
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Hanzelka, T. - Dušek, J. - Ocásek, F. - Kučera, J. - Šedý, Jiří - Beneš, J. - Pavlíková, G. - Foltán, R.
Movement of the patient and the cone beam computed tomography scanner: objectives and possible solutions
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Oral Surgery Oral Medicine Oral Pathology Oral Radiology, 2013, Vol. 116, 6, p. 769-773
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Bencze, Michal - Behuliak, Michal - Zicha, Josef
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The impact of four different classes of anesthetics on the mechanisms of blood pressure regulation in normotensive and spontaneously hypertensive rats
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Physiological Research, 2013, Vol. 62, 5, p. 471-478
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Behuliak, Michal - Pintérová, Mária - Bencze, Michal - Petrová, M. - Líšková, Silvia - Karen, Petr - Kuneš, Jaroslav - Vaněčková, Ivana - Zicha, Josef
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Ca2+ sensitization and Ca2+ entry in the control of blood pressure and adrenergic vasoconstriction in conscious Wistar-Kyoto and spontaneously hypertensive rats
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Journal of Hypertension, 2013, Vol. 31, 10, p. 2025-2035
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Šedý, Jiří - Zicha, Josef - Nedvídková, J. - Kuneš, Jaroslav
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The role of sympathetic nervous system in the development of neurogenic pulmonary edema in spinal cord-injured rats
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Journal of Applied Physiology, 2012, Vol. 112, 1, p. 1-8
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Zicha, Josef - Dobešová, Zdenka - Kuneš, Jaroslav - Vaněčková, Ivana
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Chronic endothelin A receptor blockade attenuates contribution of sympathetic nervous system to salt hypertension development in adult but not in young Dahl rats
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Acta Physiologica, 2012, Vol. 205, 1, p. 124-132
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Zicha, Josef - Dobešová, Zdenka - Vokurková, Martina - Rauchová, Hana - Hojná, Silvie - Kadlecová, Michaela - Behuliak, Michal - Vaněčková, Ivana - Kuneš, Jaroslav
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Age-dependent salt hypertension in Dahl rats: fifty years of research
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Physiological Research, 2012, Vol. 61, Suppl.1, S35-S87
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Vaněčková, Ivana - Dobešová, Zdenka - Kuneš, Jaroslav - Zicha, Josef
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The effects of repeated delivery of angiotensin II AT1 receptor antisense on distinct vasoactive systems in Ren-2 transgenic rats: young vs. adult animals
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Hypertension Research, 2012, Vol. 35, 7, p. 761-768
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Vaněčková, Ivana - Kujal, P. - Husková, Z. - Vaňourková, Z. - Vernerová, Z. - Čertíková - Chábová, V. - Škaroupková, P. - Kramer, H. J. - Tesař, V. - Červenka, L.
Effects of Combined Endothelin A Receptor and Renin-Angiotensin System Blockade on the Course of End-Organ Damage in 5/6 Nephrectomized Ren-2 Hypertensive Rats
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Kidney & Blood Pressure Research, 2012, Vol. 35, 5, p. 382-392
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Rauchová, Hana - Vokurková, Martina - Drahota, Zdeněk
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Idebenone-induced recovery of glycerol-3-phosphate and succinate oxidation inhibited by digitonin
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Physiological Research, 2012, Vol. 61, 3, p. 259-265
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Rauchová, Hana - Vokurková, Martina - Koudelová, J.
Hypoxia-induced lipid peroxidation in the brain during postnatal ontogenesis
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Physiological Research, 2012, Vol. 61, Suppl.1, S89-S101
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Kuneš, Jaroslav - Kadlecová, Michaela - Vaněčková, Ivana - Zicha, Josef
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Critical developmental periods in the pathogenesis of hypertension
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Physiological Research, 2012, Vol. 61, Suppl.1, S9-S17
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Hojná, Silvie - Jordan, M.D. - Kollias, H. - Pausova, Z.
High-fat diet induces emergence of brown-like adipocytes in white adipose tissue of spontaneously hypertensive rats
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Hypertension Research, 2012, Vol. 35, 3, p. 279-286
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Charvátová, Z. - Ošťádalová, Ivana - Zicha, Josef - Kuneš, Jaroslav - Maxová, H. - Ošťádal, Bohuslav
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Cardiac tolerance to ischemia in neonatal spontaneously hypertensive rats
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Šedý, Jiří - Kuneš, Jaroslav - Zicha, Josef
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Neurogenic pulmonary edema induced by spinal cord injury in spontaneously hypertensive and Dahl salt hypertensive rats
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Zicha, Josef - Dobešová, Zdenka - Behuliak, Michal - Kuneš, Jaroslav - Vaněčková, Ivana
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Preventive dietary potassium supplementation in young salt-sensitive Dahl rats attenuates development of salt hypertension by decreasing sympathetic vasoconstriction
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Acta Physiologica, 2011, Vol. 202, 1, p. 29-38
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Vagnerová, Karla - Loukotová, Jana - Ergang, Peter - Musílková, Jana - Mikšík, Ivan - Pácha, Jiří
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Peroxisome proliferator-activated receptor-gamma stimulates 11beta-hydroxysteroid dehydrogenase type 1 in rat vascular smooth muscle cells
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Steroids, 2011, Vol. 76, 6, p. 577-581
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Rašlová, K. - Dobiášová, Milada - Hubáček, J. A. - Bencová, D. - Siváková, D. - Danková, Z. - Franeková, J. - Jabor, A. - Gašparovič, J. - Vohnout, B.
