The Department of Experimental Hypertension is studying the mechanisms of blood pressure regulation and end-organ damage in rats with different types of experimental hypertension.
Our research is focused mainly on:
- Study of the central mechanisms of blood pressure regulation in rats with hypertension with a focus on the brain renin-angiotensin system, oxidative stress and baroreflex control of sympathetic tone – cooperation with the Institute for Translational Research in Biomedicine, Kaohsiung, Taiwan and Institute for Clinical and Experimental Medicine, Prague.
- Search for the cardiovascular, renal and metabolic mechanisms of gliflozins, a new group of antidiabetics, in experimental hypertension and chronic kidney disease – cooperation with Institute for Clinical and Experimental Medicine, Prague.
- Elucidation of the mechanisms by which renin-angiotensin and endothelin systems participate in renal damage in transgenic rats with inserted mouse renin gene (Ren-2 TGR) – cooperation with Mossakowski Medical Research Centre, Warsaw, Poland.
- Investigation of the cardiovascular effects of new analogs of neuropeptides regulating food intake in rats – cooperation with IOCHB CAS, Prague.
Projects
Achievements
Institute of Organic Chemistry and Biochemistry of the CAS (IOCB Prague) in collaboration with Institute of Physiology of the CAS developed new compounds with positive effects in experimental animal models of obesity and type II diabetes.
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Our colleagues were very successful at 26th International Meeting of International Society of Hypertension in Seoul - Michal Behuliak was awarded by the 2nd place in the section Young Investigator Award, Anna Vavřínová by Travel Grant and Josef Zicha was awarded by the 2nd place in the section Best Oral Presentation in Basic Sciences.
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Michal Behuliak was granted by the Czech Society for Hypertension, the price was awarded by the general manager of Servier in the Czech Republic.
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Mgr. Michal Behuliak, PhD. was granted with Otto Wicherle prize from the President of Czech Academy of Sciences on Monday, May 30, 2016.
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Publications
Vaněčková, Ivana - Hojná, Silvie - Kadlecová, Michaela - Vernerová, Z. - Kopkan, L. - Červenka, L. - Zicha, Josef
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Renoprotective Effects of ETA Receptor Antagonists Therapy in Experimental Non-Diabetic Chronic Kidney Disease: Is There Still Hope for the Future?
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Physiological Research 2018, roč. 67, Suppl.1, S55-S67
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IF = 1.324
[ASEP]
Šilhavý, Jan - Mlejnek, Petr - Šimáková, Miroslava - Vaněčková, Ivana - Behuliak, Michal - Kuda, Ondřej - Sticová, E. - Jirsa, M. - Pravenec, Michal
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Acute toxic effects of telmisartan in spontaneously hypertensive rats fed a high fructose diet
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Physiological Research 2018, 67(6), 851-856
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IF = 1.324
[ASEP]
Sedláková, L. - Kikerlová, S. - Husková, Z. - Červenková, L. - Čertíková - Chábová, V. - Zicha, Josef - Falck, J. R. - Imig, J. D. - Kompanowska - Jezierska, E. - Sadowski, J. - Krátký, V. - Červenka, L. - Kopkan, L.
20-Hydroxyeicosatetraenoic acid antagonist attenuates the development of malignant hypertension and reverses it once established: a study in Cyp1a1-Ren-2 transgenic rats
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Bioscience Reports 2018, 38(5)), BSR20171496
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IF = 2.899
[ASEP]
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doi
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Rauchová, Hana - Vokurková, Martina - Pavelka, Stanislav - Vaněčková, Ivana - Tribulová, N. - Soukup, Tomáš
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Red palm oil supplementation does not increase blood glucose or serum lipids levels in Wistar rats with different thyroid status
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Physiological Research 2018, roč. 67, 2, p. 307-315
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IF = 1.324
[ASEP]
Popelová, A. - Pražienková, V. - Neprašová, Barbora - Kasperová, B. J. - Hrubá, L. - Holubová, M. - Zemenová, J. - Blum, D. - Železná, B. - Galas, M. C. - Kuneš, Jaroslav - Maletínská, L.
Novel Lipidized Analog of Prolactin-Releasing Peptide Improves Memory Impairment and Attenuates Hyperphosphorylation of Tau Protein in a Mouse Model of Tauopathy
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Journal of Alzheimer's Disease 2018, roč. 62, 4, p. 1725-1736
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IF = 3.476
[ASEP]
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doi
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Popelová, A. - Kákonová, A. - Hrubá, L. - Kuneš, Jaroslav - Maletínská, L. - Železná, B.
Potential neuroprotective and anti-apoptotic properties of a long-lasting stable analog of ghrelin: an in vitro study using SH-SY5Y cells
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Physiological Research 2018, roč. 67, 2, p. 339-346
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IF = 1.324
[ASEP]
Poledne, R. - Zicha, Josef
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Human genome evolution and development of cardiovascular risk factors through natural selection
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Physiological Research 2018, roč. 67, 2, p. 155-163
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IF = 1.324
[ASEP]
Olejníková, Lucie - Polidarová, Lenka - Behuliak, Michal - Sládek, Martin - Sumová, Alena
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Circadian alignment in a foster mother improves the offspring's pathological phenotype
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Journal of Physiology 2018, 596(23), 5757-5775
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IF = 4.540
[ASEP]
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doi
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Mikulášková, Barbora - Holubová, M. - Pražienková, V. - Hrubá, L. - Zemenová, J. - Haluzík, M. - Železná, B. - Kuneš, Jaroslav - Maletínská, L.
Lipidized prolactin-releasing peptide improved glucose tolerance in metabolic syndrome: Koletsky and spontaneously hypertensive rat study
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Nutrition & Diabetes 2018, roč. 8, Jan 16, článku 5
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IF = 2.742
[ASEP]
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doi
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Holubová, M. - Hrubá, L. - Neprašová, Barbora - Majerčíková, Z. - Lacinová, Z. - Kuneš, Jaroslav - Maletínská, L. - Železná, B.
Prolactin-releasing peptide improved leptin hypothalamic signaling in obese mice
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Journal of Molecular Endocrinology 2018, roč. 60, 2, p. 85-94
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IF = 3.297
[ASEP]
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doi
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Overview of alterations in calcium sensitization during development of spontaneously hypertension in the rat The schematic representation of possible regulatory mechanisms involved in RhoA/Rho kinase pathway is demonstrated in normotensive (a), prehypertensive (b) and hypertensive (c) rats.
Recording of contraction of isolated femoral artery stimulated by norepinephrine (NE).
Aorta section – α-actin (red), nuclei (blue) and autofluorescence (green).
Adrenal section stained for tyrosine hydroxylase (detected by Vectastain ABC kit).
Recording of blood pressure.
