Introduction Department Cellular Neurophysiology

Cellular Neurophysiology

Electrophysiological recording of glutamate-induced current responses in cultured hippocampal neurons.

Our research is mainly directed to exploration of functional and pharmacological properties of ion channels, including those activated during synaptic transmission. For that purpose, we use electrophysiological methods, primarily patch clamp technique, combined with molecular-biology, immunohistochemical and microfluorometric methods (Ca²⁺imaging). Using this approach, we study properties of excitable cells, such as cultured hippocampal and granular neurons or in vitro preserved neural circuits of pyramidal neurons in the hippocampal brain slices, as well as HEK293 and COS cell lines transfected with recombinant NMDA or vanilloid receptors. The goal of our research is to comprehend the relationship between structure and function of ion channels, to characterize the actions of pharmacologically active substances and to explain the molecular mechanism by which they influence ligand-gated ion channels.

For more detailed understanding of physiological mechanisms and pharmacology of ligand-gated ion channels, we use quantitative analytical techniques (including the analysis of single ion channels, measuring of intracellular concentrations of Ca2+ and mathematical modeling).

For more information and current projects visit department´s web.

Publications

Zímová, Lucie - Sinica, Viktor - Kádková, Anna - Vyklická, Lenka - Zíma, Vlastimil - Barvík, I. - Vlachová, Viktorie . Intracellular cavity of sensor domain controls allosteric gating of TRPA1 channel . Science Signaling 2018, roč. 11, 514, článku eaan8621 . IF = 6.378 [ASEP] [ doi ]

Vyklický, Vojtěch - Krausová, Barbora - Černý, Jiří - Ladislav, Marek - Smejkalová, Tereza - Kysilov, Bohdan - Kořínek, Miloslav - Danačíková, Šárka - Horák, Martin - Chodounská, Hana - Kudová, Eva - Vyklický ml., Ladislav . Surface Expression, Function, and Pharmacology of Disease-Associated Mutations in the Membrane Domain of the Human GluN2B Subunit . Frontiers in Molecular Neuroscience 2018, roč. 11, Apr 6, článku 110 . IF = 3.902 [ASEP] [ doi ]

Uttl, Libor - Petrásek, Tomáš - Sengul, Hilal - Svojanovská, Markéta - Lobellová, Veronika - Valeš, Karel - Radostová, Dominika - Tsenov, Grygoriy - Kubová, Hana - Mikulecká, Anna - Svoboda, Jan - Stuchlík, Aleš . Chronic MK-801 Application in Adolescence and Early Adulthood: A Spatial Working Memory Deficit in Adult Long-Evans Rats But No Changes in the Hippocampal NMDA Receptor Subunits . Frontiers in Pharmacology 2018, roč. 9, Feb 12, článku 42 . IF = 3.831 [ASEP] [ doi ]

Touška, Filip - Turnquist, B. - Vlachová, Viktorie - Reeh, P. W. - Leffler, A. - Zimmermann, K. Heat-resistant action potentials require TTX-resistant sodium channels Na(V)1.8 and Na(V)1.9 . Journal of General Physiology 2018, roč. 150, 8, p. 1125-1144 . IF = 3.680 [ASEP] [ doi ]

Skřenková, Kristýna - Lee, S. - Lichnerová, Katarina - Kaniaková, M. - Hansíková, H. - Zápotocký, Martin - Suh, Y. H. - Horák, Martin . N-Glycosylation Regulates the Trafficking and Surface Mobility of GluN3A-Containing NMDA Receptors . Frontiers in Molecular Neuroscience 2018, roč. 11, Jun 4, článku 188 . IF = 3.902 [ASEP] [ doi ]

Průcha, J. - Krůšek, Jan - Dittert, Ivan - Sinica, Viktor - Kádková, Anna - Vlachová, Viktorie . Acute exposure to high‐induction electromagnetic field affects activity of model peripheral sensory neurons . Journal of Cellular and Molecular Medicine 2018, roč. 22, 2, p. 1355-1362 . IF = 4.302 [ASEP] [ doi ]

Ladislav, Marek - Černý, Jiří - Krůšek, Jan - Balík, Aleš - Vyklický ml., Ladislav . The LILI Motif of M3-S2 Linkers Is a Component of the NMDA Receptor Channel Gate . Frontiers in Molecular Neuroscience 2018, roč. 11, Apr 6, článku 113 . IF = 3.902 [ASEP] [ doi ]

Krausová, Barbora - Slavíková, Barbora - Nekardová, Michaela - Hubálková, Pavla - Vyklický, Vojtěch - Chodounská, Hana - Vyklický ml., Ladislav - Kudová, Eva . Positive Modulators of the N-Methyl-D-aspartate Receptor: Structure-Activity Relationship Study of Steroidal 3-Hemiesters . Journal of Medicinal Chemistry 2018, roč. 61, 10, p. 4505-4516 . IF = 6.253 [ASEP] [ doi ]

Kapras, Vojtěch - Vyklický, Vojtěch - Buděšínský, Miloš - Císařová, I. - Vyklický ml., Ladislav - Chodounská, Hana - Jahn, Ullrich . Total Synthesis of ent-Pregnanolone Sulfate and Its Biological Investigation at the NMDA Receptor . Organic Letters 2018, roč. 20, 4, p. 946-949 . IF = 6.492 [ASEP] [ doi ]

