Studied Diseases
Our research is focused on investigating the genetic origin of severe human diseases as well as explaining their pathogenesis. We aim to improve diagnostic techniques and to develop new methods for both efficient treatment and prevention.
- Brain
- Heart
- Metabolism
Alzheimer's Disease
Neuropathic Pain
Pain usually warns us that there is a possibly damaging stimulation and that we need to act fast to prevent the damage to our body. However, the useful pain sometimes becomes pathologic. MoreDepression
Mood disorders, and mainly depression, belong to the most frequent and life-complicating mental diseases. MoreSchizophrenia
Schizophrenia is a very severe neuropsychiatric disease whose first symptoms appear in the period of adolescence or early adulthood.Epilepsy
Epilepsy is one of the most frequent brain diseases since it affects 1 % of population. The first seizure may be triggered by a variety of events in brain – injury, bleeding, infection, or… MoreCardiac Arrhythmias
In the civilised world, cardiovascular diseases are the most frequent cause of death. The more the population ages, the more frequent cardiac arrhythmias are. MoreChronic Heart Failure
The incidence of chronic heart failure is skyrocketing in Europe. This epidemic has multiple reasons: aging of population, decreased mortality due to cardiac disorders, and wide spreading of… MoreIschemic Heart Disease
The development of ischemic heart disease results from a decreased blood flow through the myocardium, usually caused by arteriosclerosis. The myocardium suffers from ischemia (insufficient blood… MoreHypertension
Hypertension (high blood pressure) is one of the civilisation illnesses that accompany unhealthy lifestyle and spreading obesity.Yeast Infection (Candidosis)
One of the most frequent agents that cause yeast infections are yeasts of the Candida genus. They are a common constituent of human microflora. In the case of weakened immune system (as a consequence… MoreCancer
The Czech Republic is characterized by the highest incidence of colorectal carcinoma.Muscle Atrophy
Compounds that would stop faltering of unused muscles could be beneficial for elderly people, bedridden patients, or astronauts during long-term space missions. MoreInherited Metabolic Disorders
Mitochondria are cell organelles that play the role of a predominant energy producer at the molecular level.Type 2 Diabetes
Diabetes mellitus type 2 (adult-onset diabetes) is one of the most important components of metabolic syndrome. MoreObesity and Metabolic Syndrome
The combination of long-term consumption of excess food and absence of exercise, which is very common today, seriously impairs the energy balance in our organism. More
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