LVV-Hemorphin-7 Lowers
Blood Pressure in Spontaneously Hypertensive Rats:
Radiotelemetry Study
J. ČEJKA, B. ŽELEZNÁ1, J. VELEK2, J.
ZICHA, J. KUNEŠ
Institute of Physiology, Academy of Sciences of the Czech
Republic and Center for Experimental Research of Cardiovascular
Diseases, 1Institute of Molecular Genetics, and
2Institute of Organic Chemistry and Biochemistry, Academy
of Sciences of the Czech Republic, Prague, Czech Republic
Received June15, 2004
Accepted October1, 2004
Summary
Cardiovascular effects of LVV-hemorphin-7, a member of the
family of fragments from β-chain of human or bovine hemoglobin,
were studied in conscious spontaneously hypertensive (SHR) and
Wistar-Kyoto (WKY) rats by radiotelemetry. Intraperitoneal
injection of hemorphin in a dose of 100 g/kg significantly
decreased blood pressure in SHR, whereas negligible effect was
seen in normotensive WKY rats. Blood pressure changes were
accompanied by reduction of heart rate. In conclusion, a direct
effect of LVV-hemorphin-7 on blood pressure was demonstrated in
SHR. These biologically active peptides could be involved in
blood pressure regulation especially in hypertensive rats, but
the precise mechanism should be elucidated.
Key words
Hemorphin • Blood pressure • Heart rate • Hypertension • Rat
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