Kaniaková, Martina - Kletečková, Lenka - Lichnerová, Katarina - Holubová, Kristína - Skřenková, K. - Kořínek, Miloslav - Krůšek, Jan - Smejkalová, Tereza - Korábečný, J. - Valeš, Karel - Soukup, O. - Horák, Martin . 7-Methoxyderivative of tacrine is a 'foot-in-the-door' open-channel blocker of GluN1/GluN2 and GluN1/GluN3 NMDA receptors with neuroprotective activity in vivo . Neuropharmacology 2018, 140(Sep 15), 217-232 . IF = 4.249 [ASEP] [ doi ]

Boušová, Kristýna - Herman, P. - Večeř, J. - Bednárová, L. - Monincová, L. - Majer, P. - Vyklický ml., Ladislav - Vondrášek, J. - Teisinger, Jan . Shared CaM- and S100A1-binding epitopes in the distal TRPM4 N terminus . FEBS Journal 2018, roč. 285, 3, p. 599-613 . IF = 4.530 [ASEP] [ doi ]

Adla, Santosh Kumar - Slavíková, Barbora - Chodounská, Hana - Vyklický, Vojtěch - Ladislav, Marek - Hubálková, Pavla - Krausová, Barbora - Smejkalová, Tereza - Nekardová, Michaela - Šmídková, Markéta - Monincová, Lenka - Souček, Radko - Vyklický ml., Ladislav - Kudová, Eva . Strong Inhibitory Effect, Low Cytotoxicity and High Plasma Stability of Steroidal Inhibitors of N-Methyl-D-Aspartate Receptors With C-3 Amide Structural Motif . Frontiers in Pharmacology 2018, 9(Nov 12)), 1299 . IF = 3.831 [ASEP] [ doi ]

Vyklická, Lenka - Boukalová, Štěpána - Mačíková, Lucie - Chvojka, Štěpán - Vlachová, Viktorie . The human transient receptor potential vanilloid 3 channel is sensitized via the ERK pathway . Journal of Biological Chemistry.. 2017, roč. 292, 51, p. 21083-21091 . IF = 4.010 [ASEP] [ doi ]

Touška, Filip - Sattler, S. - Malsch, P. - Lewis, R. J. - Reeh, P. W. - Zimmermann, K. Ciguatoxins Evoke Potent CGRP Release by Activation of Voltage-Gated Sodium Channel Subtypes Na(V)1.9, Na(V)1.7 and Na(V)1.1 . Marine Drugs. 2017, roč. 15, 9, článku 269 . IF = 4.379 [ASEP] [ doi ]

Petrovič, Miloš - da Silva, S. V. - Clement, J. P. - Vyklický ml., Ladislav - Mulle, C. - González-González, I. M. - Henley, J. M. Metabotropic action of postsynaptic kainate receptors triggers hippocampal long-term potentiation . Nature Neuroscience. 2017, roč. 20, 4, p. 529-539 . IF = 19.912 [ASEP] [ doi ]

Maršáková, Lenka - Barvík, I. - Zíma, V. - Zímová, Lucie - Vlachová, Viktorie . The First Extracellular Linker Is Important for Several Aspects of the Gating Mechanism of Human TRPA1 Channel . Frontiers in Molecular Neuroscience. 2017, roč. 10, Jan 31, článku 16 . IF = 3.902 [ASEP] [ doi ]

Kádková, Anna - Synytsya, Viktor - Krůšek, Jan - Zímová, Lucie - Vlachová, Viktorie . Molecular Basis of TRPA1 Regulation in Nociceptive Neurons. A Review . Physiological Research. 2017, roč. 66, 3, p. 425-439 . IF = 1.324 [ASEP]

Horák, Martin - Holubová, K. - Nepovímová, E. - Krůšek, Jan - Kaniaková, Martina - Korábečný, J. - Vyklický ml., Ladislav - Kuča, K. - Stuchlík, Aleš - Říčný, J. - Valeš, K. - Soukup, O. The pharmacology of tacrine at N-methyl-D-aspartate receptors . Progress in Neuro-Psychopharmacology & Biological Psychiatry. 2017, roč. 75, Apr 3, p. 54-62 . IF = 4.185 [ASEP] [ doi ]

Gibalová, A. - Steinbachová, L. - Hafidh, S. - Bláhová, Veronika - Gadiou, Z. - Michailidis, Ch. - Müller, K. - Pleskot, Roman - Dupľáková, N. - Honys, D. Characterization of pollen-expressed bZIP protein interactions and the role of ATbZIP18 in the male gametophyte . Plant Reproduction. 2017, roč. 30, 1, p. 1-17 . IF = 2.707 [ASEP] [ doi ]

Gažová, Z. - Soukup, O. - Šepsová, V. - Šipošová, K. - Drtinová, L. - Jošt, P. - Spilovská, K. - Korábečný, J. - Nepovímová, E. - Fedunová, D. - Horák, Martin - Kaniaková, Martina - Wang, Z. J. - Hamouda, A. K. - Kuča, K. Multi-target-directed therapeutic potential of 7-methoxytacrine-adamantylamine heterodimers in the Alzheimer's disease treatment . Biochimica Et Biophysica Acta-Molecular Basis of Disease. 2017, roč. 1863, 2, p. 607-619 . IF = 5.108 [ASEP] [ doi ]

