Central clock in the brain - the suprachiasmatic nucleus. A cross section of the brain at the level of the hypothalamus is shown. Immunohistochemistry (bright field on the left and fluorescence on the right) was used to detect clock cells.
In the center of our interest is the endogenous time-keeping system, circadian clock of mammals, including humans. The system temporally regulates rhythmic processes in our body so that they take place at the proper time of day and are optimally synchronized relative to each other.
A failure of the temporal regulation has a negative impact on human health. Using in vivo and in vitro models, we study the molecular mechanisms underlying the circadian clock as well as the resulting physiological and behavioral rhythms.
We focus on the following questions:
- What are the mechanisms for entraining (synchronizing) the circadian system and what are the consequences of its failure?
- How does the circadian system develop and how is it being entrained during ontogeny?
- How is the circadian system of humans entrained in real life conditions, both in health and in disease?
Projects
We explore the entrainment of the circadian clock and its disorders on various experimental models in vivo and in vitro.
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The mammalian biological clock initiates its ontogenesis already during embryonic development in the maternal uterus. Newborn mammals are equipped with clock running in accordance with the maternal clock. We focus on investigating when and how do the newborn clock develop and entrain.
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Research in our laboratory focuses on the timing system not only in healthy volunteers but also in patients suffering from disorders associated with disrupted sleep pattern. The aim of our projects is to find connections between the functional state of the timing system and those disorders.
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Achievements
New publication: Aging does not compromise in vitro oscillation of the suprachiasmatic nuclei but makes it more vulnerable to constant light
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Publications
Shrestha, T. C. - Šuchmanová, Karolína - Houdek, Pavel - Sumová, Alena - Ralph, M. R.
Implicit time-place conditioning alters Per2 mRNA expression selectively in striatum without shifting its circadian clocks
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Scientific Reports 2018, 8(Oct 19)), 15547
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IF = 4.122
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Petrásek, Tomáš - Vojtěchová, Iveta - Lobellová, Veronika - Popelíková, Anna - Janíková, Martina - Brožka, Hana - Houdek, Pavel - Sládek, Martin - Sumová, Alena - Krištofíková, Z. - Valeš, Karel - Stuchlík, Aleš
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The McGill Transgenic Rat Model of Alzheimer's Disease Displays Cognitive and Motor Impairments, Changes in Anxiety and Social Behavior, and Altered Circadian Activity
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Frontiers in Aging Neuroscience 2018, roč. 10, Aug 28, článku 250
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IF = 3.582
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Olejníková, Lucie - Polidarová, Lenka - Sumová, Alena
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Stress affects expression of the clock gene Bmal1 in the suprachiasmatic nucleus of neonatal rats via glucocorticoid‐dependent mechanism
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Acta Physiologica 2018, roč. 223, 1, článku e13020
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IF = 5.930
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Olejníková, Lucie - Polidarová, Lenka - Behuliak, Michal - Sládek, Martin - Sumová, Alena
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Circadian alignment in a foster mother improves the offspring's pathological phenotype
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Journal of Physiology 2018, 596(23), 5757-5775
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IF = 4.540
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Novosadová, Zuzana - Polidarová, Lenka - Sládek, Martin - Sumová, Alena
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Alteration in glucose homeostasis and persistence of the pancreatic clock in aged mPer2(Luc) mice
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Scientific Reports 2018, roč. 8, Aug 3, článku 11668
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IF = 4.122
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