Organic Chemistry

Peptide libraries containing small molecule inhibitors will be constructed by click chemistry reactions. The main goal is to identify conjugates with improved selectivity and potency against various enzymes. The project combines organic synthesis, chemical biology and biochemistry experiments.

References
1. Bethany Powell Gray and Kathlynn C. Brown,” Combinatorial Peptide Libraries: Mining for Cell-Binding Peptides” Chemical Reviews 2014, 114, 1020-1081.
2. Craig S. McKay and M.G. Finn, “Click Chemistry in Complex Mixtures: Bioorthogonal Bioconjugation” Chemistry & Biology 2014, 21, 1075-1101.