Bohuslavová, Romana - Dodd, Nicole - Mácová, Iva - Chumak, Tetyana - Horák, Martin - Syka, Josef - Fritzsch, B. - Pavlínková, Gabriela . Pax2-Islet1 Transgenic Mice Are Hyperactive and Have Altered Cerebellar Foliation . Molecular Neurobiology. 2017, roč. 54, 2, p. 1352-1368 . IF = 5.076 [ASEP] [ doi ]

Adla, Santosh Kumar - Slavíková, Barbora - Šmídková, Markéta - Tloušťová, Eva - Svoboda, Martin - Vyklický, Vojtěch - Krausová, Barbora - Hubálková, Pavla - Nekardová, Michaela - Holubová, Kristina - Valeš, Karel - Buděšínský, Miloš - Vyklický ml., Ladislav - Chodounská, Hana - Kudová, Eva . Physicochemical and biological properties of novel amide-based steroidal inhibitors of NMDA receptors . Steroids. 2017, roč. 117, Jan, p. 52-61 . IF = 2.523 [ASEP] [ doi ]

Hynková, Anna - Maršáková, Lenka - Vašková, Jana - Vlachová, Viktorie . N-terminal tetrapeptide T/SPLH motifs contribute to multimodal activation of human TRPA1 channel . Scientific Reports. 2016, roč. 6, Jun 27, p. 28700 . IF = 4.259 [ASEP] [ doi ]

Bressan, E. - Touška, Filip - Vetter, I. - Kistner, K. - Kichko, T. I. - Teixeira, N. B. - Picolo, G. - Cury, Y. - Lewis, R. J. - Fischer, M. J. M. - Zimmermann, K. - Reeh, P. W. Crotalphine desensitizes TRPA1 ion channels to alleviate inflammatory hyperalgesia . Pain. 2016, roč. 157, 11, p. 2504-2516 . IF = 5.445 [ASEP] [ doi ]

Franco, R. - Casadó-Anguera, V. - Muňoz, A. - Petrovič, Miloš - Navarro, G. - Moreno, E. - Lanciego, J. L. - Labandeira-García, J. L. - Cortés, A. - Casadó, V. Hints on the Lateralization of Dopamine Binding to D-1 Receptors in Rat Striatum . Molecular Neurobiology. 2016, roč. 53, 8, p. 5436-5445 . IF = 6.190 [ASEP] [ doi ]

Vyklický, Vojtěch - Smejkalová, Tereza - Krausová, Barbora - Balík, Aleš - Kořínek, Miloslav - Borovská, Jiřina - Horák, Martin - Chvojková, Markéta - Kletečková, Lenka - Valeš, Karel - Černý, Jiří - Nekardová, Michaela - Chodounská, Hana - Kudová, Eva - Vyklický ml., Ladislav . Preferential Inhibition of Tonically over Phasically Activated NMDA Receptors by Pregnane Derivatives . Journal of Neuroscience. 2016, roč. 36, 7, p. 2161-2175 . IF = 5.988 [ASEP] [ doi ]

Kaniaková, Martina - Lichnerová, Katarina - Skřenková, Kristýna - Vyklický ml., Ladislav - Horák, Martin . Biochemical and electrophysiological characterization of N-glycans on NMDA receptor subunits . Journal of Neurochemistry. 2016, roč. 138, 4, p. 546-556 . IF = 4.083 [ASEP] [ doi ]

Slavíková, Barbora - Chodounská, Hana - Nekardová, Michaela - Vyklický, Vojtěch - Ladislav, Marek - Hubálková, Pavla - Krausová, Barbora - Vyklický ml., Ladislav - Kudová, Eva . Neurosteroid-like Inhibitors of N-Methyl-D-aspartate Receptor: Substituted 2-Sulfates and 2-Hemisuccinates of Perhydrophenanthrene . Journal of Medicinal Chemistry. 2016, roč. 59, 10, p. 4724-4739 . IF = 6.259 [ASEP] [ doi ]

Jirků, Michaela - Lánský, Zdeněk - Bednárová, L. - Šulc, Miroslav - Monincová, L. - Majer, P. - Vyklický ml., Ladislav - Vondrášek, J. - Teisinger, Jan - Boušová, Kristýna . The characterization of a novel S100A1 binding site in the N-terminus of TRPM1 . International Journal of Biochemistry and Cell Biology. 2016, roč. 78, Sep 2016, p. 186-193 . IF = 3.505 [ASEP] [ doi ]

Zíma, V. - Witschas, Katja - Hynková, Anna - Zímová, Lucie - Barvík, I. - Vlachová, Viktorie . Structural modeling and patch-clamp analysis of pain-related mutation TRPA1-N855S reveal inter-subunit salt bridges stabilizing the channel open state . Neuropharmacology. 2015, Vol. 93, Jun, p. 294-307 . IF = 4.936 [ASEP] [ doi ]

Kořínek, Miloslav - Vyklický, Vojtěch - Borovská, Jiřina - Lichnerová, Katarina - Kaniaková, Martina - Krausová, Barbora - Krůšek, Jan - Balík, Aleš - Smejkalová, Tereza - Horák, Martin - Vyklický ml., Ladislav . Cholesterol modulates open probability and desensitization of NMDA receptors . Journal of Physiology. 2015, Vol. 593, 10, p. 2279-2293 . IF = 4.731 [ASEP] [ doi ]

