2017

Ivana Mejdrová, Dominika Chalupská, Pavla Plačková, Christin Müller, Michal Šála, Martin Klíma, Adriana Baumlová, Hubert Hřebabecký, Eliška Procházková, Milan Dejmek, Dmytro Strunin, Jan Weber, Gary Lee, Marika Matoušová, Helena Mertlíková-Kaiserová, John Ziebuhr, Gabriel Birkus, Evžen Bouřa and Radim Nencka:
Rational Design of Novel Highly Potent and Selective Phosphatidylinositol 4-Kinase IIIß (PI4KB) Inhibitors as Broad-Spectrum Antiviral Agents and Tools for Chemical Biology
Journal of Medicinal Chemistry 60(1): 100-118, 2017

Jana Humpolíčková, Ivana Mejdrová, Marika Matoušová, Radim Nencka and Evžen Bouřa:
Fluorescent Inhibitors as Tools To Characterize Enzymes: Case Study of the Lipid Kinase Phosphatidylinositol 4-Kinase IIIß (PI4KB)
Journal of Medicinal Chemistry 60(1): 119-127, 2017

Kamil Hercík, Jaroslav Kozák, Michal Šála, Milan Dejmek, Hubert Hřebabecký, Eva Zborníková, Miroslav Smola, Daniel Růžek, Radim Nencka and Evžen Bouřa:
Adenosine triphosphate analogs can efficiently inhibit the Zika virus RNA-dependent RNA polymerase
Antiviral Research 137: 131-133, 2017

Jakub Šebera, Yoshikazu Hattori, Daichi Sato, David Řeha, Radim Nencka, Takashi Kohno, Chojiro Kojima, Yoshiyuki Tanaka, Vladimír Sychrovský
The mechanism of the glycosylase reaction with hOGG1 base-excision repair enzyme: concerted effect of Lys249 and Asp268 during excision of 8-oxoguanine
Nucleic Acids Research 45(9): 5231-5242, 2017

Kamil Hercik, Jiří Brynda, Radim Nencka, Evžen Bouřa
Structural basis of Zika virus methyltransferase inhibition by sinefungin
Archives of Virology 162(7): 2091-2096, 2017

Luděk Eyer, Darina Zouharová, Jana Širmarová, Martina Fojtíková, Michal Štefánik, Jan Haviernik, Radim Nencka, Erik de Clercq, Daniel Růžek
Antiviral activity of the adenosine analogue BCX4430 against West Nile virus and tick-borne flaviviruses
Antiviral Research 142: 63-67, 2017

Luděk Eyer, Hirofumi Kondo, Darina Zouharová, Minato Hirano James J. Valdés, Memi Muto, Tomáš Kastl, Shintaro Kobayashi, Jan Haviernik, Manabu Igarashi, Hiroaki Kariwa, Markéta Vaculovičová, Jiří Černý, René Kizek, Andrea Kröger, Stefan Lienenklaus, Milan Dejmek, Radim Nencka, Martin Palus, Jiří Salát, Erik De Clercq, Kentaro Yoshii, Daniel Růžek
Escape of tick-borne flavivirus from 2’-C-methylated nucleoside antivirals is mediated by a single conservative mutation in NS5 that has a dramatic effect on viral fitness
Journal of Virology doi: 10.1128/JVI.01028-17