Mini-symposium on new insights about how biological systems can be controlled with light. This traceless reagent enables a vast scope of possibilities to elucidate
the yet undiscovered facets of nature. Photoactivatable compounds such as one- and two-photon cages, molecular switches and activatable fluorophores and sensors
represent important tool for studying and control of biologically relevant processes, such as transcription, translation, protein and DNA folding and biological signalling.
PROGRAM
|
MORNING SESSION
|
| 8:50 – 9:00 |
|
Invitation and opening remarks (Tomáš SLANINA & Zdeněk HOSTOMSKÝ) |
| 9:00 – 9:45 |
|
Plenary talk
Alexander HECKEL |
|
Shedding Light on Nucleic Acids |
|
Research Topic 1: Cages and Switches
|
| 09:45 – 10:05 |
|
Nikolai GREBENOVSKY |
|
Amphidynamic Materials as Molecular Machines |
| 10:05 – 10:25 |
|
Volker HERMANNS |
|
Extending the Photochemical Toolbox |
| 10:25 – 10:45 |
|
Janik KAUFMANN |
|
Development of BODIPY-Based Light-Inducible Antisense Oligonucleotides for RNA Processing in Plants |
| 10:45 – 11:05 |
|
Coffee break |
|
Research Topic 2: RNA Control
|
| 11:05 – 11:25 |
|
Patricia MÜLLER |
|
Development of Light-Inducible AntimiRs as Therapeutic Agents |
| 11:25 – 11:45 |
|
Robin KLIMEK |
|
Regulation of Non-Coding RNA in Neurons |
| 12:05 – 13:30 |
|
Lunch break and discussions |
|
AFTERNOON SESSION
|
|
Research Topic 3: Bioorganic Chemistry of Nucleic Acids
|
| 13:30 – 14:15 |
|
Plenary talk
Michal HOCEK |
|
Modified nucleic acids for diagnostics and chemical biology |
| 14:15 – 14:35 |
|
Zuzana VANÍKOVÁ |
|
Switching of enzymatic cleavage of DNA and transcription through photocaging, deprotection and phosphorylation reactions on DNA |
|
Research Topic 4: 2-Photon Activation
|
| 14:35 – 14:55 |
|
Yvonne BECKER |
|
New Two-Photon Caging Groups and Excitation-Specific Photochemistry |
| 14:55 – 15:15 |
|
Rebekka WEBER |
|
Enhanced Two-Photon Uncaging via Intramolecular FRET |
| 15:15 – 15:30 |
|
Coffee break |
| 15:30 – 15:50 |
|
Tomáš SLANINA |
|
Catch-And-Release: More then bioconjugations |
| 15:50 – 16:35 |
|
Plenary talk
Milan VRÁBEL |
|
Bioorthogonal chemistry of heterodienes: Application in bioimaging and beyond |
| 16:35 – 16:40 |
|
Closing remarks (Tomáš SLANINA) |
|
Information for speakers:
plenary talk: 35 + 10 min, Ph.D. talk: 15 + 5 min, presentations should be uploaded in one block so that talks can follow smoothly