Kudová, Eva - Chodounská, Hana - Slavíková, Barbora - Buděšínský, Miloš - Nekardová, Michaela - Vyklický, Vojtěch - Krausová, Barbora - Švehla, Pavel - Vyklický ml., Ladislav . A New Class of Potent N-Methyl-D-Aspartate Receptor Inhibitors: Sulfated Neuroactive Steroids with Lipophilic D-Ring Modifications . Journal of Medicinal Chemistry. 2015, Vol. 58, 15, p. 5950-5966 . IF = 5.589 [ASEP] [ doi ]

Lichnerová, Katarina - Kaniaková, Martina - Park, S. P. - Skřenková, Kristýna - Wang, Y.- X. - Petralia, R. S. - Suh, Y. H. - Horák, Martin . Two N-glycosylation Sites in the GluN1 Subunit Are Essential for Releasing N-methyl-D-aspartate (NMDA) Receptors from the Endoplasmic Reticulum . Journal of Biological Chemistry. 2015, Vol. 290, 30, p. 18379-18390 . IF = 4.258 [ASEP] [ doi ]

Hubálková, Pavla . G-kvadruplexy v oblasti lidských telomer a jejich terapeutický potenciál . Chemické listy. 2015, Vol. 109, 12, p. 918-922 . IF = 0.279 [ASEP]

Šepsová, V. - Karasová, J. Z. - Tobin, G. - Jun, D. - Korábečný, J. - Cabelová, P. - Jánská, K. - Krůšek, Jan - Skřenková, K. - Kuča, M. - Valko, M. - Soukup, O. Cholinergic properties of new 7-methoxytacrine-donepezil derivatives . General Physiology and Biophysics. 2015, Vol. 34, 2, p. 189-200 . IF = 0.892 [ASEP] [ doi ]

Jirků, Michaela - Bumba, Ladislav - Bednárová, Lucie - Kubala, M. - Šulc, Miroslav - Franěk, M. - Vyklický ml., Ladislav - Vondrášek, Jiří - Teisinger, Jan - Boušová, Kristýna . Characterization of the part of N-terminal PIP2 binding site of the TRPM1 channel . Biophysical Chemistry. 2015, Vol. 207, Dec, p. 135-142 . IF = 2.363 [ASEP] [ doi ]

Witschas, Katja - Jobin, M.-L. - Korkut, D. N. - Vladan, M. M. - Salgado, G. - Lecomte, S. - Vlachová, Viktorie - Alves, I. D. Interaction of a peptide derived from C-terminus of human TRPA1 channel with model membranes mimicking the inner leaflet of the plasma membrane . Biochimica Et Biophysica Acta-Biomembranes. 2015, Vol. 1848, 5, p. 1147-1159 . IF = 3.687 [ASEP] [ doi ]

Boušová, Kristýna - Jirků, Michaela - Bumba, Ladislav - Bednárová, Lucie - Šulc, Miroslav - Franěk, M. - Vyklický ml., Ladislav - Vondrášek, Jiří - Teisinger, Jan . PIP2 and PIP3 interact with N-terminus region of TRPM4 channel . Biophysical Chemistry. 2015, Vol. 205, Oct 2015, p. 24-32 . IF = 2.363 [ASEP] [ doi ]

Vyklický, Vojtěch - Kořínek, Miloslav - Smejkalová, Tereza - Balík, Aleš - Krausová, Barbora - Kaniaková, Martina - Lichnerová, Katarina - Černý, Jiří - Krůšek, Jan - Dittert, Ivan - Horák, Martin - Vyklický ml., Ladislav . Structure, function, and pharmacology of NMDA receptor channels . Physiological Research 2014, roč. 63, suppl.1, s191-s203. ISSN 0862-8408. IF = 1.293 [ASEP]

Šepsová, V. - Krůšek, Jan - Zdarová Karasová, J. - Zemek, F. - Musílek, K. - Kuča, K. - Soukup, O. The interaction of quaternary reversible acetylcholinesterase inhibitors with the nicotinic receptor . Physiological Research. 2014, Vol. 63, 6, p. 771-777 . IF = 1.293 [ASEP]

Lichnerová, Katarina - Kaniaková, Martina - Skřenková, Kristýna - Vyklický ml., Ladislav - Horák, Martin . Distinct regions within the GluN2C subunit regulate the surface delivery of NMDA receptors . Frontiers in Cellular Neuroscience. 2014, roč. 8, nov 10, p. 375. ISSN 1662-5102. IF = 4.289 [ASEP] [ doi ]

Krůšek, Jan - Ďaďo, S. Electrode-less measurement of cell layers impedance . Physiological Research. 2014, Vol. 63, 6, p. 705-711 . IF = 1.293 [ASEP]

Khuzakhmetova, V. - Samigullin, D. - Nurullin, L. - Vyskočil, František - Nikolsky, E. - Bukharaeva, E. Kinetics of neurotransmitter release in neuromuscular synapses of newborn and adult rats . International Journal of Developmental Neuroscience 2014, roč. 34, may, p. 9-18. ISSN 0736-5748. IF = 2.58 [ASEP] [ doi ]