Association of metabolic and genetic factors with cholesterol esterification rate in HDL plasma and atherogenic index of plasma in a 40 years old Slovak population
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Physiological Research, 2011, Vol. 60, 5, p. 758-795
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Rauchová, Hana - Mráček, Tomáš - Novák, Petr - Vokurková, Martina - Soukup, Tomáš
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Glycerol-3-phosphate Dehydrogenase Expression and Oxygen Consumption in Liver Mitochondria of Female and Male Rats with Chronic Alteration of Thyroid Status
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Hormone and Metabolic Research, 2011, Vol. 43, 1, p. 43-47
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Pintérová, Mária - Kuneš, Jaroslav - Zicha, Josef
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Altered neural and vascular mechanisms in hypertension
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Líšková, Silvia - Petrová, M. - Karen, Petr - Kuneš, Jaroslav - Zicha, Josef
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Effects of aging and hypertension on the participation of endothelium-derived constricting factor (EDCF) in norepinephrine-induced contraction of rat femoral artery
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European Journal of Pharmacology, 2011, Vol. 667, 1-3, p. 265-270
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Klusoňová, Petra - Pátková, Lenka - Ergang, Peter - Mikšík, Ivan - Zicha, Josef - Kuneš, Jaroslav - Pácha, Jiří
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Local metabolism of glucocorticoids in Prague hereditary hypertriglyceridemic rats – Effect of hypertriglyceridemia and gender
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Steroids, 2011, Vol. 76, 12, p. 1252-1259
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Dobiášová, Milada - Frohlich, J. - Šedová, Michaela - Cheung, M. C. - Brown, B.G.
Cholesterol esterification and atherogenic index of plasma correlate with lipoprotein size and findings on coronary angiography
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Journal of Lipid Research, 2011, Vol. 52, 3, p. 566-571
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Behuliak, Michal - Pintérová, Mária - Kuneš, Jaroslav - Zicha, Josef
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Vasodilator efficiency of endogenous prostanoids, Ca2+-activated K+ channels and nitric oxide in rats with spontaneous, salt-dependent or NO-deficient hypertension
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Hypertension Research, 2011, Vol. 34, 8, p. 968-975
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Zicha, Josef - Vaněčková, Ivana - Kuneš, Jaroslav
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Systems Analysis in Hypertension: Complementary Role of Physiologists and Geneticists
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Physiological Research, 2010, Vol. 59, 6, p. 837-839
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Pintérová, Mária - Karen, Petr - Kuneš, Jaroslav - Zicha, Josef
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Role of nifedipine-sensitive sympathetic vasoconstriction in maintenance of high blood pressure in spontaneously hypertensive rats: effect of Gi-protein inactivation by pertussis toxin
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Journal of Hypertension, 2010, Vol. 28, 5, p. 969-978
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Paulis, L. - Pecháňová, Olga - Zicha, Josef - Barta, A. - Gardlik, R. - Celec, P. - Kuneš, Jaroslav - Šimko, F.
Melatonin interactions with blood pressure and vascular function during l-NAME-induced hypertension
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Journal of Pineal Research, 2010, Vol. 48, 2, p. 102-108
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Paulis, L. - Pecháňová, Olga - Zicha, Josef - Líšková, Silvia - Celec, P. - Müllerová, M. - Kollár, J. - Behuliak, M. - Kuneš, Jaroslav - Adamcová, M. - Šimko, F.
Melatonin improves the restoration of endothelium-derived constricting factor signalling and inner diameter in the rat femoral artery after cessation of L-NAME treatment
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Journal of Hypertension, 2010, Vol. 28, Suppl.1, S19-S24
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IF = 3.980
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Hojná, Silvie - Kuneš, Jaroslav - Zicha, Josef
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Alterations of NO synthase isoforms in brain and kidney of rats with genetic and salt hypertension
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Physiological Research, 2010, Vol. 59, 6, p. 997-1009
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IF = 1.646
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Šimko, F. - Pecháňová, Olga
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Recent trends in hypertension treatment: perspectives from animal studies
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Journal of Hypertension, 2009, Vol. 27, Suppl.6, S1-S4
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Šimko, F. - Pecháňová, Olga
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Potential roles of melatonin and chronotherapy among the new trends in hypertension treatment
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Journal of Pineal Research, 2009, Vol. 47, 2, p. 127-133
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Šimko, F. - Pecháňová, Olga - Pelouch, Václav - Krajčírovičová, K. - Müllerová, M. - Bednárová, K. - Adamcová, M. - Paulis, L.
Effect of melatonin, captopril, spironolactone and simvastatin on blood pressure and left ventricular remodelling in spontaneously hypertensive rats
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Journal of Hypertension, 2009, Vol. 27, Suppl.6, S5-S10
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IF = 4.988
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Šedý, Jiří - Zicha, Josef - Kuneš, Jaroslav - Hejčl, Aleš - Syková, Eva
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The role of nitric oxide in the development of neurogenic pulmonary edema in spinal cord-injured rats: the effect of preventive interventions
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American Journal of Physiology-Regulatory Integrative and Comparative Physiology, 2009, Vol. 297, 4, R1111-R1117
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Zobrazit více
Přehled změn vápníkové sensitizace za vývoje spontánní hypertenze potkana Schéma možných regulačních mechanismů účastnících se RhoA/Rho kinázové dráhy, které byly zjištěny u normotenzních (a), prehypertenzních (b) a hypertenzních (c) potkanů.
Průběh záznamu kontrakce izolované femorální artérie vyvolané noradrenalinem (NE, norepinefrin).
Řez aortou – značený je α-aktin (červený), jádra (modrá) a zelený signál představuje autofluorescenci.
Řez nadledvinkou barvený na tyrozin hydroxylázu (detekce pomocí Vectastain ABC kitu).
Průběh záznamu krevního tlaku.