Kaniaková, Martina - Skřenková, Kristýna - Adámek, S. - Vyskočil, František - Krůšek, Jan . Different effects of lobeline on neuronal and muscle nicotinic receptors . European Journal of Pharmacology. 2014, roč. 738, sep 5, p. 352-359. ISSN 0014-2999. IF = 2.532 [ASEP] [ doi ]

Horák, Martin - Petralia, R. S. - Kaniaková, Martina - Sans, N. ER to synapse trafficking of NMDA receptors . Frontiers in Cellular Neuroscience. 2014, roč. 8, -, p. 394. ISSN 1662-5102. IF = 4.289 [ASEP] [ doi ]

Boukalová, Štěpána - Touška, Filip - Maršáková, Lenka - Hynková, Anna - Surá, Lucie - Chvojka, Štěpán - Dittert, Ivan - Vlachová, Viktorie . Gain-of-function mutations in the transient receptor potential channels TRPV1 and TRPA1: how painful? . Physiological Research 2014, roč. 63, suppl.1, s205-s213. ISSN 0862-8408. IF = 1.293 [ASEP]

Vetter, I. - Hein, A. - Sattler, S. - Hessler, S. - Touška, Filip - Bressan, E. - Parra, A. - Hager, U. - Leffler, A. - Boukalová, Štěpána - Nissen, M. - Lewis, R. J. - Belmonte, C. - Alzheimer, Ch. - Huth, T. - Vlachová, Viktorie - Reeh, P. W. - Zimmerma . Amplified Cold Transduction in Native Nociceptors by M-Channel Inhibition . Journal of Neuroscience, 2013, Vol. 33, 42, p. 16627-16641 . IF = 6.908 [ASEP] [ doi ]

Tariq, A. - Garncarz, W. - Handl, C. - Balík, Aleš - Pusch, O. - Jantsch, M.F. RNA-interacting proteins act as site-specific repressors of ADAR2-mediated RNA editing and fluctuate upon neuronal stimulation . Nucleic Acids Research, 2013, Vol. 41, 4, p. 2581-2593 . IF = 8.278 [ASEP] [ doi ]

Soukup, O. - Jun, D. - Zdarová Karasová, J. - Patočka, J. - Musílek, K. - Korábečný, J. - Krůšek, Jan - Kaniaková, Martina - Šepsová, V. - Mandíková, J. - Trejtnar, F. - Pohanka, M. - Drtinová, L. - Pavlík, M. - Tobin, G. - Kuča, K. A Resurrection of 7-MEOTA:a comparison with Tacrine . Current Alzheimer Research, 2013, Vol. 10, 8, p. 893-906 . IF = 3.676 [ASEP]

Penn, A.C. - Balík, Aleš - Greger, I. H. Steric antisense inhibition of AMPA receptor Q/R editing reveals tight coupling to intronic editing sites and splicing . Nucleic Acids Research, 2013, Vol. 41, 2, p. 1113-1123 . IF = 8.278 [ASEP] [ doi ]

Boukalová, Štěpána - Teisinger, Jan - Vlachová, Viktorie . Protons stabilize the closed conformation of gain-of-function mutants of the TRPV1 channel . Biochimica Et Biophysica Acta-Molecular Cell Research, 2013, Vol. 1833, 3, p. 520-528 . IF = 4.808 [ASEP] [ doi ]

Balík, Aleš - Penn, A.C. - Nemoda, Z. - Greger, I. H. Activity-regulated RNA editing in select neuronal subfields in hippocampus . Nucleic Acids Research, 2013, Vol. 41, 2, p. 1124-1134 . IF = 8.278 [ASEP] [ doi ]

Adamusová, Eva - Cais, Ondřej - Vyklický, Vojtěch - Kudová, Eva - Chodounská, Hana - Horák, Martin - Vyklický ml., Ladislav . Pregnenolone sulfate activates NMDA receptor channels . Physiological Research, 2013, Vol. 62, 6, p. 731-736 . IF = 1.531 [ASEP]

Černý, Ivan - Buděšínský, Miloš - Pouzar, Vladimír - Vyklický, Vojtěch - Krausová, Barbora - Vyklický ml., Ladislav . Neuroactive steroids with perfluorobenzoyl group . Steroids, 2012, Vol. 77, 12, p. 1233-1241 . IF = 2.803 [ASEP] [ doi ]

Vetter, I. - Touška, Filip - Hess, A. - Hinsbey, R. - Sattler, S. - Lampert, A. - Sergejeva, M. - Sharov, A. - Collins, L. S. - Eberhardt, M. - Engel, M. - Cabot, P. J. - Wood, J. N. - Vlachová, Viktorie - Reeh, P. W. - Lewis, R. J. - Zimmermann, K. Ciguatoxins activate specific cold pain pathways to elicit burning pain from cooling . EMBO Journal, 2012, Vol. 31, 19, p. 3795-3808 . IF = 9.822 [ASEP] [ doi ]

Valeš, Karel - Rambousek, Lukáš - Holubová, Kristina - Svoboda, Jan - Bubeniková-Valešová, V. - Chodounská, Hana - Vyklický ml., Ladislav - Stuchlík, Aleš . 3 alpha 5 beta-Pregnanolone glutamate, a use-dependent NMDA antagonist, reversed spatial learning deficit in an animal model of schizophrenia . Behavioural Brain Research, 2012, Vol. 235, 1, p. 82-88 . IF = 3.327 [ASEP] [ doi ]

Surá, Lucie - Zíma, V. - Maršáková, Lenka - Hynková, Anna - Barvík, I. - Vlachová, Viktorie . C-terminal Acidic Cluster Is Involved in Ca2+-induced Regulation of Human Transient Receptor Potential Ankyrin 1 Channel . Journal of Biological Chemistry, 2012, Vol. 287, 22, p. 18067-18077 . IF = 4.651 [ASEP] [ doi ]

Pryazhnikov, E. - Ostroumov, A. - Druginina, O. - Vyskočil, František - Skorinkin, A. The mechanisms of inhibition of frog endplate currents with homologous derivatives of the 1,1-dimethyl-3-oxybutyl phosphonic acid . Physiological Research, 2012, Vol. 61, 4, p. 395-404 . IF = 1.531 [ASEP]

Palma-Cerda, F. - Auger, C. - Crawford, D.J. - Hodgson, A.C.C. - Reynolds, S.J. - Cowell, J.K. - Swift, K.A.D. - Cais, Ondřej - Vyklický ml., Ladislav - Corrie, J.E.T. - Ogden, D. New caged neurotransmitter analogs selective for glutamate receptor sub-types based on methoxynitroindoline and nitrophenylethoxycarbonyl caging groups . Neuropharmacology, 2012, Vol. 63, 4, p. 624-634 . IF = 4.114 [ASEP] [ doi ]

Maršáková, Lenka - Touška, Filip - Krůšek, Jan - Vlachová, Viktorie . Pore Helix Domain Is Critical to Camphor Sensitivity of Transient Receptor Potential Vanilloid 1 Channel . Anesthesiology, 2012, Vol. 116, 4, p. 903-917 . IF = 5.163 [ASEP] [ doi ]

Lindovský, Jiří - Petrov, K. - Krůšek, Jan - Reznik, V.S. - Nikolsky, E. E. - Vyskočil, František . Effect of tissue-specific acetylcholinesterase inhibitor C-547 on alpha 3 beta 4 and alpha beta epsilon delta acetylcholine receptors in COS cells . European Journal of Pharmacology, 2012, Vol. 688, 1-3, p. 22-26 . IF = 2.592 [ASEP] [ doi ]

Kapras, Vojtěch - Slavíčková, Alena - Šťastná, Eva - Vyklický ml., Ladislav - Valeš, Karel - Chodounská, Hana . Synthesis of deuterium labeled NMDA receptor inhibitor-20-Oxo-5 beta-[9,12,12-H-2(3)]pregnan-3 alpha-yl-L-glutamyl 1-ester . Steroids, 2012, Vol. 77, 3, p. 282-287 . IF = 2.803 [ASEP] [ doi ]

Kaniaková, Martina - Lichnerová, Katarina - Vyklický ml., Ladislav - Horák, Martin . Single amino acid residue in the M4 domain of GluN1 subunit regulates the surface delivery of NMDA receptors . Journal of Neurochemistry, 2012, Vol. 123, 3, p. 385-395 . IF = 3.973 [ASEP] [ doi ]

Kaniaková, Martina - Krausová, Barbora - Vyklický, Vojtěch - Kořínek, Miloslav - Lichnerová, Katarina - Vyklický ml., Ladislav - Horák, Martin . Key Amino Acid Residues within the Third Membrane Domains of NR1 and NR2 Subunits Contribute to the Regulation of the Surface Delivery of N-methyl-D-aspartate Receptors . Journal of Biological Chemistry, 2012, Vol. 287, 31, p. 26423-26434 . IF = 4.651 [ASEP] [ doi ]

Hřebabecký, Hubert - Dejmek, Milan - Dračínský, Martin - Šála, Michal - Leyssen, P. - Neyts, J. - Kaniaková, Martina - Krůšek, Jan - Nencka, Radim . Synthesis of novel azanorbornylpurine derivatives . Tetrahedron, 2012, Vol. 68, 4, p. 1286-1298 . IF = 2.803 [ASEP] [ doi ]

Borovská, Jiřina - Vyklický, Vojtěch - Šťastná, Eva - Kapras, Vojtěch - Slavíková, Barbora - Horák, Martin - Chodounská, Hana - Vyklický ml., Ladislav . Access of inhibitory neurosteroids to the NMDA receptor . British Journal of Pharmacology, 2012, Vol. 166, 3, p. 1069-1083 . IF = 5.067 [ASEP] [ doi ]

Penn, A.C. - Balík, Aleš - Wozny, Ch. - Cais, O. - Greger, I. H. Activity-Mediated AMPA Receptor Remodeling, Driven by Alternative Splicing in the Ligand-Binding Domain . Neuron, 2012, Vol. 76, 3, p. 503-510 . IF = 15.766 [ASEP] [ doi ]

Šťastná, Eva - Chodounská, Hana - Pouzar, Vladimír - Borovská, Jiřina - Vyklický ml., Ladislav . Synthesis of pregnane 3-carboxylic acids via Pd-catalyzed alkoxycarbonylation and their effect on NMDA receptor activity . Collection of Czechoslovak Chemical Communications, 2011, Vol. 76, 9, p. 1141-1161 . IF = 1.283 [ASEP] [ doi ]

Volkov, E. M. - Nurullin, L. F. - Volkov, M. E. - Nikolsky, E. E. - Vyskočil, František . Mechanisms of carbacholine and GABA action on resting membrane potential and Na+/K+-ATPase of Lumbricus terrestris body wall muscles . Comparative Biochemistry and Physiology A-Molecular & Integrative Physiology, 2011, Vol. 158, 4, p. 520-524 . IF = 2.235 [ASEP] [ doi ]

Vidrna, Lukáš - Černý, Ivan - Pouzar, Vladimír - Borovská, Jiřina - Vyklický, Vojtěch - Vyklický ml., Ladislav - Chodounská, Hana . Azido analogs of neuroactive steroids . Steroids, 2011, Vol. 76, 10/11, p. 1043-1050 . IF = 2.829 [ASEP] [ doi ]

Touška, Filip - Maršáková, Lenka - Teisinger, Jan - Vlachová, Viktorie . A “Cute” Desensitization of TRPV1 . Current Pharmaceutical Biotechnology, 2011, Vol. 12, 1, p. 122-129 . IF = 2.805 [ASEP]

Soukup, O. - Krůšek, Jan - Kaniaková, Martina - Kumar, U. K. - Oz, M. - Jun, D. - Fusek, J. - Kuča, K. - Tobin, G. Oxime reactivators and their in vivo and in vitro effects on nicotinic receptors . Physiological Research, 2011, Vol. 60, 4, p. 679-686 . IF = 1.555 [ASEP]

Samad, Abdul - Surá, Lucie - Benedikt, Jan - Ettrich, Rüdiger - Minofar, Babak - Teisinger, Jan - Vlachová, Viktorie . The C-terminal basic residues contribute to the chemical- and voltage-dependent activation of TRPA1 . Biochemical Journal, 2011, Vol. 433, 1, p. 197-204 . IF = 4.897 [ASEP] [ doi ]

Rambousek, Lukáš - Bubeníková-Valešová, V. - Kačer, P. - Syslová, K. - Kenney, Jana - Holubová, Kristina - Najmanová, V. - Zach, P. - Svoboda, Jan - Stuchlík, Aleš - Chodounská, Hana - Kapras, Vojtěch - Adamusová, Eva - Borovská, Jiřina - Vyklický ml., La . Cellular and behavioural effects of a new steroidal inhibitor of the N-methyl-d-aspartate receptor 3α5β-pregnanolone glutamate . Neuropharmacology, 2011, Vol. 61, 1-2, p. 61-68 . IF = 4.814 [ASEP]

Malomouzh, A. I. - Arkhipova, S. S. - Nikolsky, E. E. - Vyskočil, František . Immunocytochemical demonstration of M1 muscarinic acetylcholine receptors at the presynaptic and postsynaptic membranes of rat diaphragm endplates . Physiological Research, 2011, Vol. 60, 1, p. 185-188 . IF = 1.555 [ASEP]

Kořínek, Miloslav - Kapras, Vojtěch - Vyklický, Vojtěch - Adamusová, Eva - Borovská, Jiřina - Valeš, Karel - Stuchlík, Aleš - Horák, Martin - Chodounská, Hana - Vyklický ml., Ladislav . Neurosteroid modulation of N-methyl-d-aspartate receptors: Molecular mechanism and behavioral effects . Steroids, 2011, Vol. 76, 13, p. 1409-1418 . IF = 2.829 [ASEP] [ doi ]

Kaniaková, Martina - Lindovský, Jiří - Krůšek, Jan - Adámek, S. - Vyskočil, František . Dual effect of lobeline on alpha 4 beta 2 rat neuronal nicotinic receptors . European Journal of Pharmacology, 2011, Vol. 658, 2-3, p. 108-113 . IF = 2.516 [ASEP] [ doi ]

Adámek, S. - Vyskočil, František . Potassium-selective microelectrode revealed difference in threshold potassium concentration for cortical spreading depression in female and male rat brain . Brain Research, 2011, Vol. 1370, -, p. 215-219 . IF = 2.728 [ASEP] [ doi ]

Osičková, Adriana - Mašín, Jiří - Fayolle, C. - Krůšek, Jan - Basler, Marek - Pospíšilová, Eva - Leclerc, C. - Osička, Radim - Šebo, Peter . Adenylate cyclase toxin translocates across target cell membrane without forming a pore . Molecular Microbiology, 2010, Vol. 75, 6, p. 1550-1562 . IF = 4.819 [ASEP] [ doi ]

Kořínek, Miroslav - Sedláček, Miloslav - Cais, Ondřej - Dittert, Ivan - Vyklický ml., Ladislav . Temperature dependence of N-methyl-d-aspartate receptor channels and N-methyl-d-aspartate receptor excitatory postsynaptic currents . Neuroscience, 2010, Vol. 165, 3, p. 736-748 . IF = 3.215 [ASEP] [ doi ]

Boukalová, Štěpána - Maršáková, Lenka - Teisinger, Jan - Vlachová, Viktorie . Conserved Residues within the Putative S4–S5 Region Serve Distinct Functions among Thermosensitive Vanilloid Transient Receptor Potential (TRPV) Channels . Journal of Biological Chemistry, 2010, Vol. 285, 53, p. 41455-41462 . IF = 5.328 [ASEP] [ doi ]

Adámek, S. - Shakirzyanova, V. - Malomouzh, A. I. - Naumenko, N. V. - Vyskočil, František . Interaction of glutamate- and adenosine-induced decrease of acetylcholine quantal release at frog neuromuscular junction . Physiological Research, 2010, Vol. 59, 5, p. 803-810 . IF = 1.646 [ASEP]

Šťastná, Eva - Chodounská, Hana - Pouzar, Vladimír - Kapras, Vojtěch - Borovská, Jiřina - Cais, Ondřej - Vyklický ml., Ladislav . Synthesis of C3, C5, and C7 pregnane derivatives and their effect on NMDA receptor responses in cultured rat hippocampal neurons . Steroids, 2009, Vol. 74, 2, p. 256-263 . IF = 2.905 [ASEP] [ doi ]

Vyskočil, František - Malomouzh, A. I. - Nikolsky, E. E. Non-quantal acetylcholine release at the neuromuscular junction . Physiological Research, 2009, Vol. 58, 6, p. 763-784 . IF = 1.430 [ASEP]

Tyapkina, O. - Volkov, E. - Nurullin, L. - Shenkman, B. - Kozlovskaya, I. - Nikolsky, E. - Vyskočil, František . Resting membrane potential and Na+,K+-ATPase of rat fast and slow muscles during modeling of hypogravity . Physiological Research, 2009, Vol. 58, 4, p. 599-603 . IF = 1.430 [ASEP]

Shaihutdinova, A.R. - Nikolsky, E. E. - Vyskočil, František - Skorinkin, A.I. Mechanisms of the inhibition of endplate acetylcholine receptors by antiseptic chlorhexidine (experiments and models) . Naunyn-Schmiedeberg's Archiv of Pharmacology, 2009, Vol. 380, 6, p. 551-560 . IF = 2.631 [ASEP] [ doi ]

Petrovič, Miloš - Sedláček, Miloslav - Cais, Ondřej - Horák, Martin - Chodounská, Hana - Vyklický ml., Ladislav . Pregnenolone sulfate modulation of N-methyl-d-aspartate receptors is phosphorylation dependent . Neuroscience, 2009, Vol. 160, 3, p. 616-628 . IF = 3.292 [ASEP] [ doi ]

Petrov, K. - Kovyazina, I. - Zobov, V. - Bukharaeva, E. - Nikolsky, E. E. - Vyskočil, František . Different sensitivity of miniature endplate currents in rat external and internal intercostal muscles to the acetylcholinesterase inhibitor C-547 as compared with diaphragm and extensor digitorum Pontus . Physiological Research, 2009, Vol. 58, 1, p. 149-153 . IF = 1.430 [ASEP]

Brantová, O. - Asfaw, B. - Sládková, J. - Poupětová, H. - Živný, J. - Magner, M. - Krůšek, Jan - Veselá, K. - Hansíková, H. - Ledvinová, J. - Tesařová, M. - Zeman, J. Ultrastructural and functional abnormalities of mitochondria in cultivated fibroblasts from α -mannosidosis patiens . Biologia, 2009, Vol. 64, 2, p. 394-401 . IF = 0.617 [ASEP] [ doi ]

Benedikt, Jan - Samad, Abdul - Ettrich, Rüdiger - Teisinger, Jan - Vlachová, Viktorie . Essential role for the putative S6 inner pore region in the activation gating of the human TRPA1 channel . Biochimica Et Biophysica Acta-Molecular Cell Research, 2009, Vol. 1793, 7, p. 1279-1288 . IF = 4.374 [ASEP] [ doi ]

Vyklický st., Ladislav - Nováková-Toušová, Karolina - Benedikt, Jan - Samad, Abdul - Touška, Filip - Vlachová, Viktorie . Calcium-dependent desensitization of vanilloid receptor TRPV1: a mechanism possibly involved in analgesia induced by topical application of capsaicin . Physiological Research, 2008, Vol. 57, Suppl.3, S59-S68 . IF = 1.653 [ASEP]

Skorinkin, A.I. - Shaihutdinova, A.R. - Vyskočil, František . Model of concentration changes across the synaptic cleft during a single quantum release . General Physiology and Biophysics, 2008, Vol. 27, 1, p. 19-24 . IF = 0.697 [ASEP]

Sedláček, Miloslav - Kořínek, Miroslav - Petrovič, Miloš - Cais, Ondřej - Adamusová, Eva - Chodounská, Hana - Vyklický ml., Ladislav . Neurosteroid modulation of ionotropic glutamate receptors and excitatory synaptic transmission . Physiological Research, 2008, Vol. 57, Suppl.3, S49-S57 . IF = 1.653 [ASEP]

Petrovič, Miloš - Valeš, Karel - Putnikovič, B. - Djulejič, V. - Mitrovič, D. M. Ryanodine receptors, voltage-gated calcium channels and their relationship with protein kinase A in the myocardium . Physiological Research, 2008, Vol. 57, 2, p. 141-149 . IF = 1.653 [ASEP]

Ostašov, Pavel - Krůšek, Jan - Durchánková, Dana - Svoboda, Petr - Novotný, Jiří . Ca2plus responses to thyrotropin-releasing hormone and angiotensin II: the role of plasma membrane integrity and effect of G11 protein overexpression on homologous and heterologous desensitization . Cell Biochemistry and Function, 2008, Vol. 26, 2, p. 264-274 . IF = 1.333 [ASEP] [ doi ]